PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.

Cat. No.	Product name	CAS No.	Purity
TN1525	Convallatoxin	508-75-8	98%
TN1525	Convallatoxin is a natural product
T15567	Imiglitazar	250601-04-8	98%
T15567	Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist (EC50: 67 and 31 nM).
TN2228	Soyasaponin Aa	117230-33-8	98%
TN2228	Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the down...
T15336	Fonadelpar	515138-06-4	98%
T15336	Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.
T15440	GSK376501A	1010412-80-2	98%
T15440	GSK376501A is a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). It is used for the treatment of type 2 diabetes mellitus.
TN1681	Gentianine	439-89-4	98%
TN1681	Gentianine has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, and diuretic actions, it could be developed as a safe antihypertensive drug.
TN3655	Cimiside E	154822-57-8	98%
TN3655	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
T15049	Daltroban	79094-20-5	98%
T15049	Daltroban is a specific thromboxane A2 (TXA2) receptor antagonist. Daltroban shows protective effect in reperfusion injury. Daltroban increase intracellular calc...
TN2641	15-Methoxypinusolidic acid	769928-72-5	98%
TN2641	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
TN3219	7,8-Didehydrocimigenol	150972-72-8	98%
TN3219	7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
TN3989	Erycibelline	107633-95-4	98%
TN3989	Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
T10327	Ankaflavin	50980-32-0	98%
T10327	Ankaflavin is isolated from Monascus-Fermented red rice and is a PPARγ agonist with anti-inflammatory activity. It shows the selective cytotoxic effect and induc...
TMA0127	Ficusin A	173429-83-9	98%
TMA0127	Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ in...
T16739	RG-12525	120128-20-3	98%
T16739	RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pepti...
TN5149	Tirotundin	56377-67-4	98%
TN5149	Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activati...
T10506	PPAR agonist 1	539813-69-9	98%
T10506	PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.
TN1703	Glycyrin	66056-18-6	98%
TN1703	Glycyrin, one of the main PPAR-gamma ligands of licorice, can significantly decrease the blood glucose levels of genetically diabetic KK-A(y) mice.
TN5091	Tagitinin A	59979-61-2	98%
TN5091	Tagitinin A is a plant insecticidal compound, it has phytotoxic activity, it shows significant inhibition of wheat coleoptile growth, seed germination, and the g...
TN4094	Gallocatechin gallate	5127-64-0	98%
TN4094	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
TWS0787	Oroxin A	31567-75-6	98%
TWS0787	Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity against ...