| T0061 |
Clofibric acid |
Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE. |
| T0212 |
Seratrodast |
Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist d...
|
| T0214 |
Pioglitazone |
Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare ...
|
| T0214L |
Pioglitazone hydrochloride |
Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. |
| T0334 |
Rosiglitazone |
Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rar...
|
| T0448 |
Dexibuprofen |
Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX). |
| T0646 |
Mesalamine |
Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
|
| T0705 |
Triflusal |
Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative. |
| T0841 |
Bezafibrate |
Bezafibrate is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS. |
| T1088 |
Repaglinide |
Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been...
|
| T1149 |
Fenofibrate |
Fenofibrate is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic...
|
| T1238 |
Daidzein |
Daidzein is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic prope...
|
| T1264 |
Ciprofibrate |
Ciprofibrate is a fibrate derivative with antilipidemic activity. |
| T1298 |
Clofibrate |
Clofibrate is an aryloxyisobutyric acid derivate with antihyperlipidemic activity. |
| T1402 |
Fenofibric acid |
Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity. |
| T1415 |
Gemfibrozil |
Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an in...
|
| T1603 |
Glipizide |
Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity. |
| T1622 |
Rosiglitazone maleate |
Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activit...
|
| T1674 |
Nateglinide |
Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 dia...
|
| T1807 |
JW55 |
JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). |
| T1941 |
GSK3787 |
GSK3787 is a specific and irreversible PPARδ inhibitor（pIC50= 6.6）. |
| T2260 |
GW 9662 |
GW9662 is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα/δ in cells. |
| T2269 |
Pirinixic Acid |
Pirinixic Acid is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates spe...
|
| T2396 |
Ramatroban |
Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma. |
| T2413 |
FH535 |
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities. |
| T2674 |
GSK0660 |
GSK0660 is an antagonist and inverse agonist of PPARβ/δ. |
| T2985 |
Gypenoside XLIX |
Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition |
| T3000 |
Magnolol |
Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation. |
| T3062 |
WIKI4 |
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2). |
| T3090 |
Abietic Acid |
Abietic Acid is the primary component of resin acid isolated from rosin. |
| T3170 |
Troglitazone |
Troglitazone is a PPARγ agonist with anti-inflammatory and anti-tumor activity. |
| T3261 |
NVP-TNKS656 |
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor. |
| T3709 |
XMD8-87 |
XMD8-87 is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mut...
|
| T3710 |
XMD16-5 |
XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted ...
|
| T3917 |
Protopanaxatriol |
Protopanaxatriol, a major ginseng constituent, is a novel PPARγ antagonist. |
| T6151 |
GW501516 |
GW501516 is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ. |
| T6524 |
GW0742 |
GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1 nM/1.1 μM/2 μM, for human PPARδ/α/γ). |
| T6646 |
Rosiglitazone HCl |
Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. |
| T6689 |
T0070907 |
T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ. |
| T6768 |
AZ6102 |
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 ...
|
| T6926 |
Palmidrol |
Palmitoylethanolamide(PEA) , an endogenous fatty acid amide, activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM）. |
| T4353 |
SR18292 |
SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose ...
|
| T4408 |
Elafibranor |
Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 v...
|
| T4449 |
LB100 |
LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1. |
| T4628 |
MBX 8025 |
MBX-8025 has been used in trials studying the treatment of Hyperlipidemia. |
| T4S2128 |
Bilobetin |
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet. |
| T5532 |
BMS-687453 |
BMS-687453 is a potent and selective PPAR alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma i...
|
| TWS0787 |
Oroxin A |
Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity again...
|
| T5764 |
Alliin |
Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which ...
|
| T5806 |
Growth hormone releasing peptide |
Growth hormone releasing peptide ia a natual product ,and has anti-inflammatory effects, due to its inhibitory effect on PKC-induced activation of p38, JNK and ...
|
| T5891 |
D-ERYTHRO-SPHINGOSINE |
D-erythro-Sphingosine is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator |
| T7159 |
L-165041 |
L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively) |
| T7395 |
Lanifibranor |
|
| T7443 |
4'-Methoxychalcone |
4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities. |
| TQ0107 |
Pemafibrate |
Pemafibrate is a highly specific PPARα agonist (EC50: 1 nM). |
| TQ0156 |
GW1929 |
GW1929 is a potent PPAR-γ agonist (pKi: 8.84 for human PPAR-γ; pEC50s of 8.56 and 8.27 for human and murine PPAR-γ). |
| TQ0272 |
Balaglitazone |
Balaglitazone is a selective partial agonist for PPARγ (EC50: 1.351 μM for human PPARγ). |
| TQ0120 |
CDDO-Im |
CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ). |
| T8184 |
Fucosterol |
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα an...
|
| T7821 |
DG172 (dihydrochloride) |
DG172 (dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM). |
| T8374 |
LJ570 |
LJ570 is the first PPARα/γ dual agonist (PPARα,PPARγ with EC50s of 1.05 and 0.12 μM, respectively[) |
| TN1126 |
Sakuranetin |
Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects |
| TN1189 |
13-Methylberberine |
13-Methylberberine shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug |
| TN1681 |
Gentianine |
Gentianine has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, and diuretic actions, it could be developed as a safe antihypertensive drug. |
| TN1804 |
Isosilybin A |
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (...
|
| TN2228 |
Soyasaponin Aa |
Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the dow...
|
| TN2290 |
Uvaol |
Uvaol has anti-inflammatory, anti-proliferative, and vasorelaxing activities. |
| TN1055 |
Licochalcone E |
Licochalcone E is a potential LXRβ agonist. |
| TN1693 |
Glabrone |
Glabrone shows antiviral activity against influenza virus. |
| TN1703 |
Glycyrin |
Glycyrin, one of the main PPAR-gamma ligands of licorice, can significantly decrease the blood glucose levels of genetically diabetic KK-A(y) mice. |
| TN1836 |
Kudinoside D |
Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway. |
| T12527 |
PPARδ agonist |
PPARδ agonist is an agonist of PPARδ. |
| T12529 |
Pparδ agonist 2 |
Pparδ agonist 2 is an agonist of PPARδ. |
| T10044 |
13-Oxo-9E,11E-octadecadienoic acid |
13-Oxo-9E,11E-octadecadienoic acid, an isomer of 9-oxo-ODA, is a potent PPARα activator derived from tomato juice. 13-Oxo-9E,11E-octadecadienoic acid decreases...
|
| T14176 |
Aleglitazar |
Aleglitazar is being developed for the treatment of type II diabetes; It is currently in phase III clinical trials. In preliminary clinical studies, Aleglitazar...
|
| T14356 |
AVE-8134 |
AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively. |
| T10327 |
Ankaflavin |
Ankaflavin is isolated from Monascus-Fermented red rice and is a PPARγ agonist with anti-inflammatory activity. It shows the selective cytotoxic effect and ind...
|
| T16074 |
Mifobate |
Mifobate is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1]. |
| T14948 |
Chiglitazar |
Chiglitazar is a dual agonist of PPARα/γ (EC50s: 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ). |
| T15243 |
Ertiprotafib |
Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM...
|
| T15336 |
Fonadelpar |
Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy. |
| T13289 |
VCE-004.8 |
VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-ind...
|
| T15440 |
GSK376501A |
GSK376501A is a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). It is used for the treatment of type 2 diabetes mellitus. |
| T15453 |
GW7647 |
GW7647 is a potent agonist of PPARα (EC50s: 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ, and PPARδ, respectively). |
| T15567 |
Imiglitazar |
Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist (EC50: 67 and 31 nM). |
| T15575 |
Indeglitazar |
Indeglitazar is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)). |
| T15580 |
Inolitazone dihydrochloride |
Inolitazone dihydrochloride is a novel high-affinity agonist of PPARγ. It is dependent upon PPARγ for its biological activity (IC50: 0.8 nM for growth inhibi...
|
| T15581 |
Inolitazone |
Inolitazone a novel high-affinity agonist of PPARγ. It is dependent upon PPARγ for its biological activity (IC50: 0.8 nM for growth inhibition). |
| T15748 |
LG100754 |
LG100754 is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functio...
|
| T11754 |
Ketorolac D5 |
Ketorolac D5 is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM...
|
| T15945 |
MA-0204 |
MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, ...
|
| T16016 |
Maytansinol |
Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro. |
| T10506 |
PPAR agonist 1 |
PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol. |
| T10505 |
PPARα-MO-1 |
PPARα-MO-1 is a potent modulator of PPARα extracted from patent WO/2004/110982A1 (formula I). |
| T16739 |
RG-12525 |
RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pep...
|
| T17044 |
Tesaglitazar |
Tesaglitazar causes interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats. Tesaglitazar is a dual peroxisome proliferato...
|
| T8486 |
GW 6471 |
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins...
|
| TN2535 |
1-Hydroxy-2-oxopomolic acid |
1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression. |
| TN2601 |
12-O-Methylcarnosic acid |
12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibit...
|
| TN2641 |
15-Methoxypinusolidic acid |
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
|
| TN3152 |
6-Acetonyldihydrochelerythrine |
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therap...
|
| TN3219 |
7,8-Didehydrocimigenol |
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity o...
|
| TN3366 |
Ailanthoidol |
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potenti...
|
| TN3609 |
Catalposide |
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and H...
|
| TN3655 |
Cimiside E |
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1...
|
| TN3989 |
Erycibelline |
Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis. |
| TMA0127 |
Ficusin A |
Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ i...
|
| TN4094 |
Gallocatechin gallate |
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation thro...
|
| TN4374 |
Kaerophyllin |
Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting ...
|
| TN4390 |
Kihadanin B |
Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes. |
| TN4583 |
Moringin |
Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of expe...
|
| TN4670 |
Norlichexanthone |
Norlichexanthone has the potential to treat and/or prevent lifestyle-related diseases, including metabolic syndrome, type 2 diabetes, atherosclerosis and cardio...
|
| TN4860 |
Pueroside B |
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-...
|
| TN5091 |
Tagitinin A |
Tagitinin A is a plant insecticidal compound, it has phytotoxic activity, it shows significant inhibition of wheat coleoptile growth, seed germination, and the ...
|
| TN5137 |
Tetramethylkaempferol |
Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated wit...
|
| TN5149 |
Tirotundin |
Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the acti...
|
| T12296 |
Oleoylethanolamide |
Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α. |
| T3954 |
Adelmidrol |
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid. |
| T3941 |
Choline Fenofibrate |
Choline Fenofibrate is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity. |
| T3138 |
Astaxanthin |
Astaxanthin is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activit...
|
| T3056 |
Bavachinin |
Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae with potent anti-angiogenic activity. |
| T2932 |
Ginsenoside Rh1 |
Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect. |
| T8780 |
INT-131 |
INT-131, is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatmen...
|
| T6842 |
G007-LK |
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively. |
| T3362 |
Eupatilin |
Eupatilin, a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity. |
| T3254 |
PHYTOL |
Phytol, a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as...
|
| T16022 |
Arhalofenate |
Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes. |
