Primidone is an anticonvulsant of the pyrimidinedione class. |
Urethane was an antineoplastic agent .Now is used for other medicinal purposes. |
Selamectin is distributed by Zoetis. It is a topical parasiticide and antihelminthic used on dogs and cats. Parasites is be maimed by selamectin stimulating glu...
||Lithium citrate tribasic tetrahydrate
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and m...
Evans blue is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT). |
Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR. |
Piracetam, a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders. |
Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepa...
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to h...
Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent. |
Ampalex (Ampakine CX516; CX516; BDP 12), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease,...
ADX-47273 is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM). |
||Chicago Sky Blue 6B
Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice. |
MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM). |
Harmine hydrochloride is extracted from Peganum Harmala Genus. |
Decanoic Acid acts as a non-competitive AMPA receptor antagonist. |
JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM). |
PHCCC is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mG...
ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors. |
E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG. |
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 5...
(RS)-MCPG is a non-selective group I/II metabotropic glutamate receptor antagonist. |
CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 200...
FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibit...
3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGl...
Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human). |
UV0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat). |
Farampator (CX-691;Org24448) is an AMPA receptor positive modulator. |
||NBQX disodium salt
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo. |
LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM). |
VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM). |
CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over oth...
Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors. |
VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 ...
VU 0364770(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subtypes. |
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its ...
L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia. |
||L-Cysteic acid monohydrate
L-Cysteic acid is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial aspartate: alanine antiporter (AspT) exchange ...
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM. |
DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively) |
FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM). |
CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively) |
MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively) |
TCN 238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM). |
1-BCP is a centrally active drug that modulates AMPA receptor gated currents. |
JNJ-40411813 (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM). |
CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor). |
LY450108 is a potentiator of the AMPA receptor. |