GluR

Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells.Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.

Cat No.	product name
T0024	Primidone	Primidone is an anticonvulsant of the pyrimidinedione class.
T0051	Urethane	Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T0124	Selamectin	Selamectin is distributed by Zoetis. It is a topical parasiticide and antihelminthic used on dogs and cats. Parasites is be maimed by selamectin stimulating glu...
T0256	Lithium citrate tribasic tetrahydrate	Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and m...
T0313	Evans blue	Evans blue is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).
T0333	Aniracetam	Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
T0426	Piracetam	Piracetam, a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
T0675	Topiramate	Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepa...
T0875	Acetylcysteine	Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to h...
T1443	Memantine hydrochloride	Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
T1884	Ampalex	Ampalex (Ampakine CX516; CX516; BDP 12), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease,...
T2053	ADX 47273	ADX-47273 is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).
T2194	Chicago Sky Blue 6B	Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice.
T2497	MPEP hydrochloride	MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).
T2811	Harmine hydrochloride	Harmine hydrochloride is extracted from Peganum Harmala Genus.
T3379	Decanoic Acid	Decanoic Acid acts as a non-competitive AMPA receptor antagonist.
T3451	JNJ-42153605	JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
T3464	PHCCC	PHCCC is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mG...
T3473	ATPO	ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
T3477	E4CPG	E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.
T3478	Ro 67-7476	Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 5...
T3479	(RS)-MCPG	(RS)-MCPG is a non-selective group I/II metabotropic glutamate receptor antagonist.
T3482	CFMTI	CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 200...
T3483	FTIDC	FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibit...
T3486	3-MATIDA	3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGl...
T3539	Lu AF21934	Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).
T3565	UV0155041	UV0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).
T3957	Farampator	Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
T4113	NBQX disodium salt	Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
T6022	LY404039	LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
T6160	VU 0364439	VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).
T6457	CTEP	CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over oth...
T6562	Latrepirdine	Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
T6598	MPEP	MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
T6725	VU 0357121	VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
T6726	VU 0361737	VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 ...
T6727	VU 0364770	VU 0364770(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subtypes.
T4573	Cyclothiazide	Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its ...
T0326L	L-Glutamine	L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia.
T5083	L-Cysteic acid monohydrate	L-Cysteic acid is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial aspartate: alanine antiporter (AspT) exchange ...
T5884	Chelidamic acid	Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
T7304	DNQX	DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
T7292	FITM	FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).
T7178	CNQX	CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)
T7515	MTEP hydrochloride	MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)
T7494	TCN 238	TCN 238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).
T7579	1-BCP	1-BCP is a centrally active drug that modulates AMPA receptor gated currents.
TQ0094	JNJ-40411813	JNJ-40411813 (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).
TQ0114	CMPDA	CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor).
TQ0289	LY450108	LY450108 is a potentiator of the AMPA receptor.
T7706	LY404187	LY404187 is a positive allosteric modulator of AMPA receptors
T7823	IDRA-21	IDRA-21 is a positive AMPA receptor modulator.
T3484	(±)-trans-ACPD	(±)-trans-ACPD is an equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD. (±)-trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor);...
T12025	MFZ 10-7 hydrochloride	MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAM
T12118	MSOP	MSOP is a selective antagonist of group III metabotropic glutamate receptor (KD of 51 μM for the L-AP4-sensitive presynaptic mGluR).
T12520	Pomaglumetad methionil	Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
T11032	DHPG	DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluR linked to phospholipase D. DHPG ((RS)-3,5-DHPG) is an amino acid that can be used as a selective a...
T14389	AZD 9272	AZD 9272 is a antagonist of brain penetrant mGluR5.
T14615	Biphenylindanone A	Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.
T15090	Decoglurant	Decoglurant is a negative allosteric modulator of mGluR2 and mGluR3 developed as an antidepressant.
T15275	Fenobam	Fenobam is a non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kds: 54 and 31 nM for rat and human recombinant mGlu5 receptors). Fenoba...
T11311L	Foliglurax	Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).
T15369	gamma-DGG	gamma-DGG is a competitive blocker of AMPA receptor.
T10573	BMT-145027	BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50: 47 nM).
T13318	VU0650786	VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM)(IC50 of 392 nM), with a...
T13319	VU0652835	VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5)(IC50 of 81 nM).
T13323	VU6012962	VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7,IC50 of 347 nM).
T15456	GYKI53655 hydrochloride	GYKI53655 hydrochloride is an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA).
T15618	JNJ-46281222	JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a h...
T15619	JNJ-46778212	JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).
T15692	L-APB	L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively)...
T15819	LY377604	LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM). It also a β1- and β2-adrenergic receptor antagonist.
T15823	LYPLAL1-IN-1	LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.
T15830	M-110	M-110 inhibits PIM-1 and PIM-2 with similar (IC50s: 2.5 μM) and it also inhibits the proliferation of prostate cancer cell lines (IC50s: 0.6 to 0.9 μM). M-110...
T15944	M77976	M77976 is the potential for the research of obesity and diabetes. M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms...
T5509	FPTQ	FPTQ is an antagonist of mGluR1.
T16524	Philanthotoxin 74 dihydrochloride	Philanthotoxin 74 dihydrochloride is an AMPAR antagonist. Philanthotoxin 74 dihydrochloride inhibits GluR3 and GluR1 (IC50s: 263 and 296 nM, respectively).
T11906	LY 541850	LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human...
T11907	LY2140023	LY2140023 has the potential for schizophrenia.LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor ago...
T11911	LY3020371 hydrochloride	LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mG...
T17248	VU6001376	VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).
T12717	Basimglurant	Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).
T8626	4-oxo-1,4-dihydroquinoline-2-carboxylic acid	4-oxo-1,4-dihydroquinoline-2-carboxylic acid is a GluR and NMDA inhibitor.
T22641	CDPPB	CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).
T23515	VU 29	VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (E...
T10432L	AZD-8529 mesylate	AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulat...