Cart
Immunology / Inflammation COX

COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase. The specific reaction catalyzed is the conversion from arachidonic acid to Prostaglandin H2, via a short-living Prostaglandin G2 intermediate.
Cat No. product name
T4092 AG 126 The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vi...
T4101 SC-560 SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.
T6387 Ampiroxicam Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
T6465 Dexamethasone Sodium Phosphate Dexamethasone, an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid s...
T6540 Ibuprofen Lysine Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.
T6574 Lumiracoxib Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
T6687 Suprofen Suprofen is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
T6737 Zaltoprofen Zaltoprofen is a Cox-1 and Cox-2 inhibitor, which is used for the treatment of arthritis.
T6893 MK-886 MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
T6970 RK-33 RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitiza...
T4313 Tinoridine hydrochloride Tinoridine (Y-3642) is a non-steroidal anti-inflammatory drug. Tinoridine (5-100 μM), produced a concentration-dependent inhibition on the simultaneous increas...
T3S1553 Cinnamic aldehyde 1. Cinnamic aldehyde exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnam...
T4A2456 Gamabufotalin 1. Gamabufotalin , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic sta...
T6S0077 Byakangelicol 1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; ...
T6S1652 Benzoylpaeoniflorin 1. Benzoylpaeoniflorin is active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.
T4503 Talniflumate Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It pos...
T7033 Rosmanol Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activ...
T7081 CCCP CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochon...
T4643 TFAP TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor
T3868 Agnuside Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-gl...
T5032 Iguratimod Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits...
T5010 Propyphenazone (4-Isopropylantipyrine) Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective c...
T5430 8-SHOGAOL 8-Shogaol is a component of ginger and maintains anti-inflammatory activity as a cyclooxygenase-2 inhibitor.
T5460 Mofezolac Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000
T5681 ETHYL CAFFEATE ETHYL CAFFEATE is a Cox-2, iNOS, NOS II, and PGE2 inhibitor,and have antiarthritic effect in collagen-induced arthritis (CIA) mice, its mechanism of action i...
T5759 marmesin Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
T5727 CAFESTOL CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells...
T5758 sphondin Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level o...
T5688 Micheliolide Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
T5807 Stylopine hydrochloride Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
T7113 6-paradol 6-paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including anti-cancer,...
T7207 FK 3311 FK 3311 is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)
T7670 Mavacoxib Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.
T7662 6-methoxy Naphthalene Acetic Acid 6-methoxy Naphthalene Acetic Acid is a competitive inhibitor of COX(Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively)
TQ0288 Hexahydrocurcumin Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
TQ0180 Chebulagic acid Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
TQ0169 Inulicin Inulicin, an active compound isolated from Inula Britannica L., inhibits VEGF-mediated activation of Src and FAK.
T7838 Losartan Carboxaldehyde Losartan Carboxaldehyde is an endothelial cyclooxygenase (COX)-2 inhibitor.
T1402 Fenofibric acid Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
T4S2126 Ginkgetin 1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo again...
T2778 (+)-Catechin Hydrate (+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological s...
T6S0722 Isoorientin 1. Luteolin-6-C-glucoside has antioxidant activity.
T8236 RHC 80267 RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 µM in canine platelets) 
T8356 FPL 62064 FPL 62064 is a potent  dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synth...
TN1019 Beta-mangostin Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity
TN1043 Cyanidin-3-O-rutinoside chloride Cyanidin-3-O-rutinoside chloride has antioxidant activity.
TN1062 Peonidin chloride Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast ...
TN1100 Nepodin Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, w...
TN1273 4',7-Dihydroxyflavone 4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
TN1374 alpha-Chaconine Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. A...
AG 126
T4092CAS 118409-62-4
The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vi...
SC-560
T4101CAS 188817-13-2
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.
Ampiroxicam
T6387CAS 99464-64-9
Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
Dexamethasone Sodium Phosphate
T6465CAS 55203-24-2
Dexamethasone, an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid s...
Ibuprofen Lysine
T6540CAS 57469-77-9
Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.
Lumiracoxib
T6574CAS 220991-20-8
Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
Suprofen
T6687CAS 40828-46-4
Suprofen is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
Zaltoprofen
T6737CAS 74711-43-6
Zaltoprofen is a Cox-1 and Cox-2 inhibitor, which is used for the treatment of arthritis.
MK-886
T6893CAS 118414-82-7
MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
RK-33
T6970CAS 1070773-09-9
RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitiza...
Tinoridine hydrochloride
T4313CAS 25913-34-2
Tinoridine (Y-3642) is a non-steroidal anti-inflammatory drug. Tinoridine (5-100 μM), produced a concentration-dependent inhibition on the simultaneous increas...
Cinnamic aldehyde
T3S1553CAS 14371-10-9
1. Cinnamic aldehyde exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnam...
Gamabufotalin
T4A2456CAS 465-11-2
1. Gamabufotalin , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic sta...
Byakangelicol
T6S0077CAS 26091-79-2
1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; ...
Benzoylpaeoniflorin
T6S1652CAS 38642-49-8
1. Benzoylpaeoniflorin is active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.
Talniflumate
T4503CAS 66898-62-2
Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It pos...
Rosmanol
T7033CAS 80225-53-2
Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activ...
CCCP
T7081CAS 555-60-2
CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochon...
TFAP
T4643CAS 1011244-68-0
TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor
Agnuside
T3868CAS 11027-63-7
Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-gl...
Iguratimod
T5032CAS 123663-49-0
Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits...
Propyphenazone (4-Isopropylantipyrine)
T5010CAS 479-92-5
Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective c...
8-SHOGAOL
T5430CAS 36700-45-5
8-Shogaol is a component of ginger and maintains anti-inflammatory activity as a cyclooxygenase-2 inhibitor.
Mofezolac
T5460CAS 78967-07-4
Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000
ETHYL CAFFEATE
T5681CAS 102-37-4
ETHYL CAFFEATE is a Cox-2, iNOS, NOS II, and PGE2 inhibitor,and have antiarthritic effect in collagen-induced arthritis (CIA) mice, its mechanism of action i...
marmesin
T5759CAS 13849-08-6
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
CAFESTOL
T5727CAS 469-83-0
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells...
sphondin
T5758CAS 483-66-9
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level o...
Micheliolide
T5688CAS 68370-47-8
Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
Stylopine hydrochloride
T5807CAS 96087-21-7
Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
6-paradol
T7113CAS 27113-22-0
6-paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including anti-cancer,...
FK 3311
T7207CAS 116686-15-8
FK 3311 is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)
Mavacoxib
T7670CAS 170569-88-7
Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.
6-methoxy Naphthalene Acetic Acid
T7662CAS 23981-47-7
6-methoxy Naphthalene Acetic Acid is a competitive inhibitor of COX(Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively)
Hexahydrocurcumin
TQ0288CAS 36062-05-2
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
Chebulagic acid
TQ0180CAS 23094-71-5
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
Inulicin
TQ0169CAS 33627-41-7
Inulicin, an active compound isolated from Inula Britannica L., inhibits VEGF-mediated activation of Src and FAK.
Losartan Carboxaldehyde
T7838CAS 114798-36-6
Losartan Carboxaldehyde is an endothelial cyclooxygenase (COX)-2 inhibitor.
Fenofibric acid
T1402CAS 42017-89-0
Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
Ginkgetin
T4S2126CAS 481-46-9
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo again...
(+)-Catechin Hydrate
T2778CAS 225937-10-0
(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological s...
Isoorientin
T6S0722CAS 4261-42-1
1. Luteolin-6-C-glucoside has antioxidant activity.
RHC 80267
T8236CAS 83654-05-1
RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 µM in canine platelets) 
FPL 62064
T8356CAS 103141-09-9
FPL 62064 is a potent  dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synth...
Beta-mangostin
TN1019CAS 20931-37-7
Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity
Cyanidin-3-O-rutinoside chloride
TN1043CAS 18719-76-1
Cyanidin-3-O-rutinoside chloride has antioxidant activity.
Peonidin chloride
TN1062CAS 134-01-0
Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast ...
Nepodin
TN1100CAS 3785-24-8
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, w...
4',7-Dihydroxyflavone
TN1273CAS 2196-14-7
4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
alpha-Chaconine
TN1374CAS 20562-03-2
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. A...