COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.

Cat No.	product name
T16169	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 是胰蛋白酶样蛋白酶的抑制剂。 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 对 IFN-γ 活性具有抑制作用。
T7081	CCCP	CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondr...
T22790	FR 122047 hydrochloride	cyclooxygenase-1 inhibitor
T0826	Meloxicam	Meloxicam is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxic...
T0877	Gallic acid	Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T2S0618	β-Elemonic Acid	1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antica...
T19672	Amtolmetin guacil	Amtolmetin guacil is a non-acidic prodrug of tolmetin, having similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective...
T0498	Salsalate	Salsalate is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities.
T0432	Diclofenac diethylamine	Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).
T5727	CAFESTOL	CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells....
TC0036	Lup-20(29)-en-3-yl acetate	Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.
T8255	(±)-Catechin	(±)-Catechin hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress.
T7540	2,5-Di-tert-butylhydroquinone	BHQ is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.
T1296	4-Aminosalicylic acid	Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T6S0413	Pectolinarigenin	1. Pectolinarigenin exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that th...
T1867	Otenaproxesul	ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
T1555	Diclofenac sodium	Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
T0291	Flurbiprofen	Flurbiprofen is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal dise...
T2732	(-)-Epicatechin gallate	One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicid...
T0196	Diclofenac	Diclofenac is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 ...
T8656	CAY10404	CAY10404 is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptos...
T6687	Suprofen	Suprofen is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
T0858	Flufenamic acid	Flufenamic acid is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorder...
T0335	Sodium salicylate	Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
T5681	ETHYL CAFFEATE	In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-re...
T1582	Naproxen	Naproxen is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities.
T6S1487	Ginsenoside Rg5	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production a...
T12933	SM-276001	SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
T0808	Diflunisal	Diflunisal is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
T0424	Bismuth Subsalicylate	Bismuth subsalicylate is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarrh...
TN1100	Nepodin	Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
T0646	5-Aminosalicylic Acid	Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
T0477	Zileuton	Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the fo...
TQ0180	Chebulagic acid	Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
TN1660	Ganoderic acid C1	Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
TQ0288	Hexahydrocurcumin	Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
T0260	Meclofenamic acid sodium	Meclofenamate Sodium, a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities. It also inhibits prostaglandin biosy...
T30937	Cimicoxib	Cimicoxib (UR-8880) is a non-steroidal anti-inflammatory drug (NSAID), which is also a COX-2 inhibitor, used in veterinary medicine to treat pain and inflammatio...
T8236	RHC 80267	RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 µM in canine platelets)
TN1377	α-Spinasterol	α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α...
T12580	PTUPB	PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
T3981	Acacetin	Acacetin is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.
T4643	TFAP	TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor
T5431	[10]-Shogaol	10-Shogaol is an extract from ginger displaying antioxidant activity. It also may contain hypolipidemic and insulin-sensitizing effects.
T3877	Esculentoside A	Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. E...
T0825	Ebselen	Ebselen is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is th...
T8293	γ-Tocopherol	(+)-γ-Tocopherol is one of the naturally occurring forms of Vitamin E. It is the most abundant Tocopherol in soybean and corn oils.
T2230	Paeoniflorin	Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.
T7030	Anemarsaponin B	Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
T4561	Tiaprofenic acid	Tiaprofenic acid is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.