T0128L |
Vigabatrin Hydrochloride
|
1391054-02-6
|
|
|
Vigabatrin Hydrochloride (γ-Vinyl-GABA hydrochloride) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), which irreversibly in...
|
T16717 |
Radequinil
|
219846-31-8
|
98%
|
|
Radequinil is a benzodiazepine receptor partial inverse agonist. Rade quinil binds to GABA(-) and GABA(+) ligand (Kis: 5.15 and 6.11 nM, respectively).
|
TN3351 |
Aflatrem
|
70553-75-2
|
98%
|
|
Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocam...
|
T14938 |
CGP 36742
|
123690-78-8
|
98%
|
|
CGP 36742 is a selective antagonist of the GABAB receptor that can penetrate the blood-brain barrier after peripheral administration (IC50: 32 μM). It is useful ...
|
T16794 |
RO 4938581
|
883093-10-5
|
98%
|
|
RO 4938581 is an effective and selective agonist of GABAA α5 inverse (Ki: 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, ...
|
T78071 |
3-Methylglutaconic acid
|
5746-90-7
|
98%
|
|
3-Methylglutaconic acid, a primary metabolite accumulating in 3-Methylglutaconic aciduria (MGTA), induces lipid and protein oxidation, while diminishing non-enzy...
|
T78111 |
NCS-382 sodium
|
131733-92-1
|
98%
|
|
NCS-382 (sodium) is a potent antagonist of the GABA receptor, exhibiting anti-sedative and anti-hypnotic properties, with applications in neurological disease re...
|
T78560 |
U-89843A
|
157013-85-9
|
98%
|
|
U-89843A is an allosteric modulator of the GABA_A receptor, known to enhance GABA-induced Cl^- currents [1].
|
T78670 |
Xilmenolone
|
2368807-26-3
|
98%
|
|
Xilmenolone acts as a positive allosteric modulator of the GABA_A receptor [1].
|
T79399 |
E2730
|
1520073-91-9
|
98%
|
|
E2730 is a selective and noncompetitive inhibitor of the gamma-aminobutyric acid (GABA) transporter 1 (GAT1) that exhibits oral availability as well as antiepile...
|
T80013 |
Arecaidine hydrobromide
|
6013-57-6
|
98%
|
|
Arecaidine hydrobromide, a pyridine alkaloid, functions as a potent GABA uptake inhibitor and acts as a substrate for the H+-coupled amino acid transporter 1 (PA...
|
T80014 |
Guvacine hydrobromide
|
6027-92-5
|
98%
|
|
Guvacine hydrobromide, an alkaloid derived from the Areca catechu nut, serves as a potent inhibitor of GABA (GABA uptakp) uptake. It effectively inhibits rat GAB...
|
T80218 |
GAD65(247-266) epitope TFA
|
|
98%
|
|
GAD65(247-266) epitope TFA, a T cell epitope derived from islet antigens, exhibits competitive binding to the type I diabetes-associated molecule I-A g7, albeit ...
|
T80487 |
MmTx2 toxin
|
|
98%
|
|
MmTx2 toxin, extracted from the venom of the coral snake, serves as a modulator of the GABA A receptor, increasing its responsiveness to agonists. This property ...
|
T80489 |
MmTx1 toxin
|
|
98%
|
|
Micrurotoxin 1 (MmTx1 toxin) acts as an allosteric modulator of GABA A receptors, enhancing the receptor's sensitivity to its agonist [1].
|
T82357 |
GABA receptor Antagonist 1
|
|
98%
|
|
GABA receptor Antagonist 1 (compound 7w) effectively inhibits the Px RDL1 GABAR at an IC50 of 7.08 nmol/L and demonstrates insecticidal efficacy against P. xylos...
|
TN5147 |
Tilifodiolide
|
126724-95-6
|
98%
|
|
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
|
T12043 |
(-)-Bicuculline methobromide
|
73604-30-5
|
98%
|
|
(-)-Bicuculline methobromide is a potent antagonist of GABAA receptor .
|
T11686 |
Isotanshinone I
|
20958-17-2
|
98%
|
|
Isotanshinone I with IC50s of 1.13 μM and 0.432 μM for α-glucosidase and AGE, respectively. Isotanshinone I has inhibitory activity against α-glucosidase and for...
|
TN1717 |
Guvacine
|
498-96-4
|
98%
|
|
Guvacine can enhance the inhibition of spinal neurones by GABA.
|