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PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.
Cat No. product name
T9816 Arofylline Arofylline 是一种 PDE4 抑制剂,可用于哮喘的研究。
T27475 GSK356278 GSK356278 是一种有效的特异性磷酸二酯酶 4 (PDE4) 抑制剂,对人 PDE4A、PDE4B 和 PDE4D 的 pIC50 分别为 8.6、8.8 和 8.7。 GSK356278 具有抗炎、抗焦虑和增强认知的作用。
T3783 Fraxin Fraxin is a glucoside of fraxetin.
T1164 Sildenafil Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction and reduce symptoms of pulmonary arterial hypertension (PAH).
T2923 Apremilast Apremilast (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
T1681 Aminophylline Aminophylline is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.
T11533 HA155 HA-155 is a selective and potent autotaxin (ATX) inhibitor (IC50: 5.7 nM).
TN2217 Sophoflavescenol Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
T0462 Cilostazol Cilostazol is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.
T0167 Vinpocetine Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T0383 Fenspiride hydrochloride Fenspiride, an oxazolidinone spiro compound, is a drug used in the therapy of certain respiratory diseases. It is approved for use in Russia for the therapy of c...
T7876 Acetildenafil Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.
T19706 Ro 20-1724 Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase(PDE4;IC50 = 2.0 μM).
T0892 Diphylline Dyphylline is a xanthine derivative. Dyphilline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Dyphilline probably act...
T31101 CRT0273750 CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies.
T6649 (S)-(+)-Rolipram S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous s...
T2855 Icariin Icariin is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
T20792 W-7 hydrochloride W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has...
T19865 GEBR-7b GEBR-7b is a phosphodiesterase-4 (PDE4) inhibitor. GEBR-7b also stops or slows the hydrolysis of cAMP. It increases the level of cAMP in the hippocampus without ...
TP1909L1 CALP2 acetate(261969-04-4 free base) CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM. CALP2 acetate potently i...
T0070 Pentoxifylline Pentoxifylline modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase a...
T1024 Roflumilast Roflumilast is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activitie...
T2530 Levosimendan Levosimendan is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calci...
T10590 Zatolmilast BPN14770 is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).
T1056 Isoprenaline hydrochloride Isoproterenol is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties.
T2205 Acefylline Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
T22851 ICI 63197 PDE4 inhibitor
T1083L Theophylline monohydrate Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
T3224 TBA-7371 DprE1-IN-1 is a potent inhibitor of DprE1 and PDE6.
T1398 Tadalafil Tadalafil is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phos...
T6427 Butein Butein, a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EG...
T0264 Zomepirac sodium salt Zomepirac sodium salt is a prostaglandin synthetase inhibitor.
T6462 Deltarasin Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
T5S2059 Glaucine Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 produ...
T16499 Mardepodect Mardepodect is an effective and selective PDE10A inhibitor (IC50: 0.37 nM). Mardepodect has >1000-fold selectivity over other PDEs. Mardepodect can cross the blo...
T0467 Sildenafil citrate Sildenafil, a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) Inhibitor, is used extensively for erectile dysfunction and less com...
T12267 NSP-805 NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.
T0705 Triflusal Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
T1027 Luteolin Luteolin is a naturally occurring flavonoid. The flavonoids are polyphenolic compounds found as integral components of the human diet. In vitro work has concentr...
T7888 Enpp-1-IN-1 Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)
T0458 Indomethacin Indomethacin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
T23154 Piclamilast PDE4 inhibitor
T3465 Vesnarinone Vesnarinone (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal neg...
T5940 Proxyphylline Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and ...
T27172 Difamilast Difamilast is an inhibitor of phosphodiesterase IV.
T1418 Bucladesine sodium Bucladesine, PKA activator, is a cyclic nucleotide derivative that mimics the action of endogenous cAMP and is capable of permeating the cell membrane. It has va...
T6644 Rolipram Rolipram is a phosphodiesterase 4 inhibitor with antidepressant properties.
T0480 Doxofylline Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown...
T25376 Ensifentrine Ensifentrine is a inhibitor of phosphodiesterase.
T16164 MY-5445 MY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki: 1.3 μM).
Arofylline
T9816
Arofylline 是一种 PDE4 抑制剂,可用于哮喘的研究。
GSK356278
T27475
Fraxin
T3783
Fraxin is a glucoside of fraxetin.
Sildenafil
T1164
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction and reduce symptoms of pulmonary arterial hypertension (PAH).
Apremilast
T2923
Apremilast (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
Aminophylline
T1681
Aminophylline is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.
HA155
T11533
HA-155 is a selective and potent autotaxin (ATX) inhibitor (IC50: 5.7 nM).
Sophoflavescenol
TN2217
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
Cilostazol
T0462
Cilostazol is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.
Vinpocetine
T0167
Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
Fenspiride hydrochloride
T0383
Fenspiride, an oxazolidinone spiro compound, is a drug used in the therapy of certain respiratory diseases. It is approved for use in Russia for the therapy of c...
Acetildenafil
T7876
Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.
Ro 20-1724
T19706
Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase(PDE4;IC50 = 2.0 μM).
Diphylline
T0892
Dyphylline is a xanthine derivative. Dyphilline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Dyphilline probably act...
CRT0273750
T31101
CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies.
(S)-(+)-Rolipram
T6649
S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous ...
Icariin
T2855
Icariin is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
W-7 hydrochloride
T20792
W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has...
GEBR-7b
T19865
GEBR-7b is a phosphodiesterase-4 (PDE4) inhibitor. GEBR-7b also stops or slows the hydrolysis of cAMP. It increases the level of cAMP in the hippocampus without ...
CALP2 acetate(261969-04-4 free base)
TP1909L1
CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM. CALP2 acetate potently ...
Pentoxifylline
T0070
Pentoxifylline modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase a...
Roflumilast
T1024
Roflumilast is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activitie...
Levosimendan
T2530
Levosimendan is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calci...
Zatolmilast
T10590
BPN14770 is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).
Isoprenaline hydrochloride
T1056
Isoproterenol is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties.
Acefylline
T2205
Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
ICI 63197
T22851
PDE4 inhibitor
Theophylline monohydrate
T1083L
Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
TBA-7371
T3224
DprE1-IN-1 is a potent inhibitor of DprE1 and PDE6.
Tadalafil
T1398
Tadalafil is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phos...
Butein
T6427
Butein, a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit E...
Zomepirac sodium salt
T0264
Zomepirac sodium salt is a prostaglandin synthetase inhibitor.
Deltarasin
T6462
Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
Glaucine
T5S2059
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 produ...
Mardepodect
T16499
Mardepodect is an effective and selective PDE10A inhibitor (IC50: 0.37 nM). Mardepodect has >1000-fold selectivity over other PDEs. Mardepodect can cross the blo...
Sildenafil citrate
T0467
Sildenafil, a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) Inhibitor, is used extensively for erectile dysfunction and less com...
NSP-805
T12267
NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.
Triflusal
T0705
Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
Luteolin
T1027
Luteolin is a naturally occurring flavonoid. The flavonoids are polyphenolic compounds found as integral components of the human diet. In vitro work has concentr...
Enpp-1-IN-1
T7888
Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)
Indomethacin
T0458
Indomethacin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
Piclamilast
T23154
PDE4 inhibitor
Vesnarinone
T3465
Vesnarinone (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal neg...
Proxyphylline
T5940
Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and ...
Difamilast
T27172
Difamilast is an inhibitor of phosphodiesterase IV.
Bucladesine sodium
T1418
Bucladesine, PKA activator, is a cyclic nucleotide derivative that mimics the action of endogenous cAMP and is capable of permeating the cell membrane. It has va...
Rolipram
T6644
Rolipram is a phosphodiesterase 4 inhibitor with antidepressant properties.
Doxofylline
T0480
Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown...
Ensifentrine
T25376
Ensifentrine is a inhibitor of phosphodiesterase.
MY-5445
T16164
MY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki: 1.3 μM).
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