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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Cat. No. Product name CAS No. Purity Chemical Structure
TN4383 Kazinol U 1238116-48-7 98%
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces ce...
TQ0131 Rocaglamide 84573-16-0 95.32%
Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...
T3775 Armepavine 524-20-9
Armepavine exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmun...
TN4394 Kobophenol A 124027-58-3 98%
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
TP1373L Ac2-26 acetate 98%
Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1). Ac2-26 acetate decreases AnxA1 protein expression and inhibits the activation of NF-κB and M...
TN1694 Gliotoxin 67-99-2 98%
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
TN3635 Chlojaponilactone B 1449382-91-5 98%
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
TN4938 Samidin 477-33-8 98%
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
TN4038 Eupatolide 6750-25-0 98%
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
TN3587 Capillarisin 56365-38-9 98%
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN1806 Isotetrandrine 477-57-6 98%
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
TN1485 Chicanine 78919-28-5 98%
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
TN2095 Pomiferin 572-03-2 98%
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
T15601 IT-901 1584121-99-2 98%
IT-901 is an orally active and effective inhibitor of NF-κB subunit c-Rel (IC50s: 0.1 µM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively). IT-901...
TMA1777 Hydrangenol 8-O-glucoside 67600-94-6 98%
Hydrangenol 8-O-glucoside may have anti-inflammary activity.
TN3410 Anatabine 581-49-7 98%
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN4633 Neocryptotanshinone II 27468-20-8 98%
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
TN4263 Isoangustone A 129280-34-8 98%
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
T4366 Quinovic acid 465-74-7 98%
Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by ind...
TN1764 Incensole acetate 34701-53-6 98%
Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.
Kazinol U
TN4383
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces ce...
Rocaglamide
TQ0131
Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...
Armepavine
T3775
Armepavine exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmun...
Kobophenol A
TN4394
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
Ac2-26 acetate
TP1373L
Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1). Ac2-26 acetate decreases AnxA1 protein expression and inhibits the activation of NF-κB and M...
Gliotoxin
TN1694
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
Chlojaponilactone B
TN3635
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
Samidin
TN4938
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Eupatolide
TN4038
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Isotetrandrine
TN1806
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
Chicanine
TN1485
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
Pomiferin
TN2095
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
IT-901
T15601
IT-901 is an orally active and effective inhibitor of NF-κB subunit c-Rel (IC50s: 0.1 µM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively). IT-901...
Hydrangenol 8-O-glucoside
TMA1777
Hydrangenol 8-O-glucoside may have anti-inflammary activity.
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Neocryptotanshinone II
TN4633
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
Isoangustone A
TN4263
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
Quinovic acid
T4366
Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by ind...
Incensole acetate
TN1764
Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.
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