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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5168 | EGFR-IN-12 | EGFR Inhibitor | Apoptosis , EGFR |
EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells. | |||
T21954 | EGFR/ErbB-2/ErbB-4 inhibitor-2 | EGFR/ErbB2 Inhibitor | EGFR |
EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively) | |||
T2705 | Mutant EGFR inhibitor | EGFR | |
Mutant EGFR inhibitor is a selective and potent Mutated EGFR inhibitor, inhibits L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant. | |||
T10802 | CHMFL-EGFR-202 | EGFR | |
CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases). | |||
T11163 | EGFR-IN-9 | EGFR | |
EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has antitumor activity. | |||
T11158 | EGFR-IN-11 | EGFR | |
EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1. | |||
T11160 | EGFR-IN-5 | EGFR | |
EGFR-IN-5 is a selective inhibitor of EGFR. The IC50s for EGFR, EGFR(L858R), EGFR(L858R/T790M), and EGFR(L858R/T790M/C797S) are 10.4, 1.1, 34, 7.2 nM, respectively. | |||
T11162 | EGFR-IN-8 | EGFR , c-Met/HGFR | |
EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC. | |||
T11157L | EGFR-IN-1 hydrochloride | EGFR | |
EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochloride exhibits potent antitumor and antiproliferative activity... | |||
T11161 | EGFR-IN-7 | TQB3804 | EGFR |
EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor. | |||
T16162 | Mutated EGFR-IN-1 | Osimertinib analog | EGFR |
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant, and T790M resistance mutant. | |||
T35901 | EGFR-IN-99 | JBJ-03-142-02 | EGFR , HER |
EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor with antiproliferative activity for the study of non-small cell lung cancer (NSCLC). | |||
T63732 | EGFR-IN-3 | Apoptosis , EGFR | |
EGFR-IN-3 is an EGFR inhibitor with potential antitumour activity.EGFR-IN-3 inhibits EGFRwt-TK and induces apoptosis (cell death), which can cause cells to block in the G2/M phase. | |||
T75120 | EGFR-IN-76 | EGFR | |
EGFR-IN-76 is a potent EGFR inhibitor. | |||
TP1613 | [pTyr5] EGFR (988-993) | [pTyr5] EGFR 988-993 | |
[pTyr5] EGFR (988-993) is a compound obtained from the auto-phosphorylation site, Tyr992, located within the sequence of the epidermal growth factor receptor (EGFR 988-993). This compound is frequently found bound with t... | |||
T79861 | EGFR/ErbB-2 inhibitor-1 | EGFR | |
EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling. | |||
T9905 | Cetuximab | Cetuximab (anti-EGFR),C225 | EGFR |
Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM). Cetuximab has antitumor activity, inhibiting tumor cell proliferation and inducing apoptosis. | |||
T40209 | EGFR-IN-15 | ||
EGFR-IN-15 (compound I-005) is a potent EGFR inhibitor, exhibiting an IC50 value of 4 nM. This compound holds potential for oncological research applications. | |||
TQ0255 | Olafertinib | CK-101,EGFR-IN-3,RX-518 | EGFR |
Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC. | |||
T11159 | EGFR-IN-2 | EGFR | |
EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor. | |||
T27247 | EGFR-IN-542 | ||
EGFR-IN-542 is a novel EGFR inhibitor. EGFR-IN-542 significantly reduces myocardial inflammation, fibrosis, apoptosis and dysfunction. It shows promise for use in the treatment of obesity-induced cardiac complications. | |||
T11157 | EGFR-IN-1 | EGFR | |
EGFR-IN-1, an orally active and irreversible selective inhibitor targeting L858R/T790M mutant EGFR, exhibits strong antiproliferative and antitumor activity, particularly against H1975 cells and first line mutant HCC827 ... | |||
T11164 | EGFR mutant-IN-1 | EGFR | |
EGFR mutant- in-1, A 5-methylpyrimidopyridone derivative are effective selective EGFRL858R/T790M/C797S mutant inhibitors with IC50 of 27.5 nM, which significantly weakened EGFRWT effect. | |||
T69807 | EGFR-IN-451 | ||
EGFR-IN-451 is an EGFR inhibitor, attenuating Ang II-induced Kidney Fibrosis. | |||
T8525 | EGFR-IN-16 | AG473 | EGFR , FGFR |
EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells. | |||
T41099 | EGFR Protein Tyrosine Kinase Substrate | ||
EGFR Protein Tyrosine Kinase Substrate is a EGFR protein tyrosine kinase substrate. | |||
T12130 | Mutated EGFR-IN-2 | EGFR | |
Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR. | |||
T12131 | Mutated EGFR-IN-3 | EGFR | |
Mutated EGFR-IN-3 is a ATP-competitive and highly selective allosteric dibenzodiazepinone EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) inhibitor(IC50 of 12 nM and 13 nM, respectively. ) | |||
T73154 | EGFR-IN-70 | ||
EGFR-IN-70 is a potent EGFR inhibitor with IC 50 values of 23.6 and 307.5 nM for EGFR LR/TM/CS and EGFR WT , respectively. EGFR-IN-70 has anti-proliferative activity and suppresses phosphorylation of the EGFR . EGFR-IN-... | |||
T62009 | EGFR-IN-71 | ||
EGFR-IN-71 is a potent inhibitor of epidermal growth factor receptor (EGFR) (IC50= 3.7 μM). EGFR-IN-71 has research value in chordoma. | |||
T63774 | EGFR-IN-58 | ||
EGFR-IN-58 is a potent, selective, ATP-competitive inhibitor of EGFR. EGFR-IN-58 exhibits significant cytotoxicity against melanoma, colon and blood cancers. | |||
T61225 | EGFR-IN-64 | ||
EGFR-IN-64 (Compound 3c) is a highly potent inhibitor of the epidermal growth factor receptor (EGFR) with an IC 50 value of 0.33 μM. This compound, EGFR-IN-64, exhibits significant anticancer activity [1]. | |||
T64170 | EGFR-IN-18 | ||
EGFR-IN-18 is a potent inhibitor of the enzymatic activity of the L858R/T790M/C797S mutant EGFR (4.9 nM) and is also able to reduce the enzymatic activity of wild-type EGFR (47 nM). | |||
T78574 | EGFR-IN-85 | EGFR | |
EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFR signaling. It is utilized in Glioblastoma (GBM) research [1]. | |||
T63178 | EGFR-IN-39 | ||
EGFR-IN-39, an acrylamide derivative, is a potent inhibitor of EGFR. EGFR-IN-39 is an antitumor agent with low toxicity and side effects. Among them, the overexpression and mutation of epidermal growth factor receptor (E... | |||
T62457 | EGFR-IN-54 | ||
EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells. | |||
T63264 | EGFR-IN-33 | ||
EGFR-IN-33, an acrylamide derivative, is a low-toxicity antitumor agent and a potent inhibitor of EGFR. Among others, overexpression and mutation of the epidermal growth factor receptor (EGFR) has been shown to lead to u... | |||
T63282 | EGFR-IN-35 | ||
EGFR-IN-35 is a low-toxicity, acrylamide derivative antitumor agent that is a potent inhibitor of EGFR. Among others, overexpression and mutation of the epidermal growth factor receptor (EGFR) has been shown to lead to u... | |||
T62343 | EGFR-IN-40 | ||
EGFR-IN-40 (compound 3z) is a potent inhibitor of BTK (IC50: 1.2 nM), EGFR (IC50: 5.3 nM) and ITK (IC50: 46.1 nM). | |||
T60574 | EGFR-IN-53 | ||
EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1]. | |||
T79293 | EGFR-IN-79 | EGFR | |
EGFR-IN-79 (compound 21), an EGFR inhibitor, exhibits antitumor activity through ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. It effectively induces cell death in proliferating and quiescent zones of E... | |||
T79651 | EGFR-IN-83 | EGFR | |
EGFR-IN-83 (Compound 9), an EGFR inhibitor with an IC50 of 2.53 nM, exhibits antiproliferative effects on MCF-7 and MDA-MB-231 cell lines, with respective IC50 values of 2.50 μM and 1.96 μM. Furthermore, EGFR-IN-83 is ca... | |||
T61267 | EGFR-IN-68 | ||
EGFR-IN-68 (Compound 8d) is a highly effective EGFR inhibitor, demonstrated by its potent inhibition activity with an IC50 value of 0.33 μM. It exhibits notable anticancer properties [1]. | |||
T64255 | EGFR-IN-48 | ||
EGFR-IN-48 is a potent, orally active EGFR inhibitor that acts on EGFRd19/TM/CS (IC50: 0.193 nM), EGFRLR/TM/CS (IC50: 0.251 nM), EGFRWT (IC50: 10.4 nM). EGFR-IN-48 is also able to inhibit EGFR-IN-48 also inhibits the pro... | |||
T79386 | EGFR-IN-84 | EGFR | |
EGFR-IN-84 (Compound 6g), an EGFR inhibitor with an IC50 of 24 nM, impedes the growth of A549 cells with an IC50 value of 1.537 μM and is utilized for lung cancer research [1]. | |||
T63895 | EGFR-IN-62 | ||
EGFR-IN-62 is a potent inhibitor of EGFR kinase with IC50 values of 10 nM for L858R/T790 M, 29 nM for WT and 2 42 nM for L858R/T790 M/C797S. EGFR-IN-62 blocks the cell cycle of A549 and/or H1975 cells in G1/G0 phase and ... | |||
T79694 | EGFR-IN-88 | EGFR | |
EGFR-IN-88 (Compound 4i), an EGFR inhibitor with an IC50 of 87 nM, exhibits cytotoxic effects on A549 cells at an IC50 of 3.902 μM and can induce cell apoptosis [1]. | |||
T79888 | EGFR-IN-87 | EGFR | |
EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750, EGFR_L858R/T790M, and EGFR_WT, respectively, in A431 cells. It ... | |||
T73105 | EGFR-IN-28 | ||
EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity . | |||
T61513 | EGFR-IN-51 | ||
EGFR-IN-51 (Compound 6) is a highly potent EGFR inhibitor, demonstrating strong affinity with IC50 values of 0.493, 102.60, and 461.63 μM, respectively, against EGFR, EGFR L858R-TK, and EGFR T790M-TK targets. Additionall... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1181 | Gefitinib | ZD1839 | EGFR , Tyrosine Kinases , Autophagy |
Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell... | |||
T22974 | Methyl 2,5-dihydroxycinnamate | EGFR | |
EGF receptor-associated tyrosine kinases inhibitor | |||
TN1440 | Beta-Hydroxyisovalerylshikonin | EGFR , Tyrosine Kinases , Prostaglandin Receptor , Src , AMPK , Fatty Acid Synthase | |
Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines. Beta-Hydroxyisovalerylshikonin significantly de... | |||
T3870 | Cyasterone | Cyasteron | Apoptosis , EGFR |
Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising anti-cancer agent. Cyasterone has antifeeding activity. | |||
T1431 | Khellin | Amicardine,Methafrone,Visammin | EGFR , Others |
Khellin (Methafrone) is a vasodilator that also has bronchodilatory action. | |||
TL0016 | Sulforaphene | Apoptosis , ERK , EGFR , NF-κB | |
Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EG... | |||
T1737 | Genistein | NPI 031L | Apoptosis , EGFR , Endogenous Metabolite , Autophagy |
Genistein (NPI 031L) is an isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA TOPOISOMERASES, TYPE II), with antineoplastic and antitumor activities. | |||
T2995 | Chrysophanol | 3-Methylchrysazin,Chrysophanic Acid,Turkey Rhubarb | EGFR |
Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel. | |||
T0683 | Mevastatin | Compactin,ML236B | Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid |
Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials. | |||
T6427 | Butein | 2’,3,4,4’-tetrahydroxy Chalcone | Apoptosis , EGFR , Others , PDE , Autophagy |
Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR. | |||
T4183 | Lavendustin A | RG-14355,NSC 678027 | EGFR , Tyrosinase |
lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. | |||
T2851 | Daphnetin | 7,8-Dihydroxycoumarin,Daphnetol | EGFR , PKA , PKC , Parasite , Autophagy |
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-... | |||
T2894 | Norcantharidin | Norcantharadine,Endothall anhydride | EGFR , c-Met/HGFR |
Norcantharidin (Norcantharadine) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers. | |||
TN2309 | Withanolide A | EGFR , TNF , NF-κB | |
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. | |||
T4S0544 | Furanodienone | Apoptosis , HER | |
1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in BT474 and SKBR3 cells, the effect is specifically dependen... | |||
T5656 | (±)-Norcantharidin | Endothall anhydride,Norcantharidin | EGFR , c-Met/HGFR |
(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers. | |||
T36715 | Tetrac | Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid | Apoptosis , EGFR |
Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac... | |||
TJS0339 | Coumarin-3-carboxylic acid | 3-Carboxycoumarin | VEGFR |
The combination of Valproic acid with Coumarin-3-carboxylic acid (3-Carboxycoumarin) suppresses the proliferation and migration of lung cancer cells via EGFR/VEGFR2/c-Met-Akt-NF-κB signaling pathways; this combination ma... | |||
T2988 | (-)-Epigallocatechin Gallate | Epigallocatechol Gallate,EGCG | Ferroptosis , Reactive Oxygen Species , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite , Autophagy |
(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptor... | |||
TN1564 | Delphinidin 3-glucoside chloride | Delphinidin-3-O-glucoside chloride | Others |
Delphinidin-3-O-glucoside chloride has antioxidant activity. | |||
T2S0961 | Chalcone | benzylideneacetophenone,phenyl styryl ketone,Cinnamophenone,benzalacetophenone,β-phenylacrylophenone | EGFR , Antibacterial |
Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones. | |||
T13559 | Astragaloside VI | EGFR | |
Astragaloside VI could improve wound healing by activating the EGFR/ERK signaling pathway. | |||
T13126 | Tephrosin | Deguelinol I,Hydroxydeguelin | Others |
Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors, has potent antitumor activities. | |||
TN3711 | Corylifol C | ERK , EGFR , p38 MAPK , MEK | |
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor (EGFR): 1.1 and 4.4 × 10(-6) μg/ml, respectively). | |||
TN5254 | Wighteone | Erythrinin B,6-Isopentenylgenistein | Antifungal |
Wighteone (Erythrinin B) is a small molecule compound derived from Genista ephedroides with potential antifungal and anticancer activity against EGFR L858R/T790M mutant non-small cell lung cancer. | |||
TN2504 | 1,5-Dihydroxyxanthone | EGFR , AChR | |
1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have anticholinesterase activity on acetylcholinesterase (AChE) and... | |||
T2859 | Biochanin A | 4-Methylgenistein,Olmelin | EGFR , FAAH , Autophagy |
Biochanin A (4-Methylgenistein) is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. Biochanin A is a naturally occurring fatty acid amide hydrolase (FAAH) inhibitor. | |||
TN5100 | Taspine | ERK , EGFR , BCL , VEGFR , MAPK , Akt | |
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner, it has shown meaningful an... | |||
TN3525 | Boehmenan | ERK , Phosphatase , EGFR , PARP , MEK , Wnt/beta-catenin , Akt , Caspase , STAT , p53 | |
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotox... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02676 | EGFR Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-04818 | EGFR Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-00742 | EGFR Protein, Human, Recombinant (His) | Human | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPK-00902 | EGFR Protein, Rhesus macaque, Recombinant (His) | Rhesus macaque | HEK293 |
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands. The epidermal growth factor receptor is a member of t... | |||
TMPJ-00648 | EGFR vIII Protein, Human, Recombinant (His) | Human | Human Cells |
The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transm... | |||
TMPK-00426 | EGFR Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands. The epidermal growth factor receptor is a member of t... | |||
TMPJ-00647 | EGFR vIII Protein, Human, Recombinant (hFc) | Human | Human Cells |
The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transm... | |||
TMPK-00427 | EGFR Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands. The epidermal growth factor receptor is a member of t... | |||
TMPY-04529 | EGFR Protein, Human, Recombinant (aa 668-1210, His & GST) | Human | Baculovirus-Insect Cells |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPK-00425 | EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled | Human | HEK293 |
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands. The epidermal growth factor receptor is a member of t... | |||
TMPJ-00646 | EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated | Human | Human Cells |
The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transm... | |||
TMPY-03724 | EGFR Protein, Canine, Recombinant (His) | Canine | Baculovirus-Insect Cells |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-02675 | EGFR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-06524 | EGFR Protein, Feline, Recombinant (His) | Feline | Baculovirus-Insect Cells |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-02958 | EGFR Protein, Rat, Recombinant (His) | Rat | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-00128 | EGFR Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-01043 | EGFR Protein, Human, Recombinant (hFc) | Human | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPK-01073 | CLEC14A Protein, Human, Recombinant (His) | Human | HEK293 |
CLEC14A is a single-pass transmembrane glycoprotein belonging to the vascular expressed C-type lectin family. CLEC14A is found to be expressed in vascular endothelial cells during embryogenesis and is also implicated in ... | |||
TMPY-05258 | EGFR Protein, Human, Recombinant (Isoform Viii, hFc) | Human | Baculovirus-Insect Cells |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-06593 | EGFR Protein, Human, Recombinant (Isoform vIII, His & Avi), Biotinylated | Human | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-05612 | EGFR Protein, Human, Recombinant (aa 1-645, His & Avi), Biotinylated | Human | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-05637 | EGFR Protein, Human, Recombinant (aa 1-378, His & Avi), Biotinylated | Human | Baculovirus-Insect Cells |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPK-00692 | EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearran... | |||
TMPK-00689 | EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled | Human | HEK293 |
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearran... | |||
TMPK-00690 | EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled | Human | HEK293 |
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearran... | |||
TMPY-05211 | EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-375, His) | Human | Baculovirus-Insect Cells |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-06549 | EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-378, His) | Human | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPK-00691 | EGFRVIII Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearran... | |||
TMPK-00429 | HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for t... | |||
TMPK-00430 | HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for t... | |||
TMPK-00428 | HER2/ErbB2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for t... | |||
TMPY-00949 | VEGFR3/FLT4 Protein, Human, Recombinant (His) | Human | HEK293 |
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo... | |||
TMPY-02361 | VEGFR2/KDR Protein, Human, Recombinant (His) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPJ-00412 | VEGFR1/FLT-1 Protein, Human, Recombinant (hFc) | Human | Human Cells |
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 ... | |||
TMPY-01936 | VEGFR3/FLT4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo... | |||
TMPK-00645 | VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His) | Rhesus macaque | HEK293 |
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migratio... | |||
TMPY-04924 | VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPJ-00593 | VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) | Human | Human Cells |
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in a number of fundamental biological processes such as the re... | |||
TMPY-04802 | VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPK-00454 | VEGFR2/KDR Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migratio... | |||
TMPK-00445 | VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosis in several solid tumors.VEGF-R1, -R2 and -R3 were highly ... | |||
TMPY-05610 | VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-01937 | VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo... | |||
TMPK-00450 | VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class III subfamily of receptor tyrosine kinases (RTKs).yrosine-... | |||
TMPY-04940 | VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-01069 | VEGFR3/FLT4 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo... | |||
TMPY-05657 | VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-02678 | VEGFR2/KDR Protein, Rat, Recombinant (His) | Rat | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPK-00451 | VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class III subfamily of receptor tyrosine kinases (RTKs).yrosine-... | |||
TMPY-04794 | VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
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L3400 | Clinical Compound Library | 3480 compounds | |
A unique collection of 3480 compounds in clinical trial phases for high throughput screening (HTS) and high content screening (HCS); | |||
L2193 | Anti-Liver Cancer Compound Library | 1816 compounds | |
1816 species of compounds related to liver cancer that can be used in anti-liver cancer drug development and pharmacological studies. | |||
L2192 | Anti-Pancreatic Cancer Compound Library | 2267 compounds | |
A unique collection of 2267 pancreatic cancer related compounds can be used in HTS and HCS; | |||
L2191 | Anti-Breast Cancer Compound Library | 1965 compounds | |
A unique collection of 1965 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study; | |||
L1610 | FDA-Approved Kinase Inhibitor Library | 266 compounds | |
A unique collection of 266 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening. | |||
L2194 | Anti-Colorectal Cancer Compound Library | 1565 compounds | |
1565 compounds associated with colorectal cancer that can be used for high-throughput and high-content screening. | |||
L1600 | Kinase Inhibitor Library | 2720 compounds | |
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases; | |||
L9410 | Covalent Inhibitor Library | 1949 compounds | |
A unique collection of 1949 covalent Inhibitors and other molecules with common warheads like chloroacetyl,2-Chloropropionyl,Acryloyl,sulfonyl fluoride, alkyne,acrylamide, ketocarbonyl,disulfide bond, etc. |