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Microtubule Associated

Microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton. MAPs bind to the tubulin subunits that make up microtubules to regulate their stability. A large variety of MAPs have been identified in many different cell types, and they have been found to carry out a wide range of functions. These include both stabilizing and destabilizing microtubules, guiding microtubules towards specific cellular locations, cross-linking microtubules and mediating the interactions of microtubules with other proteins in the cell.
Cat No. product name
T41248 Thiocolchicine Thiocolchicine 是一种有效的微管蛋白聚合抑制剂,IC50 为 2.5 µM,Ki 为 0.7 µM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作 ADC 技术中的 ADC 细胞毒素。
T22661 CHM-1 CHM-1 是细胞凋亡的诱导剂,通过激活 Cdc2 激酶活性在人肝细胞癌中显示出有效的抗肿瘤能力。 CHM-1 在体外和体内抑制微管蛋白聚合。
T6897 Monomethyl auristatin E Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug c...
T2543 Cabazitaxel Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docet...
T2060 ELR510444 ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter ...
T9504 MAP4343 Map4343 is a 3-methyl ether derivative of pregnenolone. Map4343 binds to microtubule associated protein 2 (MAP2) in vitro and stimulates tubulin polymerization, ...
T16016 Maytansinol Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro.
T0186 Docetaxel trihydrate Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the the...
T8342 BRD9876 BRD9876 is a selective inhibitor of MM1S growth.
T7003 Leucomethylene blue mesylate TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
TN2256 Taccalonolide B Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits ...
T0006 Methylene Blue trihydrate Methylene blue is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue...
T0320 Colchicine Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin.
T1152 Albendazole Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
T14348 Auristatin E Auristatin E inhibits cell division by blocking the polymerisation of tubulin. Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor a...
T5860 CK-869 CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor(IC50 of 7 μM),and is useful tools for the investigation of the Arp2/3 complex.
T8216 T-1101 tosylate T-1101 tosylate is an inhibitor of Hec1/Nek2, with antitumor activity.
T2502 INH1 INH1 is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.
T6372 Albendazole sulfoxide Albendazole Sulfoxide (Albendazole EP Impurity B) is a metabolite of Albendazole, an anthelmintic.
T13687 Eribulin mesylate Eribulin mesylate (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin mesylate (E7389 mesylate...
T1270 Vincristine sulfate Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spi...
T0838 Triclabendazole Triclabendazole has been used in trials studying Parasitic Disease.
T0968 Paclitaxel Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree. It stabilizes microtubules in their polymerized form leading to cell death.
T2090 Lexibulin Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and lea...
T3256 MMAF Monomethyl auristatin F, an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
T15236 Entasobulin Entasobulin is an inhibitor of β-tubulin polymerization. It has a potential anticancer activity.
T1155 Mebendazole Mebendazole is a hedgehog inhibitor, used as an antihelminthic.
T18312 Mc-MMAE Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a drug-linker conjuga...
T0009 Flubendazole Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
T2220 2-Methoxyestradiol 2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing en...
T1382 Griseofulvin Griseofulvin is an antifungal agent used in the treatment of TINEA infections.
T21632 Myoseverin Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor,...
T0714 Oxfendazole Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
TN2254 Taccalonolide A Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is ...
T8188 Podophyllotoxone Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro.
T9595 LP-261 LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.
T1992 Mertansine Mertansine refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through react...
T1668 Vinblastine sulfate Vinblastine sulfate can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
T0938 Thiabendazole Thiabendazole is a benzimidazole derivative with anthelminthic property.
T6345 Tirbanibulin KX2-391 is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of colon, pancreatic, prostate and breast cance...
T5165 10-Deacetyltaxol Deacetyltaxol is extracted from Taxus brevifolia barks.
T1034 Docetaxel Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).
T3S2372 7-epi-Taxol 1. 7-Epitaxol is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.
T6888 Methylene Blue Methylene Blue(IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T6691 TAI-1 TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
T5170 KHS101 hydrochloride KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.
T1910 Ansamitocin P 3' Ansamitocin P-3 is an antibody-drug conjugate cytotoxin with antitumor activity.
T6490 Epothilone A Epothilone A is a microtubule-stabilizing agent with EC0.01 of 2 μM.
T2802 Nocodazole Nocodazole is a synthetic inhibitor of microtubule polymerization, also inhibits Abl (IC50: 0.21 μM), Abl(E255K, IC50: 0.53 μM) and Abl(T315I, IC50: 0.64 μM) in ...
T13278 Valecobulin hydrochloride Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine prodrug of S516 and a vascular disrupting agent (VDA). It is a potent inhibitor of β-tubulin polyme...
Thiocolchicine
T41248
Thiocolchicine 是一种有效的微管蛋白聚合抑制剂,IC50 为 2.5 µM,Ki 为 0.7 µM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作...
CHM-1
T22661
Monomethyl auristatin E
T6897
Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug c...
Cabazitaxel
T2543
Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docet...
ELR510444
T2060
ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter ...
MAP4343
T9504
Map4343 is a 3-methyl ether derivative of pregnenolone. Map4343 binds to microtubule associated protein 2 (MAP2) in vitro and stimulates tubulin polymerization, ...
Maytansinol
T16016
Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro.
Docetaxel trihydrate
T0186
Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the the...
BRD9876
T8342
BRD9876 is a selective inhibitor of MM1S growth.
Leucomethylene blue mesylate
T7003
TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
Taccalonolide B
TN2256
Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits ...
Methylene Blue trihydrate
T0006
Methylene blue is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue...
Colchicine
T0320
Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin.
Albendazole
T1152
Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
Auristatin E
T14348
Auristatin E inhibits cell division by blocking the polymerisation of tubulin. Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor a...
CK-869
T5860
CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor(IC50 of 7 μM),and is useful tools for the investigation of the Arp2/3 complex.
T-1101 tosylate
T8216
T-1101 tosylate is an inhibitor of Hec1/Nek2, with antitumor activity.
INH1
T2502
INH1 is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.
Albendazole sulfoxide
T6372
Albendazole Sulfoxide (Albendazole EP Impurity B) is a metabolite of Albendazole, an anthelmintic.
Eribulin mesylate
T13687
Eribulin mesylate (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin mesylate (E7389 mesylate...
Vincristine sulfate
T1270
Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spi...
Triclabendazole
T0838
Triclabendazole has been used in trials studying Parasitic Disease.
Paclitaxel
T0968
Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree. It stabilizes microtubules in their polymerized form leading to cell death.
Lexibulin
T2090
Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and lea...
MMAF
T3256
Monomethyl auristatin F, an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
Entasobulin
T15236
Entasobulin is an inhibitor of β-tubulin polymerization. It has a potential anticancer activity.
Mebendazole
T1155
Mebendazole is a hedgehog inhibitor, used as an antihelminthic.
Mc-MMAE
T18312
Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a drug-linker conjuga...
Flubendazole
T0009
Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
2-Methoxyestradiol
T2220
2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing en...
Griseofulvin
T1382
Griseofulvin is an antifungal agent used in the treatment of TINEA infections.
Myoseverin
T21632
Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor,...
Oxfendazole
T0714
Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
Taccalonolide A
TN2254
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is ...
Podophyllotoxone
T8188
Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro.
LP-261
T9595
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.
Mertansine
T1992
Mertansine refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through react...
Vinblastine sulfate
T1668
Vinblastine sulfate can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
Thiabendazole
T0938
Thiabendazole is a benzimidazole derivative with anthelminthic property.
Tirbanibulin
T6345
KX2-391 is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of colon, pancreatic, prostate and breast cance...
10-Deacetyltaxol
T5165
Deacetyltaxol is extracted from Taxus brevifolia barks.
Docetaxel
T1034
Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).
7-epi-Taxol
T3S2372
1. 7-Epitaxol is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.
Methylene Blue
T6888
Methylene Blue(IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
TAI-1
T6691
TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
KHS101 hydrochloride
T5170
KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.
Ansamitocin P 3'
T1910
Ansamitocin P-3 is an antibody-drug conjugate cytotoxin with antitumor activity.
Epothilone A
T6490
Epothilone A is a microtubule-stabilizing agent with EC0.01 of 2 μM.
Nocodazole
T2802
Nocodazole is a synthetic inhibitor of microtubule polymerization, also inhibits Abl (IC50: 0.21 μM), Abl(E255K, IC50: 0.53 μM) and Abl(T315I, IC50: 0.64 μM) ...
Valecobulin hydrochloride
T13278
Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine prodrug of S516 and a vascular disrupting agent (VDA). It is a potent inhibitor of β-tubulin polym...
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