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Neuroscience GluR

GluR

Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells.Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.
Cat No. product name
T0024 Primidone Primidone is an anticonvulsant of the pyrimidinedione class.
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T0124 Selamectin Selamectin is distributed by Zoetis. It is a topical parasiticide and antihelminthic used on dogs and cats. Parasites is be maimed by selamectin stimulating glu...
T0256 Lithium citrate tribasic tetrahydrate Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and m...
T0313 Evans blue Evans blue is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).
T0333 Aniracetam Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
T0426 Piracetam Piracetam, a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
T0675 Topiramate Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepa...
T0875 Acetylcysteine Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to h...
T1443 Memantine hydrochloride Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
T1884 Ampalex Ampalex (Ampakine CX516; CX516; BDP 12), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease,...
T2053 ADX 47273 ADX-47273 is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).
T2194 Chicago Sky Blue 6B Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice.
T2497 MPEP hydrochloride MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).
T2811 Harmine hydrochloride Harmine hydrochloride is extracted from Peganum Harmala Genus.
T3379 Decanoic Acid Decanoic Acid acts as a non-competitive AMPA receptor antagonist.
T3451 JNJ-42153605 JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
T3464 PHCCC PHCCC is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mG...
T3473 ATPO ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
T3477 E4CPG E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.
T3478 Ro 67-7476 Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 5...
T3479 (RS)-MCPG (RS)-MCPG is a non-selective group I/II metabotropic glutamate receptor antagonist.
T3482 CFMTI CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 200...
T3483 FTIDC FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibit...
T3486 3-MATIDA 3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGl...
T3539 Lu AF21934 Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).
T3565 UV0155041 UV0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).
T3957 Farampator Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
T4113 NBQX disodium salt Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
T6022 LY404039 LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
T6160 VU 0364439 VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).
T6457 CTEP CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over oth...
T6562 Latrepirdine Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
T6598 MPEP MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
T6725 VU 0357121 VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
T6726 VU 0361737 VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 ...
T6727 VU 0364770 VU 0364770(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subtypes.
T4573 Cyclothiazide Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its ...
T0326L L-Glutamine L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia.
T5083 L-Cysteic acid monohydrate L-Cysteic acid is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial aspartate: alanine antiporter (AspT) exchange ...
T5884 Chelidamic acid Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
T7304 DNQX DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
T7292 FITM FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).
T7178 CNQX CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)
T7515 MTEP hydrochloride MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)
T7494 TCN 238 TCN 238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).
T7579 1-BCP 1-BCP is a centrally active drug that modulates AMPA receptor gated currents.
TQ0094 JNJ-40411813 JNJ-40411813 (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).
TQ0114 CMPDA CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor).
TQ0289 LY450108 LY450108 is a potentiator of the AMPA receptor.
Primidone
T0024CAS 125-33-7
Primidone is an anticonvulsant of the pyrimidinedione class.
Urethane
T0051CAS 51-79-6
Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
Selamectin
T0124CAS 165108-07-6
Selamectin is distributed by Zoetis. It is a topical parasiticide and antihelminthic used on dogs and cats. Parasites is be maimed by selamectin stimulating glu...
Lithium citrate tribasic tetrahydrate
T0256CAS 6080-58-6
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and m...
Evans blue
T0313CAS 314-13-6
Evans blue is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).
Aniracetam
T0333CAS 72432-10-1
Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
Piracetam
T0426CAS 7491-74-9
Piracetam, a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
Topiramate
T0675CAS 97240-79-4
Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepa...
Acetylcysteine
T0875CAS 616-91-1
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to h...
Memantine hydrochloride
T1443CAS 41100-52-1
Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
Ampalex
T1884CAS 154235-83-3
Ampalex (Ampakine CX516; CX516; BDP 12), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease,...
ADX 47273
T2053CAS 851881-60-2
ADX-47273 is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).
Chicago Sky Blue 6B
T2194CAS 2610-05-1
Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice.
MPEP hydrochloride
T2497CAS 219911-35-0
MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).
Harmine hydrochloride
T2811CAS 343-27-1
Harmine hydrochloride is extracted from Peganum Harmala Genus.
Decanoic Acid
T3379CAS 334-48-5
Decanoic Acid acts as a non-competitive AMPA receptor antagonist.
JNJ-42153605
T3451CAS 1254977-87-1
JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
PHCCC
T3464CAS 179068-02-1
PHCCC is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mG...
ATPO
T3473CAS 252930-37-3
ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
E4CPG
T3477CAS 170846-89-6
E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.
Ro 67-7476
T3478CAS 298690-60-5
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 5...
(RS)-MCPG
T3479CAS 146669-29-6
(RS)-MCPG is a non-selective group I/II metabotropic glutamate receptor antagonist.
CFMTI
T3482CAS 864864-17-5
CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 200...
FTIDC
T3483CAS 873551-53-2
FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibit...
3-MATIDA
T3486CAS 518357-51-2
3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGl...
Lu AF21934
T3539CAS 1445605-23-1
Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).
UV0155041
T3565CAS 1093757-42-6
UV0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).
Farampator
T3957CAS 211735-76-1
Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
NBQX disodium salt
T4113CAS 118876-58-7
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
LY404039
T6022CAS 635318-11-5
LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
VU 0364439
T6160CAS 1246086-78-1
VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).
CTEP
T6457CAS 871362-31-1
CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over oth...
Latrepirdine
T6562CAS 97657-92-6
Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
MPEP
T6598CAS 96206-92-7
MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
VU 0357121
T6725CAS 433967-28-3
VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
VU 0361737
T6726CAS 1161205-04-4
VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 ...
VU 0364770
T6727CAS 61350-00-3
VU 0364770(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subtypes.
Cyclothiazide
T4573CAS 2259-96-3
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its ...
L-Glutamine
T0326LCAS 56-85-9
L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia.
L-Cysteic acid monohydrate
T5083CAS 23537-25-9
L-Cysteic acid is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial aspartate: alanine antiporter (AspT) exchange ...
Chelidamic acid
T5884CAS 138-60-3
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
DNQX
T7304CAS 2379-57-9
DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
FITM
T7292CAS 932737-65-0
FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).
CNQX
T7178CAS 115066-14-3
CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)
MTEP hydrochloride
T7515CAS 1186195-60-7
MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)
TCN 238
T7494CAS 125404-04-8
TCN 238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).
1-BCP
T7579CAS 34023-62-6
1-BCP is a centrally active drug that modulates AMPA receptor gated currents.
JNJ-40411813
TQ0094CAS 1127498-03-6
JNJ-40411813 (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).
CMPDA
TQ0114CAS 380607-77-2
CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor).
LY450108
TQ0289CAS 376594-67-1
LY450108 is a potentiator of the AMPA receptor.