15(r)lipoxin a4

Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 15(R)-LXA4 to regulate leukocyte function.[4] 15(R)-LXA4 is reported to promote resolution of inflammation in LPS-treated stromal cells derived from intermediate-stage diseased supraspinatus tendons as evidenced by increased expression of the STAT-6 pathway target genes, ALOX15 and CD206.[5]

(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide is a cannabinoid receptor antagonist/inverse agonist.

The lipoxins are trihydroxy fatty acids containing a 7,9,11,13-conjugated tetraene. Lipoxin A4 (LXA4) was first described as a metabolite of 15-HpETE and/or 15-HETE when added in vitro to isolated human leukocytes. The material obtained in this manner consists of at least four distinct isomers: 5(S), 6(S); 5(S), 6(R); and the 11-trans and 11-cis isomers of each of these. 6(S)-LXA4 is one of the original four metabolites first identified by Serhan, Nicolaou, and Samuelsson. It was considered to be an artifact by these authors because it lacked the potency of the 5(S),6(R) isomer with respect to contraction of isolated guinea pig lung parenchymal strips. It has not been possible to isolate natural LXA4 from humans or other mammals in amounts sufficient for determination of absolute stereochemistry. Most authors refer to LXA4 as the 5(S)

AP-III-a4 hydrochloride (ENOblock hydrochloride) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo. IC50 value: 0.576 uM [1]

Selina-4(15),7(11)-dien-8-one is a natural product for research related to life sciences. The catalog number is TN3467 and the CAS number is 54707-47-0.

(R)-4-Methoxydalbergione is a natural product for research related to life sciences. The catalog number is TN5798 and the CAS number is 4646-86-0.

4(15),11-Oppositadien-1-ol is a natural product for research related to life sciences. The catalog number is TN2996 and the CAS number is 70389-96-7.

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4. LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 μM.[2] LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.[2],[3],[4]

4(15),5,10(14)-Germacratrien-1-ol is a natural product for research related to life sciences. The catalog number is TN2997 and the CAS number is 81968-62-9.

Eudesm-4(15)-ene-3alpha,11-diol is a compound derived from Eudesm-4(15)-ene-3alpha,11-diol.

15(R)-HETE, a monohydroxy fatty acid, is synthesized from arachidonic acid via aspirin-acetylated COX-2, leading to the formation of specialized pro-resolving mediators 15(R)-lipoxin A4 and B4 through a transcellular mechanism involving 5-lipoxygenase (5-LO). Additionally, this compound is produced by the cytochrome P450 (CYP) isoform CYP2C9 and can be generated from arachidonic acid by COX-1 in human mast cells, where it accumulates due to its resistance to conversion into 15-KETE by 15-hydroxyprostaglandin dehydrogenase (15-PGDH). As an agonist of PPARβ/δ, 15(R)-HETE induces the expression of a target gene in NIH3T3 cells, demonstrating its biological significance.

(R)-3-((tert-Butoxycarbonyl)amino)-4-(3-fluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66938 and the CAS number is 331763-66-7.

19(R)-Hydroxylated prostaglandins (PGs) are present at µg/ml concentrations in the semen of some mammalian species, notably primates, with the majority being from the PGE series and featuring a 15(S),19(R) hydroxyl stereochemistry. These compounds are also observed in marsupials' seminal plasma, where F-type 1 and 2-series compounds are predominant. The 15(R)-hydroxy epimer represents the inverse or unnatural isomer at C-15 for these 19-hydroxylated PGs. Although the biological function of 19(R)-hydroxylated PGs remains unclear, 19(R)-hydroxylation in the F-series leads to a notable reduction in receptor-mediated biological activity in certain assays.

8-iso-15(R)-Prostaglandin F2α (8-iso-15(R) PGF2α) is a chemically distinct member within a broad group of prostaglandin-like eicosanoids, produced through the free radical peroxidation of arachidonic acid contained in membrane phospholipids. It represents the C-15 epimer of 8-isoPGF2α, distinguished as the sole isoprostane isomer extensively examined across numerous biological systems.

(R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-7,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid is a useful organic compound for research related to life sciences and the catalog number is T64669.

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpent-4-enoic acid is a useful organic compound for research related to life sciences. The catalog number is T66485 and the CAS number is 288617-76-5.

(R)-4-Carboxyphenylglycine is a NMDA receptor antagonist.

(R)-3-(4-Bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one is a useful organic compound for research related to life sciences. The catalog number is T66999 and the CAS number is 444335-16-4.

(R)-2-Amino-3-(3,5-dibromo-4-hydroxyphenyl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66789 and the CAS number is 50299-42-8.

(R)-tert-Butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate is a useful organic compound for research related to life sciences and the catalog number is T65597.

(R)-NVS-ZP7-4 is the R-isomer of NVS-ZP7-4. NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.

(S)-4-[2-(Diphenylphosphino)-1-naphthalenyl]-N-[(R)-1-phenylethoxy]phthalazine is a useful organic compound for research related to life sciences and the catalog number is T67269.

(R)-Tetrahydrofuran-3-yl 4-methylbenzenesulfonate is a useful organic compound for research related to life sciences. The catalog number is T65902 and the CAS number is 219823-47-9.

(R)-4-[2-(Diphenylphosphino)-1-naphthalenyl]-N-[(R)-1-phenylethoxy]phthalazine is a useful organic compound for research related to life sciences and the catalog number is T67274.

15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 . 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM). It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.

Carbohydrate Derivatives; Ready for glycosylation

(R)-Methyl 4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate is a useful organic compound for research related to life sciences. The catalog number is T66656 and the CAS number is 10538-59-7.

15(R)-Prostaglandin D2 functions as a DP(2) receptor (Prostaglandin Receptor) agonist with potential roles in prostatic hormone signaling and exhibits anti-inflammatory properties. It enhances actin polymerization in human eosinophils and elevates cAMP levels in platelets [1].

tert-Butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T66629 and the CAS number is 247068-82-2.

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2-fluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65537 and the CAS number is 218608-98-1.

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65588 and the CAS number is 936630-57-8.

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66021 and the CAS number is 157355-79-8.

(R)-2-Amino-2-(4-fluorophenyl)acetic acid is a useful organic compound for research related to life sciences. The catalog number is T67220 and the CAS number is 93939-74-3.

(R)-5-Hydroxy-7-(4-hydroxyphenyl)-1-phenylheptan-3-one is a natural product for research related to life sciences. The catalog number is TN6384 and the CAS number is 1961196-24-6.

(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-4-methylpentanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65027 and the CAS number is 89536-84-5.

(R)-Boc-4-methoxy-β-Phe-OH is a useful organic compound for research related to life sciences. The catalog number is T65025 and the CAS number is 500788-87-4.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is a useful organic compound for research related to life sciences. The catalog number is T66871 and the CAS number is 141942-85-0.

17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or unnatural isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity

(R)-3-(4-Bromophenyl)-3-((tert-butoxycarbonyl)amino)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65895 and the CAS number is 261380-20-5.

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66393 and the CAS number is 1204818-19-8.

(R)-5,7-Difluorochroman-4-ol is a useful organic compound for research related to life sciences. The catalog number is T67112 and the CAS number is 1270294-05-7.

15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) is a synthetic analogue of PGD2 and a selective and potent CRTH2/DP2 receptor agonist that modulates eosinophil CD11b expression, actin polymerisation and chemotaxis.

4(15)-Selinene-11,12-diol is a useful organic compound for research related to life sciences. The catalog number is T124314 and the CAS number is 73035-82-2.

(R)-2-Amino-3-(4-fluorophenyl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T64973 and the CAS number is 18125-46-7.

(R)-5-Chloro-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67331 and the CAS number is 721401-53-2.

(R)-2-Amino-3-(pyridin-4-yl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T67056 and the CAS number is 37535-50-5.

COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor with IC50 values of 0.075 μM for COX-2 and 1.97 μM for 15-LOX. It inhibits LPS-induced production of pro-inflammatory cytokines (IL-6, ROS) and exhibits targeted anti-inflammatory effects [1].

(R)-4-Amino-3-hydroxybutyric acid, also known as (R)-GABOB, acts as a modulator of GABA receptors, specifically binding to both GABAA and GABAB receptors and blocking GABA reuptake in rat brain synaptosomes. Additionally, it serves as a GABAC receptor agonist, triggering currents in patch-clamp assays with Xenopus oocytes that express the human receptor. In vivo studies reveal its capability to suppress electrical discharges in the amygdala in cats undergoing N-amidinobenzamide-triggered seizures, indicating its potential therapeutic application in managing seizure disorders.

Arbaprostil, a synthetic analog of prostaglandin E2 (PGE2) known as 15(R)-15-methyl prostaglandin E2, was developed for its cytoprotective activity. In the commercial production of bulk arbaprostil, one potential impurity is 15(R)-15-methyl Prostaglandin A2 (15(R)-15-methyl PGA2). The pharmacology and EP receptor binding affinity of 15(R)-15-methyl PGA2 have not been reported.