Home Tools
Log in
Cart

DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Cat No. product name
T36757 DMT-dU-CE Phosphoramidite DMT-dU-CE Phosphoramidite 是一个核苷分子,通常用于合成 DNA 和 DNA 测序试验。
T36756 DMT-dG(ib) Phosphoramidite DMT-dG(ib) Phosphoramidite 可用于 DNA 的合成。
T20038 2-Fluoroadenine 2-Fluoroadenine 对非增殖性和增殖性肿瘤细胞具有毒性。2-Fluoroadenine 可用于抗癌症的相关研究。
T13231L Trovafloxacin mesylate Trovafloxacin mesylate 是一种有效的特异性 pannexin 1 通道抑制剂 (PANX1, IC50 = 4 μM)。Trovafloxacin mesylate 对革兰氏阳性、革兰氏阴性和厌氧菌具有强效活性。 Trovafloxacin mesylate 阻断 DNA 促旋酶和拓扑异构酶 IV ...
T2037 TH588 TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.
T0125 Epirubicin hydrochloride Epirubicin hydrochloride is an antineoplastic agent which can inhibit Topoisomerase.
T0802 Procaine hydrochloride Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds ...
T3340 SCR7 SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).
T40192 DGTP dGTP is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
T3524 Halofuginone hydrobromide Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of...
T1617 Enrofloxacin Enrofloxacin is a veterinary antibacterial agent, used in poultry.
T1178 Temozolomide Temozolomide is a DNA alkylating agent interfering with DNA replication.
T1454 Acyclovir Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster...
T2516 Amuvatinib Amuvatinib is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.
T3772 Maslinic acid Maslinic acid is a DNA polymerase B inhibitor.
T4517 L189 L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
T26396 6-Hydroxy-DOPA 6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.
TN1244 3'-Demethylnobiletin 3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...
T19836 2-Aminopurine 2-Aminopurine is a double-stranded RNA-dependent protein kinase, protein kinase R (PKR) inhibitor.
T3279 Silver sulfadiazine Silver Sulfadiazine is a sulfonamide-based topical agent with antibacterial and antifungal activity.
T7766 Remdesivir Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)
T6856 Halofuginone Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mamm...
T13791 2-(Methylamino)-1H-purin-6(7H)-one 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids, is a modified nucleoside.
T3376 Cynaroside Cynaroside is a flavone, a flavonoid-like chemical compound. It has an anti-oxidant effect, inhibiting lipid and protein oxidation.
T6758 Anisomycin Anisomycin is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80...
T0251 Gemcitabine Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
T0684 Ribavirin Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T5363 Tempo TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin reson...
T1501 Rifabutin Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tra...
T7174 Urolithin A Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T7865 Danofloxacin Danofloxacin is a fluoroquinolone antibiotic used in veterinary medicine.
T21498 Phleomycin Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage. It is similar to Bleomycin (HY-17565A) which binds and intercalates DNA to...
T2069 TH287 TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
T1485 Methotrexate Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties.
T0681 Rifampicin Rifampicin is an antibacterial drug of the class of rifamycin.
T11020 DHODH-IN-11 DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
T1120 Dacarbazine Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.
T1428 Trifluridine Trifluridine is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, r...
TN1660 Ganoderic acid C1 Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
T1598 Rimantadine hydrochloride Rimantadine hydrochloride is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.
T1086 Vitamin D2 Ergocalciferol (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder ...
T8841 IMT1 Anticancer.
T0148 Folinic acid calcium Leucovorin calcium is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
T7539 O6-Benzylguanine O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
T4187 Gemcitabine monophosphate sodium salt hydrate Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
T1465 Mupirocin Mupirocin is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.
T0717L Enoxacin Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
T4010 Juglone Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl...
T1703 SN-38 SN-38 is an active metabolite of CPT-11.
T2601 Vidofludimus Vidofludimus (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
DMT-dU-CE Phosphoramidite
T36757
DMT-dU-CE Phosphoramidite 是一个核苷分子,通常用于合成 DNA 和 DNA 测序试验。
DMT-dG(ib) Phosphoramidite
T36756
DMT-dG(ib) Phosphoramidite 可用于 DNA 的合成。
2-Fluoroadenine
T20038
2-Fluoroadenine 对非增殖性和增殖性肿瘤细胞具有毒性。2-Fluoroadenine 可用于抗癌症的相关研究。
Trovafloxacin mesylate
T13231L
Trovafloxacin mesylate 是一种有效的特异性 pannexin 1 通道抑制剂 (PANX1, IC50 = 4 μM)。Trovafloxacin mesylate 对革兰氏阳性、革兰氏阴性...
TH588
T2037
TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.
Epirubicin hydrochloride
T0125
Epirubicin hydrochloride is an antineoplastic agent which can inhibit Topoisomerase.
Procaine hydrochloride
T0802
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds ...
SCR7
T3340
SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).
dGTP
T40192
dGTP is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
Halofuginone hydrobromide
T3524
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of...
Enrofloxacin
T1617
Enrofloxacin is a veterinary antibacterial agent, used in poultry.
Temozolomide
T1178
Temozolomide is a DNA alkylating agent interfering with DNA replication.
Acyclovir
T1454
Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster...
Amuvatinib
T2516
Amuvatinib is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.
Maslinic acid
T3772
Maslinic acid is a DNA polymerase B inhibitor.
L189
T4517
L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
6-Hydroxy-DOPA
T26396
6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.
3'-Demethylnobiletin
TN1244
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...
2-Aminopurine
T19836
2-Aminopurine is a double-stranded RNA-dependent protein kinase, protein kinase R (PKR) inhibitor.
Silver sulfadiazine
T3279
Silver Sulfadiazine is a sulfonamide-based topical agent with antibacterial and antifungal activity.
Remdesivir
T7766
Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)
Halofuginone
T6856
Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the...
2-(Methylamino)-1H-purin-6(7H)-one
T13791
2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids, is a modified nucleoside.
Cynaroside
T3376
Cynaroside is a flavone, a flavonoid-like chemical compound. It has an anti-oxidant effect, inhibiting lipid and protein oxidation.
Anisomycin
T6758
Anisomycin is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80...
Gemcitabine
T0251
Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
Ribavirin
T0684
Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
Tempo
T5363
TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin reson...
Rifabutin
T1501
Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tra...
Urolithin A
T7174
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
Danofloxacin
T7865
Danofloxacin is a fluoroquinolone antibiotic used in veterinary medicine.
Phleomycin
T21498
Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage. It is similar to Bleomycin (HY-17565A) which binds and intercalates DNA to...
TH287
T2069
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
Methotrexate
T1485
Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties.
Rifampicin
T0681
Rifampicin is an antibacterial drug of the class of rifamycin.
DHODH-IN-11
T11020
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
Dacarbazine
T1120
Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.
Trifluridine
T1428
Trifluridine is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, r...
Ganoderic acid C1
TN1660
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ...
Rimantadine hydrochloride
T1598
Rimantadine hydrochloride is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.
Vitamin D2
T1086
Ergocalciferol (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder ...
IMT1
T8841
Anticancer.
Folinic acid calcium
T0148
Leucovorin calcium is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
O6-Benzylguanine
T7539
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
Gemcitabine monophosphate sodium salt hydrate
T4187
Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
Mupirocin
T1465
Mupirocin is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.
Enoxacin
T0717L
Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
Juglone
T4010
Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl...
SN-38
T1703
SN-38 is an active metabolite of CPT-11.
Vidofludimus
T2601
Vidofludimus (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
1 2 3 4 5 6