T0004 |
Salicylamide |
Salicylamide is an over-the-counter drug with analgesic and antipyretic properties, which has similar medicinal properties to aspirin. In the over-the-counter p...
|
T0005 |
Aspirin |
Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicy...
|
T0050 |
4-Aminoantipyrine |
4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol. |
T0055 |
Glafenine |
Glafenine, a non-narcotic analgesic agent, is a non-steroidal anti-inflammatory drug (NSAID), and widely used for the therapy of pains of various origins. |
T0057 |
Famprofazone |
Famprofazone (Gewodin, Gewolen) has analgesic, anti-inflammatory, and antipyretic effects.It is a non-steroidal anti-inflammatory agent (NSAID) of the pyrazolon...
|
T0058 |
2-Ethoxybenzamide |
Anovigam is white or almost-white crystalline powder. Almost odorless. Tasteless. It is widely used as an antipyretic anodyne. |
T0065 |
Acetaminophen |
Analgesic antipyretic derivative of acetanilide. Acetaminophen has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blo...
|
T0184 |
Fenoprofen calcium dihydrate |
Fenoprofen calcium is a propionic acid derivative that is used as a non-steroidal anti-inflammatory agent. |
T0196 |
Diclofenac |
Diclofenac is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1...
|
T0212 |
Seratrodast |
Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist d...
|
T0219 |
Valdecoxib |
Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classifi...
|
T0260 |
Meclofenamate Sodium |
Meclofenamate Sodium, a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities. It also inhibits prostaglandin bios...
|
T0285 |
Isoxicam |
Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States. |
T0291 |
Flurbiprofen |
Flurbiprofen is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal dis...
|
T0321 |
Indoprofen |
Indoprofen is a non-steroidal anti-inflammatory drug. |
T0335 |
Sodium salicylate |
Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress. |
T0424 |
Bismuth subsalicylat |
Bismuth subsalicylate is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarr...
|
T0432 |
Diclofenac diethylamine |
Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID). |
T0435 |
Sulfinpyrazone |
Sulfinpyrazone is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic propertie...
|
T0436 |
Acexamic Acid |
6-Acetamidohexanoic acid is a kind of amino acids deriviate. |
T0441 |
Pasiniazid |
Pasiniazid is an anti-TB and anti-leprosy drug. |
T0443 |
Salicoside |
Salicin, a phenol β-glycoside produced from willow bark, shows anti-inflammatory functions. |
T0448 |
Dexibuprofen |
Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX). |
T0451 |
Minoxidil |
Minoxidil is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects. |
T0456 |
Cinchophen |
Cinchophen, an analgesic drug, is utilized in treating gout. |
T0458 |
Indometacin |
Indomethacin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor. |
T0459 |
Sulindac |
Sulindac is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti...
|
T0463 |
Loxoprofen |
Loxoprofen is an anti-inflammatory non-steroidal medicine. |
T0466 |
Celecoxib |
Celecoxib is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor. |
T0477 |
Zileuton |
Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the f...
|
T0484 |
Deracoxib |
Deracoxib is a non-steroidal, non-narcotic anti-inflammatory drug. It is also a selective cyclooxygenase-2 inhibitor, and IC50 Value: 70 to 150 μM(inhibition o...
|
T0498 |
Sasapyrine |
Salsalate is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities. |
T0646 |
Mesalamine |
Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
|
T0649 |
Salicylic acid |
Salicylic acid, a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase. |
T0693 |
Niflumic acid |
Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis. |
T0708 |
Oxaprozin |
Oxaprozin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxapro...
|
T0726 |
Benzydamine hydrochloride |
Benzydamine hydrochloride, a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties. |
T0734 |
Antipyrine |
Antipyrine, an antipyretic and analgesic, has been given as ear drops and by mouth. Antipyrine is frequently used to test the effects of other diseases or drugs...
|
T0758 |
Piroxicam |
Piroxicam is a non-specific COX inhibitor. |
T0778 |
Phenacetin |
Phenacetin is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. |
T0784 |
Tolfenamic Acid |
Tolfenamic acid (TA) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine. |
T0798 |
Triamcinolone |
Triamcinolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates th...
|
T0822 |
Cianidanol |
Catechin((+)-Catechin; D-Catechin) is a flavan-3-ol, a type of natural phenol and antioxidant. |
T0824 |
Nonoxynol |
Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina d...
|
T0825 |
Ebselen |
Ebselen is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and...
|
T0826 |
Meloxicam |
Meloxicam is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxi...
|
T0839 |
Ketoprofen |
Ketoprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofe...
|
T0839L |
(S)-(+)-Ketoprofen |
Dexketoprofen works by blocking the action of a substance in the body called cyclo-oxygenase. It belongs to a class of medicines called non-steroidal anti-infl...
|
T0855 |
(R)-Naproxen |
(R)-Naproxen, an anti-inflammatory agent, has antipyretic and analgesic properties. Both the acid and its sodium salt are used in the therapy of acute gout or d...
|
T0858 |
Flufenamic acid |
Flufenamic acid is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorde...
|
T0867 |
Bufexamac |
Bufexamac is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action. |
T0888 |
4-Biphenylacetic acid |
Felbinac (INN, or biphenylylacetic acid), a topical medicine, is an active metabolite of fenbufen. It is belonging to the family of medicines known as non-stero...
|
T0890 |
Mefenamic acid |
Mefenamic acid is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase. |
T0907 |
Sulfasalazine |
Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug |
T0961 |
Trometamol |
Trometamol is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachid...
|
T0980 |
Nifenazone |
Nifenazone is a pyrazole drug, used in the in the treatment of rheumatic disorders. |
T1002 |
Etodolac |
Etodolac inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, ...
|
T10032 |
COX-2-IN-2 |
COX-2-IN-2 is a selective and inducible COX2 inhibitor (IC50: 0.24 μM). |
T10033 |
COX-2-IN-1 |
COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM). |
T10152 |
4-Methylamino antipyrine |
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Meth...
|
T10152L |
4-Methylamino antipyrine hydrochloride |
4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibi...
|
T11005 |
Desmethyl Celecoxib |
Demethyl celecoxib is a selective inhibitor of COX-2 with anti-inflammatory activity (IC50 of 32 nM). with anti-inflammatory activities. Desmethyl Celecoxib is...
|
T11169 |
Eicosatetraynoic acid |
Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 µM. Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipo...
|
T11296 |
Flosulide |
Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases. |
T1133 |
Nimesulide |
Nimesulide is a relatively COX-2 selective inhibitor with analgesic and antipyretic properties. |
T11605 |
(-)-Ibuprofenamide |
(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity. |
T11660 |
Insulin levels modulator |
Insulin level regulators can be used to treat diabetes. |
T11761 |
Kinase inhibitor-1 |
Kinase inhibitor-1 is a kinase inhibitor. |
T1185 |
Rofecoxib |
Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecox...
|
T1191 |
Analgin |
Metamizole (Dipyrone) sodium hydrate is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX). Target: COX Dipyrone is a potent ana...
|
T1191L |
Dipyron |
Analgin is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. |
T1209 |
Flunixin meglumin |
Flunixin Meglumin is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity. |
T1212 |
Ketorolac tromethamine salt |
Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and antipyretic activities. |
T12227 |
Nimesulide D5 |
Nimesulide D5 is a deuterium labeled Nimesulide. Nimesulide is a selective inhibitor OF COX-2(IC50s of 70 nM-70 μM) |
T12419 |
PF-04634817 succinate |
PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM. |
T1258 |
Nabumetone |
Nabumetone(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II. |
T12580 |
PTUPB |
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively). |
T12784 |
RWJ 63556 |
RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities. |
T1280 |
Nepafenac |
Nepafenac is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification of nepafe...
|
T12800 |
(S)-(+)-Ibuprofen D3 |
(S)-(+)-Ibuprofen D3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen ,it is an inhibitor of COX-1 and COX-2 acti...
|
T12860 |
SC57666 |
SC57666 is a selective inhibitor of COX2(IC50 of 26 nM). |
T12862 |
SC58451 |
SC58451 is a potent and selective inhibitor of Cox-2. |
T1296 |
Aminopar |
Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity. |
T1301 |
Guaiacol |
Guaiacol is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anest...
|
T13160 |
Timegadine |
Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μ...
|
T1325 |
Carprofen |
Carprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. |
T13263 |
COX/5-LO-IN-1 |
COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states. |
T1376 |
2-Amino-5-methyl-3-thiophenecarbonitrile |
2-Amino-5-methyl-3-thiophenecarbonitrile is an organic compund with molecular fomula C6H6N2S. |
T1394 |
Ibuprofen |
Ibuprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inh...
|
T1401 |
Meclofenoxate hydrochloride |
Meclofenoxate hydrochloride is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cognition, an...
|
T1402 |
Fenofibric acid |
Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity. |
T1420 |
Diethylcarbamazine citrate |
Diethylcarbamazine citrate is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or L...
|
T1421 |
Aceclofenac |
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. |
T1423 |
Hydroxytoluic acid |
Hydroxytoluic Acid is a long-acting salicylate derivative with antilipidemic properties. Hydroxytoluic acid has been shown to lower plasma free fatty acid and c...
|
T1427 |
Fosfosal |
Fosfosal, used as the anti-inflammatory agent, has the anti-bacterial effect. |
T1432 |
Phenylbutazone |
Phenylbutazone is a butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ankylosing spondylit...
|
T1467 |
Acemetacin |
Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is...
|
T1468 |
Lornoxicam |
Lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properti...
|
T15345 |
FR-188582 |
FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM). |
T1541 |
Drospirenone |
Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity. |
T1544 |
Olsalazine disodium |
Olsalazine sodium is bioconverted to 5-aminosalicylic acid (5-ASA) in the colon and has anti-inflammatory activity in ulcerative colitis. |
T15449 |
GW-406381 |
GW406381 is a highly selective inhibitor of cyclooxygenase-2 (COX-2). GW406381 also attenuates spontaneous ectopic discharge in the sural nerves of rats followi...
|
T1555 |
Diclofenac sodium |
Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. |
T15571 |
Imrecoxib |
Imrecoxib is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM). It also inhibits COX1- activity (IC50: 115 nM). Imrecoxib has an anti-infla...
|
T15577 |
Indobufen |
Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activi...
|
T1558 |
ResveratrolHOT |
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc. |
T15630 |
Tilmacoxib |
Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay). |
T15645 |
Pamicogrel |
Pamicogrel is an inhibitor of COX. |
T15687 |
Thioflosulide |
Thioflosulide is a selective cyclooxygenase-2 inhibitor (IC50: 2.3 nM). It also shows anti-inflammatory activity. |
T1574 |
Etoricoxib |
Etoricoxib is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specific...
|
T1582 |
Naproxen |
Naproxen is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. |
T1582L |
Naproxen sodium |
Naproxen is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties. |
T1586 |
Tenoxicam |
Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain. |
T16291 |
NF157 |
NF157 significantly decreases the expression of metalloproteinase (MMP)-3, MMP-13, which can be used in the treatment of osteoarthritis (OA). NF157 is a highly ...
|
T16349 |
NSC-60339 |
NSC-60339 is an inhibitor of efflux pump, and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeu...
|
T16350 |
NSC-87877 |
NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits d...
|
T16419 |
Oxyphenbutazone |
Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is a phenylbutazone derivative. It has an anti-inflammatory effect. Oxyphenbutazone selectivel...
|
T16464 |
Pelubiprofen |
Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway. It also has significant anti-inflamma...
|
T16817 |
S-2474 |
S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (IC50s: 11 nM and 27 μM for COX-2 and COX-1 in human intact cells). |
T16950 |
Sudoxicam |
Sudoxicam is a reversible and orally active COX antagonist. Sudoxicam has potent anti-inflammatory, anti-edema, and antipyretic activity. |
T17036 |
Tenidap |
Tenidap is a non-steroidal anti-inflammatory drug and is a selective COX-1 inhibitor (IC50: 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively). Tenidap is ...
|
T1720 |
Amfenac Sodium Monohydrate |
Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. |
T1780 |
Parecoxib |
Parecoxib is an effective and selective COX-2 inhibitor. |
T1867 |
ATB 346 |
ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. |
T2225 |
4-Hydroxyantipyrine |
4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine. |
T2230 |
Paeoniflorin |
Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall. |
T22346 |
Indometacin Sodium |
Indomethacin Sodium is the sodium salt of indomethacin, which is a non-selective, competitive, and reversible, inhibitor of cyclooxygenases 1 and 2 with analges...
|
T22398 |
Phenidone |
Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound primarily used as a photographic developer. |
T23333 |
SC 58125 |
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also ca...
|
T2403 |
Bromfenac sodium |
Bromfenac Sodium is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophth...
|
T2550 |
Tolmetin |
Tolmetin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin...
|
T2553 |
Etofenamate |
Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain. |
T2732 |
(-)-Epicatechin gallate |
One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramici...
|
T2778 |
(+)-Catechin Hydrate |
(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological s...
|
T2826 |
Asarylaldehyde |
Asaraldehyde, a natural COX-2 inhibitor, exhibits 17-fold selectivity than COX-1. |
T2856 |
Epicatechin |
(-)-Epicatechin is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 su...
|
T2878 |
Ginsenoside Rd |
Ginsenoside Rd may have properties that inhibit or prevent the growth of tumors. |
T2972 |
Rutaecarpine |
Rutaecarpine is an inhibitor of COX-2 with IC50 of 0.28 μM. |
T2S0618 |
β-Elemonic Acid |
1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antic...
|
T3214 |
NS398 |
NS-398 is a COX-2 inhibitor wih anti-inflammatory activity. |
T3332 |
Isosteviol |
Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolys...
|
T3342 |
Xanthohumol |
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylate...
|
T3417 |
Amentoflavone |
Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in ...
|
T3500 |
Flurbiprofen Axetil |
Flurbiprofen Axetil is an anti-inflammatory used as an analgesic. |
T3744 |
Veratric acid |
Veratric acid is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowering effects. |
T3747 |
syringaldehyde |
Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia offic...
|
T3868 |
Agnuside |
Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-gl...
|
T3883 |
Roburic acid |
Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2. |
T3884 |
Neoandrographolide |
Neoandrographolide has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has anti-inflammatory eff...
|
T3954 |
Adelmidrol |
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid. |
T3981 |
Acacetin |
Acacetin is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models. |
T3P2855 |
Chamigrenal |
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7...
|
T3S0006 |
Methyl ferulate |
Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first...
|
T3S0509 |
Gaultherin |
Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, n...
|
T3S1553 |
Cinnamic aldehyde |
1. Cinnamic aldehyde exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic...
|
T4092 |
AG 126 |
The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vi...
|
T4101 |
SC560 |
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors. |
T4131 |
Arjunic acid |
Arjunic acid is a strong antioxidant and a free radical scavenger. Arjunic acid shows activity against Gram-positive and Gram-negative bacteria with MIC values ...
|
T4313 |
Tinoridine hydrochloride |
Tinoridine (Y-3642) is a non-steroidal anti-inflammatory drug. Tinoridine (5-100 μM), produced a concentration-dependent inhibition on the simultaneous increas...
|
T4503 |
Talniflumate |
Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It pos...
|
T4643 |
TFAP |
TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor |
T4A2456 |
Gamabufotalin |
1. Gamabufotalin , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic sta...
|
T4S1616 |
Sanggenone D |
Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflam...
|
T4S2126 |
Ginkgetin |
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo agains...
|
T5010 |
Propyphenazone (4-Isopropylantipyrine) |
Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective c...
|
T5032 |
Iguratimod |
Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits...
|
T5430 |
8-SHOGAOL |
8-Shogaol is a component of ginger and maintains anti-inflammatory activity as a cyclooxygenase-2 inhibitor. |
T5460 |
Mofezolac |
Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000 |
T5681 |
ETHYL CAFFEATE |
In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-...
|
T5688 |
Micheliolide |
Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response. |
T5727 |
CAFESTOL |
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells...
|
T5758 |
sphondin |
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level o...
|
T5759 |
marmesin |
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity. |
T5807 |
Stylopine hydrochloride |
Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity. |
T6387 |
Ampiroxicam |
Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. |
T6424 |
Bromfenac Sodium |
Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cycl...
|
T6465 |
Dexamethasone Sodium Phosphate |
Dexamethasone, an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid sy...
|
T6540 |
Ibuprofen Lysine |
Ibuprofen Lysine is a non-steroidal anti-inflammatory drug. |
T6574 |
Lumiracoxib |
Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4. |
T6687 |
Suprofen |
Suprofen is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. |
T6737 |
Zaltoprofen |
Zaltoprofen is a Cox-1 and Cox-2 inhibitor, which is used for the treatment of arthritis. |
T6893 |
MK886 |
MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist. |
T6970 |
RK33 |
RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitiza...
|
T6S0077 |
Byakangelicol |
1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; ...
|
T6S0722 |
Isoorientin |
1. Luteolin-6-C-glucoside has antioxidant activity. |
T6S1652 |
Benzoylpaeoniflorin |
1. Benzoylpaeoniflorin is active against cyclooxygenase-1 and cyclooxygenase-2 enzymes. |
T7033 |
Rosmanol |
Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activ...
|
T7081 |
CCCP |
CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochon...
|
T7113 |
6-paradol |
6-paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including anti-cancer,...
|
T7207 |
FK 3311 |
FK 3311 is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID) |
T7596 |
Firocoxib |
Firocoxib is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses. |
T7662 |
6-methoxy Naphthalene Acetic Acid |
6-methoxy Naphthalene Acetic Acid is a competitive inhibitor of COX(Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively) |
T7670 |
Mavacoxib |
Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity. |
T7838 |
Losartan Carboxaldehyde |
Losartan Carboxaldehyde is an endothelial cyclooxygenase (COX)-2 inhibitor. |
T8236 |
RHC 80267 |
RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 µM in canine platelets) |
T8356 |
FPL 62064 |
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synth...
|
T8505 |
Sc 236 |
Sc 236 is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively). |
T8656 |
CAY10404 |
CAY10404 is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apopto...
|
TMA0291 |
Dehydroglyasperin D |
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 ...
|
TMA1122 |
Moschamine |
Moschamine is a very potent compound that is able to inhibit COX-I by 58% and COX-II by 54%, at the concentration of 0.1 μmol L⁻1, it may suppress cAMP f...
|
TMA1570 |
Sappanone A |
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
|
TN1019 |
Beta-mangostin |
Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity |
TN1040 |
Skullcapflavone II |
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflav...
|
TN1041 |
Quercimeritrin |
Quercimeritrin has antibacterial activity, it shows promising activity against Staphylococcus aureus. |
TN1043 |
Cyanidin-3-O-rutinoside chloride |
Cyanidin-3-O-rutinoside chloride has antioxidant activity. |
TN1062 |
Peonidin chloride |
Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast ...
|
TN1100 |
Nepodin |
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, w...
|
TN1143 |
1-O-Acetyl britannilactone |
1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGF...
|
TN1171 |
1-Dehydro-6-gingerdione |
1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist. |
TN1273 |
4',7-Dihydroxyflavone |
4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2. |
TN1374 |
alpha-Chaconine |
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. A...
|
TN1377 |
alpha-Spinasterol |
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects....
|
TN1407 |
Artocarpin |
Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells. |
TN1510 |
Clematomandshurica saponin B |
Clematomandshurica saponin B shows significant inhibitory activity on cyclooxygenase-2 (IC50 = 2.58 microM). |
TN1524 |
Continentalic acid |
Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis. |
TN1562 |
Dehydromiltirone |
Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting N...
|
TN1579 |
Dihydrocucurbitacin B |
Dihydrocucurbitacin B has anti-cancer activity, it reduces cell proliferation due to a decrease in the expression of cyclins, mainly cyclin-B1 and disruption of...
|
TN1581 |
Dihydroguaiaretic acid |
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress. |
TN1606 |
(-)-Epiafzelechin |
(-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema, it exhibits a dose-dependent inhibition on the COX act...
|
TN1694 |
Gliotoxin |
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signali...
|
TN1715 |
Guaiacin |
(+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2. |
TN1723 |
Hamaudol |
Hamaudol is a chromone isolated from Saposhnikovia divaricata,has analgesic and anti-inflammary activities, it showed inhibitory activity on COX-1 and COX-2 act...
|
TN1755 |
Hyperforin |
Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts. |
TN1871 |
Ligustroside |
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosi...
|
TN1949 |
Moracin C |
Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds. |
TN2079 |
(-)-Pinoresinol |
Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, PIN can cause an upregulat...
|
TN2091 |
Polygalacin D |
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNO...
|
TN2139 |
Regaloside B |
Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity...
|
TN2139 |
Regaloside B |
Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity...
|
TN2223 |
Soyacerebroside I |
Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity. |
TN2232 |
Soyasaponin Ab |
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of...
|
TN2327 |
Zedoarondiol |
Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPK...
|
TN2330 |
Caffeic Acid 3-Methyl Phenethyl Ester |
Caffeic Acid 3-Methyl Phenethyl Ester has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane ind...
|
TN2435 |
(-)-STYLOPINE |
(-)-STYLOPINE is a natural product from Chelidonium majus L |
TN2440 |
Technical grade |
Technical grade is a natural from Magnolia sieboldii |
TN2534 |
1-Hydroxy-2,3,5-trimethoxyxanthone |
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-indepen...
|
TN2641 |
15-Methoxypinusolidic acid |
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
|
TN2775 |
2-Methoxystypandrone |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infl...
|
TN3070 |
4beta-Hydroxywithanolide E |
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic prog...
|
TN3364 |
Agrimonolide |
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation o...
|
TN3366 |
Ailanthoidol |
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potenti...
|
TN3410 |
Anatabine |
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheim...
|
TN3482 |
Bakkenolide B |
Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma. |
TN3575 |
Cannabichromene |
Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1...
|
TN3582 |
Canniprene |
Canniprene has anti-inflammatory activity, it can potently inhibit the production of inflammatory eicosanoids via the 5-lipoxygenase pathway (IC50=0.4uM) and al...
|
TN3587 |
Capillarisin |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
|
TN3694 |
Coniferaldehyde |
Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 de...
|
TN3708 |
Coronarin D |
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentratio...
|
TN3726 |
Cudraflavone B |
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and m...
|
TN3749 |
Dadahol A |
Standard reference |
TN3805 |
Dehydrogeijerin |
Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment o...
|
TN3806 |
Dehydroglyasperin C |
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
|
TN3810 |
Dehydroperilloxin |
Dehydroperilloxin possesses inhibitory activity against cyclooxygenase-1, with the IC(50) value of 30.4 microM. |
TN3839 |
Desoxo-narchinol A |
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity again...
|
TN3922 |
Effusanin E |
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p...
|
TN4013 |
Esculentic acid |
Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the...
|
TN4038 |
Eupatolide |
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
|
TN4062 |
Flavidin |
Flavidin shows very good antioxidant capacity. Flavidin can enhance fluorescent imaging, allowing more sensitive and specific cell labeling in tissues, it shoul...
|
TN4064 |
Flavoglaucin |
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
|
TN4162 |
Goshonoside F5 |
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo. |
TN4212 |
Hirsutanonol |
Hirsutanonol has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pe...
|
TN4307 |
Isolimonexic acid |
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth. |
TN4420 |
Latifolin |
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
|
TN4446 |
Longiferone B |
Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it also suppresses the iNOS and COX-2 mRNA expression. |
TN4463 |
Lupeolic acid |
Lupeolic acid has anti-inflammatory activity. |
TN4465 |
Luvangetin |
Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection again...
|
TN4489 |
Manassantin A |
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effe...
|
TN4581 |
Moracin D |
Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization ...
|
TN4582 |
Moracin T |
Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, in...
|
TN4583 |
Moringin |
Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of expe...
|
TN4584 |
Morolic acid |
Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent chang...
|
TN4586 |
Mulberrofuran A |
Mulberrofuran A can inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2, but it can increase the formation of 12-hydrox...
|
TN4592 |
Murrangatin |
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hi...
|
TN4635 |
Neoechinulin A |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block t...
|
TN4648 |
Nepetoidin B |
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated...
|
TN4659 |
Nimbin |
Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimb...
|
TN4675 |
Nortrachelogenin |
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth...
|
TN4748 |
Penduletin |
Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Pendul...
|
TN4752 |
Perilloxin |
Perilloxin possesses inhibitory activities against cyclooxygenase-1,with IC(50) values of 23.2 microM. |
TN4783 |
Picralinal |
Picralinal has anti-inflammatory and analgesic effects. |
TN4860 |
Pueroside B |
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-...
|
TN4879 |
Questinol |
Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit t...
|
TN4938 |
Samidin |
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. |
TN5011 |
Shizukaol B |
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinf...
|
TN5019 |
Siegeskaurolic acid |
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages vi...
|
TN5093 |
Taiwanhomoflavone A |
Taiwanhomoflavone A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 col...
|
TN5130 |
Tetrahydroamentoflavone |
Tetrahydroamentoflavone is a potent XO inhibitor, may be considered as a drug candidate or chemopreventive agent; it has anti-inflammatory effects, it shows in ...
|
TN5149 |
Tirotundin |
Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the acti...
|
TN5248 |
Voleneol |
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-depend...
|
TN5264 |
Xanthoxyletin |
Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory...
|
TQ0169 |
Inulicin |
Inulicin, an active compound isolated from Inula Britannica L., inhibits VEGF-mediated activation of Src and FAK. |
TQ0180 |
Chebulagic acid |
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor. |
TQ0288 |
Hexahydrocurcumin |
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1. |