2ethyl5,7dimethyl3himidazo[4,5b]pyridine

Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb-/ -T cell activation.

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. 2',3'-cGAMP sodium binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.

Trans-2-butene-1,4-dicarboxylic acid (3-Hexenedioic Acid) is a normal human unsaturated dicarboxylic acid metabolite with increased excretion in patients with Dicarboxylic aciduria caused by fatty acid metabolism disorders The urinary excretion of Trans-2-butene-1,4-dicarboxylic acid is increased in conditions of augmented mobilization of fatty acids or inhibited fatty acid oxidation.

4-Chloro-3-nitrobenzoic acid is a nitric oxide scavenger and has been used to study the effects of nitric oxide on the cardiovascular system and the effects of nitric oxide on the immune system.

(E)-3-(4-Methoxyphenyl)acrylic acid is a small molecule compound isolated from the rhizome of Etlingera pavieana (Pierre ex Gagnep.) R. M. Sm. It is a novel α-glucosidase inhibitor. (E)-3-(4-Methoxyphenyl)acrylic acid has hepatoprotective activity, antiamnesic activity, enhances cognitive effects, and can be used to lower blood pressure sugar.

2-Pyridineethanol is used as an industrial chemistry intermediate.

Ethyl indole-2-carboxylate is a indole derivative. Ethyl indole-2-carboxylate inhibits bezodiazepine receptor with IC50 of 2.2mM.

2-Methyl-4-nitroimidazole (2-MNI) is a heterocyclic compound with antimicrobial, anti-inflammatory, and antitumor activities.2-MNI has been used in a variety of fields including biochemistry, pharmacology, and biotechnology.

2-(4-Methoxyphenyl)acetic acid, a plasma metabolite, is highly sensitive and specific and can be used as a bioindicator to differentiate non-small cell carcinoma patients from healthy controls.

3-Aminopropionitrile fumarate (2:1) (β-Aminopropionitrile fumarate) is an organic compound and antirheumatic agent used in veterinary medicine.

4-(METHYLAMINO)-3-NITROBENZOIC ACID (4-Methylamino-3-nitrobenzoic acid) is an intermediate that is a yellow solid. It is mainly used in the synthesis of dabigatranate intermediates.

2-Butyl-1,2-benzisothiazolin-3-one is an orally available antimicrobial agent with antimicrobial activity commonly used in the pharmaceutical profession and food processing.

2-Acetyl-4-butyramidophenol is gray crystalline powder.

2-Ethylhexyl trans-4-methoxycinnamate is a sunscreen agent.

4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide is an aromatic enigma that is is a metabolite of the antitumor drug rafenil.

Ethyl 4-hydroxyphenylacetate is a selective inhibitor of monoamine oxidase A.

Compound Fr12622 is a useful organic compound for research related to life sciences. The catalog number is Fr12622 and the CAS number is 79047-41-9.

Compound Fr14428 is a useful organic compound for research related to life sciences. The catalog number is Fr14428 and the CAS number is 2458-12-0.

Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can moderately inhibit α-amylase activity, with the IC50 value of 0.03 umol/ml.

Compound Fr13901 is a useful organic compound for research related to life sciences. The catalog number is Fr13901 and the CAS number is 18595-18-1.

3-Hydroxy-1-(4-hydroxyphenyl)propan-1-one (3-Hydroxy-1-(4-hydroxyphenyl)-1-propanone) is a natural product derived from plant source.

Ethyl 3-hydroxybutyrate is a fragrance found in Tribolium castaneum and wine.

(1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid is a potential SSTR4 agonist.

4-Chloro-3-(trifluoromethyl)phenyl isocyanate is a biochemical reagent that can be produced by a series of reactions between o-chlorobenzotrifluoride and acetic anhydride.

4-QUinolinecarboxamide, N-[3-[[[2-[4-(aminosulfonyl)phenyl]ethyl]amino]carbonyl]phenyl]-1,2-dihydro-2-oxo- is an amine.

1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (Xanthohumol) , prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus,is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection.

2-(4-methoxyphenyl)-N-methyl-2-oxoacetamide (2-(4-methoxy-phenyl)-N-methyl-2-oxo-acetamide) is a marine derived natural products found in Polycarpa aurata.

(2S,3S)-3-Hydroxy-2-methyl-3-phenylpropanoic acid is a chemical synthesis intermediate.

Methyl 2-(Boc-aMino)-2-(oxetan-3-yl)acetate can be used as a building block for the synthesis of various biologically active molecules such as peptides, proteins, and nucleic acids.

5-(2-furyl)-N-propylisoxazole-3-carboxamide is a compound used as a molecular structural unit and is thought to be a modulator of NMDA receptors, and has been shown to be protective against glutamate-induced excitotoxicity and oxidative stress in neuronal cells. It has also been found to have anti-inflammatory activity, making it a potential therapeutic agent for diseases such as Alzheimer's disease and Parkinson's disease.

Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.

N-[2-nitro-4-(trifluoromethyl)phenyl]piperazine is a biologically active compound belonging to the piperazine group. It is an important synthetic intermediate used in the preparation of a wide range of drugs, agrochemicals and other chemicals. It is considered an inhibitor of certain enzymes involved in drug metabolism, such as cytochrome P450 enzymes, and has also been shown to have anti-inflammatory and antitumor effects.

((3S,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate is a pharmaceutical intermediate used in the synthesis of posaconazole with anticancer activity.

4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomeric counterpart of SSR-125543. SSR-125543 is a potent CRF-R1 antagonist with Ki = 1.0 nM for human CRF-R1.

1,3-Dimethyl-2-oxobenzimidazole-5-carbaldehyde serves as an intermediate.

Pyridine-4-Acetamide (4-Pyridineacetamide) is a pyridine-based ligand involved in the synthesis of W6S8 clusters.

Methyl 3-[2-[[(4R)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]methylamino]ethyl]benzoate is a biochemical reagent that can be used to synthesize active compounds.

3-Bromo-4-Methoxyphenylacetonitrile (ZINC2565991) is a marine derived natural products found in Aiolochroia crassa.

3- Phenyl- N- [1- (phenylmethyl) - 4- piperidinyl] -tricyclo[3.3.1.13, 7] decane- 1- carboxamide with antiviral activity against Ebola virus that targets the surface-exposed glycoprotein and inhibits viral entry into host cells. In vitro studies in Vero cells revealed the compound inhibits the viral replication with EC50 of 0.38 μM.

3-pyridine toxoflavin is a potent KDM4C inhibitor, IC50=19nM.

2-Hydroxy-3-methoxy chalcone has anticancer activity and inhibits colon cancer.

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea, a TNF-α agonistic compound, could induce cells to secrete TNF- α.

2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxylic acid is commonly used to synthesize compounds with anticancer and antitumor properties.

N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide, a TAU cytotoxicity inhibitor, inhibits LDH leakage of M17-TAU P301L cells with EC50 of 325nM.

1H-Pyrrole-2-carboxylic acid, 4,5-dibromo-1-methyl- (1-methyl-4,5-dibromopyrrole-2-carboxylic acid) is a marine derived natural products found in Agelas flabelliformis.

2-Amino-4'-fluorobenzophenone is a derivative of benzophenone. It is used in the synthesis of p-fluorobenzoyl chloride and has also been used as a fluorescent probe for biochemical studies such as DNA and RNA detection.

ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE used for preparation of pyrimidopyrimidines as protein kinase inhibitors.

PARP-2-IN-3 is used as a potent PARP-2 inhibitor (IC50=0.07 μM) with anti-tumor activity that induces apoptosis and necrosis in cancer cells, and can be used for the study of breast cancer.CAS 번호128-52-56-8

Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagulation factor Xa, and it can be used in the study of thrombophlebitis, atherosclerosis, cerebral embolism, stroke and pulmonary embolism.

1-(2-fluorophenyl)-3-[5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl]urea is a chemical compound.