Home Tools
Log in
Cart

HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.
Cat. No. Product name CAS No. Purity Chemical Structure
T5S0983 Absinthin 1362-42-1
1. Absinthiin is a weak HIV-1 protease inhibitor.
TN2186 Schisantherin D 64917-82-4 98%
Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
T14208 AMD 3465 185991-24-6 98%
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) i...
T16829 (S)-BI-1001 957889-73-5 98%
(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
TN4347 Jacoumaric acid 63303-42-4 98%
Jacoumaric acid is a lead molecule from the library or database of natural compounds as a HIV-1 protease inhibitor.
TN3567 Calanolide E 142566-61-8 98%
Calanolide E2 has anti-HIV activity.
TN4433 Licoarylcoumarin 125709-31-1 98%
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE st...
TN5243 Vitexilactone 61263-49-8 98%
Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse trans...
T2S0605 Liquidambaric lactone 185051-75-6 98%
Liquidambaric lactone is a compound isolated from Euonymus grandiflorus Wall.Liquidambaric lactone may have inhibitory HIV-1 reverse transcriptase activity.
TN1767 InteriotherinA 181701-06-4 98%
Interiotherin A inhibits HIV replication with the EC50 value of 3.1 micrograms/mL.
TN1235 3,4,5-Tricaffeoylquinic acid 86632-03-3 98%
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like rece...
TN4820 Pre-schisanartanin B 1033288-92-4 98%
Pre-schisanartanin B has cytotoxicity, it also has anti-HIV-1 activity.
TN5011 Shizukaol B 142279-40-1 98%
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
T10658 CA inhibitor 1 2189684-45-3 98%
CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid.
T14488 Azt-pmap 142629-81-0 98%
Azt-pmap shows anti-HIV activity[1]. Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. AZT is a nucleoside reverse transcriptase inhibitor...
TN3705 Coronalolide methyl ester 268214-50-2 98%
Coronalolide methyl ester displays significant anti-HIV activities in the HIV-1RT assay. It and coronalolide show broad cytotoxic activity against a panel of hum...
TN4555 Methyl salvionolate A 1015171-69-3 98%
Methyl salvionolate A has anti-HIV-1 activity.
TN4109 Ganolucidic acid A 98665-21-5 98%
Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficien...
TN4646 Neotripterifordin 149249-32-1 98%
Neotripterifordin shows potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.
TN4585 Moronic acid 6713-27-5 98%
Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186)...
Absinthin
T5S0983
1. Absinthiin is a weak HIV-1 protease inhibitor.
Schisantherin D
TN2186
Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
AMD 3465
T14208
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) i...
(S)-BI-1001
T16829
(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
Jacoumaric acid
TN4347
Jacoumaric acid is a lead molecule from the library or database of natural compounds as a HIV-1 protease inhibitor.
Calanolide E
TN3567
Calanolide E2 has anti-HIV activity.
Licoarylcoumarin
TN4433
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE st...
Vitexilactone
TN5243
Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse trans...
Liquidambaric lactone
T2S0605
Liquidambaric lactone is a compound isolated from Euonymus grandiflorus Wall.Liquidambaric lactone may have inhibitory HIV-1 reverse transcriptase activity.
InteriotherinA
TN1767
Interiotherin A inhibits HIV replication with the EC50 value of 3.1 micrograms/mL.
3,4,5-Tricaffeoylquinic acid
TN1235
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like rece...
Pre-schisanartanin B
TN4820
Pre-schisanartanin B has cytotoxicity, it also has anti-HIV-1 activity.
Shizukaol B
TN5011
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
CA inhibitor 1
T10658
CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid.
Azt-pmap
T14488
Azt-pmap shows anti-HIV activity[1]. Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. AZT is a nucleoside reverse transcriptase inhibitor...
Coronalolide methyl ester
TN3705
Coronalolide methyl ester displays significant anti-HIV activities in the HIV-1RT assay. It and coronalolide show broad cytotoxic activity against a panel of hum...
Methyl salvionolate A
TN4555
Methyl salvionolate A has anti-HIV-1 activity.
Ganolucidic acid A
TN4109
Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficien...
Neotripterifordin
TN4646
Neotripterifordin shows potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.
Moronic acid
TN4585
Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186)...
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16