Search Result

Search Results for " cox "

Targets

COX COX

347

Compounds

137

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T10033	COX-2-IN-1		COX
	COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).		COX
T10032	COX-2-IN-2		COX
	COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic acti...		COX
T77618	COX-2-IN-34		COX
	COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.		COX
T62061	COX-2-IN-6		COX , Prostaglandin Receptor
	COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is u...		COX , Prostaglandin Receptor
T6574	Lumiracoxib	Prexige,COX-189	COX
	Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.		COX
T7207	FK 3311	FK-3311,COX-2 Inhibitor V	COX
	FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)		COX
T13263	COX/5-LO-IN-1	Atreleuton analog	COX
	COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.		COX
T79760	COX-2-IN-35		COX
	COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory concentration (IC 50) of 4.37 nM [1].		COX
T62175	COX-2-IN-8
	COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.
T61264	COX-2-IN-19
	COX-2-IN-19 (Compound 24) is a highly potent inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 1.76 μM. Notably, COX-2-IN-19 exhibits robust in vivo anti-inflammatory activity [1].
T61714	COX-2-IN-13
	COX-2-IN-13 (compound 13e) is a highly potent and selective inhibitor of COX-2, demonstrating a remarkable IC50 value of 0.98 μM. It exhibits strong anti-inflammatory activity and has shown favorable results in vivo acut...
T62350	XO/COX/LOX-IN-1
	XO/COX/LOX-IN-1 is a potent inhibitor of xanthine oxidase/cyclooxygenase/lipoxygenase XO/COX/LOX. XO/COX/LOX-IN-1 can be used in the study of inflammatory, cancer and metabolic diseases.
T79594	COX-1/2-IN-5		COX
	COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, and exhibits anticancer activity by inhibiting liver cancer HepG2...		COX
T78706	COX-2-IN-31		COX
	COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). Additionally, it inhibits the activity of transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM). This...		COX
T78705	COX-2-IN-30		COX
	COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 10.4 μM), as well as 5-lipoxygenase (5-LOX; IC50 = 2.4 μM). ...		COX
T63480	COX-2-IN-26
	COX-2-IN-26 is a potent, orally active, selective COX-2 inhibitor that acts on COX-1 (IC50: 10.61 μM), COX-2 (IC50: 0.067 μM), and 15-LOX (IC50: 1.96 μM).COX-2-IN-26 is anti-inflammatory and has a gastrointestinal safety...
T63348	COX-2-IN-23
	COX-2-IN-23 is a selective inhibitor of COX-2, with IC50 values of 0.28 and 20.14 μM for COX-2 and COX-1, respectively.COX-2-IN-23 exhibits anti-inflammatory effects as well as low ulcerogenic effects.
T61711	COX-2-IN-14
	COX-2-IN-14 (compound 2a) is a highly potent and selective inhibitor of COX-2 (cyclooxygenase-2), with strong binding affinity at the active site of COX-2 co-crystal. Demonstrating remarkable in vivo anti-inflammatory ac...
T60978	COX-2-IN-7
	COX-2-IN-7 (compound 4a) is a potent, selective, and orally active COX-2 inhibitor which is higher selectivity than Celecoxib with an IC 50 value of 6.585 uM. COX-2-IN-7 has good anti-inflammatory and low ulcerogenic act...
T61821	COX-2-IN-16
	COX-2-IN-16 (compound 2b) is a potent, selective, and orally active inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 102 μM. It effectively reduces nitric oxide (NO) production and demonstrates anti-inflammato...
T78754	COX-2-IN-33		COX
	COX-2-IN-33 (compound 5f) is a selective COX-2 inhibitor with an IC50 value of 45.5 nM and exhibits potential as an anti-inflammatory agent. It effectively suppresses pro-inflammatory cytokine production in vivo while ma...		COX
T64109	COX-2-IN-28
	COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM).
T63943	COX-2-IN-10
	COX-2-IN-10 is a potent inhibitor of COX-2. COX-2-IN-10 exhibits inhibitory effects on the production of IL-6, TNF-α and IL-1β. COX-2-IN-10 inhibits PGE2 production in a concentration-dependent manner with an IC50 value ...
T60457	COX-2-IN-11
	COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1].
T63646	COX-2-IN-9
	COX-2-IN-9 is a selective, potent, orally active COX-2 inhibitor (IC50: 10.17 μM).COX-2-IN-9 has a higher COX-2 selectivity than Celecoxib.COX-2-IN-9 exhibits good in vivo anti-inflammatory activity and low ulcerogenic e...
T62259	COX-2-IN-21
	COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential.
T63336	COX-2-IN-29
	COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).
T61760	COX-2-IN-18
	COX-2-IN-18 (Compound 3) is a highly effective COX-2 inhibitor with strong inhibitory activity against COX-2 (IC 50 = 0.775 μM). Its potency is comparable to the reference drug Celecoxib (IC 50 = 0.153 μM). This compound...
T60566	COX-2-IN-12
	COX-2-IN-12 (compound 3b) is a potent and selective COX-2 inhibitor with an IC 50 of 19.98 μM. COX-2-IN-12 is an anti-inflammatory agent that shows safety in-vivo acute toxicity studies [1].
T64063	COX-2-IN-24
	COX-2-IN-24 is an orally active COX-2 inhibitor (IC50: 0.17 μM) with anti-inflammatory and hypo-ulcerogenic effects.
T60464	COX-2-IN-20
	COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].
T62142	COX-2-IN-17
	COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.
T79130	COX-2-IN-32		NF-κB
	COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression. Demonstrating anti-inflammatory properties, it impedes NO production in LPS-induced RAW264.7 macrophages with an IC...		NF-κB
T63215	COX-2-IN-22
	COX-2-IN-22 is a COX-2 inhibitor (IC50: 8.6 μM) that can cross the blood-brain barrier and also exhibits inhibitory effects on AChE (IC50: 2.8 μM), BChE (IC50: 6.3 μM), β-Secretase (IC50: 15.3 μM), LOX-5 (IC50: 13.9 μM) ...
T61352	COX-2/5-LOX-IN-3
	COX-2/5-LOX-IN-3 (compound 5b) is a powerful and dual inhibitor of COX-2 and 5-LOX, with IC50 values of 45.73 μM, 5.45 μM, and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. This compound, COX-2/5-LOX-IN-3, shows pro...
T62998	COX-2/15-LOX-IN-1
	COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase (15-LOX) inhibitor that acts on COX-1 (IC50: 10.65 μM), COX-2 (IC50: 0.075 μM) and 15-LOX (IC50: 2.98 μM). 25 has an anti-inflammatory effect.
T61939	Topo I/COX-2-IN-1
	Topo I/COX-2-IN-1 (1H-30) is a potent Topo I/COX-2 inhibitor with the IC50 of 0.24 μM and 4.42 μM for COX-2 and Topo I, respectively. Topo I/COX-2-IN-1 induces apoptosis and inhibits migration of cancer cells, shows anti...
T62241	Topo I/COX-2-IN-2
	Topo I/COX-2-IN-2 (Compound W10) is a potent dual Topo I (IC50: 0.90 μM) and COX-2 (IC50: 2.31 μM) inhibitor.Topo I/COX-2-IN-2 induces apoptosis in cancer cells using the mitochondrial pathway.
T79360	COX-2/15-LOX-IN-2		Lipoxygenase
	COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX. Additionally, it exhibits significant antioxidant activity [1].		Lipoxygenase
T60992	COX-1/2-IN-3
	COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].
T60630	COX/5-LOX-IN-1
	COX/5-LOX-IN-1 (compound 6b) is a potent COX/5-LOX dual inhibitor with the potential for inflammation diseases research. COX/5-LOX-IN-1 has IC50s of 1.07, 0.55, and 0.28 μM for COX-1, COX-2, and 5-LOX enzyme, respectivel...
T62103	COX-2/PI3K-IN-1
	COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).
T60769	COX-2/PI3K-IN-2
	COX-2/PI3K-IN-2 (compound 5f) has properties of anti-inflammatory and anti-cancer. COX-2/PI3K-IN-2 is a selective inhibitor of COX-2 (Ki = 3.02 nM) as well as a potent inhibitor of PI3K (IC 50 = 2.78 nM) [1].
T61196	COX-1/2-IN-1
	COX-1/2-IN-2, a potent inhibitor of both COX-1 and COX-2, demonstrates significant inhibitory activity, with IC50 values of 13.9 ± 3.21 μM for COX-1 and 6.4 ± 0.74 μM for COX-2, respectively [1].
T61865	COX-1/2-IN-2
	COX-1/2-IN-2 is a potent inhibitor of both COX-1 and COX-2, displaying significant inhibitory effects with IC50 values of 9.7 ± 0.09 μM for COX-1 and 4.6 ± 1.45 μM for COX-2, respectively [1].
T79592	COX-1/2-IN-4		COX
	COX-1/2-IN-4 (compound 2b) is a dual COX-1 and COX-2 inhibitor with respective IC50 values of 0.239 μM for COX-1 and 0.191 μM for COX-2. Additionally, it demonstrates moderate anticancer activity, exhibiting IC50 values ...		COX
T63398	COX-2/sEH-IN-1
	COX-2/sEH-IN-1 is an orally active dual inhibitor of COX-2 (IC50: 1.24 μM) and sEH (IC50: 0.40 μM), a soluble epoxide hydrolase. COX-2/sEH-IN-1 increases anti-inflammatory effects and significantly reduces cardiovascular...
T60403	COX-2/NO-IN-1
	COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS) and NO ( IC 50 of 3.52 μM) inhibitor as well as suppresses the expression of COX-2. COX-2/NO-IN-1 has anti-inflammatory effects and reduces pathological dama...
T61910	COX-2/5-LOX-IN-2
	COX-2/5-LOX-IN-2 is a benzothiophen-2-ylpyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 (5b) inhibited both COX-2 and 5-LOX. The IC50s of COX-2/5-LOX-IN-2 inhibiting COX-1, COX-2 and 5-LOX were 5.40, 0.01 and 1.78 ...
T79361	COX-2/15-LOX-IN-3		Lipoxygenase
	COX-2/15-LOX-IN-3 (compound 5k) serves as a dual inhibitor for COX-2 and 15-LOX, demonstrating inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM, respectively. This compound effectively suppresses LPS-induced cell...		Lipoxygenase

Compounds

Target: COX, Prostaglandin Receptor

Lumiracoxib

T6574

Synonym: Prexige,COX-189

Target: COX

FK 3311

T7207

Synonym: FK-3311,COX-2 Inhibitor V

Target: COX

COX/5-LO-IN-1

T13263

Synonym: Atreleuton analog

Cat No.	Product Name	Synonyms	Targets
T4S0590	Columbin		Phospholipase , COX , Parasite
	1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion.		Phospholipase , COX , Parasite
T6S0077	Byakangelicol		COX
	1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr...		COX
TN1723	Hamaudol		COX
	Hamaudol is a chromone isolated from Saposhnikovia divaricata,has analgesic and anti-inflammary activities, it showed inhibitory activity on COX-1 and COX-2 activities with values of 0.30, 0.57 mM, respectively.		COX
T3883	Roburic acid		COX
	Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.		COX
T6S0413	Pectolinarigenin	Pectolinaringenin	Others , Lipoxygenase , COX
	1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ...		Others , Lipoxygenase , COX
TQ0288	Hexahydrocurcumin		Reactive Oxygen Species , ROS , COX
	Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.		Reactive Oxygen Species , ROS , COX
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T3399	Psoralidin		Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial
	Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
T6S2023	Harpagoside		Others , COX , NO Synthase
	1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression...		Others , COX , NO Synthase
TN2139	Regaloside B		NOS , COX , NO Synthase
	Regaloside B, a phenylpropanoid isolated from Lilium longiflorum, exhibits anti-inflammatory activity by inhibiting the expression of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2).		NOS , COX , NO Synthase
T5758	Sphondin		COX , Prostaglandin Receptor
	Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.		COX , Prostaglandin Receptor
TQ0180	Chebulagic acid		SARS-CoV , Influenza Virus , Lipoxygenase , COX
	Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.		SARS-CoV , Influenza Virus , Lipoxygenase , COX
T8240	Cis-5-Dodecenoic Acid		Others
	Cis-5-Dodecenoic Acid is a monounsaturated fatty acid that has a C12 chain as a backbone and a cis double bond at the C5 position.		Others
T3877	Esculentoside A		NF-κB , COX
	Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmun...		NF-κB , COX
T3747	Syringaldehyde	Syringic aldehyde,Springaldehyde	COX
	syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity wi...		COX
T5S0045	Isofraxidin	6,8-Dimethoxyumbelliferone,Phytodolor	MMP , ERK , p38 MAPK , TLR , COX
	1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote...		MMP , ERK , p38 MAPK , TLR , COX
T8255	(±)-Catechin	(±)-Catechin hydrate	ROS , COX
	(±)-Catechin ((±)-Catechin hydrate) hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress.		ROS , COX
TN3500	Beta-Amyrone	β-Amyron	COX , AChR , PPAR , Antifection
	beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through inhibiting the expression of COX-2. beta-Amyrone exhibits a...		COX , AChR , PPAR , Antifection
T2972	Rutaecarpine	Rutacarpine,Rhetine,Rutecarpine	COX
	Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM.		COX
T7052	Gnetol		Tyrosinase , COX , HDAC , AChR
	Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ...		Tyrosinase , COX , HDAC , AChR
T6S1572	Sauchinone		ERK , p38 MAPK , NF-κB
	1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative...		ERK , p38 MAPK , NF-κB
T2778	(+)-Catechin Hydrate		Antioxidant , COX
	(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological systems.		Antioxidant , COX
T2826	Asaraldehyde	Asarylaldehyde,2,4,5-trimethoxy-Benzaldehyde,Asaronaldehyde	COX
	Asaraldehyde (2,4,5-trimethoxy-Benzaldehyde), a natural COX-2 inhibitor, exhibits 17-fold selectivity than COX-1.		COX
T4643	TFAP	N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	COX , Endogenous Metabolite
	TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor		COX , Endogenous Metabolite
T5431	[10]-Shogaol	10-Shogaol	Antioxidant , COX
	[10]-Shogaol (10-Shogaol) is an extract from ginger displaying antioxidant activity. It also may contain hypolipidemic and insulin-sensitizing effects.		Antioxidant , COX
T5430	[8]-Shogaol	8-SHOGAOL	Apoptosis , COX
	[8]-Shogaol is a component of ginger and maintains anti-inflammatory activity as a cyclooxygenase-2 inhibitor.		Apoptosis , COX
T3866	Macelignan	Anwuligan,(+)-Anwulignan	Others , COX
	Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species.		Others , COX
T0443	Salicin	Salicoside,Salicine,D-(−)-Salicin	COX
	Salicin (Salicine), a phenol β-glycoside produced from willow bark, shows anti-inflammatory functions.		COX
T7113	Paradol	6-paradol,[6]-Gingerone	COX
	Paradol ([6]-Gingerone) is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activit...		COX
T3342	Xanthohumol		Apoptosis , Others , Influenza Virus , COX , Acyltransferase , HSV
	Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows ...
TQ0169	Inulicin	1-O-Acetylbritannilactone	FAK , NF-κB , COX , Src
	Inulicin (1-O-Acetylbritannilactone), an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.		FAK , NF-κB , COX , Src
T0649	Salicylic acid	2-Hydroxybenzoic acid	Apoptosis , Mitophagy , COX , Endogenous Metabolite , Autophagy
	Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
T5759	S-(+)-Marmesin	(+)-Marmesin,(S)-Marmesin,marmesin	Lipoxygenase , COX
	S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.		Lipoxygenase , COX
T6S1543	Dehydrodiisoeugenol		Others , NF-κB , COX , Antibacterial
	1. Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in RAW264.7 murine macrophages stimulated with LPS. (2). Dehydrodiisoeugenol inhibited LPS-stimulated ...		Others , NF-κB , COX , Antibacterial
T3744	Veratric acid	Veratrumenoic acid,3,4-Dimethoxybenzoic acid	Reactive Oxygen Species , COX
	Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowering effects.		Reactive Oxygen Species , COX
T2856	(-)-Epicatechin	L-Epicatechin,Epicatechin,(-)-Epicatechol	Ferroptosis , COX , Endogenous Metabolite
	(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.		Ferroptosis , COX , Endogenous Metabolite
T5727	CAFESTOL		ERK , NF-κB , COX , PGE Synthase
	CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production...		ERK , NF-κB , COX , PGE Synthase
T6S0722	Isoorientin	Homoorientin,Luteolin-6-C-glucoside	Antioxidant , COX
	Isoorientin (Homoorientin) has antioxidant activity.		Antioxidant , COX
T1468	Lornoxicam	Ro 13-9297,Chlortenoxicam,TS110	COX , Endogenous Metabolite
	Lornoxicam (Chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. Lornoxicam differs from other oxicam co...		COX , Endogenous Metabolite
T3S0645	N-trans-Feruloyltyramine	Feruloyltyramine,N-Feruloyltyramine,Moupinamide	Others , COX
	1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s...		Others , COX
T2S2335	Dehydroevodiamine	DHED	Others , NF-κB , COX , PGE Synthase , NO Synthase
	Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood fl...		Others , NF-κB , COX , PGE Synthase , NO Synthase
T6S1487	Ginsenoside Rg5		NF-κB , COX , IGF-1R
	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...		NF-κB , COX , IGF-1R
T8293	γ-Tocopherol	(+)-γ-Tocopherol	COX
	(+)-γ-Tocopherol ((+)-γ-Tocopherol) is one of the naturally occurring forms of Vitamin E. It is the most abundant Tocopherol in soybean and corn oils.		COX
TN1377	α-Spinasterol	alpha-Spinasterol	COX , Antibacterial , TRP/TRPV Channel
	α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 v...		COX , Antibacterial , TRP/TRPV Channel
T5S2360	Corydaline	Corydalin,(+)-Corydaline	P450 , Virus Protease , Opioid Receptor , AChE
	1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastr...		P450 , Virus Protease , Opioid Receptor , AChE
T0822	Catechin	Catechinic acid,D-Catechin,(+)-Catechin,Cianidanol,Catechuic acid	Apoptosis , Influenza Virus , COX , Endogenous Metabolite
	Catechin (Cianidanol) is a flavan-3-ol, a type of natural phenol and antioxidant.		Apoptosis , Influenza Virus , COX , Endogenous Metabolite
TN1373	α-Humulene	Alpha-caryophyllene	TNF , NOS , COX
	α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production an...		TNF , NOS , COX
T0877	Gallic acid	3,4,5-Trihydroxybenzoic acid,Gallate,Benzoic acid	Apoptosis , Ferroptosis , Reactive Oxygen Species , ROS , COX , Endogenous Metabolite
	Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T0065	Acetaminophen	4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol	COX , Endogenous Metabolite , Histone Acetyltransferase
	Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity.		COX , Endogenous Metabolite , Histone Acetyltransferase
T5681	ETHYL CAFFEATE	ETHYL 3,4-DIHYDROXYCINNAMATE	NF-κB , COX , PGE Synthase , NO Synthase
	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related s...		NF-κB , COX , PGE Synthase , NO Synthase
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Natural Products

Columbin

T4S0590

Synonym:

Target: Phospholipase, COX, Parasite

Synonym: Pectolinaringenin

Target: Others, Lipoxygenase, COX

Hexahydrocurcumin

TQ0288

Synonym:

Target: Reactive Oxygen Species, ROS, COX

Jaceosidin

T3824

Synonym:

Target: Apoptosis, BCL, COX, UGT

Psoralidin

T3399

Synonym:

Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial

Harpagoside

T6S2023

Synonym:

Target: Others, COX, NO Synthase

Regaloside B

TN2139

Synonym:

Target: NOS, COX, NO Synthase

sphondin

T5758

Synonym:

Target: COX, Prostaglandin Receptor

Chebulagic acid

TQ0180

Synonym:

Target: SARS-CoV, Influenza Virus, Lipoxygenase, COX

Cis-5-Dodecenoic Acid

Synonym: Syringic aldehyde,Springaldehyde

Target: COX

Isofraxidin

T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,Phytodolor

Target: MMP, ERK, p38 MAPK, TLR, COX

(±)-Catechin

T8255

Synonym: (±)-Catechin hydrate

Target: COX, AChR, PPAR, Antifection

Rutaecarpine

T2972

Synonym: Rutacarpine,Rhetine,Rutecarpine

Target: Tyrosinase, COX, HDAC, AChR

Sauchinone

T6S1572

Synonym:

Target: ERK, p38 MAPK, NF-κB

(+)-Catechin Hydrate

T2778

Synonym:

Target: Antioxidant, COX

Asaraldehyde

T2826

Synonym: Asarylaldehyde,2,4,5-trimethoxy-Benzaldehyde,Asaronaldehyde

Target: COX

TFAP

T4643

Synonym: N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide

Target: COX, Endogenous Metabolite

[10]-Shogaol

T5431

Synonym: 10-Shogaol

Target: Antioxidant, COX

[8]-Shogaol

T5430

Synonym: 8-SHOGAOL

Target: Apoptosis, COX

Macelignan

T3866

Synonym: Anwuligan,(+)-Anwulignan

Target: Others, COX

Salicin

T0443

Synonym: Salicoside,Salicine,D-(−)-Salicin

Target: COX

Paradol

T7113

Synonym: 6-paradol,[6]-Gingerone

Target: Apoptosis, Others, Influenza Virus, COX, Acyltransferase, HSV

Inulicin

TQ0169

Synonym: 1-O-Acetylbritannilactone

Target: FAK, NF-κB, COX, Src

Salicylic acid

T0649

Synonym: 2-Hydroxybenzoic acid

Target: Apoptosis, Mitophagy, COX, Endogenous Metabolite, Autophagy

S-(+)-Marmesin

T5759

Synonym: (+)-Marmesin,(S)-Marmesin,marmesin

Target: Lipoxygenase, COX

Dehydrodiisoeugenol

T6S1543

Synonym:

Target: Others, NF-κB, COX, Antibacterial

Veratric acid

T3744

Synonym: Veratrumenoic acid,3,4-Dimethoxybenzoic acid

Target: Reactive Oxygen Species, COX

(-)-Epicatechin

T2856

Synonym: L-Epicatechin,Epicatechin,(-)-Epicatechol

Target: Ferroptosis, COX, Endogenous Metabolite

CAFESTOL

T5727

Synonym:

Target: ERK, NF-κB, COX, PGE Synthase

Isoorientin

T6S0722

Synonym: Homoorientin,Luteolin-6-C-glucoside

Target: Antioxidant, COX

Lornoxicam

T1468

Synonym: Ro 13-9297,Chlortenoxicam,TS110

Target: COX, Endogenous Metabolite

N-trans-Feruloyltyramine

T3S0645

Synonym: Feruloyltyramine,N-Feruloyltyramine,Moupinamide

Target: Others, COX

Dehydroevodiamine

T2S2335

Synonym: DHED

Target: Others, NF-κB, COX, PGE Synthase, NO Synthase

Ginsenoside Rg5

T6S1487

Synonym:

Target: NF-κB, COX, IGF-1R

γ-Tocopherol

T8293

Synonym: (+)-γ-Tocopherol

Target: COX

α-Spinasterol

TN1377

Synonym: alpha-Spinasterol

Target: COX, Antibacterial, TRP/TRPV Channel

Corydaline

T5S2360

Synonym: Corydalin,(+)-Corydaline

Target: P450, Virus Protease, Opioid Receptor, AChE

Catechin

T0822

Synonym: Catechinic acid,D-Catechin,(+)-Catechin,Cianidanol,Catechuic acid

Target: Apoptosis, Influenza Virus, COX, Endogenous Metabolite

α-Humulene

TN1373

Synonym: Alpha-caryophyllene

Target: TNF, NOS, COX

Gallic acid

T0877

Synonym: 3,4,5-Trihydroxybenzoic acid,Gallate,Benzoic acid

Target: Apoptosis, Ferroptosis, Reactive Oxygen Species, ROS, COX, Endogenous Metabolite

Acetaminophen

T0065

Synonym: 4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol

Target: COX, Endogenous Metabolite, Histone Acetyltransferase

ETHYL CAFFEATE

T5681

Synonym: ETHYL 3,4-DIHYDROXYCINNAMATE

Target: NF-κB, COX, PGE Synthase, NO Synthase

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01736	COX-2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a perox...
TMPY-04908	Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc)	CV	Baculovirus-Insect Cells

TMPY-04807	Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc)	CV	Baculovirus-Insect Cells

TMPH-01179	COX4I1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	COX4I1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPY-02481	ACOX1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, ...
TMPY-03511	COX5B Protein, Human, Recombinant (His)	Human	E. coli
	Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contribut...
TMPH-02617	COX5A Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase...
TMPH-02825	ACOX1 Protein, Mouse, Recombinant (Myc)	Mouse	E. coli
	Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway.; Shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing ch...
TMPY-03752	COX4NB Protein, Human, Recombinant (His)	Human	E. coli

TMPH-03639	COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc)	Trachypithecus cristatus	HEK293
	COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc) is expressed in HEK293.
TMPH-01180	COX5A Protein, Human, Recombinant (GST)	Human	E. coli
	COX5A Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPJ-00778	HER2/ERBB2 Protein, Human, Recombinant (His)	Human	Human Cells
	Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different...
TMPY-02900	IL-17A Protein, Mouse, Recombinant	Mouse	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-02886	IL-17A Protein, Human, Recombinant	Human	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPJ-00704	SCO1 Protein, Human, Recombinant (GST)	Human	E. coli
	Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by hi...
TMPY-03658	ETHE1 Protein, Human, Recombinant (His)	Human	E. coli
	ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytopl...
TMPJ-00776	HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	Human Cells
	Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different...
TMPJ-00777	HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc)	Human	Human Cells
	Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different...
TMPY-04023	BCCIP Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ...
TMPY-00578	BCCIP Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ...
TMPY-04888	IL-17 Protein, Rabbit, Recombinant	Rabbit	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-05342	IL-17A Protein, Cynomolgus, Recombinant	Cynomolgus	Baculovirus-Insect Cells
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-04710	IL-17 Protein, Rhesus, Recombinant	Rhesus	Baculovirus-Insect Cells
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-03568	IL-17A Protein, Human, Recombinant (His)	Human	Yeast
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-05183	IL-17A Protein, Human, Recombinant, Biotinylated	Human	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-04332	IL-17A Protein, Human, Recombinant (T26A, His)	Human	Baculovirus-Insect Cells
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-04609	IL-17 Protein, Rabbit, Recombinant (His)	Rabbit	Baculovirus-Insect Cells
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-03906	IL-17 Protein, Canine, Recombinant	Canine	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-03931	IL-17 Protein, Marmoset, Recombinant	Marmoset	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...

COX-2 Protein, Human, Recombinant (His)

TMPY-01736

Species: Human

Expression System: Baculovirus-Insect Cells

Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc)

TMPY-04908

Species: CV

Expression System: Baculovirus-Insect Cells

Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc)

TMPY-04807

Species: CV

Expression System: Baculovirus-Insect Cells

COX4I1 Protein, Human, Recombinant (His & SUMO)

TMPH-01179

Species: Human

Expression System: E. coli

ACOX1 Protein, Human, Recombinant (His)

TMPY-02481

Species: Human

Expression System: Baculovirus-Insect Cells

COX5B Protein, Human, Recombinant (His)

TMPY-03511

Species: Human

Expression System: E. coli

COX5A Protein, Mouse, Recombinant (His & SUMO)

TMPH-02617

Species: Mouse

Expression System: E. coli

ACOX1 Protein, Mouse, Recombinant (Myc)

TMPH-02825

Species: Mouse

Expression System: E. coli

COX4NB Protein, Human, Recombinant (His)

TMPY-03752

Species: Human

Expression System: E. coli

COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc)

TMPH-03639

Species: Trachypithecus cristatus

Expression System: HEK293

COX5A Protein, Human, Recombinant (GST)

TMPH-01180

Species: Human

Expression System: E. coli

HER2/ERBB2 Protein, Human, Recombinant (His)

TMPJ-00778

Species: Human

Expression System: Human Cells

IL-17A Protein, Mouse, Recombinant

TMPY-02900

Species: Mouse

Expression System: E. coli

IL-17A Protein, Human, Recombinant

TMPY-02886

Species: Human

Expression System: E. coli

SCO1 Protein, Human, Recombinant (GST)

TMPJ-00704

Species: Human

Expression System: E. coli

ETHE1 Protein, Human, Recombinant (His)

TMPY-03658

Species: Human

Expression System: E. coli

HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated

TMPJ-00776

Species: Human

Expression System: Human Cells

HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc)

TMPJ-00777

Species: Human

Expression System: Human Cells

BCCIP Protein, Human, Recombinant (His & GST)

TMPY-04023

Species: Human

Expression System: Baculovirus-Insect Cells

BCCIP Protein, Human, Recombinant

TMPY-00578

Species: Human

Expression System: Baculovirus-Insect Cells

IL-17 Protein, Rabbit, Recombinant

TMPY-04888

Species: Rabbit

Expression System: E. coli

IL-17A Protein, Cynomolgus, Recombinant

TMPY-05342

Species: Cynomolgus

Expression System: Baculovirus-Insect Cells

IL-17 Protein, Rhesus, Recombinant

TMPY-04710

Species: Rhesus

Expression System: Baculovirus-Insect Cells

IL-17A Protein, Human, Recombinant (His)

TMPY-03568

Species: Human

Expression System: Yeast

IL-17A Protein, Human, Recombinant, Biotinylated

TMPY-05183

Species: Human

Expression System: E. coli

IL-17A Protein, Human, Recombinant (T26A, His)

TMPY-04332

Species: Human

Expression System: Baculovirus-Insect Cells

IL-17 Protein, Rabbit, Recombinant (His)

TMPY-04609

Species: Rabbit

Expression System: Baculovirus-Insect Cells

IL-17 Protein, Canine, Recombinant

TMPY-03906

Species: Canine

Expression System: E. coli

IL-17 Protein, Marmoset, Recombinant

TMPY-03931

Species: Marmoset

Expression System: E. coli

Cat No.	Product Name
L4710	Nonsteroidal Anti-Inflammatory Compound Library		530 compounds
	530 non-steroidal anti-inflammatory compounds for high-throughput and high-content screening.

Libraries

Nonsteroidal Anti-Inflammatory Compound Library

L4710

Compounds: 530