15(r)-lipoxin a-4

(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide is a cannabinoid receptor antagonist/inverse agonist.

Selina-4(15),7(11)-dien-8-one is a natural product for research related to life sciences. The catalog number is TN3467 and the CAS number is 54707-47-0.

(R)-4-Methoxydalbergione is a natural product for research related to life sciences. The catalog number is TN5798 and the CAS number is 4646-86-0.

4(15),11-Oppositadien-1-ol is a natural product for research related to life sciences. The catalog number is TN2996 and the CAS number is 70389-96-7.

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

4(15),5,10(14)-Germacratrien-1-ol is a natural product for research related to life sciences. The catalog number is TN2997 and the CAS number is 81968-62-9.

Eudesm-4(15)-ene-3alpha,11-diol is a compound derived from Eudesm-4(15)-ene-3alpha,11-diol.

(R)-3-((tert-Butoxycarbonyl)amino)-4-(3-fluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66938 and the CAS number is 331763-66-7.

19(R)-Hydroxylated prostaglandins (PGs) are present at µg/ml concentrations in the semen of some mammalian species, notably primates, with the majority being from the PGE series and featuring a 15(S),19(R) hydroxyl stereochemistry. These compounds are also observed in marsupials' seminal plasma, where F-type 1 and 2-series compounds are predominant. The 15(R)-hydroxy epimer represents the inverse or unnatural isomer at C-15 for these 19-hydroxylated PGs. Although the biological function of 19(R)-hydroxylated PGs remains unclear, 19(R)-hydroxylation in the F-series leads to a notable reduction in receptor-mediated biological activity in certain assays.

8-iso-15(R)-Prostaglandin F2α (8-iso-15(R) PGF2α) is a chemically distinct member within a broad group of prostaglandin-like eicosanoids, produced through the free radical peroxidation of arachidonic acid contained in membrane phospholipids. It represents the C-15 epimer of 8-isoPGF2α, distinguished as the sole isoprostane isomer extensively examined across numerous biological systems.

(R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-7,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid is a useful organic compound for research related to life sciences and the catalog number is T64669.

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpent-4-enoic acid is a useful organic compound for research related to life sciences. The catalog number is T66485 and the CAS number is 288617-76-5.

(R)-4-Carboxyphenylglycine is a NMDA receptor antagonist.

(R)-3-(4-Bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one is a useful organic compound for research related to life sciences. The catalog number is T66999 and the CAS number is 444335-16-4.

(R)-2-Amino-3-(3,5-dibromo-4-hydroxyphenyl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66789 and the CAS number is 50299-42-8.

(R)-tert-Butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate is a useful organic compound for research related to life sciences and the catalog number is T65597.

Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 15(R)-LXA4 to regulate leukocyte function.[4] 15(R)-LXA4 is reported to promote resolution of inflammation in LPS-treated stromal cells derived from intermediate-stage diseased supraspinatus tendons as evidenced by increased expression of the STAT-6 pathway target genes, ALOX15 and CD206.[5]

(R)-NVS-ZP7-4 is the R-isomer of NVS-ZP7-4. NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.

(S)-4-[2-(Diphenylphosphino)-1-naphthalenyl]-N-[(R)-1-phenylethoxy]phthalazine is a useful organic compound for research related to life sciences and the catalog number is T67269.

(R)-Tetrahydrofuran-3-yl 4-methylbenzenesulfonate is a useful organic compound for research related to life sciences. The catalog number is T65902 and the CAS number is 219823-47-9.

(R)-4-[2-(Diphenylphosphino)-1-naphthalenyl]-N-[(R)-1-phenylethoxy]phthalazine is a useful organic compound for research related to life sciences and the catalog number is T67274.

15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 . 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM). It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.

Carbohydrate Derivatives; Ready for glycosylation

(R)-Methyl 4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate is a useful organic compound for research related to life sciences. The catalog number is T66656 and the CAS number is 10538-59-7.

15(R)-Prostaglandin D2 functions as a DP(2) receptor (Prostaglandin Receptor) agonist with potential roles in prostatic hormone signaling and exhibits anti-inflammatory properties. It enhances actin polymerization in human eosinophils and elevates cAMP levels in platelets [1].

tert-Butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T66629 and the CAS number is 247068-82-2.

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2-fluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65537 and the CAS number is 218608-98-1.

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65588 and the CAS number is 936630-57-8.

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66021 and the CAS number is 157355-79-8.

(R)-2-Amino-2-(4-fluorophenyl)acetic acid is a useful organic compound for research related to life sciences. The catalog number is T67220 and the CAS number is 93939-74-3.

(R)-5-Hydroxy-7-(4-hydroxyphenyl)-1-phenylheptan-3-one is a natural product for research related to life sciences. The catalog number is TN6384 and the CAS number is 1961196-24-6.

(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-4-methylpentanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65027 and the CAS number is 89536-84-5.

(R)-Boc-4-methoxy-β-Phe-OH is a useful organic compound for research related to life sciences. The catalog number is T65025 and the CAS number is 500788-87-4.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is a useful organic compound for research related to life sciences. The catalog number is T66871 and the CAS number is 141942-85-0.

17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or unnatural isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity

(R)-3-(4-Bromophenyl)-3-((tert-butoxycarbonyl)amino)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65895 and the CAS number is 261380-20-5.

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66393 and the CAS number is 1204818-19-8.

(R)-5,7-Difluorochroman-4-ol is a useful organic compound for research related to life sciences. The catalog number is T67112 and the CAS number is 1270294-05-7.

15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) is a synthetic analogue of PGD2 and a selective and potent CRTH2/DP2 receptor agonist that modulates eosinophil CD11b expression, actin polymerisation and chemotaxis.

4(15)-Selinene-11,12-diol is a useful organic compound for research related to life sciences. The catalog number is T124314 and the CAS number is 73035-82-2.

(R)-2-Amino-3-(4-fluorophenyl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T64973 and the CAS number is 18125-46-7.

(R)-5-Chloro-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67331 and the CAS number is 721401-53-2.

(R)-2-Amino-3-(pyridin-4-yl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T67056 and the CAS number is 37535-50-5.

COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor with IC50 values of 0.075 μM for COX-2 and 1.97 μM for 15-LOX. It inhibits LPS-induced production of pro-inflammatory cytokines (IL-6, ROS) and exhibits targeted anti-inflammatory effects [1].

(R)-4-Amino-3-hydroxybutyric acid, also known as (R)-GABOB, acts as a modulator of GABA receptors, specifically binding to both GABAA and GABAB receptors and blocking GABA reuptake in rat brain synaptosomes. Additionally, it serves as a GABAC receptor agonist, triggering currents in patch-clamp assays with Xenopus oocytes that express the human receptor. In vivo studies reveal its capability to suppress electrical discharges in the amygdala in cats undergoing N-amidinobenzamide-triggered seizures, indicating its potential therapeutic application in managing seizure disorders.

Arbaprostil, a synthetic analog of prostaglandin E2 (PGE2) known as 15(R)-15-methyl prostaglandin E2, was developed for its cytoprotective activity. In the commercial production of bulk arbaprostil, one potential impurity is 15(R)-15-methyl Prostaglandin A2 (15(R)-15-methyl PGA2). The pharmacology and EP receptor binding affinity of 15(R)-15-methyl PGA2 have not been reported.

(R)-4-Propyldihydrofuran-2(3H)-one is a useful organic compound for research related to life sciences. The catalog number is T67182 and the CAS number is 63095-51-2.

(R)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-phenylacetic acid is a useful organic compound for research related to life sciences. The catalog number is T65534 and the CAS number is 63422-71-9.

(4R,5R,6S)-4-Nitrobenzyl 3-((diphenoxyphosphoryl)oxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T66253 and the CAS number is 90776-59-3.

(R)-tert-Butyl 2-amino-4-methylpentanoate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66824 and the CAS number is 13081-32-8.