COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase. The specific reaction catalyzed is the conversion from arachidonic acid to Prostaglandin H2, via a short-living Prostaglandin G2 intermediate.

Cat No.	product name
T4092	AG 126	The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vi...
T4101	SC-560	SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.
T6387	Ampiroxicam	Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
T6465	Dexamethasone Sodium Phosphate	Dexamethasone, an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid s...
T6540	Ibuprofen Lysine	Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.
T6574	Lumiracoxib	Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
T6687	Suprofen	Suprofen is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
T6737	Zaltoprofen	Zaltoprofen is a Cox-1 and Cox-2 inhibitor, which is used for the treatment of arthritis.
T6893	MK-886	MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
T6970	RK-33	RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitiza...
T4313	Tinoridine hydrochloride	Tinoridine (Y-3642) is a non-steroidal anti-inflammatory drug. Tinoridine (5-100 μM), produced a concentration-dependent inhibition on the simultaneous increas...
T3S1553	Cinnamic aldehyde	1. Cinnamic aldehyde exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnam...
T4A2456	Gamabufotalin	1. Gamabufotalin , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic sta...
T6S0077	Byakangelicol	1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; ...
T6S1652	Benzoylpaeoniflorin	1. Benzoylpaeoniflorin is active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.
T4503	Talniflumate	Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It pos...
T7033	Rosmanol	Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activ...
T7081	CCCP	CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochon...
T4643	TFAP	TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor
T3868	Agnuside	Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-gl...
T5032	Iguratimod	Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits...
T5010	Propyphenazone (4-Isopropylantipyrine)	Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective c...
T5430	8-SHOGAOL	8-Shogaol is a component of ginger and maintains anti-inflammatory activity as a cyclooxygenase-2 inhibitor.
T5460	Mofezolac	Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000
T5681	ETHYL CAFFEATE	ETHYL CAFFEATE is a Cox-2, iNOS, NOS II, and PGE2 inhibitor，and have antiarthritic effect in collagen-induced arthritis (CIA) mice, its mechanism of action i...
T5759	marmesin	Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
T5727	CAFESTOL	CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells...
T5758	sphondin	Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level o...
T5688	Micheliolide	Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
T5807	Stylopine hydrochloride	Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
T7113	6-paradol	6-paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including anti-cancer,...
T7207	FK 3311	FK 3311 is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)
T7670	Mavacoxib	Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.
T7662	6-methoxy Naphthalene Acetic Acid	6-methoxy Naphthalene Acetic Acid is a competitive inhibitor of COX(Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively)
TQ0288	Hexahydrocurcumin	Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
TQ0180	Chebulagic acid	Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
TQ0169	Inulicin	Inulicin, an active compound isolated from Inula Britannica L., inhibits VEGF-mediated activation of Src and FAK.
T7838	Losartan Carboxaldehyde	Losartan Carboxaldehyde is an endothelial cyclooxygenase (COX)-2 inhibitor.
T1402	Fenofibric acid	Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
T4S2126	Ginkgetin	1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo again...
T2778	(+)-Catechin Hydrate	(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological s...
T6S0722	Isoorientin	1. Luteolin-6-C-glucoside has antioxidant activity.
T8236	RHC 80267	RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 µM in canine platelets)
T8356	FPL 62064	FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synth...
TN1019	Beta-mangostin	Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity
TN1043	Cyanidin-3-O-rutinoside chloride	Cyanidin-3-O-rutinoside chloride has antioxidant activity.
TN1062	Peonidin chloride	Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast ...
TN1100	Nepodin	Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, w...
TN1273	4',7-Dihydroxyflavone	4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
TN1374	alpha-Chaconine	Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. A...