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Search Results for " topoisomerase "

Targets

311

Compounds

55

Natural Products

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T67899 Topoisomerase II inhibitor 13 Topoisomerase
Topoisomerase II inhibitor 13 inhibits topoisomerase II (Topo II) that shows strong anti-proliferation activity against HL-60/MX2 cancer cells derived from HL-60 against Topo II toxicity.
T77650 Topoisomerase II inhibitor 14 Apoptosis , Antioxidant , Topoisomerase , NO Synthase
Topoisomerase II inhibitor 14 is a potent topoisomerase II inhibitor with anticancer and antioxidant activities.Topoisomerase II inhibitor 14 induces apoptosis and blocks the cell cycle in S phase.Topoisomerase II inhibi...
T78717 Topoisomerase inhibitor 2 Topoisomerase
Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].
T60766 Topoisomerase I inhibitor 3
Topoisomerase I (Compound ZML-14) inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase. Topoisomerase I inhibitor 3 is an inhibitor of topoisomerase I that interact with topoisomerase I-DNA compl...
T61017 Topoisomerase II inhibitor 6
Topoisomerase II inhibitor 6 (Compound 5) is a tryptanthrin derivative. Topoisomerase II inhibitor 6 is a potent and selective topoisomerase II inhibitor. Topoisomerase II inhibitor 6 blocks the CCRF-CEM cell cycle in th...
T64164 Topoisomerase II inhibitor 11
Topoisomerase II inhibitor 11 (compound 3d) is a potent inhibitor of Topoisomerase II (IC50: 2.89 μM). Topoisomerase II inhibitor 11 inhibits cell proliferation and has apoptotic activity by blocking the cell cycle in th...
T80968 Topoisomerase I inhibitor 10 Topoisomerase
Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity. Specifically, it demonstrates efficacy against L. donovani promastigotes with an IC50 ...
T63068 Topoisomerase II inhibitor 5
Topoisomerase II inhibitor 5 (Compound E24) is a DNAtopoisomerase II inhibitor with anticancer effects.
T61283 Topoisomerase II inhibitor 3
Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative that acts as a Type II DNA topoisomerase (topo II) inhibitor. It specifically inhibits the topo IIα/β subtypes, with an IC50 value of 0.17 μM for topo...
T79539 Topoisomerase II inhibitor 16 Topoisomerase
Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the ability to penetrate the brain and stabilize double-stranded D...
T62002 Topoisomerase I inhibitor 7
Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lympho...
T63594 Topoisomerase IIα-IN-3
Topoisomerase IIα-IN-3 is a DNA-inserting topoisomerase-Iiα inhibitor that blocks the cell cycle in G0/G1 phase and induces apoptosis.
T62225 Topoisomerase I inhibitor 8
Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells.
T62223 Topoisomerase IIα-IN-1
Topoisomerase IIα-IN-1 (compound 2) is a DNA-binding ligands and a potent inhibitor of TopoIIα, a topoisomerase. topoisomerase IIα-IN-1 shows good anti-proliferative effects on human cancer cell lines.
T60781 Topoisomerase II inhibitor 8
Topoisomerase II inhibitor 8 (compound 22) shows good anti-proliferative activities and arrest the cell cycle at G2/M phase. Topoisomerase II inhibitor 8 is a potent inhibitor of topoisomerase II (IC 50 = 0.52 μM) [1].
T80967 Topoisomerase I inhibitor 9 Topoisomerase
Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value of 34.81μM against L. donovani promastigotes [1].
T61431 Topoisomerase IIα-IN-4
Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, specifically inhibiting TopoIIα with an IC50 value of 3.8 μM and TopoIIβ with an IC50 value of 10.1 μM. It demon...
T72157 Topoisomerase II inhibitor 7
Topoisomerase II inhibitor 7, a potent inhibitor of the topoisomerase II alpha subtype, exhibits an IC50 of 3.19 μM. It effectively induces cell cycle arrest and apoptosis.
T72153 Topoisomerase IV inhibitor 1 Topoisomerase
Topoisomerase IV inhibitor 2 (compound 7d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.23 μM for TOPO IV and 0.43 μM for DNA gyrase. It also demonstrates antibacterial efficacy, w...
T61501 Topoisomerase I inhibitor 5
Topoisomerase I inhibitor 5 is an efficient inhibitor of topoisomerase I, with an IC50 value. It effectively disrupts DNA and inhibits the activity of topoisomerase I. Moreover, it can induce apoptosis in MCF-7 cells and...
T64047 Topoisomerase II inhibitor 10
Topoisomerase II inhibitor 10 is a potent inhibitor of topoisomerase II (IC50: 7.45 μM). Topoisomerase II inhibitor 10 was able to arrest the cell cycle of HepG-2 cells in the G2-M phase and induce apoptosis.
T62224 Topoisomerase IIα-IN-2
Topoisomerase IIα-IN-2 (compound 5) is a DNA-binding ligands and a potent inhibitor of the topoisomerase TopoIIα. Topoisomerase IIα-IN-2 exhibits high anti-proliferative activity in human cancer cell lines. Topoisomerase...
T60617 Topoisomerase I inhibitor 2
Topoisomerase I inhibitor 2 (ZML-8) is a highly selective DNA topoisomerase I (Top1) inhibitor that inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis with ...
T62887 Topoisomerase II inhibitor 4
Topoisomerase II inhibitor 4 (compound E17) is a potent inhibitor of topoisomerase II. Topoisomerase II inhibitor 4 has antitumour effects, blocking the cell cycle in the G2/M phase, inhibiting the proliferation of cance...
T61717 Topoisomerase I inhibitor 4
Topoisomerase I inhibitor 4 (compound 7a) is a potent inhibitor of topoisomerase I activity. It effectively inhibits the proliferation of various cancer cell lines including HepG2, A549, MCF-7, and HeLa, with IC50 values...
T62094 Topoisomerase I inhibitor 6
Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I that traps the DNA-Top1 cleavage complex and has low cytotoxicity in non-cancerous cell lines. Research value.
T63304 Topoisomerase II inhibitor 9
Topoisomerase II inhibitor 9 is a Topo II inhibitor (IC50: 0.97 μM) and DNA embedding agent (IC50: 43.51 μM) that blocks the Hep G-2 cell cycle in the G2/M phase and induces apoptosis.
T72154 Topoisomerase IV inhibitor 2 Topoisomerase
Topoisomerase IV inhibitor 2 (compound 5d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.35 μM for TOPO IV and 0.55 μM for DNA gyrase. It also demonstrates antibacterial properties,...
T79506 Topoisomerase II inhibitor 15 Topoisomerase
Topoisomerase II inhibitor 15 (compound 2g) serves as a potent apoptotic inducer, exhibiting heightened selectivity for head and neck tumors [1].
T61054 Type II topoisomerase inhibitor 1
Type II topoisomerase inhibitor 1 is able to be used in the antibacterial area. Type II topoisomerase inhibitor 1 is a potent and selective inhibitor of E. coli DNA gyrase with a IC50 value of 1.7 nM as well as forms hyd...
T61045 Topoisomerase I/II inhibitor 2
Topoisomerase I/II inhibitor 2 (compound 1a) can significantly reduce the xenograft tumor growth in mice model which can be used in treating liver cancer. Topoisomerase I/II inhibitor 2 is a DNA topoisomerase I/II dual i...
T63360 DNA topoisomerase II inhibitor 1
DNA topoisomerase II inhibitor 1 is a potent inhibitor of DNA topoisomerase II that arrests the cell cycle in sub-G1 phase and induces apoptosis with anti-value-added effects.
T31011 Coralyne chloride Topoisomerase
Coralyne Chloride is a molecular rectifier based on fluorescent DNA, which is constructed into DNA double-stranded bodies by site-specific insertion.
T61990 Topoisomerase I/II inhibitor 3
Topoisomerase I/II inhibitor 3 (compound 7) is a potent dual inhibitor of topoisomerase I (Topo I) and II (Topo II) . By inhibiting PI3K /Akt/mTOR signaling pathway, Topoisomerase I/II inhibitor 3 can inhibit cell prolif...
T63526 Topoisomerase I/II inhibitor 4
Topoisomerase I/II inhibitor 4 is a potent dual inhibitor of topoisomerase I (Topo I) and II (Topo II) with inhibitory effects on cell proliferation, invasion and migration, and induction of apoptosis, and can be used to...
T26046 Razoxane Topoisomerase
Razoxane is used as an antimitotic agent with immunosuppressive properties.
T36968 ARN-21934 Topoisomerase
ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etopo...
T7187 Genz-644282 Genz644282 Topoisomerase
Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.
T13231L Trovafloxacin mesylate Others , DNA/RNA Synthesis , Topoisomerase , Antibacterial
Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the ...
T3181 SW044248 Topoisomerase
SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
T3481 Bimolane Topoisomerase
Bimolane is a topoisomerase II inhibitor.
T6628 Pirarubicin Theprubicin,THP Topoisomerase , Antibacterial , Antibiotic , Autophagy
Pirarubicin (Theprubicin) is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II, utilized as an antineoplastic agent.
T8747 Levofloxacin hydrochloride DNA gyrase , Topoisomerase
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inh...
T4047 Bisantrene CL216942 Topoisomerase
Bisantrene (CL216942) is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and ...
T7551 Belotecan hydrochloride CKD-602 Topoisomerase
Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity
T7804 Garenoxacin mesylate hydrate Garenoxacin mesylate [USAN],BMS284756 (Mesylate hydrate) Antibacterial
Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strains.
T1060 Flumequine Flumigal,R-802 Topoisomerase , Antibacterial , Antibiotic
Flumequine (R-802) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necess...
T16522 Phenoxodiol Dehydroequol,Idronoxil,Haginin E Apoptosis , IAP , Caspase , Topoisomerase , p53
Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apop...
T16557 PNU-159682 Topoisomerase
PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin. PNU-159682 has outstanding cytotoxicity. PNU-159682 is an effective ADCs cytotoxin.
TQ0088 Exatecan Mesylate DX8951f Topoisomerase
Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).

Compounds

Topoisomerase II inhibitor 13
T67899
Synonym:
Target: Topoisomerase
Topoisomerase II inhibitor 14
T77650
Synonym:
Target: Apoptosis, Antioxidant, Topoisomerase, NO Synthase
Topoisomerase inhibitor 2
T78717
Synonym:
Target: Topoisomerase
Topoisomerase I inhibitor 3
T60766
Synonym:
Target:
Topoisomerase II inhibitor 6
T61017
Synonym:
Target:
Topoisomerase II inhibitor 11
T64164
Synonym:
Target:
Topoisomerase I inhibitor 10
T80968
Synonym:
Target: Topoisomerase
Topoisomerase II inhibitor 5
T63068
Synonym:
Target:
Topoisomerase II inhibitor 3
T61283
Synonym:
Target:
Topoisomerase II inhibitor 16
T79539
Synonym:
Target: Topoisomerase
Topoisomerase I inhibitor 7
T62002
Synonym:
Target:
Topoisomerase IIα-IN-3
T63594
Synonym:
Target:
Topoisomerase I inhibitor 8
T62225
Synonym:
Target:
Topoisomerase IIα-IN-1
T62223
Synonym:
Target:
Topoisomerase II inhibitor 8
T60781
Synonym:
Target:
Topoisomerase I inhibitor 9
T80967
Synonym:
Target: Topoisomerase
Topoisomerase IIα-IN-4
T61431
Synonym:
Target:
Topoisomerase II inhibitor 7
T72157
Synonym:
Target:
Topoisomerase IV inhibitor 1
T72153
Synonym:
Target: Topoisomerase
Topoisomerase I inhibitor 5
T61501
Synonym:
Target:
Topoisomerase II inhibitor 10
T64047
Synonym:
Target:
Topoisomerase IIα-IN-2
T62224
Synonym:
Target:
Topoisomerase I inhibitor 2
T60617
Synonym:
Target:
Topoisomerase II inhibitor 4
T62887
Synonym:
Target:
Topoisomerase I inhibitor 4
T61717
Synonym:
Target:
Topoisomerase I inhibitor 6
T62094
Synonym:
Target:
Topoisomerase II inhibitor 9
T63304
Synonym:
Target:
Topoisomerase IV inhibitor 2
T72154
Synonym:
Target: Topoisomerase
Topoisomerase II inhibitor 15
T79506
Synonym:
Target: Topoisomerase
Type II topoisomerase inhibitor 1
T61054
Synonym:
Target:
Topoisomerase I/II inhibitor 2
T61045
Synonym:
Target:
DNA topoisomerase II inhibitor 1
T63360
Synonym:
Target:
Coralyne chloride
T31011
Synonym:
Target: Topoisomerase
Topoisomerase I/II inhibitor 3
T61990
Synonym:
Target:
Topoisomerase I/II inhibitor 4
T63526
Synonym:
Target:
Razoxane
T26046
Synonym:
Target: Topoisomerase
ARN-21934
T36968
Synonym:
Target: Topoisomerase
Genz-644282
T7187
Synonym: Genz644282
Target: Topoisomerase
Trovafloxacin mesylate
T13231L
Synonym:
Target: Others, DNA/RNA Synthesis, Topoisomerase, Antibacterial
SW044248
T3181
Synonym:
Target: Topoisomerase
Bimolane
T3481
Synonym:
Target: Topoisomerase
Pirarubicin
T6628
Synonym: Theprubicin,THP
Target: Topoisomerase, Antibacterial, Antibiotic, Autophagy
Levofloxacin hydrochloride
T8747
Synonym:
Target: DNA gyrase, Topoisomerase
Bisantrene
T4047
Synonym: CL216942
Target: Topoisomerase
Belotecan hydrochloride
T7551
Synonym: CKD-602
Target: Topoisomerase
Garenoxacin mesylate hydrate
T7804
Synonym: Garenoxacin mesylate [USAN],BMS284756 (Mesylate hydrate)
Target: Antibacterial
Flumequine
T1060
Synonym: Flumigal,R-802
Target: Topoisomerase, Antibacterial, Antibiotic
Phenoxodiol
T16522
Synonym: Dehydroequol,Idronoxil,Haginin E
Target: Apoptosis, IAP, Caspase, Topoisomerase, p53
PNU-159682
T16557
Synonym:
Target: Topoisomerase
Exatecan Mesylate
TQ0088
Synonym: DX8951f
Target: Topoisomerase
1 2 3 4 5 6 7
Cat No. Product Name Synonyms Targets
TN1037 Groenlandicine Topoisomerase
Groenlandicine is a protoberberine alkaloid from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR). Groenlandicine selectively ...
T12651 Rabdosiin (+)-Rabdosiin Others
Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.
T5S1952 9-Methoxycamptothecin Apoptosis , Topoisomerase
9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.
TN4660 Niranthin Anti-infection , HBV , PAFR , Topoisomerase
Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. N...
T21065 Artemisitene Others
Artemisitene is the oxidized form of Artemisinin and is an antimalarial agent. Artemisinin precursors are the important basic substances for biosynthesis of Artemisinin, including Artemisinin B, Artemisitene, Artemisini...
T1123 Camptothecin NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT Apoptosis , Influenza Virus , Topoisomerase , Antibiotic , Antifungal
Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
T3332 Isosteviol (-)-Isosteviol IL Receptor , Potassium Channel , TNF , NF-κB , Reactive Oxygen Species , COX , Topoisomerase
Isosteviol ((-)-Isosteviol), a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysis products, steviol, isosteviol and stevio...
T5853 Rubitecan RFS 2000,9-Nitrocamptothecin Topoisomerase
Rubitecan (9-Nitrocamptothecin) is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a se...
T1166 Ellipticine NSC 71795,Elliptisine Topoisomerase
Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-6...
T6228 Irinotecan CPT-11,Topotecin,(+)-Irinotecan Topoisomerase , Autophagy
Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting...
T1521 (±)-10-Hydroxycamptothecin Hydroxy Camptothecine,10-Hydroxycamptothecin Topoisomerase
(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. S...
T4614 Ellipticine hydrochloride Ellipticine HCl,NSC 71795 (hydrochloride) Topoisomerase
Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
T0909 Nalidixic acid NSC-82174 Topoisomerase , Antibacterial , Antibiotic
Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.
T4S0797 Berberine Berberin,Umbellatine Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy
1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3....
T5S0761 Nitidine chloride Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id...
T3S1957 9-amino-CPT Aminocamptothecin,9-amino-2(S)-camptothecin,9-Aminocamptothecin Topoisomerase
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
T5784 Topotecan NSC 609669,SKF 104864A Topoisomerase , Autophagy
Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.
T5S0814 Berberine hydrogen sulphate Berberine Bisulfate,Umbellatine Sulfate Antibacterial
Berberine hydrogen sulphate (Umbellatine Sulfate) , an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria,...
T6567 Levofloxacin Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin Topoisomerase , Antibacterial , Antibiotic
Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
T1703 SN-38 NK012,SN 38 DNA/RNA Synthesis , Topoisomerase , Autophagy
SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM). SN-38 has antitumor activity and induces autophagy.
T2764 (S)-10-Hydroxycamptothecin 10-Hydroxycamptothecin,10-HCPT Apoptosis , Topoisomerase
(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
T0486L Irinotecan Hydrochloride Camptothecin 11 hydrochloride,CPT-11 hydrochloride Topoisomerase , Autophagy
Irinotecan Hydrochloride (CPT-11 hydrochloride) is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptoth...
T0132 Etoposide VP-16,VP-16-213 Apoptosis , Mitophagy , Topoisomerase , Antibacterial , Antibiotic , Autophagy
Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.
T0461 Berberine chloride Berberine hydrochloride,Benzodioxide,Natural Yellow 18 Reactive Oxygen Species , Topoisomerase , Antibacterial , Antibiotic , Autophagy
Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae and also found in many other plants. It is relatively toxic to parenterally but has been used orally for various fungal an...
TN2105 Proscillaridin A Topoisomerase
Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
T1174 Topotecan hydrochloride SKF 104864A,SKFS 104864A,NSC609699,Nogitecan HCl,NSC 609669,Topotecan HCl Apoptosis , Topoisomerase , Autophagy
Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.
T0486 Irinotecan hydrochloride trihydrate Irinotecan HCl Trihydrate,CPT-11 HCl Trihydrate Topoisomerase , Autophagy
Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.
T2830 Betulinic acid ALS-357,Lupatic acid,Betulic acid Apoptosis , Mitophagy , NF-κB , HIV Protease , Topoisomerase , Endogenous Metabolite , Aminopeptidase , Autophagy
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory propert...
T1020 Doxorubicin hydrochloride Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,NSC 123127 Apoptosis , Mitophagy , HBV , HIV Protease , Topoisomerase , Antibacterial , Antibiotic , AMPK , Autophagy
Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitum...
T6407 β-Lapachone Beta-Lapachone,NSC-26326,SL-11001,ARQ-501 IDO , Apoptosis , Topoisomerase , Autophagy
β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
T8384 Gatifloxacin hydrochloride AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride) Topoisomerase , Antibacterial , Antibiotic
Gatifloxacin hydrochloride (AM-1155 hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, which can inhibit the bacterial enzyme DNA rotase and topoisomerase IV.
T1511 Daunorubicin hydrochloride Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin Apoptosis , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic , Autophagy
Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis.
T1456 Doxorubicin Hydroxydaunorubicin,Adriamycin Topoisomerase , AMPK
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
TN1917 Mauritianin Topoisomerase
Mauritianin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica and is a topoisomerase I inhibitor.Mauritianin has cytoprotective activity.
T1737 Genistein NPI 031L Apoptosis , EGFR , Endogenous Metabolite , Autophagy
Genistein (NPI 031L) is an isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA TOPOISOMERASES, TYPE II), with antineoplastic and antitumor activities.
T3339 Sophoridine 5-Epidihydrosophocarpine,Dihydro-5-episophocarpine Apoptosis , Topoisomerase
Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity ...
T16726 Rebeccamycin Topoisomerase
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and...
T25775 Mansonone E
Mansonone E is a topoisomerase II inhibitor with cytotoxic and topo inhibitory potencies.
TQ0134 Podocarpusflavone A Topoisomerase
Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
TN2915 3-Acetoxy-27-hydroxy-20(29)-lupen 3-Acetoxy-27-hydroxy-20(29)-lupen-28-oic acid methyl ester Others
3-Acetoxy-27-hydroxy-20(29)-lupen is a potent topoisomerase II inhibitor.
TN2861 3,27-Dihydroxy-20(29)-lupen-28-oic acid methyl ester Others
3,27-Dihydroxy-20(29)-lupen-28-oic acid methyl ester is a potent topoisomerase II inhibitor.
TN4422 Lauterine Topoisomerase
Lauterine is a DNA topoisomerase inhibitor.
T26953 Carubicin hydrochloride NSC 275649,Karminomycin hydrochloride,Carubicin HCl
Carubicin HCl is an anthracycline antineoplastic antibiotic. Through intercalates into DNA and interacts with topoisomerase II, Carubicin inhibits DNA replication and repair and RNA and protein synthesis.
T21328 Carubicin carminomycin,Carminomycin I,Carminomicin I,Antibiotic R 588A,Demethyldaunomycin
Carubicin is an anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repa...
T14545 Berberine chloride hydrate Natural Yellow 18 chloride hydrate Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Parasite , Autophagy
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid commonly used as an antibiotic.Berberine chloride hydrate has antitumor activity, induces the generation of reactive oxygen species (ROS), an...
T16719 Radicicol Monorden HSP
Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol binds to the ATPase domain of Hsp90 and pr...
T14196 Alternariol Others
Alternariol (AOH), a mycotoxin synthesized by Alternaria species, displays numerous therapeutic and biological effects, including phytotoxic, cytotoxic, anti-HIV, anti-cancer, and anti-microbial properties. It functions ...
TN1734 Heveaflavone Antioxidant , Topoisomerase
Heveaflavone inhibits Topoisomerase I and scavenges DPPH free radical with anti-proliferation and antioxidant effects.
T10238 Aclacinomycin A hydrochloride Aclarubicin hydrochloride Proteasome
Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinom...
TN5133 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone HIV Protease , Topoisomerase
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptas...
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Natural Products

Groenlandicine
TN1037
Synonym:
Target: Topoisomerase
Rabdosiin
T12651
Synonym: (+)-Rabdosiin
Target: Others
9-Methoxycamptothecin
T5S1952
Synonym:
Target: Apoptosis, Topoisomerase
Niranthin
TN4660
Synonym:
Target: Anti-infection, HBV, PAFR, Topoisomerase
Artemisitene
T21065
Synonym:
Target: Others
Camptothecin
T1123
Synonym: NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT
Target: Apoptosis, Influenza Virus, Topoisomerase, Antibiotic, Antifungal
Isosteviol
T3332
Synonym: (-)-Isosteviol
Target: IL Receptor, Potassium Channel, TNF, NF-κB, Reactive Oxygen Species, COX, Topoisomerase
Rubitecan
T5853
Synonym: RFS 2000,9-Nitrocamptothecin
Target: Topoisomerase
Ellipticine
T1166
Synonym: NSC 71795,Elliptisine
Target: Topoisomerase
Irinotecan
T6228
Synonym: CPT-11,Topotecin,(+)-Irinotecan
Target: Topoisomerase, Autophagy
(±)-10-Hydroxycamptothecin
T1521
Synonym: Hydroxy Camptothecine,10-Hydroxycamptothecin
Target: Topoisomerase
Ellipticine hydrochloride
T4614
Synonym: Ellipticine HCl,NSC 71795 (hydrochloride)
Target: Topoisomerase
Nalidixic acid
T0909
Synonym: NSC-82174
Target: Topoisomerase, Antibacterial, Antibiotic
Berberine
T4S0797
Synonym: Berberin,Umbellatine
Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy
Nitidine chloride
T5S0761
Synonym:
Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite
9-amino-CPT
T3S1957
Synonym: Aminocamptothecin,9-amino-2(S)-camptothecin,9-Aminocamptothecin
Target: Topoisomerase
Topotecan
T5784
Synonym: NSC 609669,SKF 104864A
Target: Topoisomerase, Autophagy
Berberine hydrogen sulphate
T5S0814
Synonym: Berberine Bisulfate,Umbellatine Sulfate
Target: Antibacterial
Levofloxacin
T6567
Synonym: Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin
Target: Topoisomerase, Antibacterial, Antibiotic
SN-38
T1703
Synonym: NK012,SN 38
Target: DNA/RNA Synthesis, Topoisomerase, Autophagy
(S)-10-Hydroxycamptothecin
T2764
Synonym: 10-Hydroxycamptothecin,10-HCPT
Target: Apoptosis, Topoisomerase
Irinotecan Hydrochloride
T0486L
Synonym: Camptothecin 11 hydrochloride,CPT-11 hydrochloride
Target: Topoisomerase, Autophagy
Etoposide
T0132
Synonym: VP-16,VP-16-213
Target: Apoptosis, Mitophagy, Topoisomerase, Antibacterial, Antibiotic, Autophagy
Berberine chloride
T0461
Synonym: Berberine hydrochloride,Benzodioxide,Natural Yellow 18
Target: Reactive Oxygen Species, Topoisomerase, Antibacterial, Antibiotic, Autophagy
Proscillaridin A
TN2105
Synonym:
Target: Topoisomerase
Topotecan hydrochloride
T1174
Synonym: SKF 104864A,SKFS 104864A,NSC609699,Nogitecan HCl,NSC 609669,Topotecan HCl
Target: Apoptosis, Topoisomerase, Autophagy
Irinotecan hydrochloride trihydrate
T0486
Synonym: Irinotecan HCl Trihydrate,CPT-11 HCl Trihydrate
Target: Topoisomerase, Autophagy
Betulinic acid
T2830
Synonym: ALS-357,Lupatic acid,Betulic acid
Target: Apoptosis, Mitophagy, NF-κB, HIV Protease, Topoisomerase, Endogenous Metabolite, Aminopeptidase, Autophagy
Doxorubicin hydrochloride
T1020
Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,NSC 123127
Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy
β-Lapachone
T6407
Synonym: Beta-Lapachone,NSC-26326,SL-11001,ARQ-501
Target: IDO, Apoptosis, Topoisomerase, Autophagy
Gatifloxacin hydrochloride
T8384
Synonym: AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride)
Target: Topoisomerase, Antibacterial, Antibiotic
Daunorubicin hydrochloride
T1511
Synonym: Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin
Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy
Doxorubicin
T1456
Synonym: Hydroxydaunorubicin,Adriamycin
Target: Topoisomerase, AMPK
Mauritianin
TN1917
Synonym:
Target: Topoisomerase
Genistein
T1737
Synonym: NPI 031L
Target: Apoptosis, EGFR, Endogenous Metabolite, Autophagy
Sophoridine
T3339
Synonym: 5-Epidihydrosophocarpine,Dihydro-5-episophocarpine
Target: Apoptosis, Topoisomerase
Rebeccamycin
T16726
Synonym:
Target: Topoisomerase
Mansonone E
T25775
Synonym:
Target:
Podocarpusflavone A
TQ0134
Synonym:
Target: Topoisomerase
3-Acetoxy-27-hydroxy-20(29)-lupen
TN2915
Synonym: 3-Acetoxy-27-hydroxy-20(29)-lupen-28-oic acid methyl ester
Target: Others
3,27-Dihydroxy-20(29)-lupen-28-oic acid methyl ester
TN2861
Synonym:
Target: Others
Lauterine
TN4422
Synonym:
Target: Topoisomerase
Carubicin hydrochloride
T26953
Synonym: NSC 275649,Karminomycin hydrochloride,Carubicin HCl
Target:
Carubicin
T21328
Synonym: carminomycin,Carminomycin I,Carminomicin I,Antibiotic R 588A,Demethyldaunomycin
Target:
Berberine chloride hydrate
T14545
Synonym: Natural Yellow 18 chloride hydrate
Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Parasite, Autophagy
Radicicol
T16719
Synonym: Monorden
Target: HSP
Alternariol
T14196
Synonym:
Target: Others
Heveaflavone
TN1734
Synonym:
Target: Antioxidant, Topoisomerase
Aclacinomycin A hydrochloride
T10238
Synonym: Aclarubicin hydrochloride
Target: Proteasome
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
TN5133
Synonym:
Target: HIV Protease, Topoisomerase

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-01776 Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) Human HEK293
Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and...
TMPH-00558 30S ribosomal protein S11 Protein, E. coli, Recombinant (His) E. coli E. coli
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (Pa...
TMPH-03470 GyrB Protein, Salmonella typhi, Recombinant (His & Myc) Salmonella typhi E. coli
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favor...
TMPH-03132 AVPR2 Protein, Pig, Recombinant (His & SUMO) Sus scrofa (Pig) E. coli
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favor...
TMPY-01690 Carboxylesterase 2/CES2 Protein, Mouse, Recombinant (His) Mouse HEK293
Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and...
TargetMol