4μ8c

4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.

Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagulation factor Xa, and it can be used in the study of thrombophlebitis, atherosclerosis, cerebral embolism, stroke and pulmonary embolism.

4-Chloroquinolin-8-ol is a building block

Cyclopenta[c][1]benzopyran-8-ol, 1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aR,4S,9bS)-rel- is an estrogen receptor beta (ERβ) agonist.

8-CHLOROQUINAZOLIN-4(1H)-ONE is inhibitor of Poly [ADP-ribose] polymerase 1 (human)

Compound Fr13857 is a useful organic compound for research related to life sciences. The catalog number is Fr13857 and the CAS number is 31270-80-1.

Neurokinin A(4-10) TFA(97559-35-8 free base) is a tachykinin NK2 receptor agonist[1].

1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986. S 18986 is a AMPA receptor positive modulator with EC2 (Concentration that doubles the intensity of the AMPA-induced current) of 35 μM.

1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-(pyridin-4-yl)urea is a useful organic compound for research related to life sciences. The catalog number is T67700 and the CAS number is 1144075-47-7.

8-Hydroxy-4-cadinen-3-one shows significant inhibitory activity against A.thaliana seedling root growth.

4'-O-Methyllucenin II (Diosmetin 6,8-di-C-glucoside) is a useful organic compound for research related to life sciences and the catalog number is T123819.

TLR7/8 agonist 4 hydroxy-PEG6-acid, a Drug-Linker Conjugate for ADCs, comprises the TLR7/8 agonist 4 and a hydroxy-PEG6-acid linker, suitable for the synthesis of antibody-drug conjugates (ADCs) [1].

Dehydrotriferulic acid (8-O-4,8-O-4) is a compound extractable from the saponified insoluble fiber of corn bran [1].

8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone may have antifungal activity against phytopathogenic and human pathogenic fungi.

2',4'-Dihydroxy-7-methoxy-8-prenylflavan is a natural product for research related to life sciences. The catalog number is TN2720 and the CAS number is 331954-16-6.

7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine is a building block.1It has been used in the synthesis of PI3K inhibitors. 1.Scott, W.J., Hentemann, M.F., Rowley, R.B., et al.Discovery and SAR of novel 2,3-dihydroimidazo[1,2-c]quinazoline PI3K inhibitors: Identification of copanlisib (BAY 80-6946)ChemMedChem.11(14)1517-1530(2016)

Selina-4(15),7(11)-dien-8-one is a natural product for research related to life sciences. The catalog number is TN3467 and the CAS number is 54707-47-0.

7-methoxy-8-hydroxy-4-methylcoumarin is a compound isolated from Citrus aurantium.

Apigenin 6-C-alpha-L-arabinopyranosyl-8-C-beta-D-xylopyranoside is a natural product from Viola yedoensis.

Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside is a natural product for research related to life sciences. The catalog number is TN6636 and the CAS number is 1147858-78-3.

8-Hydroxy-3,5,7,3',4',5'-hexamethoxyflavone is a natural product for research related to life sciences. The catalog number is TN3279 and the CAS number is 202846-95-5.

Chrysin 8-C-glucoside is a natural product for research related to life sciences. The catalog number is TN3649 and the CAS number is 160880-89-7.

Apigenin-6-C-β-D-xylopyranosyl-8-C-α-L-arabinopyranoside, a flavonoid known for its antioxidant activity, can be isolated from the Traditional Chinese Medicine TiepiShihu [1].

8-C-Glucosyl-(R)-aloesol ((R)-Aloesinol) is a bioactive analogue of chromone [1].

[Deamino-4-valine, 8-D-arginine]-Vasopressin (dVDAVP) is a highly potent and specific antidiuretic agent, exhibiting prolonged effects [1] [2].

7-N-(4-Hydroxyphenyl)mitomycin C is a bioactive chemical.

(2R)-8-Methylsocotrin-4'-ol is a useful organic compound for research related to life sciences and the catalog number is T123862.

8 beta-(4-Acetoxy-5-hydroxytigloyloxy)costunolide is a natural product for research related to life sciences. The catalog number is TN3302 and the CAS number is 109770-86-7.

3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide inhibits multidrug resistance protein (MRP1).

4-Chloro-2-(2,6-dioxopiperidin-3-yl)-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione is a useful organic compound for research related to life sciences and the catalog number is T64660.

5'-O-Benzoyl-2'-O,4'-C-methyleneuridine is a Nucleoside Derivative - LNA related nucleoside; Protected nucleoside with NH2/OH open.

RCB-02-4-8, an ionizable cationic lipid designed for the formulation of lipid nanoparticles (LNPs), enhances mRNA delivery with proven effectiveness in increasing lung transfection efficiency in mice [1].

Ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65575 and the CAS number is 112811-71-9.

TLR7/8 agonist 4 (compound 41) is a potent agonist of TLR7/8 with anti-cancer activity [1].

5'-O-Benzoyl-3'-O-(4-methoxybenzoyl)-2'-O,4'-C-methyleneuridine is a Nucleoside Derivative - LNA-related nucleoside.

5,7,3'-Trihydroxy-4'-methoxy-8-prenylflavanone is a flavonoid from The barks of Azadirachta indica.

1,2,3,5-Tetra-O-benzoyl-4-alpha-C-vinyl-D-ribofuranose is a Carbohydrate Derivative.

DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1]. [1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.

Nucleoside Derivatives - 4-Deoxy pyrimidine nucleosides; 3’-Modified nucleosides

C-Myc Inhibitor 8 is an effective compound for cancer research, inhibiting cell viability across a range of cancer types and demonstrating growth suppression in human prostate and lung cancers within mouse models. This inhibitor specifically targets the c-Myc pathway, showcasing its potential utility in oncological studies.

1H-Pyrrolo[3,2-c]pyridin-4-amine is a useful organic compound for research related to life sciences. The catalog number is T67639 and the CAS number is 60290-23-5.

1-Cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66423 and the CAS number is 112811-57-1.

(R)-Eriodictyol-8-C-beta-D-glucopyranoside is a useful organic compound for research related to life sciences and the catalog number is T126514.

8-Chloro-4-(2-chloro-4-fluorophenoxy)quinoline is a bioactive chemical.

2'-beta-C-Methyl-4-thiouridine is a Nucleoside Derivative - Thio-nucleoside, 2'-Modified nucleoside.

Nucleosides and Reagents - 4-Deoxypyrimidine nucleoside; 2’-C-Methyl nucleoside

2'-O,4'-C-Methylenecytidine is a Nucleoside Derivative - LNA-related nucleoside.

Apigenin 6-C-(2-O-feruloyl)glucoside 8-C-glucoside is a useful organic compound for research related to life sciences and the catalog number is T126101.

TLR7/8 agonist 4 hydroxy-PEG10-acid (compound 9) is a drug-linker conjugate employed in antibody-drug conjugates (ADC). This compound exhibits remarkable antitumor activity by utilizing TLR7/8 agonist 4, which acts as a potent activator of TLR7/8. The TLR7/8 agonist 4 is linked to hydroxy-PEG10-acid, the ADC linker, via a cleavable bond. Overall, it demonstrates promising pharmaceutical potential in the context of ADC-based therapeutics.