EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

Cat. No.	Product name	CAS No.	Purity
T10256	Afatinib D6	1313874-96-2	98%
T10256	Afatinib D6 (BIBW 2992 D6) is a deuterium-labeled Afatinib. Afatinib is an irreversible EGFR family inhibitor.
T9927	Panitumumab	339177-26-3	98%
T9927	Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).
TN4638	Neolinine	112515-37-4	98%
TN4638	Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity.
T61016	EMI1	35773-42-3	98%
T61016	EMI1 is an inhibitor of EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S. EMI1 has research value in the research of mutant EGFR-associated, drug-resistant no...
TN1871	Ligustroside	35897-92-8	98%
TN1871	Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
TN3525	Boehmenan	57296-22-7	98%
TN3525	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
T10531	BGB-102	807640-87-5	98%
T10531	BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 nM, and 40.3 nM).
T11157	EGFR-IN-1	1625677-63-5	98%
T11157	EGFR-IN-1 displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity. EGFR-IN-1 is an orally a...
TN4213	Hirsutenone	41137-87-5	98%
TN4213	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
T10556	BKI-1369	1951431-22-3	98%
T10556	BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).
T4183	Lavendustin A	125697-92-9	98%
T4183	lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
T13743	JH-XI-10-02	2209085-22-1	98%
T13743	JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrade...
T2460	JAK 3 inhibitor IV	58753-54-1	98%
T2460	JAK 3 inhibitor IV is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutam...
T19489	O-Desmethyl gefitinib D8	T19489	98%
T19489	O-Desmethyl gefitinib D8 is a deuterium labeled O-Desmethyl gefitinib that is an active metabolite of Gefitinib in human plasma.
T12175	Naquotinib mesylate	1448237-05-5	98%
T12175	Naquotinib mesylate is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFR mutants and EGFR).
TN3711	Corylifol C	775351-91-2	98%
TN3711	Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
T16362	Nuvenzepine	96487-37-5	98%
T16362	Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.
T2518	ARRY-380 (analog )	937265-83-3	98%
T2518	ARRY-380 is a potent and selective HER2 inhibitor.
TN5100	Taspine	602-07-3	98%
TN5100	Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
T11717	JHU395	2079938-92-2	98%
T11717	JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST. JH...