11-deoxy-pgf-2a

11-deoxy-PGF2a, a selective activator of TREK-2 channels, stimulates DRG c-fiber nociceptor K2P currents and limits calcium influx.

2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.

2-Deoxy-2-sulfoamino-D-glucose sodium (GlcN-2S) can potentially influence arthritis.

1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a fluoro-modified nucleoside, specifically an Arabino-nucleoside.

2'-Deoxy-2'-fluorouridine serves as an intermediate in the synthesis of antiviral agents targeting influenza viruses[1].

2'-Deoxy-2'-fluoroarabinoadenosine, a nucleoside analogue with significant anti-tumor activity, is utilized in the study of tumor diseases.

2-Aminopurine-9-beta-D-(2’-deoxy)riboside, a derivative of 2-Aminopurine, is a modified nucleoside composed of a purine base linked to a (2’-deoxy)ribose sugar moiety.

2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride is a cytosine nucleoside analog with inhibitory effects on DNA methyltransferase , with potential antimetabolic and antitumor activity.

2’-Deoxy-N4-methylcytidine (N(3)-Methyl-2'-deoxycytidine) is a purine nucleoside analog with potential antitumor activity for the study of apoptosis.

2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis. The anticancer mechanism of 2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine is dependent on the inhibition of DNA synthesis.

5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate is an intermediate in the synthesis of capecitabine.

2'',3''-Di-O-acetyl-5''-deoxy-5-fuluro-D-cytidine is a derivative of capecitabine.

2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepileptic and antihypertensive activity, which can be used to study anticonvulsant and anxiety disorders.

2-Deoxy-D-galactose is a glucose analog and glucose antagonist that inhibits the maintenance of hippocampal LTP and can suppress tumor growth by inhibiting the glycolytic process.

2′-Deoxy-2′-fluoroguanosine is a nucleoside analog that potently inhibits influenza virus A and B strains(EC90 <0.35 μM). 2'-Deoxy-2'-fluoroguanosine is an inhibitor of influenza virus replication in the upper respiratory tract, improving fever and nasal inflammation.

2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml.4,5In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin or paclitaxel .6 1.Kang, H.T., and Hwang, E.S.2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimeticLife Sci.78(12)1392-1399(2006) 2.Aft, R.L., Zhang, F.W., and Gius, D.Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell deathBr. J. Cancer87(7)805-812(2002) 3.Ralser, M., Wamelink, M.M., Struys, E.A., et al.A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growthProc. Natl. Acad. Sci. USA105(46)17807-17811(2008) 4.Liu, H., Savaraj, N., Priebe, W., et al.Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: A strategy for solid tumor therapy (Model C)Biochem. Pharmacol.64(12)1745-1751(2002) 5.Zhang, X.D., Deslandes, E., Villedieu, M., et al.Effect of 2-deoxy-D-glucose on various malignant cell lines in vitroAnticancer Res.26(5A)3561-3566(2006) 6.Maschek, G., Savaraj, N., Priebe, W., et al.2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivoCancer Res.64(1)31-34(2004)

2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.

Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.

Cis-11-Methyl-2-dodecenoic acid functions as a quorum sensing (QS) signal and a diffusion signaling factor (DSF) within extracellular microbial and fungal communication systems. It plays a pivotal role in regulating virulence and biofilm formation among diverse bacterial pathogens [1].

11-deoxy Prostaglandin E1 is a prostaglandin E1 analogue that has bronchodilator activity and can inhibit histamine-induced bronchoconstriction and cause relaxation of tracheal strips in isolated guinea pigs.

Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a useful organic compound for research related to life sciences and the catalog number is T67406.

11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF2α in guinea pigs.

2-deoxy-2-fluoro-D-Glucose (2-FG) is a derivative of glucose with anticancer activity.1It inhibits the growth of 143B osteosarcoma cells grown under normoxic and hypoxic conditions when used at concentrations of 6 and 24 mM.

Nucleoside Derivatives –Fluoro-modified nucleosides, 5-Modified pyrimidine nucleosides, Arabino-nucleosides, 2’-Modified nucleosides

N4-Benzoyl-2’-deoxy-2’-fluoro-b-D-arabinocytidine is a useful organic compound for research related to life sciences and the catalog number is TNU1174.

Nucleoside Derivatives - 6-Modified purine nucleosides; Drugs and Inhibitors; Prodrug of anticancer agent 6-methylpurine; used for gene therapy

Nucleoside Derivatives - Halo-nucleosides, 5’-Modified nucleosides, 2’-Modified nucleosides

Nucleoside Derivatives - 2’-Modified nucleosides, 8-Modified purine nucleosides, Halo-nucleosides, Fluoro-modified nucleosides

3'-Deoxy-2',5'-di-O-acetyl-8-hydroxyguanosine is a Nucleoside Derivative - 8-Modified purine nucleoside; 3'-Deoxy nucleoside.

3',5'-Di-O-acetyl-2'-deoxy-5,N3-dimethyl uridine is a Nucleoside Derivative - N-Alkylated nucleoside.

Nucleoside Derivatives - 8-Aza-7-deaza-purine nucleoside

Nucleoside Derivatives - 6-Modified purine nucleosides; Halo-nucleosides; Fluoro-modified nucleosides

2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits broad antitumor activity specifically targeting indolent lymphoid malignancies through mechanisms that include inhibition of DNA synthesis and induction of apoptosis, among others [1].

Nucleoside Derivatives - Fluoro-modified nucleosides; N-Methylated alkylated nucleosides

6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a pyrimidine nucleoside analog, exhibits a broad spectrum of biochemical and anticancer activities, including inhibition of DNA and RNA synthesis, antiviral effects, and immunomodulatory effects [1].

2-Amino-4-chloro-5-iodo-N2-pivaloyl-7-[2-deoxy-3,5-di-O- (4-methylbenzoyl)-b-D-ribofuanosyl]-7H-pyrrolo[2,3-d]pyrimidine is a Nucleoside Derivative - 7-Deazapurine nucleoside; Halo-nucleoside.

2-Amino-6-chloro-9-(3-deoxy-beta-D-ribofuranosyl)-9H-purine is a nucleoside derivative, specifically a 3'-deoxy nucleoside and halo-nucleoside, serving as a scaffold and template.

Nucleoside Derivatives - Fluoro-modified nucleosides; 2’-Modified nucleosides; 5-Modified pyrimidine nucleosides; Metabolite of FMAU

Nucleoside Derivatives - 7-Deaza-purine nucleosides; 6-De-aminopurine nucleosides

Fluoro-modified nucleoside, halo-nucleoside; arabino-nucleoside

7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide featuring 7-Deazaadenine.

Nucleoside Derivatives - Azido nucleosides, 5-Modified pyrimidine nucleosides, 2’-Modified nucleosides

5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine is a Nucleoside Derivative - 5'-Modified nucleoside; Azido-nucleoside; 2'-Modified nucleoside.

2'-Deoxy-2'-fluoro-4'-thio-b-D-arabinouridine is a Nucleoside Derivative - Thio-nucleoside;Fluoro-modified -nucleoside.

Nucleoside Derivatives - 2’-Modified nucleosides; Amino nucleosides

Fluoro-modified nucleoside; 2/6/8-Modified purine nucleoside; Arabino-nucleoside

9-(2'-O-Acetyl-5'-O-benzoyl-3'-deoxy-beta-D-ribofuranosyl)-6-chloropurine is a Nucleoside Derivative used as a 3'-Deoxy nucleoside, Halo-nucleoside, scaffold, and template.

Isocytidine derivative; fluoro-modified nucleoside