PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.

Cat No.	product name
T0061	Clofibric acid	Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
T0212	Seratrodast	Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist d...
T0214	Pioglitazone	Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare ...
T0214L	Pioglitazone hydrochloride	Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
T0334	Rosiglitazone	Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rar...
T0448	Dexibuprofen	Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T0646	Mesalamine	Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
T0705	Triflusal	Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
T0841	Bezafibrate	Bezafibrate is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
T1088	Repaglinide	Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been...
T1149	Fenofibrate	Fenofibrate is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic...
T1238	Daidzein	Daidzein is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic prope...
T1264	Ciprofibrate	Ciprofibrate is a fibrate derivative with antilipidemic activity.
T1298	Clofibrate	Clofibrate is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.
T1402	Fenofibric acid	Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
T1415	Gemfibrozil	Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an in...
T1603	Glipizide	Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T1622	Rosiglitazone maleate	Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activit...
T1674	Nateglinide	Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 dia...
T1807	JW55	JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
T1941	GSK3787	GSK3787 is a specific and irreversible PPARδ inhibitor（pIC50= 6.6）.
T2068	LB-100	LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1.
T2260	GW 9662	GW9662 is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα/δ in cells.
T2269	Pirinixic Acid	Pirinixic Acid is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates spe...
T2396	Ramatroban	Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.
T2413	FH535	FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T2674	GSK0660	GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
T2985	Gypenoside XLIX	Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition.
T3000	Magnolol	Magnolol is a dual agonist of RXRα( EC50=10.4 µM) and PPARγ(EC50=17.7 µM). It blocks TNF-α-induced NF-KB activation.
T3062	WIKI4	WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
T3090	Abietic Acid	Abietic Acid is the primary component of resin acid isolated from rosin.
T3170	Troglitazone	Troglitazone is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
T3261	NVP-TNKS656	NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
T3709	XMD8-87	XMD8-87 is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mut...
T3710	XMD16-5	XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted ...
T3917	Protopanaxatriol	Protopanaxatriol, a major ginseng constituent, is a novel PPARγ antagonist.
T6151	Endurobol	GW501516 is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.
T6524	GW0742	GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1nM/1.1μM/2 μM, for human PPARδ/α/γ).
T6646	Rosiglitazone HCl	Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
T6689	T0070907	T0070907(IC50=1 nM) ，an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
T6768	AZ6102	AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 ...
T6926	Palmidrol	Palmitoylethanolamide(PEA) ，an endogenous fatty acid amide， activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM）.
T4353	SR-18292	SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose ...
T4408	Elafibranor	Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 v...
T4449	LB-100	LB-100 is a water-soluble protein phosphatase 2A (PP2A) inhibitor (IC50: 0.85/3.87 μM, in BxPc-3/Panc-1 cells).
T4628	MBX 8025	MBX-8025 has been used in trials studying the treatment of Hyperlipidemia.
T4S2128	Bilobetin	Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
T5532	BMS-687453	BMS-687453 is a potent and selective PPAR alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma i...
TWS0787	Oroxin A	Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity again...
T5764	Alliin	Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which ...