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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Cat No. product name
T4S0969 Obtusifolin 1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppre...
T11096 DRI-C21045 Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.D...
T2921 Sinomenine hydrochloride Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.
TN1182 11-​Keto-​beta-​boswellic acid 11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifeste...
T6454 CORM-3 CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
T3384 Wedelolactone Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
T5727 CAFESTOL CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells....
T25150 BI-69A11 BI-69A11 is a dual AKT and NFkB pathway inhibitor. It enhances the susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt...
T0020 Sodium 4-aminosalicylate dihydrate Aminosalicylate Sodium is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Aminosalicylate s...
T1296 4-Aminosalicylic acid Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T3005 4-Hydroxychalcone 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.
T3S0807 Berbamine 1. Berbamine has high binding affinity toward the (GGA);G-quadruplex. 2. Berbamine and its derivatives are promising agents to suppress liver cancer growth by ta...
T3772 Maslinic acid Maslinic acid is a DNA polymerase B inhibitor.
T9105 NF-κB-IN-1 NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κ...
TN1009 Epimagnolin B Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
T0200 α-Lipoic Acid Thioctic acid is an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by c...
TN1244 3'-Demethylnobiletin 3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...
T2830 Betulinic acid Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretrov...
T4361 CBL0137 hydrochloride CBL0137 activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperone...
TQ0198 Phorbol 12-myristate 13-acetate Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
T6S1966 Curculigoside 1. Curculigoside can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic...
T0335 Sodium salicylate Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
TN5284 Sodium Houttuyfonate Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including ...
T7889 C25-140 C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
T5681 ETHYL CAFFEATE In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-re...
T6S1487 Ginsenoside Rg5 1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production a...
T0304 Methylthiouracil Methylthiouracil is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.
T2140 Parthenolide (-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
T3012 Mangiferin Mangiferin is used for antidiabetes. Extracted from Mangifera indica L.
T9582 CLEFMA CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
T2761 Naringin dihydrochalcone Naringin Dihydrochalcone(Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.
T0167 Vinpocetine Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T5701 OPHIOPOGONIN D Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
T3913 Saikosaponin D Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
T0646 5-Aminosalicylic Acid Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
T2733 Sarsasapogenin Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing pl...
T3860 Isoliquiritin apioside Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced act...
T5S1891 Flaconitine Analgesic activity.
TN1660 Ganoderic acid C1 Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
TN1691 Glabrol Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
TN2244 Sulfuretin Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its abili...
TN4234 Hydrangenol Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PCA...
T2992 Pinocembrin Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.
TN1525 Convallatoxin Convallatoxin is a natural product
T0607 Dihydroartemisinin Dihydroartemisinin is a metabolite of artemisinin.
T9033 BTYNB MDK6620 is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and reduces a...
T0694 Pranlukast Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
T2861 Tyrosol Tyrosol is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives.
T5S2129 Sciadopitysin Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin sh...
TN1141 Isodeoxyelephantopin Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
Obtusifolin
T4S0969
1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppre...
DRI-C21045
T11096
Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.D...
Sinomenine hydrochloride
T2921
Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.
11-​Keto-​beta-​boswellic acid
TN1182
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifeste...
CORM-3
T6454
CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
Wedelolactone
T3384
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
CAFESTOL
T5727
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells....
BI-69A11
T25150
BI-69A11 is a dual AKT and NFkB pathway inhibitor. It enhances the susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt...
Sodium 4-aminosalicylate dihydrate
T0020
Aminosalicylate Sodium is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Aminosalicylate s...
4-Aminosalicylic acid
T1296
Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
4-Hydroxychalcone
T3005
4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.
Berbamine
T3S0807
1. Berbamine has high binding affinity toward the (GGA);G-quadruplex. 2. Berbamine and its derivatives are promising agents to suppress liver cancer growth by ta...
Maslinic acid
T3772
Maslinic acid is a DNA polymerase B inhibitor.
NF-κB-IN-1
T9105
NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. ...
Epimagnolin B
TN1009
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
α-Lipoic Acid
T0200
Thioctic acid is an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by c...
3'-Demethylnobiletin
TN1244
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...
Betulinic acid
T2830
Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretrov...
CBL0137 hydrochloride
T4361
CBL0137 activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperon...
Phorbol 12-myristate 13-acetate
TQ0198
Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
Curculigoside
T6S1966
1. Curculigoside can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic...
Sodium salicylate
T0335
Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
Sodium Houttuyfonate
TN5284
Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including ...
C25-140
T7889
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
ETHYL CAFFEATE
T5681
In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-r...
Ginsenoside Rg5
T6S1487
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production a...
Methylthiouracil
T0304
Methylthiouracil is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.
Parthenolide
T2140
(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
Mangiferin
T3012
Mangiferin is used for antidiabetes. Extracted from Mangifera indica L.
CLEFMA
T9582
CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
Naringin dihydrochalcone
T2761
Naringin Dihydrochalcone(Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.
Vinpocetine
T0167
Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
OPHIOPOGONIN D
T5701
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
Saikosaponin D
T3913
Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
5-Aminosalicylic Acid
T0646
Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
Sarsasapogenin
T2733
Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing pl...
Isoliquiritin apioside
T3860
Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced act...
Flaconitine
T5S1891
Analgesic activity.
Ganoderic acid C1
TN1660
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ...
Glabrol
TN1691
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
Sulfuretin
TN2244
Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its abili...
Hydrangenol
TN4234
Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PCA...
Pinocembrin
T2992
Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.
Convallatoxin
TN1525
Convallatoxin is a natural product
Dihydroartemisinin
T0607
Dihydroartemisinin is a metabolite of artemisinin.
BTYNB
T9033
MDK6620 is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and redu...
Pranlukast
T0694
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
Tyrosol
T2861
Tyrosol is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives.
Sciadopitysin
T5S2129
Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin sh...
Isodeoxyelephantopin
TN1141
Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
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