TP1897L1 |
JIP-1 (153-163) acetate(438567-88-5 free base)
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JNK
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Peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Bind... |
T2845 |
Imperatorin
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Ammidin , 8-Isopentenyloxypsoralene , Marmelosin , 8-Isoamylenoxypsoralen , Pentosalen |
TRP/TRPV Channel
,
AChR
,
AChE
,
NOD
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Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density... |
TMS2181 |
Trans-Zeatin
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(E)-Zeatin |
Endogenous Metabolite
,
ERK
,
MEK
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Trans-Zeatina is the member of the plant growth hormone family known as cytokinins, which regulate cell division, develo... |
T9428 |
HM43239
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FLT
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HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 int... |
T2171 |
SEW2871
|
SEW2871 |
S1P Receptor
,
LPL Receptor
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Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice. |
T6920 |
ON123300
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c-RET
,
FGFR
,
JAK
,
AMPK
,
Src
,
PDGFR
,
CDK
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ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM... |
T2940 |
6-Hydroxyflavone
|
6-HF |
GABA Receptor
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6-Hydroxyflavone is a noncompetitive inhibitors of cytochrome P450 2C9. It is a flavone, a type of chemical compound. It... |
T3856 |
Tenuifoliside A
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Others
,
ERK
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Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which i... |
TQ0138 |
K145 hydrochloride
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Apoptosis
,
S1P Receptor
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K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM. |
T5S1058 |
Triptonide
|
PG 492 , NSC 165677 |
Apoptosis
,
Wnt/beta-catenin
,
Autophagy
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1. Triptonide is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities.... |
T23046 |
N-tert-butyl-α-Phenylnitrone
|
(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide |
ROS
,
COX
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COX-2 inhibitor |
T0860L |
Mefloquine
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Ro215998 , Ro-215998 , Ro 215998 , WR 142490 , Lariam |
Others
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Mefloquine is a phospholipid-interacting antimalarial drug effective against Plasmodium Falciparium with very few side e... |
T11225 |
ERK-IN-2
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ERK
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ERK-IN-2 is a ERK2 inhibitor with an IC 50 value of 1.8 nM. ERK-IN-2 might cause off-target toxicity and/or off-target a... |
T39726 |
SHP389
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|
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SHP389 is an allosteric SHP2 inhibitor, with an IC 50 of 36 nM for both SHP2 and p-ERK. |
T39159 |
Edaxeterkib
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|
|
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Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer. |
T61122 |
ZINC12409120
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ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting FGF23:α-Klotho interaction to inhibit ER... |
T17261 |
Xantocillin
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Others
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Xanthocillin is a marine agent. Xanthocillin also induces autophagy through inhibition of the MEK/ERK pathway. |
T27654 |
JG26
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JG-26 , JG 26 |
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JG26 is an ADAM17 inhibitor. JG26 inhibits AngII-induced EGFR transactivation and ERK activation in vascular smooth musc... |
T28140 |
NCG21
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NCG 21 , NCG-21 |
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NCG21 is a GPR120 agonist, which showed potent extracellular signal-regulated kinase (ERK) activation in a cloned GPR120... |
T60821 |
ACA-28
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ACA-28 (compound 2a) is a potent modulator of ERK MAPK signaling that induces apoptosis with ERK hyperactivation therefo... |