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Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR (IC50: 1.3 nM).

Pembrolizumab (MK-3475) is a humanized monoclonal antibody inhibiting the PD-1 receptor and the first in the class of agents called the HER2 dimerization inhibitors that impairs the ability of HER2 to bind to other members of the HER family.

Desformylflustrabromine hydrochloride (dFBr hydrochloride) is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.

Terbufibrol reduces the levels of serum total cholesterol in normal and hypercholesterolemic male rats.

Lifibrol (U-83860) is an inhibitor of cholesterol synthesis.Lifibrol has anticholesterol and hypolipidemic properties and promotes the conversion of LDL Apo B-100 in patients with hypercholesterolemia and mixed hyperlipidemia.

Immethridine dihydrobromide is a novel, highly potent and selective histamine H3 receptor (H3R) agonist that inhibits dendritic cell function and alleviates experimental autoimmune encephalomyelitis.Immethridine dihydrobromide MesV induces depolarization of neurons and the MMN and prevents cardiorenal and renal injury. injury.

16α-Bromoepiandrosterone (BEA) is a water-soluble synthetic sterol related to DHEA and is used in studies of type II diabetes and non-diabetic tuberculosis infections.

Cerebrocrast (IOS-11212) is an anti-inflammatory and hypoglycemic activity that promotes H+ and Cl- cotransport in rat liver mitochondria, blocks human platelet activation, and can be used to study diabetes.

8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimulated insulin release.

Pamabrom is a diuretic, used for the relief of temporary water weight gain, bloating, swelling and full feeling associated with the premenstrual and menstrual periods.

Trimethyloctadecylammonium bromide is an inhibitor of Dynamin I (IC50: 1.9 μM) and also inhibits Dynamin II.

Theobromine (3,7-Dimethylxanthine), a xanthine alkaloid, is used as a bronchodilator and as a vasodilator.

Prifinium bromide is a quaternary ammon antimuscarinic. It inhibits hyperkinesia of the digestive organs and urinary tract and has a spasmolytic action.

3-Bromo-4-Methoxyphenylacetonitrile (ZINC2565991) is a marine derived natural products found in Aiolochroia crassa.

2,7-Dibromo-9H-Carbazole (2,7-Dibromocarbazole) is a marine derived natural products found in Kyrtuthrix maculans.

6-Bromovanillin is a biochemical reagent utilized in the synthesis of caridopa, an aromatic amino acid decarboxylase inhibitor.

Vortioxetine hydrobromide (Lu AA21004 hydrobromide) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A 1B 3A 7 receptor and SERT (IC50: 15 33 3.7 19 1.6 nM).

Hexamethonium Bromide (Hexamethonium Dibromide), a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier.

Tetradecyltrimethylammonium bromide (MitMAB) is a Dynamin GTPase activity inhibitor and a cationic surfactant with asymmetrical structure.

5-Bromouracil disrupts nucleosome positioning by inducing A-form-like DNA.

Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).

Methyl 4-bromopyrrole-2-carboxylate (4-Bromo-2-(methoxycarbonyl)-1H-pyrrole) is a marine derived natural products found in Lissodendoryx sp.

5-Bromo-5-nitro-1,3-dioxane (Bronidox) is an antimicrobial compound that inhibits bacterial enzyme activity.

Decamethonium bromide (Syncurine) is a neuromuscular blocker and nicotinic AChR partial agonist.

2,4,6-Tribromophenyl caproate is a potent antifungal agent.

Tert-Butyl5-bromo-1H-indole-1-carboxylate (N-Boc-5-bromoindole) is an indole derivative with therapeutic potential for pain, inflammation, and other conditions.

2-Bromo-6-methoxynaphthalene was used in the synthesis of nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone] by Heck reaction.

3-Bromo-7-nitroindazole is a specific neuronal nitric oxide synthase (nNOS) inhibitor that affects the synthesis of the intercellular messenger NO throughout the brain and body.

5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione (5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) is a synthetic compound. It has been used as a catalyst and as a tool in enzyme kinetic studies; it has also been used in studies of enzyme inhibition, as well as in drug receptor interaction studies.

Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.

Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting, mono-quaternary steroid that functions as a non-depolarizing neuromuscular blocking agent with muscle relaxant properties.

Eletriptan hydrobromide (Eletriptan HBr) is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B 1D [5-HT1B 1D] receptor.

Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromide salt form of propantheline, a quaternary ammonium compound structurally related to belladonna alkaloids. An aspartic acid residue present in the N-terminal portion of the third transmembrane helix of the muscarinic receptor is believed to form an ionic bond with the tertiary or quaternary nitrogen of the antagonist. Antagonism leads to a reduction of exocrine glands secretions and to relax the bronchial muscle and reduce tone and motility of intestinal smooth muscle.

Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.

Methylbenactyzium Bromide (Semulgin) is an anticonvulsant that is the active metabolite of trimethadione.

2-Bromohexadecanoic acid (2-BP) is a non-metabolizable palmitate analog, an agonist of PPARδ, which acts as a palmitoylation inhibitor and inhibits DHHC-mediated palmitoylation.

bis(p-methoxyphenyl)iodonium bromide (Di(p-anisyl)iodonium Bromide) is a bromide salt consisting of two p-methoxyphenyl iodonium molecules linked together by a bromide ion. It has been used as a reagent in the synthesis of polymers, in the preparation of nanoparticles and in the synthesis of organic dyes. It has also been used to study the structure and reactivity of organic molecules and to study the structure and reactivity of inorganic molecules.

Tetraethylammonium bromide (TEA bromide) can selectively block potassium channels.

Bromhexine Impurity B reagent used in the preparation of Ambroxol and Bromhexine (B678600) metabolites Ambroxol EP Impurity E.

Teneligliptin hydrobromide (MP-513 (hydrobromide)) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

1-Bromo-6-chlorohexane (Hexane, 1-bromo-6-chloro-) is used as PROTAC linker.

3,5-Dibromo-4-methoxybenzoic acid was isolated from the Malagasy sponge Amphimedon sp.

2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2].

Pyridostigmine bromide (Mestinon) is a cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants.

2,6-Dibromophenol (2,6-Dibromo-phenol) is extracted from the skin and muscle of flatfish.

Ipratropium Bromide (Sch 1000) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema.

Bromothymol Blue, a pH indicator, appears yellow in acidic conditions and blue in alkaline environments.

Citalopram hydrobromide (XU-62-320) , a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system (CNS). Citalopram hydrobromide is the orally bioavailable hydrobromide salt of the racemic bicyclic phthalene derivative citalopram with antidepressant activity. This agent has minimal effects on the CNS neuronal reuptake of norepinephrine (NE) and dopamine (DA).