PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat No.	product name
T9816	Arofylline	Arofylline 是一种 PDE4 抑制剂，可用于哮喘的研究。
T27475	GSK356278	GSK356278 是一种有效的特异性磷酸二酯酶 4 (PDE4) 抑制剂，对人 PDE4A、PDE4B 和 PDE4D 的 pIC50 分别为 8.6、8.8 和 8.7。 GSK356278 具有抗炎、抗焦虑和增强认知的作用。
T3783	Fraxin	Fraxin is a glucoside of fraxetin.
T1164	Sildenafil	Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction and reduce symptoms of pulmonary arterial hypertension (PAH).
T2923	Apremilast	Apremilast (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
T1681	Aminophylline	Aminophylline is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.
T11533	HA155	HA-155 is a selective and potent autotaxin (ATX) inhibitor (IC50: 5.7 nM).
TN2217	Sophoflavescenol	Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
T0462	Cilostazol	Cilostazol is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.
T0167	Vinpocetine	Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T0383	Fenspiride hydrochloride	Fenspiride, an oxazolidinone spiro compound, is a drug used in the therapy of certain respiratory diseases. It is approved for use in Russia for the therapy of c...
T7876	Acetildenafil	Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.
T19706	Ro 20-1724	Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase(PDE4;IC50 = 2.0 μM).
T0892	Diphylline	Dyphylline is a xanthine derivative. Dyphilline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Dyphilline probably act...
T31101	CRT0273750	CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies.
T6649	(S)-(+)-Rolipram	S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous s...
T2855	Icariin	Icariin is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
T20792	W-7 hydrochloride	W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has...
T19865	GEBR-7b	GEBR-7b is a phosphodiesterase-4 (PDE4) inhibitor. GEBR-7b also stops or slows the hydrolysis of cAMP. It increases the level of cAMP in the hippocampus without ...
TP1909L1	CALP2 acetate(261969-04-4 free base)	CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM. CALP2 acetate potently i...
T0070	Pentoxifylline	Pentoxifylline modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase a...
T1024	Roflumilast	Roflumilast is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activitie...
T2530	Levosimendan	Levosimendan is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calci...
T10590	Zatolmilast	BPN14770 is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).
T1056	Isoprenaline hydrochloride	Isoproterenol is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties.
T2205	Acefylline	Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
T22851	ICI 63197	PDE4 inhibitor
T1083L	Theophylline monohydrate	Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
T3224	TBA-7371	DprE1-IN-1 is a potent inhibitor of DprE1 and PDE6.
T1398	Tadalafil	Tadalafil is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phos...
T6427	Butein	Butein, a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EG...
T0264	Zomepirac sodium salt	Zomepirac sodium salt is a prostaglandin synthetase inhibitor.
T6462	Deltarasin	Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
T5S2059	Glaucine	Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 produ...
T16499	Mardepodect	Mardepodect is an effective and selective PDE10A inhibitor (IC50: 0.37 nM). Mardepodect has >1000-fold selectivity over other PDEs. Mardepodect can cross the blo...
T0467	Sildenafil citrate	Sildenafil, a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) Inhibitor, is used extensively for erectile dysfunction and less com...
T12267	NSP-805	NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.
T0705	Triflusal	Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
T1027	Luteolin	Luteolin is a naturally occurring flavonoid. The flavonoids are polyphenolic compounds found as integral components of the human diet. In vitro work has concentr...
T7888	Enpp-1-IN-1	Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)
T0458	Indomethacin	Indomethacin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
T23154	Piclamilast	PDE4 inhibitor
T3465	Vesnarinone	Vesnarinone (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal neg...
T5940	Proxyphylline	Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and ...
T27172	Difamilast	Difamilast is an inhibitor of phosphodiesterase IV.
T1418	Bucladesine sodium	Bucladesine, PKA activator, is a cyclic nucleotide derivative that mimics the action of endogenous cAMP and is capable of permeating the cell membrane. It has va...
T6644	Rolipram	Rolipram is a phosphodiesterase 4 inhibitor with antidepressant properties.
T0480	Doxofylline	Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown...
T25376	Ensifentrine	Ensifentrine is a inhibitor of phosphodiesterase.
T16164	MY-5445	MY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki: 1.3 μM).