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Metabolism PPAR

PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
Cat No. product name
T0061 Clofibric acid Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
T0212 Seratrodast Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist d...
T0214 Pioglitazone Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare ...
T0214L Pioglitazone hydrochloride Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
T0334 Rosiglitazone Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rar...
T0448 Dexibuprofen Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T0646 Mesalamine Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
T0705 Triflusal Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
T0841 Bezafibrate Bezafibrate is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
T1088 Repaglinide Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been...
T1149 Fenofibrate Fenofibrate is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic...
T1238 Daidzein Daidzein is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic prope...
T1264 Ciprofibrate Ciprofibrate is a fibrate derivative with antilipidemic activity.
T1298 Clofibrate Clofibrate is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.
T1402 Fenofibric acid Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
T1415 Gemfibrozil Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an in...
T1603 Glipizide Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T1622 Rosiglitazone maleate Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activit...
T1674 Nateglinide Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 dia...
T1807 JW55 JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
T1941 GSK3787 GSK3787 is a specific and irreversible PPARδ inhibitor(pIC50= 6.6).
T2068 LB-100 LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1.
T2260 GW 9662 GW9662 is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα/δ in cells.
T2269 Pirinixic Acid Pirinixic Acid is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates spe...
T2396 Ramatroban Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.
T2413 FH535 FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T2674 GSK0660 GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
T2985 Gypenoside XLIX Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition.
T3000 Magnolol Magnolol is a dual agonist of RXRα( EC50=10.4 µM) and PPARγ(EC50=17.7 µM). It blocks TNF-α-induced NF-KB activation.
T3062 WIKI4 WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
T3090 Abietic Acid Abietic Acid is the primary component of resin acid isolated from rosin.
T3170 Troglitazone Troglitazone is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
T3261 NVP-TNKS656 NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
T3709 XMD8-87 XMD8-87 is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mut...
T3710 XMD16-5 XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted ...
T3917 Protopanaxatriol Protopanaxatriol, a major ginseng constituent, is a novel PPARγ antagonist.
T6151 Endurobol GW501516 is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.
T6524 GW0742 GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1nM/1.1μM/2 μM, for human PPARδ/α/γ).
T6646 Rosiglitazone HCl Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
T6689 T0070907 T0070907(IC50=1 nM) ,an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
T6768 AZ6102 AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 ...
T6926 Palmidrol Palmitoylethanolamide(PEA) ,an endogenous fatty acid amide, activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM).
T4353 SR-18292 SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose ...
T4408 Elafibranor Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 v...
T4449 LB-100 LB-100 is a water-soluble protein phosphatase 2A (PP2A) inhibitor (IC50: 0.85/3.87 μM, in BxPc-3/Panc-1 cells).
T4628 MBX 8025 MBX-8025 has been used in trials studying the treatment of Hyperlipidemia.
T4S2128 Bilobetin Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
T5532 BMS-687453 BMS-687453 is a potent and selective PPAR alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma i...
TWS0787 Oroxin A Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity again...
T5764 Alliin Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which ...
Clofibric acid
T0061CAS 882-09-7
Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
Seratrodast
T0212CAS 112665-43-7
Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist d...
Pioglitazone
T0214CAS 111025-46-8
Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare ...
Pioglitazone hydrochloride
T0214LCAS 112529-15-4
Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
Rosiglitazone
T0334CAS 122320-73-4
Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rar...
Dexibuprofen
T0448CAS 51146-56-6
Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
Mesalamine
T0646CAS 89-57-6
Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
Triflusal
T0705CAS 322-79-2
Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
Bezafibrate
T0841CAS 41859-67-0
Bezafibrate is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
Repaglinide
T1088CAS 135062-02-1
Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been...
Fenofibrate
T1149CAS 49562-28-9
Fenofibrate is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic...
Daidzein
T1238CAS 486-66-8
Daidzein is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic prope...
Ciprofibrate
T1264CAS 52214-84-3
Ciprofibrate is a fibrate derivative with antilipidemic activity.
Clofibrate
T1298CAS 637-07-0
Clofibrate is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.
Fenofibric acid
T1402CAS 42017-89-0
Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
Gemfibrozil
T1415CAS 25812-30-0
Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an in...
Glipizide
T1603CAS 29094-61-9
Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
Rosiglitazone maleate
T1622CAS 155141-29-0
Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activit...
Nateglinide
T1674CAS 105816-04-4
Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 dia...
JW55
T1807CAS 664993-53-7
JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
GSK3787
T1941CAS 188591-46-0
GSK3787 is a specific and irreversible PPARδ inhibitor(pIC50= 6.6).
LB-100
T2068CAS 1026680-07-8
LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1.
GW 9662
T2260CAS 22978-25-2
GW9662 is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα/δ in cells.
Pirinixic Acid
T2269CAS 50892-23-4
Pirinixic Acid is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates spe...
Ramatroban
T2396CAS 116649-85-5
Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.
FH535
T2413CAS 108409-83-2
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
GSK0660
T2674CAS 1014691-61-2
GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
Gypenoside XLIX
T2985CAS 94987-08-3
Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition.
Magnolol
T3000CAS 528-43-8
Magnolol is a dual agonist of RXRα( EC50=10.4 µM) and PPARγ(EC50=17.7 µM). It blocks TNF-α-induced NF-KB activation.
WIKI4
T3062CAS 838818-26-1
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
Abietic Acid
T3090CAS 514-10-3
Abietic Acid is the primary component of resin acid isolated from rosin.
Troglitazone
T3170CAS 97322-87-7
Troglitazone is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
NVP-TNKS656
T3261CAS 1419949-20-4
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
XMD8-87
T3709CAS 1234480-46-6
XMD8-87 is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mut...
XMD16-5
T3710CAS 1345098-78-3
XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted ...
Protopanaxatriol
T3917CAS 1453-93-6
Protopanaxatriol, a major ginseng constituent, is a novel PPARγ antagonist.
Endurobol
T6151CAS 317318-70-0
GW501516 is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.
GW0742
T6524CAS 317318-84-6
GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1nM/1.1μM/2 μM, for human PPARδ/α/γ).
Rosiglitazone HCl
T6646CAS 302543-62-0
Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
T0070907
T6689CAS 313516-66-4
T0070907(IC50=1 nM) ,an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
AZ6102
T6768CAS 1645286-75-4
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 ...
Palmidrol
T6926CAS 544-31-0
Palmitoylethanolamide(PEA) ,an endogenous fatty acid amide, activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM).
SR-18292
T4353CAS 2095432-55-4
SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose ...
Elafibranor
T4408CAS 923978-27-2
Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 v...
LB-100
T4449CAS 1632032-53-1
LB-100 is a water-soluble protein phosphatase 2A (PP2A) inhibitor (IC50: 0.85/3.87 μM, in BxPc-3/Panc-1 cells).
MBX 8025
T4628CAS 851528-79-5
MBX-8025 has been used in trials studying the treatment of Hyperlipidemia.
Bilobetin
T4S2128CAS 521-32-4
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
BMS-687453
T5532CAS 1000998-59-3
BMS-687453 is a potent and selective PPAR alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma i...
Oroxin A
TWS0787CAS 31567-75-6
Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity again...
Alliin
T5764CAS 556-27-4
Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which ...