PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat. No.	Product name	CAS No.	Purity
T12372	PAT-505	1782070-22-7	98%
T12372	PAT-505 is a selective, noncompetitive and orally available inhibitor of autotaxin(IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma)....
T16272	Naproxen etemesil	385800-16-8	98%
T16272	Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naprox...
T16482	PF-05085727	1415637-72-7	98%
T16482	PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11. PF-05085727 is an effective, selective and brain penetrant inhibitor of cGMP-dependent ...
T12315	OR-1896	220246-81-1	98%
T12315	OR-1896 is an active long-lived Levosimendan metabolite, is a highly selective inhibitor of phosphodiesterase (PDE) III isoformand a powerful vasodilator.
T10316	AN3199	1187187-10-5	98%
T10316	AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.
T10416	Autotaxin-IN-4	2156655-86-4	98%
T10416	Autotaxin-IN-4 is an Autotaxin inhibitor extracted from patent WO2018212534A1 (compound 51). It has the potential to treat idiopathic pulmonary fibrosis.
T63190	Cudetaxestat	1782070-21-6	98%
T63190	Cudetaxestat (BLD-0409) is a potent and orally active inhibitor of autotaxin (ATX).
T10417	Autotaxin-IN-5	2156655-99-9	98%
T10417	Autotaxin-IN-5 is an Autotaxin inhibitor extracted from patent WO2018212534A1 (compound 63). It has the potential to treat idiopathic pulmonary fibrosis.
T13232	TyK2-IN-2	2098466-94-3	98%
T13232	TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
T10994L	Deltasonamide 2 hydrochloride	T10994L	98%
T10994L	Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.
T0096	Vardenafil	224785-90-4	98%
T0096	Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific ...
TN1843	Kushenol K	101236-49-1	98%
TN1843	Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K s...
T14962	CI-1044	197894-84-1	98%
T14962	CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).
T16484	PF-05180999	1394033-54-5	98%
T16484	PF-05180999 is an inhibitor of phosphodiesterase 2A (IC50: 1.6 nM).
TN2095	Pomiferin	572-03-2	98%
TN2095	Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
TN4665	Norbraylin	60796-64-7	98%
TN4665	Norbraylin is a natural product from Toddalia asiatica.
T10481L	BAY 73-6691	794568-92-6	98%
T10481L	BAY 73-6691 is an inhibitor of brain penetrant PDE9A.
T12394	PDE5-IN-2	2244517-61-9	98%
T12394	PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)
T16976	TAK-915	1476727-50-0	98%
T16976	TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM). TAK-915 is >4100-fold more selectivity for PDE2A than...
T14352	Autotaxin-IN-1	1619971-30-0	98%
T14352	Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treat...