HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
TN4605	Myriceric acid B	55497-79-5	98%
TN4605	Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scaveng...
T14208	AMD 3465	185991-24-6	98%
T14208	AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) i...
T0742	Papaverine hydrochloride	61-25-6	98%
T0742	Papaverine hydrochloride can used in an effective manner in the management of renal colic pain in patients unresponsive to commonly used conventional agents. Pap...
T6589	MK-2048	869901-69-9	98%
T6589	MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.
TN2284	Triptonine B	168009-85-6	98%
TN2284	Triptonine B demonstrates potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.
T60742	HIV-1 integrase inhibitor 8	1568-80-5	98%
T60742	HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor.
T16112	ML67-33	1443290-89-8	98%
T16112	ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator ...
TN3567	Calanolide E	142566-61-8	98%
TN3567	Calanolide E2 has anti-HIV activity.
T16555	PNU-103017	166335-18-8	98%
T16555	PNU-103017 is an inhibitor of HIV protease.
TN1708	Gomisin M2	82425-45-4	98%
TN1708	Gomisin M2 is an anti-HIV agent.
TN3152	6-Acetonyldihydrochelerythrine	22864-92-2	98%
TN3152	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
TN2186	Schisantherin D	64917-82-4	98%
TN2186	Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
T10658	CA inhibitor 1	2189684-45-3	98%
T10658	CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid.
T16829	(S)-BI-1001	957889-73-5	98%
T16829	(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
T5S0983	Absinthin	1362-42-1	98%
T5S0983	1. Absinthiin is a weak HIV-1 protease inhibitor.
TN5177	Trigothysoid N	1501943-08-3	98%
TN5177	Trigothysoid N may have anti-HIV activity.
T10928	Cytochalasin A	14110-64-6	98%
T10928	Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), ...
TN2231	Soyasaponin II	55319-36-3	98%
TN2231	Soyasaponin II has antiviral effects, it can inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1.
T14831	Bryostatin 1	83314-01-6	98%
T14831	Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain...
TN1194	16beta,17-Dihydroxy-ent-kaurane-19-oic acid	74365-74-5	98%
TN1194	16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 ...