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Search Result

Search Results for " ppar "

Targets

PPAR PPAR

150

Compounds

39

Natural Products

7

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T10506 PPAR agonist 1 PPAR
PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.
T39516 Bocidelpar PPAR
Bocidelpar is a modulator of PPARδ with an EC50 of 7.80 nM and improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy muscle cells.
T22708 Darglitazone CP-86325 PPAR
Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid metabolism.
TQ0156 GW1929 PPAR
GW1929 is a potent PPAR-γ agonist (pKi: 8.84 for human PPAR-γ; pEC50s of 8.56 and 8.27 for human and murine PPAR-γ).
T5532 BMS-687453 PPAR
BMS-687453 is a potent and selective PPAR alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays.
T15945 MA-0204 PPAR
MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively). It is a potential treatmen...
T6689 T0070907 PPAR
T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
T8374 LJ570 PPAR
LJ570 is the first PPARα/γ dual agonist (PPARα,PPARγ with EC50s of 1.05 and 0.12 μM, respectively[)
T1941 GSK3787 PPAR
GSK3787 is a specific and irreversible PPARδ inhibitor（pIC50= 6.6）.
T4408 Elafibranor GFT505 PPAR
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively.
T16350 NSC-87877 Apoptosis , Phosphatase
NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).
T7395 Lanifibranor IVA337 PPAR
Lanifibranor (IVA337) is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively, for transactivation activ...
T7159 L-165041 PPAR
L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)
T2674 GSK0660 PPAR
GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
T24827 SR 16832 SR-16832,SR16832 PPAR
SR 16832 is a dual-site PPARγ inhibitor. It also inhibits the binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonist GW 9662 and T 0070907.
T9808 Tetradecylthioacetic acid PPAR
Tetradecylthioacetic acid is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including acti...
T8486 GW6471 GW 6471 PPAR
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.
T2413 FH535 Wnt/beta-catenin , PPAR
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T3954 Adelmidrol NF-κB , COX , PPAR
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
T0061 Clofibric acid Chlorofibrinic acid PPAR , Drug Metabolite
Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
T21764 MCC-555 Isaglitazone,Netoglitazone PPAR
MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.
T0841 Bezafibrate BM15075 PPAR
Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
T21955 GQ-16 PPAR
GQ-16 is a partial agonist of PPARγ with a Ki of 160 nM. GQ-16 reduces adipogenic actions and promotes insulin Sensitization without weight gain.
T1264 Ciprofibrate Win35833 PPAR
Ciprofibrate (Win35833) is a fibrate derivative with antilipidemic activity.
T10900 CUDA PPAR , Epoxide Hydrolase
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR...
T9766 GW590735 PPAR
GW590735 is an effective and selective PPARα agonist with an EC50 of 4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW590735 can be used in dyslipidemia studies.
T1149 Fenofibrate Procetofen,Lipanthyl,Lipantil P450 , PPAR , Autophagy
Fenofibrate (Lipanthyl) is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.
T1298 Clofibrate Clofibrato,Clofibratum,Ethyl clofibrate PPAR
Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.
T23389 SR1664 SR 1664 PPAR
SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPAR...
T6911 NSC-87877 disodium NSC87877 Apoptosis , Phosphatase
NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduce...
T4628 Seladelpar MBX 8025 PPAR
Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.
T15821 LY518674 LY-674 PPAR
LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα).
T2269 Pirinixic Acid Wy-14643,NSC 310038 PPAR
Pirinixic Acid (NSC 310038) is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates specific peroxisome proliferator-activated recepto...
T6829 EPI-001 EPI001,EPI 001 Apoptosis , Androgen Receptor , PPAR
EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ～6 μM and a selective PPAR-gamma modulator.
T1402 Fenofibric acid Trilipix,FNF acid,NSC 281318 MMP , COX , PPAR
Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
T9756 AZD-9574 PARP
AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.
T13289 EHP-101 VCE-​004.8 Cannabinoid Receptor , HIF/HIF Prolyl-Hydroxylase , PPAR
EHP-101 (VCE-004.8) is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents diet-induced obesity.
T1415 Gemfibrozil CI-719,Jezil,Decrelip,Lopid P450 , Adrenergic Receptor , PPAR
Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi...
T7821 DG172 dihydrochloride DG172 (dihydrochloride),DG-172 dihydrochloride PPAR
DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
T8638 NPC 15199 FMOC-L-Leucine Others
NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.
T15581 Inolitazone RS5444,Efatutazone,CS-7017 PPAR
Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.
T1461 Candesartan CV 11974 RAAS
Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.
T3941 Choline Fenofibrate Trilipix,ABT-335 P450 , COX , PPAR
Choline Fenofibrate (Trilipix) is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.
T16074 Mifobate SR-202 PPAR
Mifobate (SR-202) is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1].
T0214 Pioglitazone U 72107 Ferroptosis , PPAR
Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury.
T3170 Troglitazone CS-045,Romozin,Rezulin,Romglizone,Noscal,Prelay Apoptosis , Ferroptosis , PPAR , Autophagy
Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
T8505 SC-236 Sc 236 Apoptosis , COX , PPAR
SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).
T0509 Cloxiquine 5-Chloro-8-quinolinol,Dermofungin,Dermofongin Antibacterial , Antibiotic , PPAR , Parasite , Antifungal
Cloxiquine (Dermofongin) is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.
T2260 GW9662 TIMTEC-BB SBB006523,GW 9662 PPAR
GW9662 (TIMTEC-BB SBB006523) is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα/δ in cells.
T1622 Rosiglitazone maleate BRL 49653C,BRL 49653 Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.

Compounds

PPAR agonist 1
T10506
Synonym:
Target: PPAR
Bocidelpar
T39516
Synonym:
Target: PPAR
Darglitazone
T22708
Synonym: CP-86325
Target: PPAR
GW1929
TQ0156
Synonym:
Target: PPAR
BMS-687453
T5532
Synonym:
Target: PPAR
MA-0204
T15945
Synonym:
Target: PPAR
T0070907
T6689
Synonym:
Target: PPAR
LJ570
T8374
Synonym:
Target: PPAR
GSK3787
T1941
Synonym:
Target: PPAR
Elafibranor
T4408
Synonym: GFT505
Target: PPAR
NSC-87877
T16350
Synonym:
Target: Apoptosis, Phosphatase
Lanifibranor
T7395
Synonym: IVA337
Target: PPAR
L-165041
T7159
Synonym:
Target: PPAR
GSK0660
T2674
Synonym:
Target: PPAR
SR 16832
T24827
Synonym: SR-16832,SR16832
Target: PPAR
Tetradecylthioacetic acid
T9808
Synonym:
Target: PPAR
GW6471
T8486
Synonym: GW 6471
Target: PPAR
FH535
T2413
Synonym:
Target: Wnt/beta-catenin, PPAR
Adelmidrol
T3954
Synonym:
Target: NF-κB, COX, PPAR
Clofibric acid
T0061
Synonym: Chlorofibrinic acid
Target: PPAR, Drug Metabolite
MCC-555
T21764
Synonym: Isaglitazone,Netoglitazone
Target: PPAR
Bezafibrate
T0841
Synonym: BM15075
Target: PPAR
GQ-16
T21955
Synonym:
Target: PPAR
Ciprofibrate
T1264
Synonym: Win35833
Target: PPAR
CUDA
T10900
Synonym:
Target: PPAR, Epoxide Hydrolase
GW590735
T9766
Synonym:
Target: PPAR
Fenofibrate
T1149
Synonym: Procetofen,Lipanthyl,Lipantil
Target: P450, PPAR, Autophagy
Clofibrate
T1298
Synonym: Clofibrato,Clofibratum,Ethyl clofibrate
Target: PPAR
SR1664
T23389
Synonym: SR 1664
Target: PPAR
NSC-87877 disodium
T6911
Synonym: NSC87877
Target: Apoptosis, Phosphatase
Seladelpar
T4628
Synonym: MBX 8025
Target: PPAR
LY518674
T15821
Synonym: LY-674
Target: PPAR
Pirinixic Acid
T2269
Synonym: Wy-14643,NSC 310038
Target: PPAR
EPI-001
T6829
Synonym: EPI001,EPI 001
Target: Apoptosis, Androgen Receptor, PPAR
Fenofibric acid
T1402
Synonym: Trilipix,FNF acid,NSC 281318
Target: MMP, COX, PPAR
AZD-9574
T9756
Synonym:
Target: PARP
EHP-101
T13289
Synonym: VCE-​004.8
Target: Cannabinoid Receptor, HIF/HIF Prolyl-Hydroxylase, PPAR
Gemfibrozil
T1415
Synonym: CI-719,Jezil,Decrelip,Lopid
Target: P450, Adrenergic Receptor, PPAR
DG172 dihydrochloride
T7821
Synonym: DG172 (dihydrochloride),DG-172 dihydrochloride
Target: PPAR
NPC 15199
T8638
Synonym: FMOC-L-Leucine
Target: Others
Inolitazone
T15581
Synonym: RS5444,Efatutazone,CS-7017
Target: PPAR
Candesartan
T1461
Synonym: CV 11974
Target: RAAS
Choline Fenofibrate
T3941
Synonym: Trilipix,ABT-335
Target: P450, COX, PPAR
Mifobate
T16074
Synonym: SR-202
Target: PPAR
Pioglitazone
T0214
Synonym: U 72107
Target: Ferroptosis, PPAR
Troglitazone
T3170
Synonym: CS-045,Romozin,Rezulin,Romglizone,Noscal,Prelay
Target: Apoptosis, Ferroptosis, PPAR, Autophagy
SC-236
T8505
Synonym: Sc 236
Target: Apoptosis, COX, PPAR
Cloxiquine
T0509
Synonym: 5-Chloro-8-quinolinol,Dermofungin,Dermofongin
Target: Antibacterial, Antibiotic, PPAR, Parasite, Antifungal
GW9662
T2260
Synonym: TIMTEC-BB SBB006523,GW 9662
Target: PPAR
Rosiglitazone maleate
T1622
Synonym: BRL 49653C,BRL 49653
Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy
1 2 3
Cat No. Product Name Synonyms Targets
TN1693 Glabrone Influenza Virus , PPAR
Glabrone shows antiviral activity against influenza virus.
T2824 Pedunculoside Others , Fatty Acid Synthase
Pedunculoside is extracted from Ilex rotunda Thunb.
T3867 Alpinetin (-)-alpinetin BCL , PPAR
Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeutic agent CDDP. Alpinetin has strong anti-he...
T4S2128 Bilobetin PKA , PPAR
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
TN7060 Methyl oleanonate PPAR
3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties.
T2879 Fisetin TNF , Sirtuin , PPAR
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidant, anticancer, neuroprotection effects.
T2985 Gypenoside XLIX PPAR
Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition
T2855 Icariin Ieariline PDE , PPAR , Autophagy
Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
T1238 Daidzein Isoflavone Endogenous Metabolite , PPAR
Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties.
TN1018 Angeloylgomisin H PPAR
Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.
T3362 Eupatilin NSC 122413 PPAR , Autophagy
Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.
T4S1545 Licarin B (-)-Licarin B,Licarine B transporter , Antibacterial , PPAR
1.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.
TN1990 Norathyriol Akt , DNA/RNA Synthesis , AMPK , PPAR
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
T5S0788 Oroxin A Baicalein 7-O-glucoside PPAR
Oroxin A (Baicalein 7-O-glucoside) has antitussive and expectorant effects.
T6917 Oleuropein Apoptosis , Aromatase , ROS , PPAR
Oleuropein is an antioxidant polyphenol isolated from olive leaf.
T12296 Oleoylethanolamide N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide Endogenous Metabolite , PPAR
Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α.
T5S1550 Cinnamyl alcohol Cinnamic Alcohol,Styryl Carbinol PPAR
Cinnamyl alcohol (Styryl Carbinol) readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.
T5701 OPHIOPOGONIN D RAAS , Calcium Channel , NF-κB , PPAR
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
T3000 Magnolol NSC 293099,5,5'-Diallyl-2,2'-biphenyldiol NF-κB , Retinoid Receptor , Antibacterial , PPAR , p53 , Autophagy
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T3403 Glabridin Q-100692,KB-289522,LS-176045 Reactive Oxygen Species , Tyrosinase , GABA Receptor , Antibacterial , PPAR
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on...
T1051 Retinoic acid Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin Retinoid Receptor , Endogenous Metabolite , PPAR , Autophagy
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferat...
T6S0117 Avicularin Fenicularin ERK
Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX...
T19500 Palmitelaidic Acid trans-Palmitoleic acid,9-trans-Hexadecenoic acid Glucokinase , AMPK , PPAR
Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.
T4S1173 Agrimol B Sirtuin , PPAR
1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
T2S0633 Raspberry ketone Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone PPAR
1. Raspberry ketone (p-Hydroxybenzyl acetone) is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of the RK-oligomer, the exposure of human skin to RK can...
TN3500 Beta-Amyrone β-Amyron COX , AChR , PPAR , Antifection
beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through inhibiting the expression of COX-2. beta-Amyrone exhibits a...
T0646 5-Aminosalicylic Acid Mesalazine,5-ASA,Mesalamine NF-κB , Lipoxygenase , COX , Glutathione Peroxidase , Endogenous Metabolite , PAK , PPAR
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.
TN1525 Convallatoxin NF-κB , P-gp , PPAR
Convallatoxin is a natural product
T1633 β-Carotene Carotaben,Beta-Carotene,Provitamin A Apoptosis , ROS , Endogenous Metabolite
β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene...
T3138 Astaxanthin β-Carotene-4,4'-dione,Ovoester,AstaXin,AstaREAL,trans-Astaxanthin Reactive Oxygen Species , PPAR
Astaxanthin (trans-Astaxanthin) is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activity. It is present in most red-colored aqu...
T2932 Ginsenoside Rh1 Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1 IL Receptor , TNF , Endogenous Metabolite , PPAR , Interleukin
Ginsenoside Rh1 (Sanchinoside B2) , one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
T14046 Anandamide (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide Cannabinoid Receptor , Endogenous Metabolite
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous sy...
T2946 Tanshinone IIA sulfonate sodium Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium CaMK , P450 , Calcium Channel
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor...
TN2601 12-O-Methylcarnosic acid Reductase
12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of 5α-Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity...
T4956 Tetrahydroxystilbene-2-O-β-D-glucoside tetrahydroxyl diphenylethylene-2-o-gluco,EH-201 Others
Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astroc...
TN1703 Glycyrin HCV Protease , PPAR , Antifection
Glycyrin, one of the main PPAR-gamma ligands of licorice, can significantly decrease the blood glucose levels of genetically diabetic KK-A(y) mice.
TN4860 Pueroside B COX , PPAR
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A rece...
TN3219 7,8-Didehydrocimigenol ERK , IκB/IKK , TNF , NF-κB , Akt , PPAR
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of V...
TN3655 Cimiside E ERK , TNF , ROS , Akt , PI3K , PKC , PPAR
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.Cimiside E may b...

Natural Products

Glabrone
TN1693
Synonym:
Target: Influenza Virus, PPAR
Pedunculoside
T2824
Synonym:
Target: Others, Fatty Acid Synthase
Alpinetin
T3867
Synonym: (-)-alpinetin
Target: BCL, PPAR
Bilobetin
T4S2128
Synonym:
Target: PKA, PPAR
Methyl oleanonate
TN7060
Synonym:
Target: PPAR
Fisetin
T2879
Synonym:
Target: TNF, Sirtuin, PPAR
Gypenoside XLIX
T2985
Synonym:
Target: PPAR
Icariin
T2855
Synonym: Ieariline
Target: PDE, PPAR, Autophagy
Daidzein
T1238
Synonym: Isoflavone
Target: Endogenous Metabolite, PPAR
Angeloylgomisin H
TN1018
Synonym:
Target: PPAR
Eupatilin
T3362
Synonym: NSC 122413
Target: PPAR, Autophagy
Licarin B
T4S1545
Synonym: (-)-Licarin B,Licarine B
Target: transporter, Antibacterial, PPAR
Norathyriol
TN1990
Synonym:
Target: Akt, DNA/RNA Synthesis, AMPK, PPAR
Oroxin A
T5S0788
Synonym: Baicalein 7-O-glucoside
Target: PPAR
Oleuropein
T6917
Synonym:
Target: Apoptosis, Aromatase, ROS, PPAR
Oleoylethanolamide
T12296
Synonym: N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide
Target: Endogenous Metabolite, PPAR
Cinnamyl alcohol
T5S1550
Synonym: Cinnamic Alcohol,Styryl Carbinol
Target: PPAR
OPHIOPOGONIN D
T5701
Synonym:
Target: RAAS, Calcium Channel, NF-κB, PPAR
Magnolol
T3000
Synonym: NSC 293099,5,5'-Diallyl-2,2'-biphenyldiol
Target: NF-κB, Retinoid Receptor, Antibacterial, PPAR, p53, Autophagy
Glabridin
T3403
Synonym: Q-100692,KB-289522,LS-176045
Target: Reactive Oxygen Species, Tyrosinase, GABA Receptor, Antibacterial, PPAR
Retinoic acid
T1051
Synonym: Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin
Target: Retinoid Receptor, Endogenous Metabolite, PPAR, Autophagy
Avicularin
T6S0117
Synonym: Fenicularin
Target: ERK
Palmitelaidic Acid
T19500
Synonym: trans-Palmitoleic acid,9-trans-Hexadecenoic acid
Target: Glucokinase, AMPK, PPAR
Agrimol B
T4S1173
Synonym:
Target: Sirtuin, PPAR
Raspberry ketone
T2S0633
Synonym: Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone
Target: PPAR
beta-Amyrone
TN3500
Synonym: β-Amyron
Target: COX, AChR, PPAR, Antifection
5-Aminosalicylic Acid
T0646
Synonym: Mesalazine,5-ASA,Mesalamine
Target: NF-κB, Lipoxygenase, COX, Glutathione Peroxidase, Endogenous Metabolite, PAK, PPAR
Convallatoxin
TN1525
Synonym:
Target: NF-κB, P-gp, PPAR
β-Carotene
T1633
Synonym: Carotaben,Beta-Carotene,Provitamin A
Target: Apoptosis, ROS, Endogenous Metabolite
Astaxanthin
T3138
Synonym: β-Carotene-4,4'-dione,Ovoester,AstaXin,AstaREAL,trans-Astaxanthin
Target: Reactive Oxygen Species, PPAR
Ginsenoside Rh1
T2932
Synonym: Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1
Target: IL Receptor, TNF, Endogenous Metabolite, PPAR, Interleukin
Anandamide
T14046
Synonym: (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide
Target: Cannabinoid Receptor, Endogenous Metabolite
Tanshinone IIA sulfonate sodium
T2946
Synonym: Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium
Target: CaMK, P450, Calcium Channel
12-O-Methylcarnosic acid
TN2601
Synonym:
Target: Reductase
Tetrahydroxystilbene-2-O-β-D-glucoside
T4956
Synonym: tetrahydroxyl diphenylethylene-2-o-gluco,EH-201
Target: Others
Glycyrin
TN1703
Synonym:
Target: HCV Protease, PPAR, Antifection
Pueroside B
TN4860
Synonym:
Target: COX, PPAR
7,8-Didehydrocimigenol
TN3219
Synonym:
Target: ERK, IκB/IKK, TNF, NF-κB, Akt, PPAR
Cimiside E
TN3655
Synonym:
Target: ERK, TNF, ROS, Akt, PI3K, PKC, PPAR

Recombinant Proteins

Species：
Human (3)
Mouse (3)
Xenopus laevis (1)
Expression System：
E. coli (6)
Baculovirus-Insect Cells (1)
Tag：
His (2)
N-terminal 6xHis-tagged (2)
His,GST (1)
N-terminal 10xHis-tagged (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
Cat No. Product Name Species Expression System
TMPY-02575 PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling even...
TMPY-06837 PPAR alpha/PPARA Protein, Mouse, Recombinant (His) Mouse E. coli
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcell...
TMPY-06830 PPAR alpha/PPARA Protein, Human, Recombinant (His) Human E. coli
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcell...
TMPH-02827 PPAR gamma Protein, Mouse, Recombinant (His) Mouse E. coli
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the tra...
TMPH-03711 PPAR gamma Protein, Xenopus laevis, Recombinant (His) Xenopus laevis E. coli
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcript...
TMPH-03755 Ppard Protein, Human, Recombinant (His) Human E. coli
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosape...
TMPH-02855 PML Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and vi...
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