Search Result

Search Results for "erk"

Targets

Libraries

Anti-Pancreatic Cancer Compound Library DGK Inhibitors Library

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Compounds

Cat No.	Product Name
TP1897L1	JIP-1 (153-163) acetate(438567-88-5 free base)		JNK
	Peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Bind...		JNK
T2845	Imperatorin	Ammidin , 8-Isopentenyloxypsoralene , Marmelosin , 8-Isoamylenoxypsoralen , Pentosalen	TRP/TRPV Channel , AChR , AChE , NOD
	Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density...		TRP/TRPV Channel , AChR , AChE , NOD
TMS2181	Trans-Zeatin	(E)-Zeatin	Endogenous Metabolite , ERK , MEK
	Trans-Zeatina is the member of the plant growth hormone family known as cytokinins, which regulate cell division, develo...		Endogenous Metabolite , ERK , MEK
T9428	HM43239		FLT
	HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 int...		FLT
T2171	SEW2871	SEW2871	S1P Receptor , LPL Receptor
	Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.		S1P Receptor , LPL Receptor
T6920	ON123300		c-RET , FGFR , JAK , AMPK , Src , PDGFR , CDK
	ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM...		c-RET , FGFR , JAK , AMPK , Src , PDGFR , CDK
T2940	6-Hydroxyflavone	6-HF	GABA Receptor
	6-Hydroxyflavone is a noncompetitive inhibitors of cytochrome P450 2C9. It is a flavone, a type of chemical compound. It...		GABA Receptor
T3856	Tenuifoliside A		Others , ERK
	Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which i...		Others , ERK
TQ0138	K145 hydrochloride		Apoptosis , S1P Receptor
	K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM.		Apoptosis , S1P Receptor
T5S1058	Triptonide	PG 492 , NSC 165677	Apoptosis , Wnt/beta-catenin , Autophagy
	1. Triptonide is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities....		Apoptosis , Wnt/beta-catenin , Autophagy
T23046	N-tert-butyl-α-Phenylnitrone	(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide	ROS , COX
	COX-2 inhibitor		ROS , COX
T0860L	Mefloquine	Ro215998 , Ro-215998 , Ro 215998 , WR 142490 , Lariam	Others
	Mefloquine is a phospholipid-interacting antimalarial drug effective against Plasmodium Falciparium with very few side e...		Others
T11225	ERK-IN-2		ERK
	ERK-IN-2 is a ERK2 inhibitor with an IC 50 value of 1.8 nM. ERK-IN-2 might cause off-target toxicity and/or off-target a...		ERK
T39726	SHP389
	SHP389 is an allosteric SHP2 inhibitor, with an IC 50 of 36 nM for both SHP2 and p-ERK.
T39159	Edaxeterkib
	Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer.
T61122	ZINC12409120
	ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting FGF23:α-Klotho interaction to inhibit ER...
T17261	Xantocillin		Others
	Xanthocillin is a marine agent. Xanthocillin also induces autophagy through inhibition of the MEK/ERK pathway.		Others
T27654	JG26	JG-26 , JG 26
	JG26 is an ADAM17 inhibitor. JG26 inhibits AngII-induced EGFR transactivation and ERK activation in vascular smooth musc...
T28140	NCG21	NCG 21 , NCG-21
	NCG21 is a GPR120 agonist, which showed potent extracellular signal-regulated kinase (ERK) activation in a cloned GPR120...
T60821	ACA-28
	ACA-28 (compound 2a) is a potent modulator of ERK MAPK signaling that induces apoptosis with ERK hyperactivation therefo...