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HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.
Cat. No. Product name CAS No. Purity Chemical Structure
TN4605 Myriceric acid B 55497-79-5 98%
Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scaveng...
T14208 AMD 3465 185991-24-6 98%
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) i...
T0742 Papaverine hydrochloride 61-25-6 98%
Papaverine hydrochloride can used in an effective manner in the management of renal colic pain in patients unresponsive to commonly used conventional agents. Pap...
T6589 MK-2048 869901-69-9 98%
MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.
TN2284 Triptonine B 168009-85-6 98%
Triptonine B demonstrates potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.
T60742 HIV-1 integrase inhibitor 8 1568-80-5 98%
HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor.
T16112 ML67-33 1443290-89-8 98%
ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator ...
TN3567 Calanolide E 142566-61-8 98%
Calanolide E2 has anti-HIV activity.
T16555 PNU-103017 166335-18-8 98%
PNU-103017 is an inhibitor of HIV protease.
TN1708 Gomisin M2 82425-45-4 98%
Gomisin M2 is an anti-HIV agent.
TN3152 6-Acetonyldihydrochelerythrine 22864-92-2 98%
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
TN2186 Schisantherin D 64917-82-4 98%
Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
T10658 CA inhibitor 1 2189684-45-3 98%
CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid.
T16829 (S)-BI-1001 957889-73-5 98%
(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
T5S0983 Absinthin 1362-42-1 98%
1. Absinthiin is a weak HIV-1 protease inhibitor.
TN5177 Trigothysoid N 1501943-08-3 98%
Trigothysoid N may have anti-HIV activity.
T10928 Cytochalasin A 14110-64-6 98%
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), ...
TN2231 Soyasaponin II 55319-36-3 98%
Soyasaponin II has antiviral effects, it can inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1.
T14831 Bryostatin 1 83314-01-6 98%
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain...
TN1194 16beta,17-Dihydroxy-ent-kaurane-19-oic acid 74365-74-5 98%
16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 ...
Myriceric acid B
TN4605
Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scaveng...
AMD 3465
T14208
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) i...
Papaverine hydrochloride
T0742
Papaverine hydrochloride can used in an effective manner in the management of renal colic pain in patients unresponsive to commonly used conventional agents. Pap...
MK-2048
T6589
MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.
Triptonine B
TN2284
Triptonine B demonstrates potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.
HIV-1 integrase inhibitor 8
T60742
HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor.
ML67-33
T16112
ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator ...
Calanolide E
TN3567
Calanolide E2 has anti-HIV activity.
PNU-103017
T16555
PNU-103017 is an inhibitor of HIV protease.
Gomisin M2
TN1708
Gomisin M2 is an anti-HIV agent.
6-Acetonyldihydrochelerythrine
TN3152
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
Schisantherin D
TN2186
Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
CA inhibitor 1
T10658
CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid.
(S)-BI-1001
T16829
(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
Absinthin
T5S0983
1. Absinthiin is a weak HIV-1 protease inhibitor.
Trigothysoid N
TN5177
Trigothysoid N may have anti-HIV activity.
Cytochalasin A
T10928
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), ...
Soyasaponin II
TN2231
Soyasaponin II has antiviral effects, it can inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1.
Bryostatin 1
T14831
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain...
16beta,17-Dihydroxy-ent-kaurane-19-oic acid
TN1194
16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 ...
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