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Search Results for " achr "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9889	M4 mAChR agonist-1	4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-	AChR
	M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM).		AChR
T5655	MAChR-IN-1 hydrochloride		AChR
	mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm.		AChR
T12165	NAChR agonist 1	DUN71755	AChR
	nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.		AChR
T24167	Inflachromene	ICM	Others
	Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial...		Others
T61064	NAChR antagonist 1
	nAChR antagonist 1 (compound B15) is a highly effective antagonist of α7 nAChR, demonstrating an IC50 value of 3.3 μM. Its versatility makes it an ideal candidate for investigating the pathogenesis of schizophrenia, Alzh...
T124630	Carpachromene
	Carpachromene is a useful organic compound for research related to life sciences and the catalog number is T124630.
T62317	α7 nAchR-JAK2-STAT3 agonist 1
	α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β...
T26370	(25S)-delta7-Dafachronic acid
	(25S)-delta7-Dafachronic acid, an orphan nuclear receptor DAF-12 ligand, inhibits the dauer-promoting activity of DAF-12.
T5476	MAChr-in-1		AChR
	mAChR-IN-1 is muscarinic cholinergic receptor(mAChR) antagonist (IC50=17 nM).		AChR
T40177	NAChR agonist 2
	Compound 8, identified as a selective alpha4beta2 (α4β2) neuronal acetylcholine receptor (nAChR) agonist, demonstrates a dissociation constant (Kd) of 26 nM, indicating high affinity for this receptor subtype.
T68540	Sargachromanol E
	Sargachromanol E is a compound isolated from the marine brown alga, Sargassum horneri. It has been studied for its inhibitory effect on skin ageing.
T74396	NAChR modulator-1
	nAChR modulator-1, a insecticide, is a insect nAChR orthosteric modulator [1] .
T33300	Metachrome yellow	Acid Chrome Yellow 2GW,Java Unichrome Yellow GT,Alizarin Yellow GG,RV 1,C.I. 14025
	Metachrome yellow is a dye.
T74397	NAChR modulator-2
	nAChR modulator-2, a insecticide, is a insect nAChR orthosteric modulator [1] .
T123924	Werneriachromene; 3-(2.2-Dimethyl-2H-1-benzopyran-
	Werneriachromene; 3-(2.2-Dimethyl-2H-1-benzopyran- is a useful organic compound for research related to life sciences. The catalog number is T123924 and the CAS number is 92632-00-3.
T125780	Drynachromoside A
	Drynachromoside A is a useful organic compound for research related to life sciences and the catalog number is T125780.
T83182	AChRα(97-116)
	AChRα(97-116), a peptide implicated in experimental autoimmune myasthenia gravis (EAMG) induction, serves as a targeted agent in this autoimmune disorder [1].
T39771	NAChR agonist CMPI hydrochloride
	CMPI hydrochloride, a potent and selective nAChR agonist, functions as a positive allosteric modulator (PAM) specifically targeting the α4:α4 subunit interface of the nAChR. It enhances the response of the (α4)3(β2)2 nAC...
T131597	Tachrosin
	Tachrosin is a useful organic compound for research related to life sciences and the catalog number is T131597.
T81888	MAChR antagonist 1
	Compound 4a, a mAChR antagonist, exhibits K i values of 255 nM for M1 and M5 subtypes, and lower values of 121 nM and 158 nM for M3 and M4 subtypes, respectively [1].
T0818	Decamethonium bromide	Decacuran,Syncurine	AChR , AChE
	Decamethonium bromide (Syncurine) is a neuromuscular blocker and nicotinic AChR partial agonist.		AChR , AChE
T0286	Bephenium (hydroxynaphthoate)	Bephenium Hydroxynaphthoate	Parasite
	Bephenium hydroxynaphthoate is a B-type AChR activator, formerly used in the treatment of hookworm infections and ascariasis.		Parasite
T0703	Flavoxate hydrochloride	Flavoxate HCl,NSC-114649,DW61,Rec-7-0040	AChR
	Flavoxate hydrochloride (DW61) , a muscarinic AChR antagonist, is used in the therapy of various urinary syndromes and as an antispasmodic.		AChR
T0166	Pancuronium dibromide	Pancuronium bromide,Pavulon	AChR
	Pancuronium dibromide (Pavulon), a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide(Pancuronium bromide) blocking neuromuscular transmission is achieved by competing ...		AChR
T25538	Iperoxo	Iperoxo iodide	AChR
	Iperoxo (Iperoxo iodide) is an agonist of Muscarinic AChR and can be used to probe activation-related conformational transitions of muscarinic receptors.		AChR
T6684	Succinylcholine Chloride Dihydrate	choline chloride succinate,Succinyldicholine dichloride,Suxamethonium Chloride Dihydrate	AChR
	Succinylcholine Chloride Dihydrate (Succinyldicholine dichloride) is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.		AChR
T6607	Nitenpyram	Niterndipoine,Bestguard,Capstar	AChR
	Nitenpyram (Capstar) is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.		AChR
T0287	Hexamethonium Bromide	Gangliostat,Simpatoblock,Hexamethonium Dibromide	Apoptosis , Dopamine Receptor , AChR
	Hexamethonium Bromide (Hexamethonium Dibromide), a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier.		Apoptosis , Dopamine Receptor , AChR
T0427	Homatropine Methylbromide	Homatropine methobromide	AChR
	Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.		AChR
T1628	Rivastigmine tartrate	SDZ-ENA 713,ENA 713	AChR , AChE
	Rivastigmine tartrate (SDZ-ENA 713) is a carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON...		AChR , AChE
T0720	Gallamine triethiodide	Benzkurin,Flaxedil	AChR
	Gallamine triethiodide (Benzkurin), a synthetic inhibiting drug, is nondepolarizing.		AChR
T76555	Rabies Virus Matrix Protein Fragment(RV-MAT)
	Rabies Virus Matrix Protein Fragment (RV-MAT), a polypeptide, selectively binds to the acetylcholine receptor (AChR) located on the cell surface [1].
T33289	Meproadifen
	Meproadifen enhances activation and desensitization of the acetylcholine receptor-ionic channel complex (AChR).
T68362	RJR-2429
	RJR-2429 is a potent AChR agonist.
T60399	Bephenium
	Bephenium is an activator of B-type AChR which is anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis.
T74690	Monarsen
	Monarsen (EN101), a synthetic 20-base antisense oligodeoxynucleotide targeting the human AChE gene, is utilized in researching autoimmune myasthenia gravis (MG). This neuromuscular disorder is characterized by autoantibo...
T75283	Atracurium
	Atracurium (BW-33A free acid) is a potent, competitive, non-depolarizing neuromuscular blocking agent and an AChR receptor antagonist. It induces bronchoconstriction and neuromuscular blockade, in addition to promoting a...
T80338	RVG	Rabies Virus Glycoprotein-29,RVG29,RDP
	RVG29, a peptide originating from Rabies Virus Glycoprotein, specifically targets the α-7 subunit of nicotinic acetylcholine receptors (AchR) on neuronal cells, thereby facilitating the transport of Mycobacterium tubercu...
T76342	α-Conotoxin M I
	α-Conotoxin M I selectively inhibits mAChR and α1β1γδ nAChR without affecting nicotine-stimulated dopamine release. It belongs to the α-conotoxins class, which are small, disulfide-rich peptides known to competitively in...

Compounds

M4 mAChR agonist-1

T9889

Synonym: 4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-

Target: AChR

mAChR-IN-1 hydrochloride

α7 nAchR-JAK2-STAT3 agonist 1

T62317

Synonym:

Target:

(25S)-delta7-Dafachronic acid

Synonym: Acid Chrome Yellow 2GW,Java Unichrome Yellow GT,Alizarin Yellow GG,RV 1,C.I. 14025

Werneriachromene; 3-(2.2-Dimethyl-2H-1-benzopyran-

nAChR agonist CMPI hydrochloride

Decamethonium bromide

T0818

Synonym: Decacuran,Syncurine

Target: AChR, AChE

Bephenium (hydroxynaphthoate)

T0286

Synonym: Bephenium Hydroxynaphthoate

Target: Parasite

Flavoxate hydrochloride

T0703

Synonym: Flavoxate HCl,NSC-114649,DW61,Rec-7-0040

Target: AChR

Pancuronium dibromide

T0166

Synonym: Pancuronium bromide,Pavulon

Target: AChR

Iperoxo

T25538

Synonym: Iperoxo iodide

Target: AChR

Succinylcholine Chloride Dihydrate

T6684

Synonym: choline chloride succinate,Succinyldicholine dichloride,Suxamethonium Chloride Dihydrate

Target: AChR

Nitenpyram

T6607

Synonym: Niterndipoine,Bestguard,Capstar

Target: AChR

Hexamethonium Bromide

T0287

Synonym: Gangliostat,Simpatoblock,Hexamethonium Dibromide

Target: Apoptosis, Dopamine Receptor, AChR

Homatropine Methylbromide

T0427

Synonym: Homatropine methobromide

Target: AChR

Rivastigmine tartrate

T1628

Synonym: SDZ-ENA 713,ENA 713

Target: AChR, AChE

Gallamine triethiodide

T0720

Synonym: Benzkurin,Flaxedil

Target: AChR

Rabies Virus Matrix Protein Fragment(RV-MAT)

Synonym: Rabies Virus Glycoprotein-29,RVG29,RDP

Cat No.	Product Name	Synonyms	Targets
TN7250	Torachrysone Triglucoside	1-[8-[(O-β-D-Glucopyranosyl-(1→3)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl)oxy]-1-hydroxy-6-methoxy-3-methyl-2-naphthalenyl]ethanone	Others
	Torachrysone Triglucoside is a glucoside isolated from cassia seeds with potential antitumor activity.		Others
TN7253	Torachrysone gentiobioside
	Torachrysone gentiobioside is a phenolic glycoside isolated from cassia seeds.
TN7248	Torachrysone tetraglucoside		Antioxidant , Antifungal
	Torachrysone tetraglucoside is a phenolic glycoside isolated from the leguminous plant cassia with antioxidant and antimicrobial activities.		Antioxidant , Antifungal
TN2277	Torachrysone-8-O-b-D-glucoside	Torachrysone 8-O-glucoside	Antifection
	Torachrysone-8-O-b-D-glucoside shows alpha-glucosidase inhibitory activities, it may be used for the management of type 2 diabetes.		Antifection
TN1774	Isobavachromene		Others , Antibacterial
	Isobavachromene is an inhibitor of NADH-Ubiquinone oxidoreductase and ornithine decarboxylase. Isobavachromene has antifungal activity.		Others , Antibacterial
T5525	Shiraiachrome A
	Shiraiachrome A is a natural product for research related to life sciences. The catalog number is T5525 and the CAS number is 124709-39-3.
TN2278	Torachrysone		Antifection
	Torachrysone shows promising antioxidant activity. Torachrysone, toralactone , aloe-emodin, rhein and emodin show noticeable antibacterial effects on four strains of methicillin-resistant Staphylococcus aureus with a min...		Antifection
TN6176	Platachromone B	5,7,4'-Trihydroxy-8-isoprenyl-2-styrylchromone
	Platachromone B is a natural product for research related to life sciences. The catalog number is TN6176 and the CAS number is 1606149-63-6.
TN6413	Torosachrysone 8-O-beta-gentiobioside
	Torosachrysone 8-O-beta-gentiobioside is a natural product for research related to life sciences. The catalog number is TN6413 and the CAS number is 94356-13-5.
TN5759	Platachromone A	5,7,4'-Trihydroxy-6-isoprenyl-2-styrylchromone
	Platachromone A is a natural product for research related to life sciences. The catalog number is TN5759 and the CAS number is 1606149-62-5.
TN1434	Bavachromene		BACE
	Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.		BACE
T81818	Metachromins X
	Metachromin X, a sesquiterpene quinone, halts the cell cycle of HeLa/Fucci2 cells at the S/G2/M phase [1].
TN2418	Cassiachromone		Others
	Cassiachromone has antiplasmodial activity		Others
T0962	L-Hyoscyamine	Daturine,Hyoscyamine	AChR
	L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as w...		AChR
T73856	Anagyrine hydrochloride
	Anagyrine hydrochloride ((-)-Anagyrine hydrochloride), a quinolizidine alkaloid discovered in Lupinus albus, interacts with both muscarinic and nicotinic acetylcholine receptors, demonstrating IC50 values of 132 and 2096...

Natural Products

Torachrysone Triglucoside

TN7250

Synonym: 1-[8-[(O-β-D-Glucopyranosyl-(1→3)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl)oxy]-1-hydroxy-6-methoxy-3-methyl-2-naphthalenyl]ethanone

Target: Others

Torachrysone gentiobioside

TN7253

Synonym:

Target:

Torachrysone tetraglucoside

TN7248

Synonym:

Target: Antioxidant, Antifungal

Torachrysone-8-O-b-D-glucoside

TN2277

Synonym: Torachrysone 8-O-glucoside

Target: Others, Antibacterial

Synonym: 5,7,4'-Trihydroxy-8-isoprenyl-2-styrylchromone

Target:

Torosachrysone 8-O-beta-gentiobioside

Synonym: 5,7,4'-Trihydroxy-6-isoprenyl-2-styrylchromone

Synonym: Daturine,Hyoscyamine

Target: AChR

Anagyrine hydrochloride

T73856

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02487	CHRNA1 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-00872	CHRNE Protein, Human, Recombinant (His & Myc)	Human	E. coli
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-01763	CHRNB2 Protein, Human, Recombinant (His & V5)	Human	E. coli
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
TMPJ-01188	CORO6 Protein, Human, Recombinant (His)	Human	E. coli
	Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are...
TMPH-00874	CHRNG Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-00873	CHRNG Protein, Human, Recombinant (His)	Human	Yeast
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-00871	CHRNA1 Protein, Human, Recombinant (His)	Human	E. coli
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-02486	CHRNA1 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-01762	CHRNA3 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-01718	MUSK Protein, Human, Recombinant (His)	Human	Yeast
	Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to ...
TMPY-04414	MUSK Protein, Human, Recombinant (aa 433-783, His & GST)	Human	Baculovirus-Insect Cells
	Muscle, skeletal receptor tyrosine-protein kinase, also known as Muscle-specific tyrosine-protein kinase receptor, Muscle-specific kinase receptor, and MUSK, is a single-pass type I membrane protein that belongs to the p...