T12372 |
PAT-505
|
1782070-22-7
|
98%
|
|
PAT-505 is a selective, noncompetitive and orally available inhibitor of autotaxin(IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma)....
|
T16272 |
Naproxen etemesil
|
385800-16-8
|
98%
|
|
Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naprox...
|
T16482 |
PF-05085727
|
1415637-72-7
|
98%
|
|
PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11. PF-05085727 is an effective, selective and brain penetrant inhibitor of cGMP-dependent ...
|
T12315 |
OR-1896
|
220246-81-1
|
98%
|
|
OR-1896 is an active long-lived Levosimendan metabolite, is a highly selective inhibitor of phosphodiesterase (PDE) III isoformand a powerful vasodilator.
|
T10316 |
AN3199
|
1187187-10-5
|
98%
|
|
AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.
|
T10416 |
Autotaxin-IN-4
|
2156655-86-4
|
98%
|
|
Autotaxin-IN-4 is an Autotaxin inhibitor extracted from patent WO2018212534A1 (compound 51). It has the potential to treat idiopathic pulmonary fibrosis.
|
T63190 |
Cudetaxestat
|
1782070-21-6
|
98%
|
|
Cudetaxestat (BLD-0409) is a potent and orally active inhibitor of autotaxin (ATX).
|
T10417 |
Autotaxin-IN-5
|
2156655-99-9
|
98%
|
|
Autotaxin-IN-5 is an Autotaxin inhibitor extracted from patent WO2018212534A1 (compound 63). It has the potential to treat idiopathic pulmonary fibrosis.
|
T13232 |
TyK2-IN-2
|
2098466-94-3
|
98%
|
|
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
|
T10994L |
Deltasonamide 2 hydrochloride
|
T10994L
|
98%
|
|
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.
|
T0096 |
Vardenafil
|
224785-90-4
|
98%
|
|
Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific ...
|
TN1843 |
Kushenol K
|
101236-49-1
|
98%
|
|
Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K s...
|
T14962 |
CI-1044
|
197894-84-1
|
98%
|
|
CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).
|
T16484 |
PF-05180999
|
1394033-54-5
|
98%
|
|
PF-05180999 is an inhibitor of phosphodiesterase 2A (IC50: 1.6 nM).
|
TN2095 |
Pomiferin
|
572-03-2
|
98%
|
|
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
|
TN4665 |
Norbraylin
|
60796-64-7
|
98%
|
|
Norbraylin is a natural product from Toddalia asiatica.
|
T10481L |
BAY 73-6691
|
794568-92-6
|
98%
|
|
BAY 73-6691 is an inhibitor of brain penetrant PDE9A.
|
T12394 |
PDE5-IN-2
|
2244517-61-9
|
98%
|
|
PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)
|
T16976 |
TAK-915
|
1476727-50-0
|
98%
|
|
TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM). TAK-915 is >4100-fold more selectivity for PDE2A than...
|
T14352 |
Autotaxin-IN-1
|
1619971-30-0
|
98%
|
|
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treat...
|