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Immunology/Inflammation COX

COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase. The specific reaction catalyzed is the conversion from arachidonic acid to Prostaglandin H2, via a short-living Prostaglandin G2 intermediate.
Cat No. product name
T0004 Salicylamide Salicylamide is an over-the-counter drug with analgesic and antipyretic properties, which has similar medicinal properties to aspirin. In the over-the-counter p...
T0005 Aspirin Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicy...
T0050 4-Aminoantipyrine 4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol.
T0055 Glafenine Glafenine, a non-narcotic analgesic agent, is a non-steroidal anti-inflammatory drug (NSAID), and widely used for the therapy of pains of various origins.
T0057 Famprofazone Famprofazone (Gewodin, Gewolen) has analgesic, anti-inflammatory, and antipyretic effects.It is a non-steroidal anti-inflammatory agent (NSAID) of the pyrazolon...
T0058 2-Ethoxybenzamide Anovigam is white or almost-white crystalline powder. Almost odorless. Tasteless. It is widely used as an antipyretic anodyne.
T0065 Acetaminophen Analgesic antipyretic derivative of acetanilide. Acetaminophen has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blo...
T0184 Fenoprofen calcium dihydrate Fenoprofen calcium is a propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.
T0196 Diclofenac Diclofenac is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1...
T0212 Seratrodast Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist d...
T0219 Valdecoxib Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classifi...
T0260 Meclofenamate Sodium Meclofenamate Sodium, a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities. It also inhibits prostaglandin bios...
T0285 Isoxicam Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States.
T0291 Flurbiprofen Flurbiprofen is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal dis...
T0321 Indoprofen Indoprofen is a non-steroidal anti-inflammatory drug.
T0335 Sodium salicylate Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
T0424 Bismuth subsalicylat Bismuth subsalicylate is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarr...
T0432 Diclofenac diethylamine Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).
T0435 Sulfinpyrazone Sulfinpyrazone is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic propertie...
T0436 Acexamic Acid 6-Acetamidohexanoic acid is a kind of amino acids deriviate.
T0441 Pasiniazid Pasiniazid is an anti-TB and anti-leprosy drug.
T0443 Salicoside Salicin, a phenol β-glycoside produced from willow bark, shows anti-inflammatory functions.
T0448 Dexibuprofen Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T0451 Minoxidil Minoxidil is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.
T0456 Cinchophen Cinchophen, an analgesic drug, is utilized in treating gout.
T0458 Indometacin Indomethacin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
T0459 Sulindac Sulindac is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti...
T0463 Loxoprofen Loxoprofen is an anti-inflammatory non-steroidal medicine.
T0466 Celecoxib Celecoxib is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor.
T0477 Zileuton Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the f...
T0484 Deracoxib Deracoxib is a non-steroidal, non-narcotic anti-inflammatory drug. It is also a selective cyclooxygenase-2 inhibitor, and IC50 Value: 70 to 150 μM(inhibition o...
T0498 Sasapyrine Salsalate is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities.
T0646 Mesalamine Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
T0649 Salicylic acid Salicylic acid, a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
T0693 Niflumic acid Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
T0708 Oxaprozin Oxaprozin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxapro...
T0726 Benzydamine hydrochloride Benzydamine hydrochloride, a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties.
T0734 Antipyrine Antipyrine, an antipyretic and analgesic, has been given as ear drops and by mouth. Antipyrine is frequently used to test the effects of other diseases or drugs...
T0758 Piroxicam Piroxicam is a non-specific COX inhibitor.
T0778 Phenacetin Phenacetin is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market.
T0784 Tolfenamic Acid Tolfenamic acid (TA) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine.
T0798 Triamcinolone Triamcinolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry,  triamcinolone binds to and activates th...
T0822 Cianidanol Catechin((+)-Catechin; D-Catechin) is a flavan-3-ol, a type of natural phenol and antioxidant.
T0824 Nonoxynol Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina d...
T0825 Ebselen Ebselen is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and...
T0826 Meloxicam Meloxicam is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxi...
T0839 Ketoprofen Ketoprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofe...
T0839L (S)-(+)-Ketoprofen Dexketoprofen works by blocking the action of a substance in the body called cyclo-oxygenase. It belongs to a class of medicines called non-steroidal anti-infl...
T0855 (R)-Naproxen (R)-Naproxen, an anti-inflammatory agent, has antipyretic and analgesic properties. Both the acid and its sodium salt are used in the therapy of acute gout or d...
T0858 Flufenamic acid Flufenamic acid is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorde...
T0867 Bufexamac Bufexamac is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.
T0888 4-Biphenylacetic acid Felbinac (INN, or biphenylylacetic acid), a topical medicine, is an active metabolite of fenbufen. It is belonging to the family of medicines known as non-stero...
T0890 Mefenamic acid Mefenamic acid is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
T0907 Sulfasalazine Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T0961 Trometamol Trometamol is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachid...
T0980 Nifenazone Nifenazone is a pyrazole drug, used in the in the treatment of rheumatic disorders.
T1002 Etodolac Etodolac inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, ...
T10032 COX-2-IN-2 COX-2-IN-2 is a selective and inducible COX2 inhibitor (IC50: 0.24 μM).
T10033 COX-2-IN-1 COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).
T10152 4-Methylamino antipyrine 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Meth...
T10152L 4-Methylamino antipyrine hydrochloride 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibi...
T11005 Desmethyl Celecoxib Demethyl celecoxib is a selective inhibitor of COX-2 with anti-inflammatory activity (IC50 of 32 nM). with anti-inflammatory activities. Desmethyl Celecoxib is...
T11169 Eicosatetraynoic acid Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 µM. Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipo...
T11296 Flosulide Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.
T1133 Nimesulide Nimesulide is a relatively COX-2 selective inhibitor with analgesic and antipyretic properties.
T11605 (-)-Ibuprofenamide (-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.
T11660 Insulin levels modulator Insulin level regulators can be used to treat diabetes.
T11761 Kinase inhibitor-1 Kinase inhibitor-1 is a kinase inhibitor.
T1185 Rofecoxib Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecox...
T1191 Analgin Metamizole (Dipyrone) sodium hydrate is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX). Target: COX Dipyrone is a potent ana...
T1191L Dipyron Analgin is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
T1209 Flunixin meglumin Flunixin Meglumin is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity.
T1212 Ketorolac tromethamine salt Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and antipyretic activities.
T12227 Nimesulide D5 Nimesulide D5 is a deuterium labeled Nimesulide. Nimesulide is a selective inhibitor OF COX-2(IC50s of 70 nM-70 μM)
T12419 PF-04634817 succinate PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.
T1258 Nabumetone Nabumetone(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II.
T12580 PTUPB PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
T12784 RWJ 63556 RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.
T1280 Nepafenac Nepafenac is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification of nepafe...
T12800 (S)-(+)-Ibuprofen D3 (S)-(+)-Ibuprofen D3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen ,it is an inhibitor of COX-1 and COX-2 acti...
T12860 SC57666 SC57666 is a selective inhibitor of COX2(IC50 of 26 nM).
T12862 SC58451 SC58451 is a potent and selective inhibitor of Cox-2.
T1296 Aminopar Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T1301 Guaiacol Guaiacol is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anest...
T13160 Timegadine Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μ...
T1325 Carprofen Carprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.
T13263 COX/5-LO-IN-1 COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.
T1376 2-Amino-5-methyl-3-thiophenecarbonitrile 2-Amino-5-methyl-3-thiophenecarbonitrile is an organic compund with molecular fomula C6H6N2S.
T1394 Ibuprofen Ibuprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inh...
T1401 Meclofenoxate hydrochloride Meclofenoxate hydrochloride is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cognition, an...
T1402 Fenofibric acid Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
T1420 Diethylcarbamazine citrate Diethylcarbamazine citrate is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or L...
T1421 Aceclofenac Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.
T1423 Hydroxytoluic acid Hydroxytoluic Acid is a long-acting salicylate derivative with antilipidemic properties. Hydroxytoluic acid has been shown to lower plasma free fatty acid and c...
T1427 Fosfosal Fosfosal, used as the anti-inflammatory agent, has the anti-bacterial effect.
T1432 Phenylbutazone Phenylbutazone is a butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ankylosing spondylit...
T1467 Acemetacin Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is...
T1468 Lornoxicam Lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properti...
T15345 FR-188582 FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).
T1541 Drospirenone Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T1544 Olsalazine disodium Olsalazine sodium is bioconverted to 5-aminosalicylic acid (5-ASA) in the colon and has anti-inflammatory activity in ulcerative colitis.
T15449 GW-406381 GW406381 is a highly selective inhibitor of cyclooxygenase-2 (COX-2). GW406381 also attenuates spontaneous ectopic discharge in the sural nerves of rats followi...
T1555 Diclofenac sodium Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
T15571 Imrecoxib Imrecoxib is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM). It also inhibits COX1- activity (IC50: 115 nM). Imrecoxib has an anti-infla...
T15577 Indobufen Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activi...
T1558 ResveratrolHOT Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T15630 Tilmacoxib Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay).
T15645 Pamicogrel Pamicogrel is an inhibitor of COX.
T15687 Thioflosulide Thioflosulide is a selective cyclooxygenase-2 inhibitor (IC50: 2.3 nM). It also shows anti-inflammatory activity.
T1574 Etoricoxib Etoricoxib is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specific...
T1582 Naproxen Naproxen is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities.
T1582L Naproxen sodium Naproxen is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties.
T1586 Tenoxicam Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.
T16291 NF157 NF157 significantly decreases the expression of metalloproteinase (MMP)-3, MMP-13, which can be used in the treatment of osteoarthritis (OA). NF157 is a highly ...
T16349 NSC-60339 NSC-60339 is an inhibitor of efflux pump, and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeu...
T16350 NSC-87877 NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits d...
T16419 Oxyphenbutazone Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is a phenylbutazone derivative. It has an anti-inflammatory effect. Oxyphenbutazone selectivel...
T16464 Pelubiprofen Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway. It also has significant anti-inflamma...
T16817 S-2474 S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (IC50s: 11 nM and 27 μM for COX-2 and COX-1 in human intact cells).
T16950 Sudoxicam Sudoxicam is a reversible and orally active COX antagonist. Sudoxicam has potent anti-inflammatory, anti-edema, and antipyretic activity.
T17036 Tenidap Tenidap is a non-steroidal anti-inflammatory drug and is a selective COX-1 inhibitor (IC50: 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively). Tenidap is ...
T1720 Amfenac Sodium Monohydrate Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety.
T1780 Parecoxib Parecoxib is an effective and selective COX-2 inhibitor.
T1867 ATB 346 ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
T2225 4-Hydroxyantipyrine 4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine.
T2230 Paeoniflorin Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.
T22346 Indometacin Sodium Indomethacin Sodium is the sodium salt of indomethacin, which is a non-selective, competitive, and reversible, inhibitor of cyclooxygenases 1 and 2 with analges...
T22398 Phenidone Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound primarily used as a photographic developer.
T23333 SC 58125 SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also ca...
T2403 Bromfenac sodium Bromfenac Sodium is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophth...
T2550 Tolmetin Tolmetin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin...
T2553 Etofenamate Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.
T2732 (-)-Epicatechin gallate One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramici...
T2778 (+)-Catechin Hydrate (+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological s...
T2826 Asarylaldehyde Asaraldehyde, a natural COX-2 inhibitor, exhibits 17-fold selectivity than COX-1.
T2856 Epicatechin (-)-Epicatechin is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 su...
T2878 Ginsenoside Rd Ginsenoside Rd may have properties that inhibit or prevent the growth of tumors.
T2972 Rutaecarpine Rutaecarpine is an inhibitor of COX-2 with IC50 of 0.28 μM.
T2S0618 β-Elemonic Acid 1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antic...
T3214 NS398 NS-398 is a COX-2 inhibitor wih anti-inflammatory activity.
T3332 Isosteviol Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolys...
T3342 Xanthohumol Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylate...
T3417 Amentoflavone Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in ...
T3500 Flurbiprofen Axetil Flurbiprofen Axetil is an anti-inflammatory used as an analgesic.
T3744 Veratric acid Veratric acid is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowering effects.
T3747 syringaldehyde Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia offic...
T3868 Agnuside Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-gl...
T3883 Roburic acid Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.
T3884 Neoandrographolide Neoandrographolide has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has anti-inflammatory eff...
T3954 Adelmidrol Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
T3981 Acacetin Acacetin is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.
T3P2855 Chamigrenal β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7...
T3S0006 Methyl ferulate Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first...
T3S0509 Gaultherin Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, n...
T3S1553 Cinnamic aldehyde 1. Cinnamic aldehyde exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic...
T4092 AG 126 The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vi...
T4101 SC560 SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.
T4131 Arjunic acid Arjunic acid is a strong antioxidant and a free radical scavenger. Arjunic acid shows activity against Gram-positive and Gram-negative bacteria with MIC values ...
T4313 Tinoridine hydrochloride Tinoridine (Y-3642) is a non-steroidal anti-inflammatory drug. Tinoridine (5-100 μM), produced a concentration-dependent inhibition on the simultaneous increas...
T4503 Talniflumate Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It pos...
T4643 TFAP TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor
T4A2456 Gamabufotalin 1. Gamabufotalin , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic sta...
T4S1616 Sanggenone D Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflam...
T4S2126 Ginkgetin 1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo agains...
T5010 Propyphenazone (4-Isopropylantipyrine) Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective c...
T5032 Iguratimod Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits...
T5430 8-SHOGAOL 8-​Shogaol is a component of ginger and maintains anti-inflammatory activity as a cyclooxygenase-2 inhibitor.
T5460 Mofezolac Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000
T5681 ETHYL CAFFEATE In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-...
T5688 Micheliolide Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
T5727 CAFESTOL CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells...
T5758 sphondin Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level o...
T5759 marmesin Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
T5807 Stylopine hydrochloride Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
T6387 Ampiroxicam Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
T6424 Bromfenac Sodium Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cycl...
T6465 Dexamethasone Sodium Phosphate Dexamethasone, an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid sy...
T6540 Ibuprofen Lysine Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.
T6574 Lumiracoxib Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
T6687 Suprofen Suprofen is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
T6737 Zaltoprofen Zaltoprofen is a Cox-1 and Cox-2 inhibitor, which is used for the treatment of arthritis.
T6893 MK886 MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
T6970 RK33 RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitiza...
T6S0077 Byakangelicol 1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; ...
T6S0722 Isoorientin 1. Luteolin-6-C-glucoside has antioxidant activity.
T6S1652 Benzoylpaeoniflorin 1. Benzoylpaeoniflorin is active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.
T7033 Rosmanol Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activ...
T7081 CCCP CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochon...
T7113 6-paradol 6-paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including anti-cancer,...
T7207 FK 3311 FK 3311 is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)
T7596 Firocoxib Firocoxib is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses.
T7662 6-methoxy Naphthalene Acetic Acid 6-methoxy Naphthalene Acetic Acid is a competitive inhibitor of COX(Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively)
T7670 Mavacoxib Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.
T7838 Losartan Carboxaldehyde Losartan Carboxaldehyde is an endothelial cyclooxygenase (COX)-2 inhibitor.
T8236 RHC 80267 RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 µM in canine platelets)
T8356 FPL 62064 FPL 62064 is a potent  dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synth...
T8505 Sc 236 Sc 236 is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).
T8656 CAY10404 CAY10404 is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apopto...
TMA0291 Dehydroglyasperin D Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 ...
TMA1122 Moschamine Moschamine is a very potent compound that is able to inhibit COX-I by 58% and COX-II by 54%, at the concentration of 0.1 μmol L⁻1, it may suppress cAMP f...
TMA1570 Sappanone A Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
TN1019 Beta-mangostin Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity
TN1040 Skullcapflavone II Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflav...
TN1041 Quercimeritrin Quercimeritrin has antibacterial activity, it shows promising activity against Staphylococcus aureus.
TN1043 Cyanidin-3-O-rutinoside chloride Cyanidin-3-O-rutinoside chloride has antioxidant activity.
TN1062 Peonidin chloride Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast ...
TN1100 Nepodin Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, w...
TN1143 1-O-Acetyl britannilactone 1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGF...
TN1171 1-Dehydro-6-gingerdione 1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
TN1273 4',7-Dihydroxyflavone 4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
TN1374 alpha-Chaconine Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. A...
TN1377 alpha-Spinasterol α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects....
TN1407 Artocarpin Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells.
TN1510 Clematomandshurica saponin B Clematomandshurica saponin B shows significant inhibitory activity on cyclooxygenase-2 (IC50 = 2.58 microM).
TN1524 Continentalic acid Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis.
TN1562 Dehydromiltirone Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting N...
TN1579 Dihydrocucurbitacin B Dihydrocucurbitacin B has anti-cancer activity, it reduces cell proliferation due to a decrease in the expression of cyclins, mainly cyclin-B1 and disruption of...
TN1581 Dihydroguaiaretic acid Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress.
TN1606 (-)-Epiafzelechin (-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema, it exhibits a dose-dependent inhibition on the COX act...
TN1694 Gliotoxin Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signali...
TN1715 Guaiacin (+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
TN1723 Hamaudol Hamaudol is a chromone isolated from Saposhnikovia divaricata,has analgesic and anti-inflammary activities, it showed inhibitory activity on COX-1 and COX-2 act...
TN1755 Hyperforin Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts.
TN1871 Ligustroside Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosi...
TN1949 Moracin C Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.
TN2079 (-)-Pinoresinol Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, PIN can cause an upregulat...
TN2091 Polygalacin D Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNO...
TN2139 Regaloside B Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity...
TN2139 Regaloside B Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity...
TN2223 Soyacerebroside I Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity.
TN2232 Soyasaponin Ab Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of...
TN2327 Zedoarondiol Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPK...
TN2330 Caffeic Acid 3-Methyl Phenethyl Ester Caffeic Acid 3-Methyl Phenethyl Ester has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane ind...
TN2435 (-)-STYLOPINE (-)-STYLOPINE is a natural product from Chelidonium majus L
TN2440 Technical grade Technical grade is a natural from Magnolia sieboldii
TN2534 1-Hydroxy-2,3,5-trimethoxyxanthone 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-indepen...
TN2641 15-Methoxypinusolidic acid 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
TN2775 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infl...
TN3070 4beta-Hydroxywithanolide E 4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic prog...
TN3364 Agrimonolide Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation o...
TN3366 Ailanthoidol Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potenti...
TN3410 Anatabine Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheim...
TN3482 Bakkenolide B Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.
TN3575 Cannabichromene Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1...
TN3582 Canniprene Canniprene has anti-inflammatory activity, it can potently inhibit the production of inflammatory eicosanoids via the 5-lipoxygenase pathway (IC50=0.4uM) and al...
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
TN3694 Coniferaldehyde Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 de...
TN3708 Coronarin D Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentratio...
TN3726 Cudraflavone B Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and m...
TN3749 Dadahol A Standard reference
TN3805 Dehydrogeijerin Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment o...
TN3806 Dehydroglyasperin C Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
TN3810 Dehydroperilloxin Dehydroperilloxin possesses inhibitory activity against cyclooxygenase-1, with the IC(50) value of 30.4 microM.
TN3839 Desoxo-narchinol A Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity again...
TN3922 Effusanin E Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p...
TN4013 Esculentic acid Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the...
TN4038 Eupatolide Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
TN4062 Flavidin Flavidin shows very good antioxidant capacity. Flavidin can enhance fluorescent imaging, allowing more sensitive and specific cell labeling in tissues, it shoul...
TN4064 Flavoglaucin Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
TN4162 Goshonoside F5 Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN4212 Hirsutanonol Hirsutanonol has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pe...
TN4307 Isolimonexic acid Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
TN4420 Latifolin Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
TN4446 Longiferone B Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it also suppresses the iNOS and COX-2 mRNA expression.
TN4463 Lupeolic acid Lupeolic acid has anti-inflammatory activity.
TN4465 Luvangetin Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection again...
TN4489 Manassantin A Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effe...
TN4581 Moracin D Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization ...
TN4582 Moracin T Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, in...
TN4583 Moringin Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of expe...
TN4584 Morolic acid Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent chang...
TN4586 Mulberrofuran A Mulberrofuran A can inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2, but it can increase the formation of 12-hydrox...
TN4592 Murrangatin Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hi...
TN4635 Neoechinulin A Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block t...
TN4648 Nepetoidin B Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated...
TN4659 Nimbin Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimb...
TN4675 Nortrachelogenin Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth...
TN4748 Penduletin Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Pendul...
TN4752 Perilloxin Perilloxin possesses inhibitory activities against cyclooxygenase-1,with IC(50) values of 23.2 microM.
TN4783 Picralinal Picralinal has anti-inflammatory and analgesic effects.
TN4860 Pueroside B Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-...
TN4879 Questinol Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit t...
TN4938 Samidin Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
TN5011 Shizukaol B Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinf...
TN5019 Siegeskaurolic acid Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages vi...
TN5093 Taiwanhomoflavone A Taiwanhomoflavone A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 col...
TN5130 Tetrahydroamentoflavone Tetrahydroamentoflavone is a potent XO inhibitor, may be considered as a drug candidate or chemopreventive agent; it has anti-inflammatory effects, it shows in ...
TN5149 Tirotundin Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the acti...
TN5248 Voleneol 1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-depend...
TN5264 Xanthoxyletin Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory...
TQ0169 Inulicin Inulicin, an active compound isolated from Inula Britannica L., inhibits VEGF-mediated activation of Src and FAK.
TQ0180 Chebulagic acid Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
TQ0288 Hexahydrocurcumin Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
Salicylamide
T0004CAS 65-45-2
Salicylamide is an over-the-counter drug with analgesic and antipyretic properties, which has similar medicinal properties to aspirin. In the over-the-counter p...
Aspirin
T0005CAS 50-78-2
Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicy...
4-Aminoantipyrine
T0050CAS 83-07-8
4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol.
Glafenine
T0055CAS 3820-67-5
Glafenine, a non-narcotic analgesic agent, is a non-steroidal anti-inflammatory drug (NSAID), and widely used for the therapy of pains of various origins.
Famprofazone
T0057CAS 22881-35-2
Famprofazone (Gewodin, Gewolen) has analgesic, anti-inflammatory, and antipyretic effects.It is a non-steroidal anti-inflammatory agent (NSAID) of the pyrazolon...
2-Ethoxybenzamide
T0058CAS 938-73-8
Anovigam is white or almost-white crystalline powder. Almost odorless. Tasteless. It is widely used as an antipyretic anodyne.
Acetaminophen
T0065CAS 103-90-2
Analgesic antipyretic derivative of acetanilide. Acetaminophen has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blo...
Fenoprofen calcium dihydrate
T0184CAS 53746-45-5
Fenoprofen calcium is a propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.
Diclofenac
T0196CAS 15307-86-5
Diclofenac is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1...
Seratrodast
T0212CAS 112665-43-7
Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist d...
Valdecoxib
T0219CAS 181695-72-7
Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classifi...
Meclofenamate Sodium
T0260CAS 6385-02-0
Meclofenamate Sodium, a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities. It also inhibits prostaglandin bios...
Isoxicam
T0285CAS 34552-84-6
Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States.
Flurbiprofen
T0291CAS 5104-49-4
Flurbiprofen is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal dis...
Indoprofen
T0321CAS 31842-01-0
Indoprofen is a non-steroidal anti-inflammatory drug.
Sodium salicylate
T0335CAS 54-21-7
Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
Bismuth subsalicylat
T0424CAS 14882-18-9
Bismuth subsalicylate is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarr...
Diclofenac diethylamine
T0432CAS 78213-16-8
Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).
Sulfinpyrazone
T0435CAS 57-96-5
Sulfinpyrazone is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic propertie...
Acexamic Acid
T0436CAS 57-08-9
6-Acetamidohexanoic acid is a kind of amino acids deriviate.
Pasiniazid
T0441CAS 2066-89-9
Pasiniazid is an anti-TB and anti-leprosy drug.
Salicoside
T0443CAS 138-52-3
Salicin, a phenol β-glycoside produced from willow bark, shows anti-inflammatory functions.
Dexibuprofen
T0448CAS 51146-56-6
Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
Minoxidil
T0451CAS 38304-91-5
Minoxidil is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.
Cinchophen
T0456CAS 132-60-5
Cinchophen, an analgesic drug, is utilized in treating gout.
Indometacin
T0458CAS 53-86-1
Indomethacin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
Sulindac
T0459CAS 38194-50-2
Sulindac is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti...
Loxoprofen
T0463CAS 68767-14-6
Loxoprofen is an anti-inflammatory non-steroidal medicine.
Celecoxib
T0466CAS 169590-42-5
Celecoxib is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor.
Zileuton
T0477CAS 111406-87-2
Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the f...
Deracoxib
T0484CAS 169590-41-4
Deracoxib is a non-steroidal, non-narcotic anti-inflammatory drug. It is also a selective cyclooxygenase-2 inhibitor, and IC50 Value: 70 to 150 μM(inhibition o...
Sasapyrine
T0498CAS 552-94-3
Salsalate is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities.
Mesalamine
T0646CAS 89-57-6
Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
Salicylic acid
T0649CAS 69-72-7
Salicylic acid, a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
Niflumic acid
T0693CAS 4394-00-7
Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
Oxaprozin
T0708CAS 21256-18-8
Oxaprozin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxapro...
Benzydamine hydrochloride
T0726CAS 132-69-4
Benzydamine hydrochloride, a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties.
Antipyrine
T0734CAS 60-80-0
Antipyrine, an antipyretic and analgesic, has been given as ear drops and by mouth. Antipyrine is frequently used to test the effects of other diseases or drugs...
Piroxicam
T0758CAS 36322-90-4
Piroxicam is a non-specific COX inhibitor.
Phenacetin
T0778CAS 62-44-2
Phenacetin is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market.
Tolfenamic Acid
T0784CAS 13710-19-5
Tolfenamic acid (TA) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine.
Triamcinolone
T0798CAS 124-94-7
Triamcinolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry,  triamcinolone binds to and activates th...
Cianidanol
T0822CAS 154-23-4
Catechin((+)-Catechin; D-Catechin) is a flavan-3-ol, a type of natural phenol and antioxidant.
Nonoxynol
T0824CAS 26027-38-3
Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina d...
Ebselen
T0825CAS 60940-34-3
Ebselen is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and...
Meloxicam
T0826CAS 71125-38-7
Meloxicam is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxi...
Ketoprofen
T0839CAS 22071-15-4
Ketoprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofe...
(S)-(+)-Ketoprofen
T0839LCAS 22161-81-5
Dexketoprofen works by blocking the action of a substance in the body called cyclo-oxygenase. It belongs to a class of medicines called non-steroidal anti-infl...
(R)-Naproxen
T0855CAS 23979-41-1
(R)-Naproxen, an anti-inflammatory agent, has antipyretic and analgesic properties. Both the acid and its sodium salt are used in the therapy of acute gout or d...
Flufenamic acid
T0858CAS 530-78-9
Flufenamic acid is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorde...
Bufexamac
T0867CAS 2438-72-4
Bufexamac is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.
4-Biphenylacetic acid
T0888CAS 5728-52-9
Felbinac (INN, or biphenylylacetic acid), a topical medicine, is an active metabolite of fenbufen. It is belonging to the family of medicines known as non-stero...
Mefenamic acid
T0890CAS 61-68-7
Mefenamic acid is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
Sulfasalazine
T0907CAS 599-79-1
Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
Trometamol
T0961CAS 77-86-1
Trometamol is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachid...
Nifenazone
T0980CAS 2139-47-1
Nifenazone is a pyrazole drug, used in the in the treatment of rheumatic disorders.
Etodolac
T1002CAS 41340-25-4
Etodolac inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, ...
COX-2-IN-2
T10032CAS 134729-13-8
COX-2-IN-2 is a selective and inducible COX2 inhibitor (IC50: 0.24 μM).
COX-2-IN-1
T10033CAS 787623-48-7
COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).
4-Methylamino antipyrine
T10152CAS 519-98-2
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Meth...
4-Methylamino antipyrine hydrochloride
T10152LCAS 856307-27-2
4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibi...
Desmethyl Celecoxib
T11005CAS 170569-87-6
Demethyl celecoxib is a selective inhibitor of COX-2 with anti-inflammatory activity (IC50 of 32 nM). with anti-inflammatory activities. Desmethyl Celecoxib is...
Eicosatetraynoic acid
T11169CAS 1191-85-1
Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 µM. Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipo...
Flosulide
T11296CAS 80937-31-1
Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.
Nimesulide
T1133CAS 51803-78-2
Nimesulide is a relatively COX-2 selective inhibitor with analgesic and antipyretic properties.
(-)-Ibuprofenamide
T11605CAS 121839-78-9
(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.
Insulin levels modulator
T11660CAS 1019254-94-4
Insulin level regulators can be used to treat diabetes.
Kinase inhibitor-1
T11761CAS 2135696-72-7
Kinase inhibitor-1 is a kinase inhibitor.
Rofecoxib
T1185CAS 162011-90-7
Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecox...
Analgin
T1191CAS 5907-38-0
Metamizole (Dipyrone) sodium hydrate is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX). Target: COX Dipyrone is a potent ana...
Dipyron
T1191LCAS 68-89-3
Analgin is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
Flunixin meglumin
T1209CAS 42461-84-7
Flunixin Meglumin is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity.
Ketorolac tromethamine salt
T1212CAS 74103-07-4
Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and antipyretic activities.
Nimesulide D5
T12227CAS 1330180-22-7
Nimesulide D5 is a deuterium labeled Nimesulide. Nimesulide is a selective inhibitor OF COX-2(IC50s of 70 nM-70 μM)
PF-04634817 succinate
T12419CAS 2140301-98-8
PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.
Nabumetone
T1258CAS 42924-53-8
Nabumetone(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II.
PTUPB
T12580CAS 1287761-01-6
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
RWJ 63556
T12784CAS 190967-35-2
RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.
Nepafenac
T1280CAS 78281-72-8
Nepafenac is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification of nepafe...
(S)-(+)-Ibuprofen D3
T12800CAS 1329643-44-8
(S)-(+)-Ibuprofen D3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen ,it is an inhibitor of COX-1 and COX-2 acti...
SC57666
T12860CAS 158959-32-1
SC57666 is a selective inhibitor of COX2(IC50 of 26 nM).
SC58451
T12862CAS 168433-84-9
SC58451 is a potent and selective inhibitor of Cox-2.
Aminopar
T1296CAS 65-49-6
Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
Guaiacol
T1301CAS 90-05-1
Guaiacol is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anest...
Timegadine
T13160CAS 71079-19-1
Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μ...
Carprofen
T1325CAS 53716-49-7
Carprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.
COX/5-LO-IN-1
T13263CAS 154355-75-6
COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.
2-Amino-5-methyl-3-thiophenecarbonitrile
T1376CAS 138564-58-6
2-Amino-5-methyl-3-thiophenecarbonitrile is an organic compund with molecular fomula C6H6N2S.
Ibuprofen
T1394CAS 15687-27-1
Ibuprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inh...
Meclofenoxate hydrochloride
T1401CAS 3685-84-5
Meclofenoxate hydrochloride is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cognition, an...
Fenofibric acid
T1402CAS 42017-89-0
Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
Diethylcarbamazine citrate
T1420CAS 1642-54-2
Diethylcarbamazine citrate is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or L...
Aceclofenac
T1421CAS 89796-99-6
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.
Hydroxytoluic acid
T1423CAS 83-40-9
Hydroxytoluic Acid is a long-acting salicylate derivative with antilipidemic properties. Hydroxytoluic acid has been shown to lower plasma free fatty acid and c...
Fosfosal
T1427CAS 6064-83-1
Fosfosal, used as the anti-inflammatory agent, has the anti-bacterial effect.
Phenylbutazone
T1432CAS 50-33-9
Phenylbutazone is a butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ankylosing spondylit...
Acemetacin
T1467CAS 53164-05-9
Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is...
Lornoxicam
T1468CAS 70374-39-9
Lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properti...
FR-188582
T15345CAS 189699-82-9
FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).
Drospirenone
T1541CAS 67392-87-4
Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
Olsalazine disodium
T1544CAS 6054-98-4
Olsalazine sodium is bioconverted to 5-aminosalicylic acid (5-ASA) in the colon and has anti-inflammatory activity in ulcerative colitis.
GW-406381
T15449CAS 221148-46-5
GW406381 is a highly selective inhibitor of cyclooxygenase-2 (COX-2). GW406381 also attenuates spontaneous ectopic discharge in the sural nerves of rats followi...
Diclofenac sodium
T1555CAS 15307-79-6
Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
Imrecoxib
T15571CAS 395683-14-4
Imrecoxib is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM). It also inhibits COX1- activity (IC50: 115 nM). Imrecoxib has an anti-infla...
Indobufen
T15577CAS 63610-08-2
Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activi...
Resveratrol HOT
T1558CAS 501-36-0
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
Tilmacoxib
T15630CAS 180200-68-4
Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay).
Pamicogrel
T15645CAS 101001-34-7
Pamicogrel is an inhibitor of COX.
Thioflosulide
T15687CAS 158205-05-1
Thioflosulide is a selective cyclooxygenase-2 inhibitor (IC50: 2.3 nM). It also shows anti-inflammatory activity.
Etoricoxib
T1574CAS 202409-33-4
Etoricoxib is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specific...
Naproxen
T1582CAS 22204-53-1
Naproxen is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities.
Naproxen sodium
T1582LCAS 26159-34-2
Naproxen is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties.
Tenoxicam
T1586CAS 59804-37-4
Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.
NF157
T16291CAS 104869-26-3
NF157 significantly decreases the expression of metalloproteinase (MMP)-3, MMP-13, which can be used in the treatment of osteoarthritis (OA). NF157 is a highly ...
NSC-60339
T16349CAS 70-09-7
NSC-60339 is an inhibitor of efflux pump, and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeu...
NSC-87877
T16350CAS 56990-57-9
NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits d...
Oxyphenbutazone
T16419CAS 129-20-4
Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is a phenylbutazone derivative. It has an anti-inflammatory effect. Oxyphenbutazone selectivel...
Pelubiprofen
T16464CAS 69956-77-0
Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway. It also has significant anti-inflamma...
S-2474
T16817CAS 158089-95-3
S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (IC50s: 11 nM and 27 μM for COX-2 and COX-1 in human intact cells).
Sudoxicam
T16950CAS 34042-85-8
Sudoxicam is a reversible and orally active COX antagonist. Sudoxicam has potent anti-inflammatory, anti-edema, and antipyretic activity.
Tenidap
T17036CAS 120210-48-2
Tenidap is a non-steroidal anti-inflammatory drug and is a selective COX-1 inhibitor (IC50: 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively). Tenidap is ...
Amfenac Sodium Monohydrate
T1720CAS 61618-27-7
Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety.
Parecoxib
T1780CAS 198470-84-7
Parecoxib is an effective and selective COX-2 inhibitor.
ATB 346
T1867CAS 1226895-20-0
ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
4-Hydroxyantipyrine
T2225CAS 1672-63-5
4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine.
Paeoniflorin
T2230CAS 23180-57-6
Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.
Indometacin Sodium
T22346CAS 74252-25-8
Indomethacin Sodium is the sodium salt of indomethacin, which is a non-selective, competitive, and reversible, inhibitor of cyclooxygenases 1 and 2 with analges...
Phenidone
T22398CAS 92-43-3
Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound primarily used as a photographic developer.
SC 58125
T23333CAS 162054-19-5
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also ca...
Bromfenac sodium
T2403CAS 120638-55-3
Bromfenac Sodium is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophth...
Tolmetin
T2550CAS 26171-23-3
Tolmetin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin...
Etofenamate
T2553CAS 30544-47-9
Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.
(-)-Epicatechin gallate
T2732CAS 1257-08-5
One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramici...
(+)-Catechin Hydrate
T2778CAS 225937-10-0
(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological s...
Asarylaldehyde
T2826CAS 4460-86-0
Asaraldehyde, a natural COX-2 inhibitor, exhibits 17-fold selectivity than COX-1.
Epicatechin
T2856CAS 490-46-0
(-)-Epicatechin is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 su...
Ginsenoside Rd
T2878CAS 52705-93-8
Ginsenoside Rd may have properties that inhibit or prevent the growth of tumors.
Rutaecarpine
T2972CAS 84-26-4
Rutaecarpine is an inhibitor of COX-2 with IC50 of 0.28 μM.
β-Elemonic Acid
T2S0618CAS 28282-25-9
1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antic...
NS398
T3214CAS 123653-11-2
NS-398 is a COX-2 inhibitor wih anti-inflammatory activity.
Isosteviol
T3332CAS 27975-19-5
Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolys...
Xanthohumol
T3342CAS 6754-58-1
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylate...
Amentoflavone
T3417CAS 1617-53-4
Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in ...
Flurbiprofen Axetil
T3500CAS 91503-79-6
Flurbiprofen Axetil is an anti-inflammatory used as an analgesic.
Veratric acid
T3744CAS 93-07-2
Veratric acid is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowering effects.
syringaldehyde
T3747CAS 134-96-3
Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia offic...
Agnuside
T3868CAS 11027-63-7
Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-gl...
Roburic acid
T3883CAS 6812-81-3
Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.
Neoandrographolide
T3884CAS 27215-14-1
Neoandrographolide has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has anti-inflammatory eff...
Adelmidrol
T3954CAS 1675-66-7
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
Acacetin
T3981CAS 480-44-4
Acacetin is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.
Chamigrenal
T3P2855CAS 19912-84-6
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7...
Methyl ferulate
T3S0006CAS 22329-76-6
Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first...
Gaultherin
T3S0509CAS 490-67-5
Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, n...
Cinnamic aldehyde
T3S1553CAS 14371-10-9
1. Cinnamic aldehyde exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic...
AG 126
T4092CAS 118409-62-4
The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vi...
SC560
T4101CAS 188817-13-2
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.
Arjunic acid
T4131CAS 31298-06-3
Arjunic acid is a strong antioxidant and a free radical scavenger. Arjunic acid shows activity against Gram-positive and Gram-negative bacteria with MIC values ...
Tinoridine hydrochloride
T4313CAS 25913-34-2
Tinoridine (Y-3642) is a non-steroidal anti-inflammatory drug. Tinoridine (5-100 μM), produced a concentration-dependent inhibition on the simultaneous increas...
Talniflumate
T4503CAS 66898-62-2
Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It pos...
TFAP
T4643CAS 1011244-68-0
TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor
Gamabufotalin
T4A2456CAS 465-11-2
1. Gamabufotalin , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic sta...
Sanggenone D
T4S1616CAS 81422-93-7
Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflam...
Ginkgetin
T4S2126CAS 481-46-9
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo agains...
Propyphenazone (4-Isopropylantipyrine)
T5010CAS 479-92-5
Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective c...
Iguratimod
T5032CAS 123663-49-0
Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits...
8-SHOGAOL
T5430CAS 36700-45-5
8-​Shogaol is a component of ginger and maintains anti-inflammatory activity as a cyclooxygenase-2 inhibitor.
Mofezolac
T5460CAS 78967-07-4
Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000
ETHYL CAFFEATE
T5681CAS 102-37-4
In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-...
Micheliolide
T5688CAS 68370-47-8
Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
CAFESTOL
T5727CAS 469-83-0
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells...
sphondin
T5758CAS 483-66-9
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level o...
marmesin
T5759CAS 13849-08-6
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
Stylopine hydrochloride
T5807CAS 96087-21-7
Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
Ampiroxicam
T6387CAS 99464-64-9
Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
Bromfenac Sodium
T6424CAS 91714-93-1
Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cycl...
Dexamethasone Sodium Phosphate
T6465CAS 55203-24-2
Dexamethasone, an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid sy...
Ibuprofen Lysine
T6540CAS 57469-77-9
Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.
Lumiracoxib
T6574CAS 220991-20-8
Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
Suprofen
T6687CAS 40828-46-4
Suprofen is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
Zaltoprofen
T6737CAS 74711-43-6
Zaltoprofen is a Cox-1 and Cox-2 inhibitor, which is used for the treatment of arthritis.
MK886
T6893CAS 118414-82-7
MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
RK33
T6970CAS 1070773-09-9
RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitiza...
Byakangelicol
T6S0077CAS 26091-79-2
1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; ...
Isoorientin
T6S0722CAS 4261-42-1
1. Luteolin-6-C-glucoside has antioxidant activity.
Benzoylpaeoniflorin
T6S1652CAS 38642-49-8
1. Benzoylpaeoniflorin is active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.
Rosmanol
T7033CAS 80225-53-2
Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activ...
CCCP
T7081CAS 555-60-2
CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochon...
6-paradol
T7113CAS 27113-22-0
6-paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including anti-cancer,...
FK 3311
T7207CAS 116686-15-8
FK 3311 is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)
Firocoxib
T7596CAS 189954-96-9
Firocoxib is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses.
6-methoxy Naphthalene Acetic Acid
T7662CAS 23981-47-7
6-methoxy Naphthalene Acetic Acid is a competitive inhibitor of COX(Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively)
Mavacoxib
T7670CAS 170569-88-7
Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.
Losartan Carboxaldehyde
T7838CAS 114798-36-6
Losartan Carboxaldehyde is an endothelial cyclooxygenase (COX)-2 inhibitor.
RHC 80267
T8236CAS 83654-05-1
RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 µM in canine platelets)
FPL 62064
T8356CAS 103141-09-9
FPL 62064 is a potent  dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synth...
Sc 236
T8505CAS 170569-86-5
Sc 236 is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).
CAY10404
T8656CAS 340267-36-9
CAY10404 is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apopto...
Dehydroglyasperin D
TMA0291CAS 517885-72-2
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 ...
Moschamine
TMA1122CAS 68573-23-9
Moschamine is a very potent compound that is able to inhibit COX-I by 58% and COX-II by 54%, at the concentration of 0.1 μmol L⁻1, it may suppress cAMP f...
Sappanone A
TMA1570CAS 102067-84-5
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
Beta-mangostin
TN1019CAS 20931-37-7
Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity
Skullcapflavone II
TN1040CAS 55084-08-7
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflav...
Quercimeritrin
TN1041CAS 491-50-9
Quercimeritrin has antibacterial activity, it shows promising activity against Staphylococcus aureus.
Cyanidin-3-O-rutinoside chloride
TN1043CAS 18719-76-1
Cyanidin-3-O-rutinoside chloride has antioxidant activity.
Peonidin chloride
TN1062CAS 134-01-0
Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast ...
Nepodin
TN1100CAS 3785-24-8
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, w...
1-O-Acetyl britannilactone
TN1143CAS 681457-46-5
1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGF...
1-Dehydro-6-gingerdione
TN1171CAS 76060-35-0
1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
4',7-Dihydroxyflavone
TN1273CAS 2196-14-7
4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
alpha-Chaconine
TN1374CAS 20562-03-2
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. A...
alpha-Spinasterol
TN1377CAS 481-18-5
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects....
Artocarpin
TN1407CAS 7608-44-8
Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells.
Clematomandshurica saponin B
TN1510CAS 916649-91-7
Clematomandshurica saponin B shows significant inhibitory activity on cyclooxygenase-2 (IC50 = 2.58 microM).
Continentalic acid
TN1524CAS 19889-23-7
Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis.
Dehydromiltirone
TN1562CAS 116064-77-8
Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting N...
Dihydrocucurbitacin B
TN1579CAS 13201-14-4
Dihydrocucurbitacin B has anti-cancer activity, it reduces cell proliferation due to a decrease in the expression of cyclins, mainly cyclin-B1 and disruption of...
Dihydroguaiaretic acid
TN1581CAS 66322-34-7
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress.
(-)-Epiafzelechin
TN1606CAS 24808-04-6
(-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema, it exhibits a dose-dependent inhibition on the COX act...
Gliotoxin
TN1694CAS 67-99-2
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signali...
Guaiacin
TN1715CAS 36531-08-5
(+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
Hamaudol
TN1723CAS 735-46-6
Hamaudol is a chromone isolated from Saposhnikovia divaricata,has analgesic and anti-inflammary activities, it showed inhibitory activity on COX-1 and COX-2 act...
Hyperforin
TN1755CAS 11079-53-1
Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts.
Ligustroside
TN1871CAS 35897-92-8
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosi...
Moracin C
TN1949CAS 69120-06-5
Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.
(-)-Pinoresinol
TN2079CAS 81446-29-9
Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, PIN can cause an upregulat...
Polygalacin D
TN2091CAS 66663-91-0
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNO...
Regaloside B
TN2139CAS 114420-67-6
Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity...
Regaloside B
TN2139CAS 114420-67-6
Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity...
Soyacerebroside I
TN2223CAS 114297-20-0
Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity.
Soyasaponin Ab
TN2232CAS 118194-13-1
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of...
Zedoarondiol
TN2327CAS 98644-24-7
Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPK...
Caffeic Acid 3-Methyl Phenethyl Ester
TN2330CAS 71835-85-3
Caffeic Acid 3-Methyl Phenethyl Ester has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane ind...
(-)-STYLOPINE
TN2435CAS 4312-32-7
(-)-STYLOPINE is a natural product from Chelidonium majus L
Technical grade
TN2440CAS 537-33-7
Technical grade is a natural from Magnolia sieboldii
1-Hydroxy-2,3,5-trimethoxyxanthone
TN2534CAS 22804-49-5
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-indepen...
15-Methoxypinusolidic acid
TN2641CAS 769928-72-5
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
2-Methoxystypandrone
TN2775CAS 85122-21-0
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infl...
4beta-Hydroxywithanolide E
TN3070CAS 54334-04-2
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic prog...
Agrimonolide
TN3364CAS 21499-24-1
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation o...
Ailanthoidol
TN3366CAS 156398-61-7
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potenti...
Anatabine
TN3410CAS 581-49-7
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheim...
Bakkenolide B
TN3482CAS 18455-98-6
Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.
Cannabichromene
TN3575CAS 20675-51-8
Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1...
Canniprene
TN3582CAS 70677-47-3
Canniprene has anti-inflammatory activity, it can potently inhibit the production of inflammatory eicosanoids via the 5-lipoxygenase pathway (IC50=0.4uM) and al...
Capillarisin
TN3587CAS 56365-38-9
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
Coniferaldehyde
TN3694CAS 20649-42-7
Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 de...
Coronarin D
TN3708CAS 119188-37-3
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentratio...
Cudraflavone B
TN3726CAS 19275-49-1
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and m...
Dadahol A
TN3749CAS 405281-76-7
Standard reference
Dehydrogeijerin
TN3805CAS 16850-91-2
Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment o...
Dehydroglyasperin C
TN3806CAS 199331-35-6
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
Dehydroperilloxin
TN3810CAS 263241-09-4
Dehydroperilloxin possesses inhibitory activity against cyclooxygenase-1, with the IC(50) value of 30.4 microM.
Desoxo-narchinol A
TN3839CAS 53859-06-6
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity again...
Effusanin E
TN3922CAS 76470-15-0
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p...
Esculentic acid
TN4013CAS 103974-74-9
Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the...
Eupatolide
TN4038CAS 6750-25-0
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
Flavidin
TN4062CAS 83924-98-5
Flavidin shows very good antioxidant capacity. Flavidin can enhance fluorescent imaging, allowing more sensitive and specific cell labeling in tissues, it shoul...
Flavoglaucin
TN4064CAS 523-73-9
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
Goshonoside F5
TN4162CAS 90851-28-8
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
Hirsutanonol
TN4212CAS 41137-86-4
Hirsutanonol has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pe...
Isolimonexic acid
TN4307CAS 73904-93-5
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
Latifolin
TN4420CAS 10154-42-4
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
Longiferone B
TN4446CAS 1639810-67-5
Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it also suppresses the iNOS and COX-2 mRNA expression.
Lupeolic acid
TN4463CAS 87355-32-6
Lupeolic acid has anti-inflammatory activity.
Luvangetin
TN4465CAS 483-92-1
Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection again...
Manassantin A
TN4489CAS 88497-87-4
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effe...
Moracin D
TN4581CAS 69120-07-6
Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization ...
Moracin T
TN4582CAS 1146113-27-0
Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, in...
Moringin
TN4583CAS 73255-40-0
Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of expe...
Morolic acid
TN4584CAS 559-68-2
Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent chang...
Mulberrofuran A
TN4586CAS 68978-04-1
Mulberrofuran A can inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2, but it can increase the formation of 12-hydrox...
Murrangatin
TN4592CAS 37126-91-3
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hi...
Neoechinulin A
TN4635CAS 51551-29-2
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block t...
Nepetoidin B
TN4648CAS 55486-06-1
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated...
Nimbin
TN4659CAS 5945-86-8
Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimb...
Nortrachelogenin
TN4675CAS 34444-37-6
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth...
Penduletin
TN4748CAS 569-80-2
Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Pendul...
Perilloxin
TN4752CAS 263249-77-0
Perilloxin possesses inhibitory activities against cyclooxygenase-1,with IC(50) values of 23.2 microM.
Picralinal
TN4783CAS 20045-06-1
Picralinal has anti-inflammatory and analgesic effects.
Pueroside B
TN4860CAS 100692-54-4
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-...
Questinol
TN4879CAS 35688-09-6
Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit t...
Samidin
TN4938CAS 477-33-8
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Shizukaol B
TN5011CAS 142279-40-1
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinf...
Siegeskaurolic acid
TN5019CAS 52645-97-3
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages vi...
Taiwanhomoflavone A
TN5093CAS 265120-00-1
Taiwanhomoflavone A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 col...
Tetrahydroamentoflavone
TN5130CAS 48236-96-0
Tetrahydroamentoflavone is a potent XO inhibitor, may be considered as a drug candidate or chemopreventive agent; it has anti-inflammatory effects, it shows in ...
Tirotundin
TN5149CAS 56377-67-4
Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the acti...
Voleneol
TN5248CAS 70389-88-7
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-depend...
Xanthoxyletin
TN5264CAS 84-99-1
Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory...
Inulicin
TQ0169CAS 33627-41-7
Inulicin, an active compound isolated from Inula Britannica L., inhibits VEGF-mediated activation of Src and FAK.
Chebulagic acid
TQ0180CAS 23094-71-5
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
Hexahydrocurcumin
TQ0288CAS 36062-05-2
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
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