T13848 |
SMARCA-BD ligand 1 for Protac
|
1997319-92-2
|
98%
|
|
SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2
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T15397 |
GNE-049
|
1936421-41-8
|
98%
|
|
GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, resp...
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T5439 |
BRD4 degrader AT1
|
2098836-45-2
|
98%
|
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BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
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T12551 |
PROTAC BRD4 ligand-1
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2313230-51-0
|
98%
|
|
PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET.
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T17249 |
VZ185
|
2306193-61-1
|
98%
|
|
VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
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T17147 |
TPOP146
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2018300-62-2
|
98%
|
|
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
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T13835 |
PROTAC BRD4 Degrader-3
|
2313234-00-1
|
98%
|
|
PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
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T41180 |
JQAD1
|
2417097-18-6
|
98%
|
|
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a ce...
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T10522 |
BET-IN-6
|
T10522
|
98%
|
|
BET-IN-6 is a potent and high affnity BRD2/BRD4 inhibitor. BET-IN-6 is the ligand for target protein BRD2/4, and is used for the systhesis of PROTAC BRD2/BRD4 de...
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T14550 |
BETd-260
|
2093388-62-4
|
98%
|
|
BETd-260 is a potent degrader of BET based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
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T13977 |
(R)-UT-155
|
2031161-54-1
|
98%
|
|
(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.
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T13834 |
PROTAC BRD4 Degrader-2
|
2185795-53-1
|
98%
|
|
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
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T64375 |
UNC 1021
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|
98%
|
|
UNC 1021 is a selective L3MBTL3 inhibitor (IC50 = 0.048 μM).
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T13890 |
SMARCA-BD ligand 1 for Protac dihydrochloride
|
2369053-68-7
|
98%
|
|
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
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T13715L |
GSK9311
|
1923851-49-3
|
98%
|
|
GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negativ...
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T11597L |
IACS-9571 Hydrochloride (1800477-30-8 free base)
|
T11597L
|
98%
|
|
IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
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T13715 |
GSK9311 hydrochloride
|
2253733-09-2
|
98%
|
|
GSK9311 hydrochloride, a less active analog of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain (pIC50s: 6.0 and 4.3 f...
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T17297 |
ZXH-3-26
|
2243076-67-5
|
98%
|
|
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
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T13086 |
I-BET762 carboxylic acid
|
1300019-38-8
|
98%
|
|
I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
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T15484 |
HJB97
|
2093391-24-1
|
98%
|
|
HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1)...
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