T23010 |
MNI 137
|
946619-21-2
|
98%
|
|
MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.
|
T15369 |
Gamma-DGG
|
6729-55-1
|
98%
|
|
gamma-DGG is a competitive blocker of AMPA receptor.
|
T10808 |
CHPG sodium salt
|
1303993-73-8
|
98%
|
|
CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...
|
T11911 |
LY3020371 hydrochloride
|
1377615-44-5
|
98%
|
|
LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu...
|
T35028 |
Valiglurax
|
1976050-09-5
|
98%
|
|
Valiglurax, also known as VU0652957 and VU2957, is a potent, selective, CNS penetrant, and orally bioavailable mGlu4 PAM. VU2957 possessed attractive in vitro an...
|
T15618 |
JNJ-46281222
|
1254980-38-5
|
98%
|
|
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a hi...
|
T4009 |
NS 1209
|
205645-02-9
|
98%
|
|
NS1209 is a AMPA receptor antagonist.
|
T6562 |
Latrepirdine dihydrochloride
|
97657-92-6
|
98%
|
|
Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
|
T11906 |
LY 541850
|
852679-76-6
|
98%
|
|
LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human io...
|
T11311L |
Foliglurax
|
1883329-51-8
|
98%
|
|
Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).
|
T12520 |
Pomaglumetad methionil
|
956385-05-0
|
98%
|
|
Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
|
T14389 |
AZD 9272
|
327056-26-8
|
98%
|
|
AZD 9272 is a antagonist of brain penetrant mGluR5.
|
T27854 |
LSN2463359
|
1401031-52-4
|
98%
|
|
LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.
|
TQ0114 |
CMPDA
|
380607-77-2
|
98%
|
|
CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor).
|
T15456 |
GYKI 53655 hydrochloride
|
143692-48-2
|
98%
|
|
GYKI53655 hydrochloride is an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA).
|
T13319 |
VU0652835
|
1848252-81-2
|
98%
|
|
VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).
|
T11907 |
Pomaglumetad methionil anhydrous
|
635318-55-7
|
98%
|
|
LY2140023 has the potential for schizophrenia.LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agon...
|
T15619 |
JNJ-46778212
|
1363281-27-9
|
98%
|
|
JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).
|
T15823 |
LYPLAL1-IN-1
|
1966129-74-7
|
98%
|
|
LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.
|
T17248 |
VU6001376
|
1968546-34-0
|
98%
|
|
VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).
|