T6574 |
Lumiracoxib
|
COX-189 , Prexige |
COX
|
|
Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity... |
T11005 |
Desmethyl Celecoxib
|
|
COX
|
|
Demethyl celecoxib is a selective inhibitor of COX-2 with anti-inflammatory activity (IC50 of 32 nM). with anti-inflamma... |
T1555 |
Diclofenac sodium
|
GP 45840 |
Apoptosis
,
COX
|
|
Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is prima... |
T2403 |
Bromfenac sodium hydrate
|
Bromfenac monosodium salt sesquihydrate , Bromfenac sodium |
COX
|
|
Bromfenac Sodium is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and ... |
T22092 |
Indomethacin heptyl ester
|
|
COX
|
|
Indomethacin heptyl ester is a non-selective inhibitor of both COX-1 and COX-2 |
T0867 |
Bufexamac
|
Bufexamic acid |
COX
,
HDAC
|
|
Bufexamac is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action. |
T6S1543 |
Dehydrodiisoeugenol
|
|
Others
,
NF-κB
,
COX
,
Antibacterial
|
|
1. Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in... |
T10619 |
Bromelain
|
|
Others
,
Apoptosis
|
|
Bromelain is an anti-inflammatory drug derived from pineapple stem. It acts through down-regulation of plasma kininogen,... |
T7030 |
Anemarsaponin B
|
|
p38 MAPK
,
NF-κB
,
MEK
,
COX
,
NO Synthase
|
|
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhi... |
T0065 |
Acetaminophen
|
4'-Hydroxyacetanilide , Paracetamol , 4-Acetamidophenol , APAP |
COX
,
Histone Acetyltransferase
,
Endogenous Metabolite
|
|
Analgesic antipyretic derivative of acetanilide. Acetaminophen has weak anti-inflammatory properties and is used as a co... |
TL0004 |
FERULIC ACID METHYL ESTER
|
Methyl ferulate , Methyl 4'-hydroxy-3'-methoxycinnamate |
p38 MAPK
,
Autophagy
|
|
Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis)... |
T23046 |
N-tert-butyl-α-Phenylnitrone
|
(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide |
ROS
,
COX
|
|
COX-2 inhibitor |
T61714 |
COX-2-IN-13
|
|
|
|
COX-2-IN-13 (compound 13e) is a potent and selective inhibitor of COX-2 with an IC 50 of 0.98 μM. COX-2-IN-13 is an anti... |
T61264 |
COX-2-IN-19
|
|
|
|
COX-2-IN-19 (Compound 24) is a potent COX-2 inhibitor with an IC 50 of 1.76 μM. COX-2-IN-19 shows in vivo anti-inflammat... |
T62061 |
COX-2-IN-6
|
|
|
|
COX-2-IN-6 is a gut-restricted selective cyclooxygenase-2 (COX-2) inhibitor. |
T61821 |
COX-2-IN-16
|
|
|
|
COX-2-IN-16 (compound 2b) is a potent, selective and orally active COX-2 inhibitor with an IC 50 of 102 μM. COX-2-IN-16 ... |
T60978 |
COX-2-IN-7
|
|
|
|
COX-2-IN-7 (compound 4a) is a potent, selective, and orally active COX-2 inhibitor which is higher selectivity than Cele... |
T60992 |
COX-1/2-IN-3
|
|
|
|
COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low ... |
T60630 |
COX/5-LOX-IN-1
|
|
|
|
COX/5-LOX-IN-1 (compound 6b) is a potent COX/5-LOX dual inhibitor with the potential for inflammation diseases research.... |
T60769 |
COX-2/PI3K-IN-2
|
|
|
|
COX-2/PI3K-IN-2 (compound 5f) has properties of anti-inflammatory and anti-cancer. COX-2/PI3K-IN-2 is a selective inhibi... |