PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.

Cat. No.	Product name	CAS No.	Purity
T12527	Mavodelpar free acid	942594-93-6	98%
T12527	PPARδ agonist is an selective agonist of PPARδ.
T38715	MSDC-0602K	1314533-27-1	98%
T38715	MSDC-0602K (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the ...
T17044	Tesaglitazar	251565-85-2	98%
T17044	Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα a...
T15049	Daltroban	79094-20-5	98%
T15049	Daltroban is a specific thromboxane A2 (TXA2) receptor antagonist. Daltroban shows protective effect in reperfusion injury. Daltroban increase intracellular calc...
T12527L	Mavodelpar free acid hydrochloride		98%
T12527L	Mavodelpar free acid hydrochloride is a potent PPARδ agonist (patent US20180071304, compound example 10).
T68022	Sulotroban	72131-33-0	98%
T68022	sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.
T68022L	Sulotroban potassium		98%
T68022L	Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.
T26986	Cevoglitazar	839673-52-8	98%
T26986	Cevoglitazar is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.
T37974	(S)-Coriolic acid	29623-28-7	98%
T37974	(S)-Coriolic acid is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involv...
TWS0787	Oroxin A	31567-75-6	98%
TWS0787	Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity against ...
TN3366	Ailanthoidol	156398-61-7	98%
TN3366	Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
T15580	Inolitazone dihydrochloride	223132-38-5	98%
T15580	Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth. Ino...
T10505	PPARα-MO-1	810677-36-2	98%
T10505	PPARα-MO-1 is a potent modulator of PPARα extracted from patent WO/2004/110982A1 (formula I).
TN1681	Gentianine	439-89-4	98%
TN1681	Gentianine is an effective Swertiamarin derivative, which has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, diuretic and other effects, and has t...
T15336	Fonadelpar	515138-06-4	98%
T15336	Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.
T16739	RG-12525	120128-20-3	98%
T16739	RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pepti...
TN4390	Kihadanin B	73793-68-7	98%
TN4390	Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
TN3219	7,8-Didehydrocimigenol	150972-72-8	98%
TN3219	7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
TN3989	Erycibelline	107633-95-4	98%
TN3989	Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
T15440	GSK376501A	1010412-80-2	98%
T15440	GSK376501A is a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). It is used for the treatment of type 2 diabetes mellitus.