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PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.
Cat. No. Product name CAS No. Purity Chemical Structure
TN2259 Taurocholic acid 81-24-3 98%
Taurocholic acid is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholang...
T12464 PI3Kγ inhibitor 1 1172118-03-4 98%
PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.
TN3806 Dehydroglyasperin C 199331-35-6 98%
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN3218 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one 100667-52-5 98%
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
TN3655 Cimiside E 154822-57-8 98%
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
T12465 PI3Kγ inhibitor 2 1315538-79-4 98%
PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).
T13311 Vps34-IN-2 1523404-29-6 98%
Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).
T12455 PI3K/HDAC-IN-1 2361418-52-0 98%
PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).
TN1033 Sennidin A 641-12-3 98%
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
TN1594 DL-Syringaresinol 1177-14-6 98%
(+)-Syringaresinol shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 microg/ml.
TN3726 Cudraflavone B 19275-49-1 98%
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
TMA0291 Dehydroglyasperin D 517885-72-2 98%
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN1504 Citreorosein 481-73-2 98%
Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both...
T12275 NVP-QAV-572 957209-68-6 98%
NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).
T10660 CAL-130 1431697-74-3 98%
CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
T12456 PI3K-IN-10 2211922-64-2 98%
PI3K-IN-10 is a potent inhibitor of pan-PI3K .
T12457 PI3K-IN-6 1842380-77-1 98%
PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).
TN1367 Alismol 87827-55-2 98%
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for ...
T13973 (Z)-GW 5074 1233748-60-1 98%
(Z)-GW 5074 interacts with both mHTT (mutant huntingtin protein) and LC3.
TN3753 Dalbergioidin 30368-42-4 98%
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
Taurocholic acid
TN2259
Taurocholic acid is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholang...
PI3Kγ inhibitor 1
T12464
PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.
Dehydroglyasperin C
TN3806
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
TN3218
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
Cimiside E
TN3655
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
PI3Kγ inhibitor 2
T12465
PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).
Vps34-IN-2
T13311
Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).
PI3K/HDAC-IN-1
T12455
PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).
Sennidin A
TN1033
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
DL-Syringaresinol
TN1594
(+)-Syringaresinol shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 microg/ml.
Cudraflavone B
TN3726
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
Dehydroglyasperin D
TMA0291
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
Citreorosein
TN1504
Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both...
NVP-QAV-572
T12275
NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).
CAL-130
T10660
CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
PI3K-IN-10
T12456
PI3K-IN-10 is a potent inhibitor of pan-PI3K .
PI3K-IN-6
T12457
PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).
Alismol
TN1367
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for ...
(Z)-GW 5074
T13973
(Z)-GW 5074 interacts with both mHTT (mutant huntingtin protein) and LC3.
Dalbergioidin
TN3753
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
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