T2377 |
Pilaralisib analogue
|
XL147 analogue , SAR245408 |
DNA-PK
,
Apoptosis
,
PI3K
|
|
XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ. |
T11129L |
Duvelisib (R enantiomer) hydrochloride
|
INK1197 R enantiomer HCl , Duvelisib (R enantiomer) hydrochloride(1261590-48-0 Free base) , IPI-145 R enantiomer HCl |
PI3K
|
|
Duvelisib (R enantiomer) hydrochloride is a PI3K inhibitor. Duvelisib (R enantiomer) hydrochloride is the less active en... |
T2008 |
LY294002
|
NSC 697286 , SF 1101 , LY 294002 |
Casein Kinase
,
DNA-PK
,
Apoptosis
,
PI3K
,
Autophagy
|
|
LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It also blocks autophagoso... |
T11052L |
Disitertide acetate
|
Disitertide acetate(272105-42-7 Free base) , P144 acetate |
TGF-beta/Smad
|
|
Disitertide acetate is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block th... |
T2235 |
Dactolisib
|
NVP-BEZ235 , BEZ235 |
PI3K
,
ATM/ATR
,
Autophagy
,
mTOR
|
|
Dactolisib is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110... |
T3S0013 |
Ethyl trans-caffeate
|
Ethyl caffeate , Caffeic Acid Ethyl Ester |
Others
|
|
1. Ethyl caffeate has anti-inflammatory activity. 2. Ethyl caffeate may as a promising natural compound for future appli... |
T60196 |
IHMT-PI3Kδ-372 S-isomer
|
|
PI3K
|
|
IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 S-isomer shows h... |
T5831 |
Selective PI3Kδ Inhibitor 1
|
|
PI3K
|
|
Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM). |
T28416 |
PIK-108
|
PIK108 , PIK 108 |
PI3K
|
|
PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ... |
T2248 |
AS-605240
|
AS 605240 |
PI3K
,
Autophagy
|
|
AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM). |
T2746 |
Sophocarpine monohydrate
|
Sophocarpine |
Apoptosis
,
Influenza Virus
,
Akt
,
PI3K
,
Autophagy
,
AMPK
|
|
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. |
TL0006 |
Cichoric Acid
|
Chicoric Acid , Dicaffeoyltartaric acid |
Reactive Oxygen Species
,
HIV Protease
|
|
Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tiss... |
T2256 |
CNX-1351
|
|
PI3K
|
|
CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor. |
T61966 |
PI3K-IN-26
|
|
|
|
PI3K-IN-26 is an effective PI3K inhibitor. PI3K-IN-26 inhibits the proliferation of SU-DHL-6 cells, IC50= 36 nM (WO20160... |
T61618 |
PI3K-IN-38
|
|
|
|
PI3K-IN-38 (compound 123) is an orally active PI3K inhibitor with IC 50 of 0.541 μM (PI3K-α). PI3K-IN-38 shows activitie... |
T61516 |
PI3K/mTOR Inhibitor-3
|
|
|
|
PI3K/mTOR Inhibitor-3 (compound 12), an imidazoline, is a potent PI3K and mTOR dual inhibitor. PI3K/mTOR Inhibitor-3 has... |
T60564 |
PI3K/Akt/mTOR-IN-2
|
|
|
|
PI3K/Akt/mTOR-IN-2 is an inhibitor of PI3K/AKT/mTOR pathway. PI3K/Akt/mTOR-IN-2 can induce cancer cell cycle arrest and ... |
T60769 |
COX-2/PI3K-IN-2
|
|
|
|
COX-2/PI3K-IN-2 (compound 5f) has properties of anti-inflammatory and anti-cancer. COX-2/PI3K-IN-2 is a selective inhibi... |
T30989 |
CLR457
|
CLR 457 , CLR-457 |
|
|
CLR457 is an oral bioavailable phosphatidylinositol 3-kinase (PI3K) pan inhibitor with potential anti-tumor activity. CL... |
T29615 |
ACP-319
|
ACP319 |
|
|
ACP-319 is an oral phosphatidylinositol 3-kinase (PI3K) inhibitor that can prevent the activation of PI3K/AKT (protein k... |