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AChR

An acetylcholine receptor (abbreviated AChR) is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter.
Cat No. product name
T27579 ICL-CCIC-0019 ICL-CCIC-0019 是胆碱激酶 α (ChoKα) 的抑制剂。 ICL-CCIC-0019 诱导癌细胞系 G1 期阻滞、内质网应激和凋亡。
T9889 M4 mAChR agonist-1  M4 mAChR agonist-1 是一种有效的 M4 mAChR 激动剂(EC50 >10 μM)。
T9694 Emraclidine Emraclidine 是一种毒蕈碱 M4 受体阳性变构调节剂,可用于神经系统疾病研究。
T37196 5-AAM-2-CP 5-AAM-2-CP 是Acetamiprid的主要代谢物之一。 Acetamiprid 是一种 nAChR 激动剂,是一种新烟碱类杀虫剂。
T19940 Sulfoxaflor Sulfoxaflor 是 nAChR1 和 nAChR2 亚型的激动剂,是一种作用于昆虫中枢神经系统的内吸性杀虫剂。 Sulfoxaflor用于防治吸食汁液的昆虫,如褐飞虱、烟粉虱、桃蚜和棉蚜。
T6478 Donepezil Hydrochloride Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
T12525 Pozanicline dihydrochloride Pozanicline dihydrochloride is an orally bioavailable agonist of nicotinic acetylcholine receptor (nAChR) (Ki of 16.7 nM)
T0802 Procaine hydrochloride Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds ...
T1540 Doxepin hydrochloride Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mech...
T0678 Amitriptyline hydrochloride Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
T1199 Mitotane Mitotane is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormone...
T7591 Coluracetam Coluracetam(MKC-231) is a Choline Uptake Enhancer.
TP2065L α-Conotoxin PIA acetate α-Conotoxin PIA acetate is an antagonist of nicotinic acetylcholine receptor (nAChR) mainly targeting α6 and α3 subunits.
T8702 SKF-83566 SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 n...
T0302 Triflupromazine hydrochloride Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
T0684 Ribavirin Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T29137 VU0453595 VU0453595 is a M1 positive allosteric modulator (PAM).
TN2217 Sophoflavescenol Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
T6618 Orphenadrine Citrate Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
T8551 Nitrobenzylthioinosine Nitrobenzylthioinosine is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.
T23116 Oxotremorine sesquifumarate Muscarinic agonist
T38272 Thiacloprid Thiacloprid is a neonicotinoid insecticide that acts as a selective agonist at insect nicotinic acetylcholine receptors (nAChRs) with IC50values of 2.7 and 860 n...
T7671 Myosmine Myosmine is a minor tobacco alkaloid that is structurally related to nicotine.
T2782 Catharanthine Catharanthine suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).
T8236 RHC 80267 RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 µM in canine platelets)
T0086 Galanthamine hydrobromide Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
T6301 Tosedostat CHR-2797 is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. CHR-2797 is converted intracellularly in...
T0970 Racanisodamine Anisodamine is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.
T9419 Fesoterodine Fesoterodine is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is u...
T0074L Chlorprothixene hydrochloride Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a t...
T14140 Agaric acid Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus i...
T0236 Azatadine dimaleate Azatadine dimaleate is an inhibitor for histamine(IC50=6.5 nM) and cholinergic(IC50=10 nM).
T9569L PTI-125 HCl PTI-125 HCl binds and reverses an altered conformation of the scaffolding protein filamin A found in Alzheimer's disease brain.
T8040 Cholesterol myristate Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic ace...
T12085 MN58b MN58b is a selective inhibitor of choline kinase α (CHKα).
T1049 Oxybutynin chloride Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the mus...
T6426 Buclizine dihydrochloride Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Bu...
T4494 CLOZAPINE N-OXIDE Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produ...
T17244 VU0467154 VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. The response to ACh with pEC50s of 7.75, 6.2, and 6 for a rat, human, a...
T1285 Anethole trithione Anethole trithione is a bile secretion-stimulating drug that restores salivation and relieves the discomfort of dry mouth in chemotherapy-induced xerostomia.
T14065 9-Ethyladenine 9-Ethyladenine is an APRT (adenine phosphoribosyltransferase) partially inhibitor of [1].
T2845 Imperatorin Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T2571 Benactyzine hydrochloride Benactyzine hydrochloride is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to invest...
T0765 Fomepizole Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase...
T0172 Maprotiline hydrochloride Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, in...
T1215 Nicardipine hydrochloride Nicardipine Hydrochloride is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicar...
T13385 Zamifenacin fumarate Zamifenacin fumarate is a potent antagonist of gut-selective muscarinic M3 receptor.
T0338 Minaprine Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T2663 GTS-21 dihydrochloride GTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.
T3026 (-)-Huperzine A Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibit...
ICL-CCIC-0019
T27579
ICL-CCIC-0019 是胆碱激酶 α (ChoKα) 的抑制剂。 ICL-CCIC-0019 诱导癌细胞系 G1 期阻滞、内质网应激和凋亡。
M4 mAChR agonist-1 
T9889
M4 mAChR agonist-1 是一种有效的 M4 mAChR 激动剂(EC50 >10 μM)。
Emraclidine
T9694
Emraclidine 是一种毒蕈碱 M4 受体阳性变构调节剂,可用于神经系统疾病研究。
5-AAM-2-CP
T37196
5-AAM-2-CP 是Acetamiprid的主要代谢物之一。 Acetamiprid 是一种 nAChR 激动剂,是一种新烟碱类杀虫剂。
Sulfoxaflor
T19940
Donepezil Hydrochloride
T6478
Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
Pozanicline dihydrochloride
T12525
Pozanicline dihydrochloride is an orally bioavailable agonist of nicotinic acetylcholine receptor (nAChR) (Ki of 16.7 nM)
Procaine hydrochloride
T0802
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds ...
Doxepin hydrochloride
T1540
Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mech...
Amitriptyline hydrochloride
T0678
Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
Mitotane
T1199
Mitotane is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormone...
Coluracetam
T7591
Coluracetam(MKC-231) is a Choline Uptake Enhancer.
α-Conotoxin PIA acetate
TP2065L
α-Conotoxin PIA acetate is an antagonist of nicotinic acetylcholine receptor (nAChR) mainly targeting α6 and α3 subunits.
SKF-83566
T8702
SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 n...
Triflupromazine hydrochloride
T0302
Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
Ribavirin
T0684
Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
VU0453595
T29137
VU0453595 is a M1 positive allosteric modulator (PAM).
Sophoflavescenol
TN2217
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
Orphenadrine Citrate
T6618
Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
Nitrobenzylthioinosine
T8551
Nitrobenzylthioinosine is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.
Oxotremorine sesquifumarate
T23116
Muscarinic agonist
Thiacloprid
T38272
Thiacloprid is a neonicotinoid insecticide that acts as a selective agonist at insect nicotinic acetylcholine receptors (nAChRs) with IC50values of 2.7 and 860 n...
Myosmine
T7671
Myosmine is a minor tobacco alkaloid that is structurally related to nicotine.
Catharanthine
T2782
Catharanthine suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).
RHC 80267
T8236
RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 µM in canine platelets)
Galanthamine hydrobromide
T0086
Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
Tosedostat
T6301
CHR-2797 is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. CHR-2797 is converted intracellularly in...
Racanisodamine
T0970
Anisodamine is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.
Fesoterodine
T9419
Fesoterodine is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is u...
Chlorprothixene hydrochloride
T0074L
Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a t...
Agaric acid
T14140
Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus i...
Azatadine dimaleate
T0236
Azatadine dimaleate is an inhibitor for histamine(IC50=6.5 nM) and cholinergic(IC50=10 nM).
PTI-125 HCl
T9569L
PTI-125 HCl binds and reverses an altered conformation of the scaffolding protein filamin A found in Alzheimer's disease brain.
Cholesterol myristate
T8040
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic ace...
MN58b
T12085
MN58b is a selective inhibitor of choline kinase α (CHKα).
Oxybutynin chloride
T1049
Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the mus...
Buclizine dihydrochloride
T6426
Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Bu...
CLOZAPINE N-OXIDE
T4494
Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produ...
VU0467154
T17244
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. The response to ACh with pEC50s of 7.75, 6.2, and 6 for a rat, human, a...
Anethole trithione
T1285
Anethole trithione is a bile secretion-stimulating drug that restores salivation and relieves the discomfort of dry mouth in chemotherapy-induced xerostomia.
9-Ethyladenine
T14065
9-Ethyladenine is an APRT (adenine phosphoribosyltransferase) partially inhibitor of [1].
Imperatorin
T2845
Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
Benactyzine hydrochloride
T2571
Benactyzine hydrochloride is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to invest...
Fomepizole
T0765
Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase...
Maprotiline hydrochloride
T0172
Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, in...
Nicardipine hydrochloride
T1215
Nicardipine Hydrochloride is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicar...
Zamifenacin fumarate
T13385
Zamifenacin fumarate is a potent antagonist of gut-selective muscarinic M3 receptor.
Minaprine
T0338
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
GTS-21 dihydrochloride
T2663
GTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.
(-)-Huperzine A
T3026
Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibit...
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