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GABA Receptor

The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled receptors, also called metabotropic receptors.
Cat No. product name
T21793 CGP 35348 CGP 35348 是 GABAB 受体的选择性拮抗剂 (EC50 = 34 μM)。 CGP 35348 可用于研究白化新生小鼠脑损伤后的神经肌肉协调和空间学习。
T3698 Alpha-Asarone Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.
T12930 SKF89976A hydrochloride SKF89976A hydrochloride is a selective inhibitor of GABA transporter (GAT-1)(IC50s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, re...
TN1217 2'-O-Methylisoliquiritigenin 2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.
TN1325 (2S)-6-Prenylnaringenin 6-Prenylnaringenin is an isomer of the potent phytoestrogen, 8-prenylnaringenin.
T22301 L-838417 D9 L-838417 is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].
T3173 DAA-1106 DAA1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), acting as a potent and selective agonist at the peripheral benzodiazepine ...
T7699 AZD7325 AZD-7325 is a GABA-Aα2,3 -selective receptor modulator.
T12207 NEO 376 NEO 376 is a selective 5-HT1 receptor, GABA receptor and dopamine receptor modulator, showing anti-psychotic actively.
T2S1464 Thiocolchicoside Thiocolchicoside (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonis...
T2983 3,4,5-Trimethoxycinnamic acid 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex...
T5880 Aminooxyacetic acid hemihydrochloride Aminooxyacetic acid hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
T8040 Cholesterol myristate Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic ace...
T32098L Homocarnosine acetate Homocarnosine acetate is a dipeptide unique to brain consisting of γ-aminobutyric acid (GABA) and histidine. Homocarnosine acetate has antioxidant and anti-infla...
T0710 L-Cycloserine L-cycloserine irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminotransferase in E. coli, as well in the brains of various animals, results in incre...
T10618 Broflanilide Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL ...
T2720 Ginsenoside Rc Ginsenoside Rc is one of the ginsenosides from Panax ginseng, inhibits the expression of TNF-α and IL-1β.
T5330 Fluralaner Fluralaner is an isoxazoline ectoparasiticide. It potently and selectively inhibits binding of the GABA receptor channel blocker EBOB to housefly head membranes ...
T7064 Valproic Acid Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mol...
T2979 DL-Menthol DL-Menthol is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-m...
T22616 Bretazenil GABAA benzodiazepine site partial agonist
T0715 Chlormezanone Chlormezanone is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
TN1432 Bacopasaponin C Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property.
T1602 Valproic acid sodium salt Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blo...
T13150 THIP THIP is a selective agonist of δ-aminobutyric acid type A receptor (δ-GABAAR),and exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs.
T15212 Emamectin Benzoate Emamectin Benzoate, by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as ...
T3318 Wogonoside Wogonoside acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.
T0958 Penicillin G sodium salt Penicillin G sodium is a penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effe...
T5754 Kavain Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of trans...
T2998 Dihydromyricetin Dihydromyricetin is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of ...
T3403 Glabridin Glabridin may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-gluc...
T3782 Jujuboside A Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, having neurophysiological inhibitory effects, used as a potential therapeutic agent for the tr...
T22348 Isonipecotic acid Isonipecotic acid is a heterocyclic compound. Isonipecotic acid mainly characterized as a GABAA receptor partial agonist.
T5S1882 Songorine 1. Napellonine shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.
TN1023 Miltirone Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.
T11684 Isoguvacine hydrochloride Isoguvacine hydrochloride is a GABA receptor agonist.
T2749 Ginkgolide A Ginkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inf...
T16539 Piperazine citrate Piperazine Citrate, an organic compound, consists of a six-membered ring, containing two nitrogen atoms at opposite positions in the ring. It used as an Anthelmi...
T23104 Ocinaplon GABAA receptors modulator
T8193 α-Thujone Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T23481 U 89843A Positive allosteric modulator of GABAA receptors
T2775 Baicalin Baicalin is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV properties.
T36520 COR659 COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effe...
T23339 SCS GABAA receptor antagonist
T4590 (+)-Kavain Kawain is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
T0675 Topiramate Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepat...
T37190 L-Allylglycine L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo...
T9424 Temgicoluril Temgicoluril acts on GABA Receptor.
T2S1814 P-Hydroxybenzaldehyde 1. 4-Hydroxybenzaldehyde shows an inhibitory effect on the GABA transaminase to contribute to an antiepileptic and anticonvulsive activity, and its inhibitory ac...
CGP 35348
T21793
CGP 35348 是 GABAB 受体的选择性拮抗剂 (EC50 = 34 μM)。 CGP 35348 可用于研究白化新生小鼠脑损伤后的神经肌肉协调和空间学习。...
alpha-Asarone
T3698
Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.
SKF89976A hydrochloride
T12930
SKF89976A hydrochloride is a selective inhibitor of GABA transporter (GAT-1)(IC50s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells,...
2'-O-Methylisoliquiritigenin
TN1217
2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.
(2S)-6-Prenylnaringenin
TN1325
6-Prenylnaringenin is an isomer of the potent phytoestrogen, 8-prenylnaringenin.
L-838417 D9
T22301
L-838417 is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].
DAA-1106
T3173
DAA1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), acting as a potent and selective agonist at the peripheral benzodiazepine ...
AZD7325
T7699
AZD-7325 is a GABA-Aα2,3 -selective receptor modulator.
NEO 376
T12207
NEO 376 is a selective 5-HT1 receptor, GABA receptor and dopamine receptor modulator, showing anti-psychotic actively.
Thiocolchicoside
T2S1464
Thiocolchicoside (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonis...
3,4,5-Trimethoxycinnamic acid
T2983
3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex...
Aminooxyacetic acid hemihydrochloride
T5880
Aminooxyacetic acid hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
Cholesterol myristate
T8040
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic ace...
Homocarnosine acetate
T32098L
Homocarnosine acetate is a dipeptide unique to brain consisting of γ-aminobutyric acid (GABA) and histidine. Homocarnosine acetate has antioxidant and anti-infl...
L-Cycloserine
T0710
L-cycloserine irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminotransferase in E. coli, as well in the brains of various animals, results in inc...
Broflanilide
T10618
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL ...
Ginsenoside Rc
T2720
Ginsenoside Rc is one of the ginsenosides from Panax ginseng, inhibits the expression of TNF-α and IL-1β.
Fluralaner
T5330
Fluralaner is an isoxazoline ectoparasiticide. It potently and selectively inhibits binding of the GABA receptor channel blocker EBOB to housefly head membranes ...
Valproic Acid
T7064
Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mol...
DL-Menthol
T2979
DL-Menthol is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (...
Bretazenil
T22616
GABAA benzodiazepine site partial agonist
Chlormezanone
T0715
Chlormezanone is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
Urethane
T0051
Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
Bacopasaponin C
TN1432
Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property.
Valproic acid sodium salt
T1602
Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blo...
THIP
T13150
Emamectin Benzoate
T15212
Emamectin Benzoate, by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as ...
Wogonoside
T3318
Wogonoside acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.
Penicillin G sodium salt
T0958
Penicillin G sodium is a penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effe...
Kavain
T5754
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of tran...
Dihydromyricetin
T2998
Dihydromyricetin is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of ...
Glabridin
T3403
Glabridin may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-gluc...
Jujuboside A
T3782
Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, having neurophysiological inhibitory effects, used as a potential therapeutic agent for the tr...
Isonipecotic acid
T22348
Isonipecotic acid is a heterocyclic compound. Isonipecotic acid mainly characterized as a GABAA receptor partial agonist.
Songorine
T5S1882
1. Napellonine shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.
Miltirone
TN1023
Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.
Isoguvacine hydrochloride
T11684
Isoguvacine hydrochloride is a GABA receptor agonist.
Ginkgolide A
T2749
Ginkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inf...
Piperazine citrate
T16539
Piperazine Citrate, an organic compound, consists of a six-membered ring, containing two nitrogen atoms at opposite positions in the ring. It used as an Anthelmi...
Ocinaplon
T23104
GABAA receptors modulator
α-Thujone
T8193
Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
U 89843A
T23481
Positive allosteric modulator of GABAA receptors
Baicalin
T2775
Baicalin is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV properties.
COR659
T36520
COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effe...
SCS
T23339
GABAA receptor antagonist
(+)-Kavain
T4590
Kawain is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
Topiramate
T0675
Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepat...
L-Allylglycine
T37190
L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex viv...
Temgicoluril
T9424
Temgicoluril acts on GABA Receptor.
p-Hydroxybenzaldehyde
T2S1814
1. 4-Hydroxybenzaldehyde shows an inhibitory effect on the GABA transaminase to contribute to an antiepileptic and anticonvulsive activity, and its inhibitory ac...
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