8(14)-abietenic acid

8(14)-Abietenic acid, a racemic abietane diterpenoid, functions as a dual activator of PPARα/γ.

8-Amino-1-Naphthalenesulfonic Acid is a naphthalene derivative used as a fluorescent dye and as a reagent in organic synthesis. It is a highly fluorescent compound with a high Stokes shift, making it an ideal fluorescent marker for a wide range of biological systems.

Oleuropeic acid 8-O-glucoside is a natural product for research related to life sciences. The catalog number is TN4706 and the CAS number is 865887-46-3.

(3ξ,4ξ,5ξ,6ξ,7ξ,11ξ)-3,6-Dihydroxy-8-oxo-9-eremophilene-12-oic acid, a phytotoxin recently identified in Alternaria alternata ssp. tenuissima isolates, is associated with fruit spots on apples.

7,10-dihydroxy-8(E)-Octadecenoic acid is a hydroxy fatty acid and metabolite of oleic acid that is produced byP. aeruginosafrom vegetable oils.1It is active against the food-borne pathogenic bacteriaS. aureus,S. typhimurium,L. monocytogenes,B. subtilis, andE. coli(MIC50s = 31.3, 125, 125, 62.5, and 250 μg/ml, respectively), as well as the plant pathogenic bacteriaErwinia,R. solanacearum,C. glutamicum, andP. syringae(MIC90s = 125, 125, 250, and 500 μg/ml, respectively).2,1 1.Sohn, H.-R., Bae, J.-H., Hou, C.T., et al.Antibacterial activity of a 7,10-dihydroxy-8(E)-octadecenoic acid against plant pathogenic bacteriaEnzyme Microb. Technol.53(3)152-153(2013) 2.Chen, K.Y., Kim, I.H., Hou, C.T., et al.Monoacylglycerol of 7,10-dihydroxy-8(E)-octadecenoic acid enhances antibacterial activities against food-borne bacteriaJ. Agric. Food Chem.67(29)8191-8196(2019)

11(Z),14(Z),17(Z)-Eicosatrienoic acid, an unsaturated fatty acid, supports the sustained replication of functional mitochondria in Saccharomyces cerevisiae (KD115) [1].

TLR7/8 agonist 4 hydroxy-PEG6-acid, a Drug-Linker Conjugate for ADCs, comprises the TLR7/8 agonist 4 and a hydroxy-PEG6-acid linker, suitable for the synthesis of antibody-drug conjugates (ADCs) [1].

Dehydrotriferulic acid (8-O-4,8-O-4) is a compound extractable from the saponified insoluble fiber of corn bran [1].

Compound 4, 14-Benzoylmesaconine-8-palmitate, is a lipo-alkaloid that can be isolated from A. toxicum [1].

'(2E,4E)-8-Hydroxy-2,7-dimethyl-decadien-(2,4)-disaeure-(1,10)-dioic acid, a natural product isolated from Bunge auriculata flowers, exhibits antioxidant and anti-inflammatory activities [1].'

15,16-Epoxy-12R-hydroxylabda-8(17),13(16),14-triene is a natural product for research related to life sciences. The catalog number is TN2631 and the CAS number is 61597-55-5.

6'-O-Cinnamoyl-8-epikingisidic acid is a natural product from Ligustrum lucidum.

14-methyl Pentadecanoic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, A. indica leaf extract, and C. vulgaris and H. pluvialis microalgae. It is a major component of the vancomycin-induced biofilm produced by vancomycin-resistant S. aureus (VRSA). 14-methyl Pentadecanoic acid methyl ester has been used as a standard for the quantification of 14-methyl pentadecanoic acid in various foods by GC-MS.

(R)-8-Azido-2-(Fmoc-amino)octanoic acid, a non-cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs).

Compound 9, 15-Nor-14-oxolabda-8(17),12E-diene-18-oic acid, is an isolated compound derived from the roots of Chloranthus spicatus [1].

12E,14-Trien-19-oic acid, a diterpenoid isolated from the Bhutanese medicinal plant Shug Chher, may be utilized in research investigating platelet aggregation [1].

8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione is a natural product for research related to life sciences. The catalog number is TN5610 and the CAS number is 76497-89-7.

9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory effect of the pine needles and may play an important role in the allelopathy of red pine.

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

8,8a-Dihydro-8-hydroxygambogic acid, a natural compound extracted from the resin of Garcinia hanburyi, exhibits anticancer activity [1].

17(13→14)-Abeo-ent-3S*,13S*,16-trihydroxystrob-8(15)-ene is a sesquiterpene lactone of natural origin that exhibits anti-inflammatory properties [1].

8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibly through modulation of NOX activit

5(Z),8(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid that can be a substrate for 5-lipoxygenase (5-LO). 5-LO from RBL-1 cells converts this fatty acid to 5-hydroxy-6,8,14-eicosatrienoic acid and 5-hydroperoxy-6,8,14-eicosatrienoic acid. Due to the lack of a double bond at C-11, this particular fatty acid cannot be used in leukotriene A formation.

ent-11alpha-Hydroxyabieta-8(14),13(15)-dien-16,12alpha-olide shows significant cytotoxic activity against ANA-1 and Jurkat cells with IC50 values 7.12 x 10(-3) and 1.79 x 10(-2) microM.

13-Oxopodocarp-8(14)-en-18-oic acid is a natural product for research related to life sciences. The catalog number is TN2619 and the CAS number is 63976-69-2.

14-Pentadecenoic acid, a 15-carbon long-chain fatty acid with an alkene functional group on the terminal carbon of its aliphatic tail, has been observed to undergo oxidation due to the growth of M. cerificans at the expense of the parent alkene. This compound is utilized in the creation of fibrous scaffold biomaterials for tissue engineering purposes and in constructing metallomesogenic side-chain polymers for coating capillary columns in gas chromatography applications.

Mead acid, a 20-carbon ω-9 polyunsaturated fatty acid, experiences elevated levels in human plasma under conditions of essential fatty acid deficiency. As 1,25(Z),8(Z),11(Z)-Eicosatrienoic Acid methyl ester (Mead acid methyl ester), it frequently serves as a standard for fatty acid analysis, particularly after fatty acids have been transesterified into methyl esters.

8'-Oxo-6-hydroxydihydrophaseic acid is a natural product from Illicium dunnianum.

Diclofop-methyl is a common post-growth herbicide commonly used in agriculture. It enhances proton permeability of isolated oat root vesicle membranes.

Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined. 1.Serhan, C.N., Gotlinger, K., Hong, S., et al.Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienesJ. Immunol.176(3)1848-1859(2006) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Schwab, J.M., Chiang, N., Arita, M., et al.Resolvin E1 and protectin D1 activate inflammation-resolution programmesNature447(7146)869-874(2007)

8-Quinolinesulfonic Acid is a useful organic compound for research related to life sciences. The catalog number is T65419 and the CAS number is 85-48-3.

1,2-Dinor-3-oxo-6,10-farnesadien-14-oic acid; Z-Fo is a useful organic compound for research related to life sciences. The catalog number is T126203 and the CAS number is 1217271-08-3.

1-Cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66423 and the CAS number is 112811-57-1.

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

ent-14,15-Dinor-13-oxolabda-8(17),11-dien-18-oic acid is a natural product of Chloranthus, Chloranthaceae. The catalog number is TN3934 and the CAS number is 875585-30-1. ent-14,15-Dinor-13-oxolabda-8(17),11-dien-18-oic acid can be used as a reference standard.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylnon-8-enoic acid is a useful organic compound for research related to life sciences. The catalog number is T66542 and the CAS number is 1311933-83-1.

15,16-Dihydroxy-8(17),13-labdadien-18-oic acid is a useful organic compound for research related to life sciences and the catalog number is T129903.

7α-Methoxy-5α,6α-epoxyergosta-8(14),22-dien-3β-ol is a natural product for research related to life sciences. The catalog number is TN5314 and the CAS number is 1207441-49-3.

TLR7/8 agonist 4 hydroxy-PEG10-acid (compound 9) is a drug-linker conjugate employed in antibody-drug conjugates (ADC). This compound exhibits remarkable antitumor activity by utilizing TLR7/8 agonist 4, which acts as a potent activator of TLR7/8. The TLR7/8 agonist 4 is linked to hydroxy-PEG10-acid, the ADC linker, via a cleavable bond. Overall, it demonstrates promising pharmaceutical potential in the context of ADC-based therapeutics.

1, 14-tetradecanedioic-2, 2, 13, 13-d4 acid is a deuterated compound of 1, 14-tetradecanedioic acid. 1, 14-tetradecanedioic acid has a CAS number of 821-38-5. Tetradecanedioic acid is a C14 dicarboxylic acid.

Des(8-14)brevinin-1PMa is a host-defense peptide known for its potent antimicrobial properties, particularly against Staphylococcus aureus and Echerichia coli. Additionally, this compound demonstrates hemolytic activity [1].

TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride, a Drug-Linker Conjugate for ADC synthesis, is the hydrochloride variant of TLR7/8 agonist 4 hydroxy-PEG6-acid, comprising the TLR7/8 agonist 4 component attached to the hydroxy-PEG6-acid linker [1].

7,15-Dihydroxy-4,4,14-trimethyl-3,11-dioxochol-8-en-24-oic acid is a ganoderma triterpenoid found in Ganoderma Lucidum Karst. This compound is acknowledged as a significant bioactive ingredient. It can be employed in the investigation of different etiologies.

11(Z),14(Z)-Eicosadienoic acid, an unsaturated fatty acid, inhibits [3 H] leukotriene B4 (LTB4) binding to pig neutrophil membranes, displaying anti-inflammatory activities with an inhibition constant (Ki) of 3 μM [1] [2].

7-Amino-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a useful organic compound for research related to life sciences and the catalog number is T67151.

1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66948 and the CAS number is 112811-72-0.

8-Hydroxyoctanoic acid is a useful organic compound for research related to life sciences. The catalog number is T124255 and the CAS number is 764-89-6.

8(E),10(E),12(Z)-Octadecatrienoic acid is a conjugated polyunsaturated fatty acid (PUFA) that has been found inC. officinalisseed oil and has anticancer activity.1,2,3It inhibits the growth of Caco-2 cells when used at concentrations ranging from 10 to 50 μM.28(E),10(E),12(Z)-Octadecatrienoic acid (10 μM) induces formation of thiobarbituric acid reactive substances (TBARS) and apoptosis in DLD-1 colorectal adenocarcinoma cells.3It also inhibits prostaglandin biosynthesis in sheep vesicular gland microsomes (IC50= 31 μM).4 1.Crombie, L., and Holloway, S.J.The biosynthesis of calendic acid, octadeca-(8E,10E, 12Z)-trienoic, acid, by developing marigold seeds: origins of (E,E,Z) and (Z,E,Z) conjugated triene acids in higher plantsJ. Chem. Soc. Perk. T. 12425-2434(1985) 2.Yasui, Y., Hosokawa, M., Kohno, H., et al.Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cellsAnticancer Res.26(3A)1855-1860(2006) 3.Shinohara, N., Ito, J., Tsuduki, T., et al.Jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of miceJ. Oleo Sci.61(8)433-441(2012) 4.Nugteren, D.H., and Christ-Hazelhof, E.Naturally occurring conjugated octadecatrienoic acids are strong inhibitors of prostaglandin biosynthesisProstaglandins33(3)403-417(1987)