1 {1h pyrrolo[2,3 d]pyrimidin 4 yl}piperazine dihydrochloride

Aldose reductase-IN-1 (AT-001) is a aldose reductase inhibitor (IC50: 28.9 pM).

1-Palmitoyl-sn-glycero-3-phosphocholine (1-Hexadecanoyl-sn-glycero-3-phosphocholine) is a phosphocholine utilized in the design of fluorescent probes.

Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy.

CD38 inhibitor 1 is an inhibitor of CD38. For hCD38 and mouse CD38, the IC50s are 7.3 nM and 1.9 nM.

T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 µM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects.

TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research[1].

SIRT1-IN-1, a selective SIRT1 inhibitor with an IC50 of 205 nM, also demonstrates antiviral activity as an inhibitor of cytomegalovirus (CMV).

Necrostatin-1 (Nec-1) is a specific RIP1 inhibitor and necrotic apoptosis inhibitor, which inhibits TNF-α-induced necrotic apoptosis and also inhibits IDO.

diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity, catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. It binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.

2-Hydroxy-1-methoxyanthraquinone (Alizarin 1-methyl ether) is a natural product isolated from Morinda lucida Benth. (Rubiaceae) with antibacterial activity.

GLP-1(7-36) amide (MKC 253) is a peptide hormone released from intestinal L-cells upon nutrient intake. It binds to the GLP-1 receptor in the pancreas, enhancing insulin secretion from pancreatic β-cells and increasing insulin expression, thereby exhibiting antidiabetic effects.

Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis. Ferrostatin-1 potently inhibits Erastin-induced ferroptosis in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and antifungal activities.

Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is an agonist of toll-like receptor 1 2 (TLR1 2) (EC50 of 0.47 ng mL for human TLR1 2).

1-Methylimidazole is a metabolite of 1-methyl-2-thioimidazole (methimazole) which inhibits bone resorption.

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid is a chemical agent.

4-Chloro-3-(trifluoromethyl)phenyl isocyanate is a biochemical reagent that can be produced by a series of reactions between o-chlorobenzotrifluoride and acetic anhydride.

2-Amino-4'-fluorobenzophenone is a derivative of benzophenone. It is used in the synthesis of p-fluorobenzoyl chloride and has also been used as a fluorescent probe for biochemical studies such as DNA and RNA detection.

Exo-1 (Methyl 3-(4-fluorobenzoyl)-6-methyl-2-pyridinecarboxylate) is a synthetic compound that has been shown to affect the metabolism of various nutrients, as well as the regulation of various hormones. It has also been shown to have anti-inflammatory and anti-tumor effects.

3-Bromo-4-Methoxyphenylacetonitrile (ZINC2565991) is a marine derived natural products found in Aiolochroia crassa.

7-Methoxy-1-tetralone may have insecticidal activity.

2',4'-Dihydroxyacetophenone (Resacetophenone) is an alkyl-phenylketone.

5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. 5-Hydroxy-1-methylhydantoin is a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. 5-Hydroxy-1-methylhydantoin inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that 5-Hydroxy-1-methylhydantoin may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.

1-Phenyl-1, 2-ethanediol is O-benzyl oxime ether derivatives and used as pesticides.

3-Methyl-2-oxobutanoic acid (2-Oxoisovaleric acid) is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. 3-Methyl-2-oxobutanoic acid is a neurotoxin, an acidogen, and a metabotoxin. A neurotoxin causes damage to nerve cells and nerve tissues. 3-Methyl-2-oxobutanoic acid is a keto-acid, which is a subclass of organic acids. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis.

(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) is a chiral aromatic compound involved in phenylalanine metabolism. It is likely produced from phenylpyruvate via lactate dehydrogenase. The D-form is derived from bacterial sources, while the L-form is endogenous. Phenyllactate levels are normally very low in blood or urine, but high levels indicate phenylketonuria (PKU) and hyperphenylalaninemia (HPA). PKU is due to a deficiency of phenylalanine hydroxylase (PAH), causing phenylalanine to convert to phenylpyruvic acid rather than tyrosine.

Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure, however it also exhibits anti-inflammatory effects. Methyl

3-Methylbut-2-enoic acid (Senecioic acid) appears in the urine of patients with 3-Methylcrotonic aciduria, which is a disorder characterized by urine that contains increased amounts of 3-methylcrotonic acid.

1-Aminohydantoin hydrochloride is a significant metabolite of furantoin in animal tissues. It binds covalently to tissue proteins, is released under slightly acidic conditions, and can be detected by derivatization with 2-nitrobenzaldehyde forming a nitrophenyl derivative of AHD. It is used in assays to determine veterinary drug residues in meat and milk.

3-Diethylamino-1-propanol exhibits anticonvulsant effects.

6-Chloro-1-tetralone (6-chloro-3;5-Chloro-1-Indomone) is an important intermediate for the synthesis of pharmaceutical compounds.

4-Chloro-3-nitrobenzoic acid is a nitric oxide scavenger and has been used to study the effects of nitric oxide on the cardiovascular system and the effects of nitric oxide on the immune system.

2-O-α-D-Glucopyranosyl-L-ascorbic Acid (ASCORBYL GLUCOSIDE), a glucoside derivative of ascorbic acid, exhibits anti-cancer properties upon enzymatic conversion to ascorbic acid.

H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones

Dolutegravir intermediate-1 (1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) is a new synthetic Dolutegravir intermediate. Dolutegravir is an integrase inhibitor developed for the treatment of human immunodeficiency virus (HIV)-1 infection.

Trans-2-butene-1,4-dicarboxylic acid (3-Hexenedioic Acid) is a normal human unsaturated dicarboxylic acid metabolite with increased excretion in patients with Dicarboxylic aciduria caused by fatty acid metabolism disorders The urinary excretion of Trans-2-butene-1,4-dicarboxylic acid is increased in conditions of augmented mobilization of fatty acids or inhibited fatty acid oxidation.

Potassium 7-hydroxy-1-naphthalenesulfona (2-Naphthol-8-sulfonic Acid Potassium Salt) is naturally present in the fruit of the Rubiaceae gardenia, the flowers of the Iridaceae crocus, and the flowers and leaves of the Scrophulariaceae Scrophulariaceae.

1-Indanone (Indan-1-one) is the intermediate od Indinavir.

1-Hexadecanol (Hexadecan-1-ol), a fatty alcoholis, is utilized for making other chemicals.

1-Dodecanol, an endogenous metabolite and saturated fatty alcohol derived from coconut oil fatty acids, is characterized by a floral odor. It is utilized in detergents, Lepidopteran pheromone sex attractant, lubricating oils, pesticides, and pharmaceuticals.

2-Pyridylethylamine dihydrochloride is a Histamine H1 receptor agonist.

1-Nonanol (Nonan-1-ol) is a fragrance with antifungal activity that acts by disrupting cell membrane integrity and mitochondrial function.

2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.

1-Heptadecanol is a long-chain primary alcohol with antibacterial activity derived from Solena amplexicaulis leaves [1]. [1]. Soumendranath Chatterjee, et al. Antibacterial Activity of Long-Chain Primary Alcohols from Solena amplexicaulis Leaves. Proceedings of the Zoological Society volume 71, pages313-319(2018).

N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound used in the synthesis of PROTAC MG-277 [1].

3-Amino-2-piperidinone is a metabolite from all living organisms and can be used as a cyclic ornithine analogue.

1-(6-Methoxy-2-naphthyl)ethanol is used as pharmaceutical intermediates.

2-(1H-Indol-3-yl)ethan-1-ol (3-(2-Hydroxyethyl)indole) is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation.

4'-(2-Methylpropyl)acetophenone (4-Isobutylacetophenone) is used as pharmaceutical intermediates.