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GluR

Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells.Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.
Cat. No. Product name CAS No. Purity Chemical Structure
T23010 MNI 137 946619-21-2 98%
MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.
T15369 Gamma-DGG 6729-55-1 98%
gamma-DGG is a competitive blocker of AMPA receptor.
T10808 CHPG sodium salt 1303993-73-8 98%
CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...
T11911 LY3020371 hydrochloride 1377615-44-5 98%
LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu...
T35028 Valiglurax 1976050-09-5 98%
Valiglurax, also known as VU0652957 and VU2957, is a potent, selective, CNS penetrant, and orally bioavailable mGlu4 PAM. VU2957 possessed attractive in vitro an...
T15618 JNJ-46281222 1254980-38-5 98%
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a hi...
T4009 NS 1209 205645-02-9 98%
NS1209 is a AMPA receptor antagonist.
T6562 Latrepirdine dihydrochloride 97657-92-6 98%
Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
T11906 LY 541850 852679-76-6 98%
LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human io...
T11311L Foliglurax 1883329-51-8 98%
Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).
T12520 Pomaglumetad methionil 956385-05-0 98%
Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
T14389 AZD 9272 327056-26-8 98%
AZD 9272 is a antagonist of brain penetrant mGluR5.
T27854 LSN2463359 1401031-52-4 98%
LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.
TQ0114 CMPDA 380607-77-2 98%
CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor).
T15456 GYKI 53655 hydrochloride 143692-48-2 98%
GYKI53655 hydrochloride is an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA).
T13319 VU0652835 1848252-81-2 98%
VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).
T11907 Pomaglumetad methionil anhydrous 635318-55-7 98%
LY2140023 has the potential for schizophrenia.LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agon...
T15619 JNJ-46778212 1363281-27-9 98%
JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).
T15823 LYPLAL1-IN-1 1966129-74-7 98%
LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.
T17248 VU6001376 1968546-34-0 98%
VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).
MNI 137
T23010
MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.
gamma-DGG
T15369
gamma-DGG is a competitive blocker of AMPA receptor.
CHPG sodium salt
T10808
CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...
LY3020371 hydrochloride
T11911
LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu...
Valiglurax
T35028
Valiglurax, also known as VU0652957 and VU2957, is a potent, selective, CNS penetrant, and orally bioavailable mGlu4 PAM. VU2957 possessed attractive in vitro an...
JNJ-46281222
T15618
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a hi...
NS 1209
T4009
NS1209 is a AMPA receptor antagonist.
Latrepirdine dihydrochloride
T6562
Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
LY 541850
T11906
LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human io...
Foliglurax
T11311L
Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).
Pomaglumetad methionil
T12520
Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
AZD 9272
T14389
AZD 9272 is a antagonist of brain penetrant mGluR5.
LSN2463359
T27854
LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.
CMPDA
TQ0114
CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor).
GYKI 53655 hydrochloride
T15456
GYKI53655 hydrochloride is an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA).
VU0652835
T13319
VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).
Pomaglumetad methionil anhydrous
T11907
LY2140023 has the potential for schizophrenia.LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agon...
JNJ-46778212
T15619
JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).
LYPLAL1-IN-1
T15823
LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.
VU6001376
T17248
VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).
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