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5-HT Receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission.
Cat. No. Product name CAS No. Purity Chemical Structure
TN4713 Onitisin 53823-03-3 98%
Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
T0338 Minaprine 25905-77-5 98%
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T13007 ST1936 oxalate 1782228-83-4 98%
ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, re...
TQ0130 CP-809101 479683-64-2 98%
CP-809101 is an effective and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors).
T13021 Sulamserod 219757-90-1 98%
Sulamserod is an antagonist of 5-HT4 receptor, has antiarrhythmic activities.
T15414 GR 113808 144625-51-4 98%
GR 113808 displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. GR 113808 is a potent and highly selective antagonist of 5-HT4 r...
T12215 Nexopamil racemate 116759-35-4 98%
Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on platelet aggregation in vitro and on thrombus formation in vivo...
TN4092 Galanolactone 115753-79-2 98%
Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with ...
T2S0118 Daurinoline 2831-75-6 98%
Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a ...
T22340 Granisetron 109889-09-0 98%
Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy.
T4375 Methiothepin maleate 19728-88-2 98%
Methiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
T17275 YM348 372163-84-3 98%
YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).
T12859L SB 243213 dihydrochloride 1780372-25-9 98%
SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for h...
T6655 SB-269970 hydrochloride 261901-57-9 98%
SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.
T10989 Dehydroaripiprazole 129722-25-4 98%
Dehydroaripiprazole is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms d...
T16711 Flesinoxan 98206-10-1 98%
Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).
T15760 Lintopride 107429-63-0 98%
Lintopride is an antagonist of 5HT4. It has moderate 5HT3 antagonist properties.
T13339 Wf-516 310392-94-0 98%
Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activit...
T10075L2 2-Methyl-5-HT hydrochloride 845861-49-6 98%
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.
T10837L Clocapramine 47739-98-0 98%
Clocapramine is a D2 and 5-HT2A receptors antagonist.
Onitisin
TN4713
Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
Minaprine
T0338
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
ST1936 oxalate
T13007
ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, re...
CP-809101
TQ0130
CP-809101 is an effective and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors).
Sulamserod
T13021
Sulamserod is an antagonist of 5-HT4 receptor, has antiarrhythmic activities.
GR 113808
T15414
GR 113808 displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. GR 113808 is a potent and highly selective antagonist of 5-HT4 r...
Nexopamil racemate
T12215
Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on platelet aggregation in vitro and on thrombus formation in vivo...
Galanolactone
TN4092
Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with ...
Daurinoline
T2S0118
Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a ...
Granisetron
T22340
Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy.
Methiothepin maleate
T4375
Methiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
YM348
T17275
YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).
SB 243213 dihydrochloride
T12859L
SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for h...
SB-269970 hydrochloride
T6655
SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.
Dehydroaripiprazole
T10989
Dehydroaripiprazole is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms d...
Flesinoxan
T16711
Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).
Lintopride
T15760
Lintopride is an antagonist of 5HT4. It has moderate 5HT3 antagonist properties.
Wf-516
T13339
Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activit...
2-Methyl-5-HT hydrochloride
T10075L2
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.
Clocapramine
T10837L
Clocapramine is a D2 and 5-HT2A receptors antagonist.
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