oxide

Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.

4-Methylmorpholine N-oxide is often used as a co-oxidant and sacrificial catalyst in oxidation reactions.

Nickel(II) oxide is the chemical compound with the formula NiO. It is the principal oxide of nickel.

4-Nitroquinoline 1-oxide (4-NQO) is a chemical carcinogen that induces mutations in bacteria, fungi, and animals through the formation of large amounts of purine adducts.

Diphenyl oxide (Oxydibenzene) is used in the manufacture of spices and dyes.

Adenosine N1-oxide (1-Oxoadenosine), which is found in royal jelly, inhibited the secretion of inflammatory mediators by activated macrophages and reduced lethality in lipopolysaccharide (LPS)-induced endotoxin shock.

Olanzapine N-Oxide is a metabolite of Olanzapine which shows antipsychotic activity.

Caryophyllene oxide is isolated from Aegle marmelos, with anti-inflammatory activity.

Rinderine N-oxide, a pyrrolizidine alkaloid, is present in R. graeca [1].

Mirtazapine N-oxide is a metabolite of mirtazapine.1It is formed from mirtazapine by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4 in human liver microsomes.

Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM and 0.3 nM).

Nicotinic acid N-oxide (Nicotinic acid 1-oxide) is a nicotinic acid derivative, used to treat hyperlipoidemia.

Sarracine N-oxide is a natural product of Senecio, Asteraceae. The catalog number is TN4952 and the CAS number is 19038-27-8. Sarracine N-oxide can be used as a reference standard.

Netupitant N-oxide D6 is a Netupitant metabolite, is the deuterium labeled Netupitant N-oxide.

Netupitant N-oxide is a highly selective antagonist of NK1 receptor, is Netupitant metabolite.

2-C-Methylene-myo-inositol oxide (NSC 45109), an inositol derivative, promotes pseudohyphal growth in Saccharomyces species [1].

Palonosetron N-oxide is a metabolite of the serotonin (5-HT) receptor subtype 5-HT3antagonist palonosetron .1It is also a potential impurity in palonosetron preparations.2Palonosetron N-oxide is a degradation product formed by exposure to oxidative stress. 1.Stoltz, R.A., Cyong, J.-C., Shah, A., et al.Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjectsJ. Clin. Pharmacol.44(5)520-531(2004) 2.Vishnu Murthy, M., Srinivas, K., Kumar, R., et al.Development and validation of a stability-indicating LC method for determining palonosetron hydrochloride, its related compounds and degradation products using naphthalethyl stationary phaseJ. Pharm. Biomed. Anal.56(2)429-435(2011)

Acetylseneciphylline N-oxide is a pyrrolizine alkaloid.

1-Methoxycarbonyl-beta-carboline-N-oxide is a natural product for research related to life sciences. The catalog number is TN6652 and the CAS number is 74690-74-7.

Propiverine N-oxide (hydrochloride) is the major metabolite of propiverine in human plasma or urine.

Manoyl oxide is a proposed intermediate in the biosynthesis of forskolin and other medically important labdane-type terpenoids.

Echinatine N-oxide is a natural product for research related to life sciences. The catalog number is TN3915 and the CAS number is 20267-93-0.

Thioacetamide-S-oxide, a metabolite of Thiocetamide, functions as a δ-aminolevulinic acid (ALA) synthetase inhibitor [1].

Abiraterone sulfate N-oxide, a carboxylic acid and major metabolite of Abiraterone, is utilized in prostate cancer research [1] [2].

Canthin-6-one N-oxide has broad spectrum antifungal, leishmanicidal and trypanocidal activities.

Leontalbinine N-oxide is a lupin alkaloid from Sophora flavescen seeds.

Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM and 0.3 nM).

alpha-Pinene oxide is a natural product for research related to life sciences. The catalog number is TN6695 and the CAS number is 1686-14-2.

Venetoclax N-oxide is an impurity of Venetoclax. Venetoclax (ABT-199; GDC-0199), a highly potent, selective, and orally bioavailable inhibitor of Bcl-2, demonstrates a Ki value of less than 0.01 nM [1].

Koumine N-oxide is a natural product from Gelsemium elegans.

Trimetazidine-N-oxide is the major active metabolite of Trimetazidine. Trimetazidine is a selective long-chain inhibitor of 3-ketoyl coenzyme A thiolase (IC50: 75 nM), has anti-oxidant, anti-inflammatory, antinociceptive, and gastroprotective properties.

Heliotrine N-oxide is the pyrrolizidine alkaloid (PA) N-oxide counterpart of Heliotrine. It induces the generation of pyrrolic DNA adducts, potentially initiating PA-induced liver tumors in vivo.

Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD; Kd = 70 nM) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD (IC50 = 25.8 nM). It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 μM). Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 (Ki = 15 μM in human liver microsomes).

Galanthamine N-Oxide, an alkaloid extracted from Zephyranthes concolor bulbs, effectively inhibits acetylcholinesterase (AChE) from electric eel with an EC50 of 26.2 μM. It acts as a significant inhibitor of substrate accommodation within the active sites of Torpedo californica AChE (TcAChE), human AChE (hAChE), and human BChE (hBChE) enzymes.

Laserine oxide is a useful organic compound for research related to life sciences. The catalog number is T124156 and the CAS number is 82433-10-1.

Voriconazole N-oxide is a major metabolite of the triazole antifungal voriconazole . It is formed via oxidation of voriconazole by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C19.

Isotetrandrine N-2'-oxide is a natural product for research related to life sciences. The catalog number is TN4335 and the CAS number is 70191-83-2.

Emtricitabine, a potent nucleoside reverse transcriptase inhibitor, is employed for managing HIV infection. Emtricitabine S-oxide, also known as Emtricitabine sulfoxide, represents a significant degradation byproduct of Emtricitabine.

Levofloxacin N-oxide is an inactive metabolite of the antibiotic levofloxacin . Levofloxacin N-oxide is also a degradation product of levofloxacin that is formed through exposure to daylight or hydrogen peroxide.

Bismuth(III) oxide is a common starting point for bismuth chemistry. It is usually obtained as a by-product of the smelting of copper and lead ores. Bismuth trioxide is commonly used as a replacement of red lead to produce the “Dragon's eggs” effect in fi

9-Angeloylretronecine N-oxide is a natural product for research related to life sciences. The catalog number is TN3312 and the CAS number is 27773-86-0.

3,5-Dimethyl-4-nitropyridine 1-oxide is a useful organic compound for research related to life sciences. The catalog number is T67494 and the CAS number is 14248-66-9.

Phenylarsine Oxide (Oxophenylarsine) is a membrane-permeable tyrosine phosphatase inhibitor with an IC50 value of 18 µM that stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle.

Lasiocarpine N-oxide is a natural compound found to be higher in many tea bags, herbal drugs and honey by mass spectrometry.

Latifoline N-oxide is a useful organic compound for research related to life sciences and the catalog number is T123821.

Vallesamine N-oxide is a natural product for research related to life sciences. The catalog number is TN5219 and the CAS number is 126594-73-8.

Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell (Ac-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys) is a peptide that inhibits the function of NOSs as a result it blocks the production of NO. Because of the invol

Capramidopropylamine oxide is a biochemical.

2-(((6-(Difluoromethoxy)-1H-benzo[d]imidazol-2-yl)sulfonyl)methyl)-3,4-dimethoxypyridine 1-oxide is a useful organic compound for research related to life sciences. The catalog number is T67420 and the CAS number is 953787-55-8.

Trimipramine N-oxide, an active metabolite of the tricyclic antidepressant trimipramine, effectively inhibits human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT), and the human organic cation transporters (hOCT1 and hOCT2), with IC50 values of 11.7, 3.59, 9.4, 9.35, and 27.4 nM, respectively. It is utilized in the research of depression and anxiety [1].