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PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
Cat No. product name
T9766 GW590735 GW590735 是一种有效的选择性 PPARα 激动剂,对 PPARα 的 EC50 为 4 nM,比 PPARδ 和 PPARγ 的选择性至少高 500 倍。 GW590735 可用于血脂异常研究。
T9767 CC618 CC618 是一种选择性 PPARβ/δ 拮抗剂,IC50 为 10.0 μM。
T1674 Nateglinide Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diab...
T10900 CUDA CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the a...
T19500 Palmitelaidic Acid Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
T3090 Abietic Acid Abietic Acid is the primary component of resin acid isolated from rosin.
T5701 OPHIOPOGONIN D Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
TQ0120 CDDO-Im CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
T0646 5-Aminosalicylic Acid Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
T1622 Rosiglitazone maleate Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity...
T4S1173 Agrimol B 1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
T19094 2,3-Butanediol 2,3-Butanediol is a butanediol derived from the bioconversion of natural resources.
TN1525 Convallatoxin Convallatoxin is a natural product
T1603 Glipizide Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T1051 Retinoic acid Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell pr...
T0334 Rosiglitazone Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rare...
T2396 Ramatroban Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.
T5S1550 Cinnamyl alcohol 1. Cinnamyl alcohol readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.
T6893 MK-886 MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
T2855 Icariin Icariin is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
T24827 SR 16832 SR 16832 is a dual-site PPARγ inhibitor. It also inhibits the binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orth...
T22596 BADGE PPARγ antagonist
T23389 SR1664 SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphoryl...
T3138 Astaxanthin Astaxanthin is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activity...
T2932 Ginsenoside Rh1 Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
T6829 EPI-001 EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ~6 μM and a selective PPAR-gamma modulator.
T3000 Magnolol Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T0214 Pioglitazone Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare i...
TN7060 Methyl oleanonate 3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties.
T3867 Alpinetin Alpinetin has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeut...
T3403 Glabridin Glabridin may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-gluc...
T0212 Seratrodast Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist de...
T8699 GFT505 GFT505 (Elafibranor) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
T2838 Naringenin Naringenin is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate me...
T3709 XMD8-87 XMD8-87 is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation muta...
T12268 NTP42 NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
T8184 Fucosterol Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and ...
T3170 Troglitazone Troglitazone is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
T1149 Fenofibrate Fenofibrate is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic ...
T3710 XMD16-5 XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted m...
T4S2128 Bilobetin Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
T3254 PHYTOL Phytol, a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as ...
T2S0633 Raspberry ketone 1. 4-(4-Hydroxyphenyl)-2-butanone(RK) is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of th...
T0509 Cloxiquine Cloxyquin is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.
TN1126 Sakuranetin Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
T0061 Clofibric acid Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
T13803 N-Oleoyl glycine N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte
T6926 Palmitoylethanolamide Palmitoylethanolamide(PEA) , an endogenous fatty acid amide, activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM).
T0214L Pioglitazone hydrochloride Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
T22708 Darglitazone PPARγ agonist with antidiabetic actions
GW590735
T9766
CC618
T9767
CC618 是一种选择性 PPARβ/δ 拮抗剂,IC50 为 10.0 μM。
Nateglinide
T1674
Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diab...
CUDA
T10900
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the a...
Palmitelaidic Acid
T19500
Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
Abietic Acid
T3090
Abietic Acid is the primary component of resin acid isolated from rosin.
OPHIOPOGONIN D
T5701
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
CDDO-Im
TQ0120
CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
5-Aminosalicylic Acid
T0646
Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
Rosiglitazone maleate
T1622
Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity...
Agrimol B
T4S1173
1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
2,3-Butanediol
T19094
2,3-Butanediol is a butanediol derived from the bioconversion of natural resources.
Convallatoxin
TN1525
Convallatoxin is a natural product
Glipizide
T1603
Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
Retinoic acid
T1051
Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell pr...
Rosiglitazone
T0334
Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rare...
Ramatroban
T2396
Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.
Cinnamyl alcohol
T5S1550
1. Cinnamyl alcohol readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.
MK-886
T6893
MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
Icariin
T2855
Icariin is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
SR 16832
T24827
SR 16832 is a dual-site PPARγ inhibitor. It also inhibits the binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the or...
BADGE
T22596
PPARγ antagonist
SR1664
T23389
SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phospho...
Astaxanthin
T3138
Astaxanthin is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activity...
Ginsenoside Rh1
T2932
Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
EPI-001
T6829
EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ~6 μM and a selective PPAR-gamma modulator.
Magnolol
T3000
Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
Pioglitazone
T0214
Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare i...
Methyl oleanonate
TN7060
3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties.
Alpinetin
T3867
Alpinetin has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeut...
Glabridin
T3403
Glabridin may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-gluc...
Seratrodast
T0212
Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist de...
GFT505
T8699
GFT505 (Elafibranor) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
Naringenin
T2838
Naringenin is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate me...
XMD8-87
T3709
XMD8-87 is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation muta...
NTP42
T12268
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
Fucosterol
T8184
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and...
Troglitazone
T3170
Troglitazone is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
Fenofibrate
T1149
Fenofibrate is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic ...
XMD16-5
T3710
XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted m...
Bilobetin
T4S2128
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
PHYTOL
T3254
Phytol, a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as ...
Raspberry ketone
T2S0633
1. 4-(4-Hydroxyphenyl)-2-butanone(RK) is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of th...
Cloxiquine
T0509
Cloxyquin is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.
Sakuranetin
TN1126
Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
Clofibric acid
T0061
Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
N-Oleoyl glycine
T13803
N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte
Palmitoylethanolamide
T6926
Palmitoylethanolamide(PEA) , an endogenous fatty acid amide, activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM).
Pioglitazone hydrochloride
T0214L
Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
Darglitazone
T22708
PPARγ agonist with antidiabetic actions
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