HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T5S0983	Absinthin	1362-42-1
T5S0983	1. Absinthiin is a weak HIV-1 protease inhibitor.
TN2186	Schisantherin D	64917-82-4	98%
TN2186	Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
T14208	AMD 3465	185991-24-6	98%
T14208	AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) i...
T16829	(S)-BI-1001	957889-73-5	98%
T16829	(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
TN4347	Jacoumaric acid	63303-42-4	98%
TN4347	Jacoumaric acid is a lead molecule from the library or database of natural compounds as a HIV-1 protease inhibitor.
TN3567	Calanolide E	142566-61-8	98%
TN3567	Calanolide E2 has anti-HIV activity.
TN4433	Licoarylcoumarin	125709-31-1	98%
TN4433	Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE st...
TN5243	Vitexilactone	61263-49-8	98%
TN5243	Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse trans...
T2S0605	Liquidambaric lactone	185051-75-6	98%
T2S0605	Liquidambaric lactone is a compound isolated from Euonymus grandiflorus Wall.Liquidambaric lactone may have inhibitory HIV-1 reverse transcriptase activity.
TN1767	InteriotherinA	181701-06-4	98%
TN1767	Interiotherin A inhibits HIV replication with the EC50 value of 3.1 micrograms/mL.
TN1235	3,4,5-Tricaffeoylquinic acid	86632-03-3	98%
TN1235	3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like rece...
TN4820	Pre-schisanartanin B	1033288-92-4	98%
TN4820	Pre-schisanartanin B has cytotoxicity, it also has anti-HIV-1 activity.
TN5011	Shizukaol B	142279-40-1	98%
TN5011	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
T10658	CA inhibitor 1	2189684-45-3	98%
T10658	CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid.
T14488	Azt-pmap	142629-81-0	98%
T14488	Azt-pmap shows anti-HIV activity[1]. Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. AZT is a nucleoside reverse transcriptase inhibitor...
TN3705	Coronalolide methyl ester	268214-50-2	98%
TN3705	Coronalolide methyl ester displays significant anti-HIV activities in the HIV-1RT assay. It and coronalolide show broad cytotoxic activity against a panel of hum...
TN4555	Methyl salvionolate A	1015171-69-3	98%
TN4555	Methyl salvionolate A has anti-HIV-1 activity.
TN4109	Ganolucidic acid A	98665-21-5	98%
TN4109	Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficien...
TN4646	Neotripterifordin	149249-32-1	98%
TN4646	Neotripterifordin shows potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.
TN4585	Moronic acid	6713-27-5	98%
TN4585	Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186)...