T0024 |
Primidone |
Primidone is an anticonvulsant of the pyrimidinedione class. |
T0051 |
Urethane |
Urethane was an antineoplastic agent .Now is used for other medicinal purposes. |
T0124 |
Selamectin |
Selamectin is distributed by Zoetis. It is a topical parasiticide and antihelminthic used on dogs and cats. Parasites is be maimed by selamectin stimulating glu...
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T0256 |
Lithium citrate tribasic tetrahydrate |
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and m...
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T0313 |
Evans blue |
Evans blue is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT). |
T0333 |
Aniracetam |
Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR. |
T0426 |
Piracetam |
Piracetam, a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders. |
T0675 |
Topiramate |
Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepa...
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T0875 |
Acetylcysteine |
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to h...
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T1443 |
Memantine hydrochloride |
Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent. |
T1884 |
Ampalex |
Ampalex (Ampakine CX516; CX516; BDP 12), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease,...
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T2053 |
ADX 47273 |
ADX-47273 is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM). |
T2194 |
Chicago Sky Blue 6B |
Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice. |
T2497 |
MPEP hydrochloride |
MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM). |
T2811 |
Harmine hydrochloride |
Harmine hydrochloride is extracted from Peganum Harmala Genus. |
T3379 |
Decanoic Acid |
Decanoic Acid acts as a non-competitive AMPA receptor antagonist. |
T3451 |
JNJ42153605 |
JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM). |
T3464 |
PHCCC |
PHCCC is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mG...
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T3473 |
ATPO |
ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors. |
T3477 |
E4CPG |
E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG. |
T3478 |
Ro 67-7476 |
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50...
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T3479 |
(RS)-MCPG |
(RS)-MCPG is a non-selective group I/II metabotropic glutamate receptor antagonist. |
T3482 |
CFMTI |
CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 200...
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T3483 |
FTIDC |
FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibit...
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T3486 |
3-MATIDA |
3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGl...
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T3539 |
Lu AF21934 |
Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human). |
T3565 |
UV0155041 |
UV0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat). |
T3957 |
Farampator |
Farampator (CX-691;Org24448) is an AMPA receptor positive modulator. |
T4113 |
NBQX disodium salt |
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo. |
T6022 |
LY404039 |
LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM). |
T6160 |
VU 0364439 |
VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM). |
T6457 |
CTEP |
CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over oth...
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T6562 |
Latrepirdine |
Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antih...
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T6598 |
MPEP |
MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors. |
T6725 |
VU 0357121 |
VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
T6726 |
VU 0361737 |
VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 ...
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T6727 |
VU 0364770 |
VU 0364770(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subtypes. |
T4573 |
Cyclothiazide |
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its ...
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T0326L |
L-Glutamine |
L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia. |
T5083 |
L-Cysteic acid monohydrate |
L-Cysteic acid is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial aspartate: alanine antiporter (AspT) exchange ...
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T5884 |
Chelidamic acid |
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM. |
T7304 |
DNQX |
DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively) |
T7292 |
FITM |
FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM). |
T7178 |
CNQX |
CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively) |
T7515 |
MTEP hydrochloride |
MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively) |
T7494 |
TCN 238 |
TCN 238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM). |
T7579 |
1-BCP |
1-BCP is a centrally active drug that modulates AMPA receptor gated currents. |
TQ0094 |
JNJ-40411813 |
JNJ-40411813 (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM). |
TQ0114 |
CMPDA |
CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor). |
TQ0289 |
LY450108 |
LY450108 is a potentiator of the AMPA receptor. |
T7706 |
LY404187 |
LY404187 is a positive allosteric modulator of AMPA receptors |
T7823 |
IDRA-21 |
IDRA-21 is a positive AMPA receptor modulator. |
T3484 |
(±)-trans-ACPD |
(±)-trans-ACPD is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. (±)-trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor...
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T12025 |
MFZ 10-7 hydrochloride |
MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAM |
T12118 |
MSOP |
MSOP is a selective antagonist of group III metabotropic glutamate receptor (KD of 51 μM for the L-AP4-sensitive presynaptic mGluR). |
T12520 |
Pomaglumetad methionil |
Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039. |
T11032 |
DHPG |
DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluR linked to phospholipase D. DHPG ((RS)-3,5-DHPG) is an amino acid that can be used as a selective a...
|
T14389 |
AZD 9272 |
AZD 9272 is a antagonist of brain penetrant mGluR5. |
T14615 |
Biphenylindanone A |
Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders. |
T15090 |
Decoglurant |
Decoglurant is a negative allosteric modulator of mGluR2 and mGluR3 developed as an antidepressant. |
T15275 |
Fenobam |
Fenobam is a non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kds: 54 and 31 nM for rat and human recombinant mGlu5 receptors). Fenoba...
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T11311L |
Foliglurax |
Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM). |
T15369 |
gamma-DGG |
gamma-DGG is a competitive blocker of AMPA receptor. |
T10573 |
BMT-145027 |
BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50: 47 nM). |
T13318 |
VU0650786 |
VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with an...
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T13319 |
VU0652835 |
VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM). |
T13323 |
VU6012962 |
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM). |
T15456 |
GYKI53655 hydrochloride |
GYKI53655 hydrochloride is an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA). |
T15618 |
JNJ-46281222 |
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a h...
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T15619 |
JNJ-46778212 |
JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM). |
T15692 |
L-APB |
L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively)...
|
T15819 |
LY377604 |
LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM). It also a β1- and β2-adrenergic receptor antagonist. |
T15823 |
LYPLAL1-IN-1 |
LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production. |
T15830 |
M-110 |
M-110 inhibits PIM-1 and PIM-2 with similar (IC50s: 2.5 μM) and it also inhibits the proliferation of prostate cancer cell lines (IC50s: 0.6 to 0.9 μM). M-110...
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T15944 |
M77976 |
M77976 is the potential for the research of obesity and diabetes. M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms...
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T5509 |
FPTQ |
FPTQ is an antagonist of mGluR1. |
T16524 |
Philanthotoxin 74 dihydrochloride |
Philanthotoxin 74 dihydrochloride is an AMPAR antagonist. Philanthotoxin 74 dihydrochloride inhibits GluR3 and GluR1 (IC50s: 263 and 296 nM, respectively). |
T11906 |
LY 541850 |
LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human...
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T11907 |
LY2140023 |
LY2140023 has the potential for schizophrenia.LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor ago...
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T11911 |
LY3020371 hydrochloride |
LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mG...
|
T17248 |
VU6001376 |
VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM). |
T12717 |
Basimglurant |
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). |
T8626 |
4-oxo-1,4-dihydroquinoline-2-carboxylic acid |
4-oxo-1,4-dihydroquinoline-2-carboxylic acid is a GluR and NMDA inhibitor. |
T22641 |
CDPPB |
CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5). |
T23515 |
VU 29 |
VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (E...
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T10432L |
AZD-8529 mesylate |
AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulat...
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T4500 |
ADX88178 |
ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4. |
T3010 |
Xanthurenic Acid |
Xanthurenic acid, a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mG...
|
T8862 |
ML 254 |
ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Rice...
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T8779 |
HBT1 |
HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons...
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T8457 |
NPS2390 |
NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively) |
T8435 |
YM90K hydrochloride |
YM90K hydrochloride is an antagonist of AMPA receptor. |
T8434 |
SIB-1757 |
SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM) |
T6871 |
L-Glutamic acid monosodium salt |
L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor. |
T6468 |
D-glutamine |
D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code. |