PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.

Cat No.	product name
T0061	Clofibric acid	Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
T0212	Seratrodast	Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist d...
T0214	Pioglitazone	Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare ...
T0214L	Pioglitazone hydrochloride	Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
T0334	Rosiglitazone	Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rar...
T0448	Dexibuprofen	Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T0646	Mesalamine	Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
T0705	Triflusal	Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
T0841	Bezafibrate	Bezafibrate is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
T1088	Repaglinide	Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been...
T1149	Fenofibrate	Fenofibrate is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic...
T1238	Daidzein	Daidzein is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic prope...
T1264	Ciprofibrate	Ciprofibrate is a fibrate derivative with antilipidemic activity.
T1298	Clofibrate	Clofibrate is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.
T1402	Fenofibric acid	Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
T1415	Gemfibrozil	Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an in...
T1603	Glipizide	Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T1622	Rosiglitazone maleate	Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activit...
T1674	Nateglinide	Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 dia...
T1807	JW55	JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
T1941	GSK3787	GSK3787 is a specific and irreversible PPARδ inhibitor（pIC50= 6.6）.
T2260	GW 9662	GW9662 is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα/δ in cells.
T2269	Pirinixic Acid	Pirinixic Acid is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates spe...
T2396	Ramatroban	Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.
T2413	FH535	FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T2674	GSK0660	GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
T2985	Gypenoside XLIX	Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition.
T3000	Magnolol	Magnolol is a dual agonist of RXRα( EC50=10.4 µM) and PPARγ(EC50=17.7 µM). It blocks TNF-α-induced NF-KB activation.
T3062	WIKI4	WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
T3090	Abietic Acid	Abietic Acid is the primary component of resin acid isolated from rosin.
T3170	Troglitazone	Troglitazone is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
T3261	NVP-TNKS656	NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
T3709	XMD8-87	XMD8-87 is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mut...
T3710	XMD16-5	XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted ...
T3917	Protopanaxatriol	Protopanaxatriol, a major ginseng constituent, is a novel PPARγ antagonist.
T6151	Endurobol	GW501516 is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.
T6524	GW0742	GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1nM/1.1μM/2 μM, for human PPARδ/α/γ).
T6646	Rosiglitazone HCl	Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
T6689	T0070907	T0070907(IC50=1 nM) ，an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
T6768	AZ6102	AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 ...
T6926	Palmidrol	Palmitoylethanolamide(PEA) ，an endogenous fatty acid amide， activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM）.
T4353	SR-18292	SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose ...
T4408	Elafibranor	Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 v...
T4449	LB-100	LB-100 is a water-soluble protein phosphatase 2A (PP2A) inhibitor (IC50: 0.85/3.87 μM, in BxPc-3/Panc-1 cells).
T4628	MBX 8025	MBX-8025 has been used in trials studying the treatment of Hyperlipidemia.
T4S2128	Bilobetin	Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
T5532	BMS-687453	BMS-687453 is a potent and selective PPAR alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma i...
TWS0787	Oroxin A	Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity again...
T5764	Alliin	Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which ...
T5806	Growth hormone releasing peptide	Growth hormone releasing peptide ia a natual product ,and has anti-inflammatory effects, due to its inhibitory effect on PKC-induced activation of p38, JNK and ...
T5891	D-ERYTHRO-SPHINGOSINE	D-erythro-Sphingosine is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator
T7159	L-165041	L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)
T7395	Lanifibranor
T7443	4'-Methoxychalcone	4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.
TQ0107	Pemafibrate	Pemafibrate is a highly specific PPARα agonist (EC50: 1 nM).
TQ0156	GW1929	GW1929 is a potent PPAR-γ agonist (pKi: 8.84 for human PPAR-γ; pEC50s of 8.56 and 8.27 for human and murine PPAR-γ).
TQ0272	Balaglitazone	Balaglitazone is a selective partial agonist for PPARγ (EC50: 1.351 μM for human PPARγ).
TQ0120	CDDO-Im	CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
T8184	Fucosterol	Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα an...
T7821	DG172 (dihydrochloride)	DG172 (dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
T8374	LJ570	LJ570 is the first PPARα/γ dual agonist (PPARα,PPARγ with EC50s of 1.05 and 0.12 μM, respectively[)
TN1126	Sakuranetin	Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
TN1189	13-Methylberberine	13-Methylberberine shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug
TN1681	Gentianine	Gentianine has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, and diuretic actions, it could be developed as a safe antihypertensive drug.
TN1804	Isosilybin A	Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (...
TN2228	Soyasaponin Aa	Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the dow...
TN2290	Uvaol	Uvaol has anti-inflammatory, anti-proliferative, and vasorelaxing activities.
TN1055	Licochalcone E	Licochalcone E is a potential LXRβ agonist.
TN1693	Glabrone	Glabrone shows antiviral activity against influenza virus.
TN1703	Glycyrin	Glycyrin, one of the main PPAR-gamma ligands of licorice, can significantly decrease the blood glucose levels of genetically diabetic KK-A(y) mice.
TN1836	Kudinoside D	Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
T12527	PPARδ agonist	PPARδ agonist is an agonist of PPARδ.
T12529	Pparδ agonist 2	Pparδ agonist 2 is an agonist of PPARδ.
T10044	13-Oxo-9E,11E-octadecadienoic acid	13-Oxo-9E,11E-octadecadienoic acid, an isomer of 9-oxo-ODA, is a potent PPARα activator derived from tomato juice. 13-Oxo-9E,11E-octadecadienoic acid decreases...
T14176	Aleglitazar	Aleglitazar is being developed for the treatment of type II diabetes; It is currently in phase III clinical trials. In preliminary clinical studies, Aleglitazar...
T14356	AVE-8134	AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively.
T10327	Ankaflavin	Ankaflavin is isolated from Monascus-Fermented red rice and is a PPARγ agonist with anti-inflammatory activity. It shows the selective cytotoxic effect and ind...
T16074	Mifobate	Mifobate is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1].
T14948	Chiglitazar	Chiglitazar is a dual agonist of PPARα/γ (EC50s: 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ).
T15243	Ertiprotafib	Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM...
T15336	Fonadelpar	Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.
T13289	VCE-004.8	VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-ind...
T15440	GSK376501A	GSK376501A is a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). It is used for the treatment of type 2 diabetes mellitus.
T15453	GW7647	GW7647 is a potent agonist of PPARα (EC50s: 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ, and PPARδ, respectively).
T15567	Imiglitazar	Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist (EC50: 67 and 31 nM).
T15575	Indeglitazar	Indeglitazar is orally available pan-agonist of peroxisome proliferator-activated receptor (PPAR). It is used for all three PPAR subtypes alpha (α), delta (δ)...
T15580	Inolitazone dihydrochloride	Inolitazone dihydrochloride is a novel high-affinity agonist of PPARγ. It is dependent upon PPARγ for its biological activity (IC50: 0.8 nM for growth inhibi...
T15581	Inolitazone	Inolitazone a novel high-affinity agonist of PPARγ. It is dependent upon PPARγ for its biological activity (IC50: 0.8 nM for growth inhibition).
T15748	LG100754	LG100754 is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functio...
T11754	Ketorolac D5	Ketorolac D5 is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM...
T15945	MA-0204	MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, ...
T16016	Maytansinol	Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro.
T10506	PPAR agonist 1	PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.
T10505	PPARα-MO-1	PPARα-MO-1 is a potent modulator of PPARα extracted from patent WO/2004/110982A1 (formula I).
T16739	RG-12525	RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pep...
T17044	Tesaglitazar	Tesaglitazar causes interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats. Tesaglitazar is a dual peroxisome proliferato...
T8486	GW 6471	GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins...
TN2535	1-Hydroxy-2-oxopomolic acid	1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
TN2601	12-O-Methylcarnosic acid	12-O-Methylcarnosic acid has antioxidant activity, it is effective preventing gastric lesions. 12-O-Methylcarnosic acid can suppress melanin production with dow...
TN2641	15-Methoxypinusolidic acid	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
TN3152	6-Acetonyldihydrochelerythrine	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therap...
TN3219	7,8-Didehydrocimigenol	7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity o...
TN3366	Ailanthoidol	Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potenti...
TN3609	Catalposide	Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and H...
TN3655	Cimiside E	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1...
TN3989	Erycibelline	Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
TMA0127	Ficusin A	Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ i...
TN4094	Gallocatechin gallate	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation thro...
TN4374	Kaerophyllin	Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting ...
TN4390	Kihadanin B	Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
TN4583	Moringin	Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of expe...
TN4670	Norlichexanthone	Norlichexanthone has the potential to treat and/or prevent lifestyle-related diseases, including metabolic syndrome, type 2 diabetes, atherosclerosis and cardio...
TN4860	Pueroside B	Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-...
TN5091	Tagitinin A	Tagitinin A is a plant insecticidal compound, it has phytotoxic activity, it shows significant inhibition of wheat coleoptile growth, seed germination, and the ...
TN5137	Tetramethylkaempferol	Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated wit...
TN5149	Tirotundin	Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the acti...