PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat. No.	Product name	CAS No.	Purity
T67815	Uk-50001	857900-47-1	98%
T67815	uk-50001 is a phosphodiesterase (PDE) 4 inhibitor that can be used for many diseases, especially inflammation, allergies, respiratory diseases, disorders and con...
T28881	Sulmazole	73384-60-8	98%
T28881	Sulmazole is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Sulmazole has been ...
T31020	CP 461	227619-96-7	98%
T31020	CP 461, a specific PDE2A inhibitor, is a novel pro-apoptotic compound that inhibits cyclic GMP phosphodiesterase but not cyclooxygenase-1 or -2. CP 461 inhibits ...
T33422	MK-0873	500355-52-2	98%
T33422	MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.
T10409	ATX inhibitor 5	2402772-45-4	98%
T10409	ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50 : 15.3 nM) that reduces the level of CCl4-induced hepatic fibrosis and has anti-hep...
T67965	Torbafylline	105102-21-4	98%
T67965	Torbafylline, a xanthine derivative, is a phosphodiesterase (PDE) inhibitor that attenuates burn-induced protein hydrolysis in rat skeletal muscle through activa...
T3465L	Vesnarinone HCl	T3465L	98%
T3465L	Vesnarinone HCl is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decrea...
T27632	Isomazole	86315-52-8	98%
T27632	Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.
T33589	Nanterinone	102791-47-9	98%
T33589	Nanterinone, an orally available partial phosphodiesterase inhibitor, is a novel positive inotropic and balanced vasodilator compound.Nanterinone, when administe...
T31792	Filaminast	141184-34-1	98%
T31792	Filaminast is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.
T25373	EMD57439	148714-88-9	98%
T25373	EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).
T28991	Tofimilast	185954-27-2	98%
T28991	Tofimilast, a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.
T68138	Saterinone	102669-89-6	98%
T68138	Saterinone is a potent and selective phosphodiesterase III inhibitor and a potent antagonist of the vascular α-1-adrenoceptor. Saterinone has vasodilatory proper...
T28367	PF-04822163	1798334-07-2	98%
T28367	PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.
T4480	Vardenafil dihydrochloride	224789-15-5	98%
T4480	Vardenafil dihydrochloride is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
TN2217	Sophoflavescenol	216450-65-6	98%
TN2217	Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
T19706	Ro 20-1724	29925-17-5	98%
T19706	Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase(PDE4;IC50 = 2.0 μM).
T12315	OR-1896	220246-81-1	98%
T12315	OR-1896 is an active long-lived Levosimendan metabolite, is a highly selective inhibitor of phosphodiesterase (PDE) III isoformand a powerful vasodilator.
T22491	2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide	107522-19-0	98%
T22491	2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.
T10994	Deltasonamide 2	2088485-34-9	98%
T10994	Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.