T38737L |
SDKPDMAEIEKFDKSK acetate
|
SDKPDMAEIEKFDKSK acetate(1339864-27-5 free base) |
Others
|
|
SDKPDMAEIEKFDKSK acetate is a thymosin β4 derivative. Thymosin β4 inhibits PDGF-BB-induced fibrogenesis, proliferation a... |
T9156 |
CDC25B-IN-2
|
|
Phosphatase
,
mTOR
|
|
BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer prog... |
T33296 |
Merodantoin
|
|
Apoptosis
|
|
Merodantoin is an apoptosis inducer and triggers cell apoptosis associated with ROS-dependent autophagy. Merodantoin tar... |
T28072 |
MLN-3897
|
AVE-9897 , CCR1 antagonist 10 |
CCR
|
|
MLN-3897 is an orally active antagonist of CCR1 with a Ki of 2.3 nM for 125I-MIP-1α binding to THP-1 cell membranes. MLN... |
T4444 |
A-674563 HCl (552325-73-2(free base))
|
|
ERK
,
Akt
,
PKA
,
PKC
,
CDK
|
|
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits ... |
T9996 |
NCT-58
|
NCT58 |
HSP
|
|
NCT-58 is a potent C-terminal HSP90 inhibitor. NCT-58 does not induce the heat shock response (HSR). NCT-58 elicits ant... |
T35528L |
TD52 dihydrochloride
|
TD52 dihydrochloride(1798328-24-1 Free base) , TD52 2HCl |
Others
|
|
TD52 dihydrochloride, an Erlotinib derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A... |
T2171 |
SEW2871
|
SEW2871 |
S1P Receptor
,
LPL Receptor
|
|
Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice. |
T6429 |
Caffeic Acid Phenethyl Ester
|
CAPE , Phenylethyl Caffeate |
NF-κB
,
Apoptosis
|
|
Caffeic Acid Phenethyl Ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress ... |
T6920 |
ON123300
|
|
c-RET
,
FGFR
,
JAK
,
AMPK
,
Src
,
PDGFR
,
CDK
|
|
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM... |
T4S1419 |
(±)-Praeruptorin A
|
Praeruptorin A , (-)-Praeruptorin A |
Calcium Channel
,
p38 MAPK
,
Akt
|
|
1. Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ... |
T3800 |
Typhaneoside
|
Aervitrin |
Others
,
Autophagy
|
|
Typhaneoside is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Sha... |
T2940 |
6-Hydroxyflavone
|
6-HF |
GABA Receptor
|
|
6-Hydroxyflavone is a noncompetitive inhibitors of cytochrome P450 2C9. It is a flavone, a type of chemical compound. It... |
TL0006 |
Cichoric Acid
|
Chicoric Acid , Dicaffeoyltartaric acid |
Reactive Oxygen Species
,
HIV Protease
|
|
Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tiss... |
T2746 |
Sophocarpine monohydrate
|
Sophocarpine |
Apoptosis
,
Influenza Virus
,
Akt
,
PI3K
,
Autophagy
,
AMPK
|
|
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. |
TQ0138 |
K145 hydrochloride
|
|
Apoptosis
,
S1P Receptor
|
|
K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM. |
T9831 |
MKC-1
|
inhibit , mTOR , Apoptosis , Protein kinase B , PKB , MKC 1 , renal cell cancer , Caki-1 , Ro-31-7453 , Mammalian target of Rapamycin , orally active , Microtubule/Tubulin , MKC-1 , Akt , pancreatic cancer , Inhibitor , MKC1 |
Akt
,
Microtubule Associated
,
Apoptosis
,
mTOR
|
|
MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic ... |
T5429 |
Theaflavin 3,3'-digallate
|
8-Gingerol , TFDG |
HIV Protease
,
Virus Protease
,
Antioxidant
,
HSV
|
|
8-Gingerol (TFDG), a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory ... |
T61680 |
AKT-IN-5
|
|
|
|
AKT-IN-5 (Example 8) is a Akt inhibitor with IC 50 values of 450 nM and 400 nM for Akt1 and Akt2, respectively [1]. |
T61756 |
APN/AKT-IN-1
|
|
|
|
APN/AKT-IN-1 is a potent and dual inhibitor of APN and AKT with IC 50 s of 0.21 and 0.27 μM, respectively. APN/AKT-IN-1 ... |