PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.

Cat No.	product name
T9766	GW590735	GW590735 是一种有效的选择性 PPARα 激动剂，对 PPARα 的 EC50 为 4 nM，比 PPARδ 和 PPARγ 的选择性至少高 500 倍。 GW590735 可用于血脂异常研究。
T9767	CC618	CC618 是一种选择性 PPARβ/δ 拮抗剂，IC50 为 10.0 μM。
T1674	Nateglinide	Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diab...
T10900	CUDA	CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the a...
T19500	Palmitelaidic Acid	Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
T3090	Abietic Acid	Abietic Acid is the primary component of resin acid isolated from rosin.
T5701	OPHIOPOGONIN D	Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
TQ0120	CDDO-Im	CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
T0646	5-Aminosalicylic Acid	Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
T1622	Rosiglitazone maleate	Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity...
T4S1173	Agrimol B	1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
T19094	2,3-Butanediol	2,3-Butanediol is a butanediol derived from the bioconversion of natural resources.
TN1525	Convallatoxin	Convallatoxin is a natural product
T1603	Glipizide	Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T1051	Retinoic acid	Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell pr...
T0334	Rosiglitazone	Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rare...
T2396	Ramatroban	Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.
T5S1550	Cinnamyl alcohol	1. Cinnamyl alcohol readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.
T6893	MK-886	MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
T2855	Icariin	Icariin is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
T24827	SR 16832	SR 16832 is a dual-site PPARγ inhibitor. It also inhibits the binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orth...
T22596	BADGE	PPARγ antagonist
T23389	SR1664	SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphoryl...
T3138	Astaxanthin	Astaxanthin is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activity...
T2932	Ginsenoside Rh1	Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
T6829	EPI-001	EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ～6 μM and a selective PPAR-gamma modulator.
T3000	Magnolol	Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T0214	Pioglitazone	Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare i...
TN7060	Methyl oleanonate	3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties.
T3867	Alpinetin	Alpinetin has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeut...
T3403	Glabridin	Glabridin may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-gluc...
T0212	Seratrodast	Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist de...
T8699	GFT505	GFT505 (Elafibranor) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
T2838	Naringenin	Naringenin is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate me...
T3709	XMD8-87	XMD8-87 is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation muta...
T12268	NTP42	NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
T8184	Fucosterol	Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and ...
T3170	Troglitazone	Troglitazone is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
T1149	Fenofibrate	Fenofibrate is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic ...
T3710	XMD16-5	XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted m...
T4S2128	Bilobetin	Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
T3254	PHYTOL	Phytol, a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as ...
T2S0633	Raspberry ketone	1. 4-(4-Hydroxyphenyl)-2-butanone(RK) is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of th...
T0509	Cloxiquine	Cloxyquin is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.
TN1126	Sakuranetin	Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
T0061	Clofibric acid	Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
T13803	N-Oleoyl glycine	N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte
T6926	Palmitoylethanolamide	Palmitoylethanolamide(PEA) , an endogenous fatty acid amide, activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM）.
T0214L	Pioglitazone hydrochloride	Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
T22708	Darglitazone	PPARγ agonist with antidiabetic actions