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Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling
MAPK Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
Compound Libraries Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD Drug-like Compound Libraries Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
Fragment Libraries General Fragment Libraries Characteristic Fragment Libraries Custom Compound Library

Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
Cat. No. Product name CAS No. Purity Chemical Structure
T13848 SMARCA-BD ligand 1 for Protac 1997319-92-2 98%
SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2
T15397 GNE-049 1936421-41-8 98%
GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, resp...
T5439 BRD4 degrader AT1 2098836-45-2 98%
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
T12551 PROTAC BRD4 ligand-1 2313230-51-0 98%
PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET.
T17249 VZ185 2306193-61-1 98%
VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
T17147 TPOP146 2018300-62-2 98%
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
T13835 PROTAC BRD4 Degrader-3 2313234-00-1 98%
PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
T41180 JQAD1 2417097-18-6 98%
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a ce...
T10522 BET-IN-6 T10522 98%
BET-IN-6 is a potent and high affnity BRD2/BRD4 inhibitor. BET-IN-6 is the ligand for target protein BRD2/4, and is used for the systhesis of PROTAC BRD2/BRD4 de...
T14550 BETd-260 2093388-62-4 98%
BETd-260 is a potent degrader of BET based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
T13977 (R)-UT-155 2031161-54-1 98%
(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.
T13834 PROTAC BRD4 Degrader-2 2185795-53-1 98%
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
T64375 UNC 1021 98%
UNC 1021 is a selective L3MBTL3 inhibitor (IC50 = 0.048 μM).
T13890 SMARCA-BD ligand 1 for Protac dihydrochloride 2369053-68-7 98%
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
T13715L GSK9311 1923851-49-3 98%
GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negativ...
T11597L IACS-9571 Hydrochloride (1800477-30-8 free base) T11597L 98%
IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
T13715 GSK9311 hydrochloride 2253733-09-2 98%
GSK9311 hydrochloride, a less active analog of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain (pIC50s: 6.0 and 4.3 f...
T17297 ZXH-3-26 2243076-67-5 98%
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
T13086 I-BET762 carboxylic acid 1300019-38-8 98%
I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
T15484 HJB97 2093391-24-1 98%
HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1)...
SMARCA-BD ligand 1 for Protac
T13848
SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2
GNE-049
T15397
GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, resp...
BRD4 degrader AT1
T5439
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
PROTAC BRD4 ligand-1
T12551
PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET.
VZ185
T17249
VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
TPOP146
T17147
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
PROTAC BRD4 Degrader-3
T13835
PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
JQAD1
T41180
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a ce...
BET-IN-6
T10522
BET-IN-6 is a potent and high affnity BRD2/BRD4 inhibitor. BET-IN-6 is the ligand for target protein BRD2/4, and is used for the systhesis of PROTAC BRD2/BRD4 de...
BETd-260
T14550
BETd-260 is a potent degrader of BET based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
(R)-UT-155
T13977
(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.
PROTAC BRD4 Degrader-2
T13834
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
UNC 1021
T64375
UNC 1021 is a selective L3MBTL3 inhibitor (IC50 = 0.048 μM).
SMARCA-BD ligand 1 for Protac dihydrochloride
T13890
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
GSK9311
T13715L
GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negativ...
IACS-9571 Hydrochloride (1800477-30-8 free base)
T11597L
IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
GSK9311 hydrochloride
T13715
GSK9311 hydrochloride, a less active analog of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain (pIC50s: 6.0 and 4.3 f...
ZXH-3-26
T17297
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
I-BET762 carboxylic acid
T13086
I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
HJB97
T15484
HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1)...
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