1,3 dibromo 5,5 dimethylhydantoin

1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTAC.

Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) is a thalidomide-based Cereblon ligand that binds to the IRAK4 protein ligand via a linker to form PROTACIRAK4 degrader-1.

Thalidomide-5-methyl is a Thalidomide-based cereblon (CRBN) ligand used for the recruitment of CRBN protein.

Thalidomide-5-NH2-CH2-COOH (compound 114) is a selective inhibitor of the protomyosin receptor kinase and a ligand for E3 ligase, offering potential for studying various diseases.

Thalidomide-5-propargyne-NH2 hydrochloride, a Thalidomide-derived cereblon ligand, is utilized in recruiting CRBN protein and can be linked to a protein ligand via a linker to form PROTACs [for protein degradation].

Pomalidomide-5-C10-NH2 hydrochloride, a Pomalidomide-derived cereblon (CRBN) ligand, facilitates the recruitment of CRBN protein. This compound can be tethered to a protein ligand via a linker to construct a PROTAC [1].

Pomalidomide-5-C11-NH2 hydrochloride is a Pomalidomide-derived cereblon (CRBN) ligand that facilitates CRBN protein recruitment and can be conjugated to a protein ligand via a linker to create a PROTAC [1].

PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound targeting and degrading α-synuclein aggregates, with a DC50 value of 7.51 μM and a maximum degradation rate (Dmax) of 89%. It incorporates the probe molecule sery308 and E3 ligase ligands, suitable for neurological disease research [1].

Pomalidomide-5-C8-NH2 hydrochloride, a Pomalidomide-based cereblon (CRBN) ligand, is instrumental in the recruitment of CRBN protein. This compound can be linked to the protein ligand via a linker to form PROTAC [1].

Thalidomide-5-NH-PEG1-NH2 hydrochloride is a Thalidomide-based cereblon ligand designed for CRBN protein recruitment. It facilitates the formation of PROTAC molecules by linking to target protein ligands, such as THAL-SNS-032, via a connector.

Lenalidomide 5'-piperazine, a cerebellar ligand utilized in PROTAC development, facilitates the binding of an E3 ligand to its terminal piperazine. This connection enables subsequent chemical reactions aimed at generating a protein deactivator, employing a rigid linker [1].

Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases. Chem.Commun.(Camb) 55 1821 PMID:30672516

Thalidomide-5-CH2-NH2 (hydrochloride) is a Thalidomide derivative that acts as a cereblon ligand for CRBN protein recruitment. This compound can be linked to a protein ligand via a linker to form PROTACs.

PROTAC EGFR Degrader 5 (Compound 10), a potent degrader of EGFR Del19 in HCC827 cells, achieves this with a DC50 of 34.8 nM. This compound effectively induces apoptosis in HCC827 cells and causes cell cycle arrest in the G1 phase [1].

K-Ras ligand-Linker Conjugate 5 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker for E3 ligases, such as VHL, CRBN, MDM2, and IAP. This conjugate is crucial for synthesizing PROTAC K-Ras Degrader-1, displaying a degradation efficacy of ≥70% in SW1573 cells [1].

PROTAC BRD9 Degrader-5 is a proteolysis targeting chimera (PROTAC) designed to specifically degrade Bromodomain-containing protein 9 (BRD9).

Fmoc-5-aminopentanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Thalidomide-5-O-C2-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated via a linker to form PROTACs [1].

Thalidomide-5-O-C4-NH2 hydrochloride, a cereblon ligand derived from Thalidomide, facilitates the recruitment of CRBN protein. It can be tethered to a ligand for protein recruitment through a linker, enabling the formation of PROTACs [1].

Thalidomide-5-O-C14-NH2 hydrochloride, a cereblon ligand based on Thalidomide, facilitates the recruitment of CRBN protein. By incorporating a linker, this compound can be conjugated to a ligand to create PROTACs [1].

Thalidomide-5-NH-PEG2-NH2 hydrochloride is a cereblon ligand based on Thalidomide, designed to recruit CRBN proteins. It has the capability to be linked with target protein ligands via a linker, facilitating the formation of PROTAC molecules, such as THAL-SNS-032.

Thalidomide-Piperazine 5-fluoride hydrochloride, a derivative of the cereblon (CRBN) inhibitor Thalidomide, serves as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase), facilitating the synthesis of PROTACs [1].

Methyl 1-Boc-azetidine-3-carboxylate, catalog number T66490 and CAS number 610791-05-4, is a valuable organic compound for life sciences research.

PROTAC IRAK4 degrader-5 is a Cereblon-based compound designed to selectively degrade IRAK4.

1-N-Boc-3-hydroxyazetidine (catalog number: T67084, CAS number: 141699-55-0) is a valuable organic compound used in life sciences research.

cIAP1 Ligand-Linker Conjugates 5 is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 5, is specifically designed for the development of SNIPERs[1].

Pomalidomide-5-O-CH3, a derivative of Pomalidomide, serves as a specific ligand for cereblon (CRBN) protein recruitment. It can be linked to the protein ligand to create a PROTAC.

Thalidomide-5-propoxyethanamine acts as a cereblon (CRBN) ligand derived from Thalidomide, and it serves the purpose of recruiting the CRBN protein.

PROTAC BRD4 Degrader-5 is a PROTAC-based compound that efficiently degrades BRD4 in both HER2-positive and HER2-negative breast cancer cell lines[1].

Thalidomide-5-PEG2-Cl, a Thalidomide-derived cereblon ligand, serves as the ligand for the recruitment of CRBN protein. It can be conjugated to the protein ligand via a linker to produce PROTACs.

Thalidomide-5-O-C3-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates CRBN protein recruitment and can be conjugated to a protein ligand via a linker to synthesize PROTACs [1].

Thalidomide-5-O-C5-NH2 hydrochloride, a Thalidomide-derived cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated via a linker to form PROTACs [1].

Thalidomide-5-O-C6-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated via a linker to another ligand to form proteolysis-targeting chimeras (PROTACs) [1].

Thalidomide-5-O-C7-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates CRBN protein recruitment. This compound can be tethered to a protein-targeting ligand using a linker, enabling the formation of PROTACs [1].

Thalidomide-5-PEG7-NH2 hydrochloride is a Thalidomide-based cereblon ligand used for CRBN protein recruitment, and it can be conjugated to a protein ligand with a linker to create PROTACs [1].

5-Maleimidovaleric acid, a cleavable linker for antibody-drug conjugates (ADCs) synthesis, is employed as an ADC linker[1].

1-Cbz-azetidine-3-carboxylic acid (catalog number: T66609, CAS number: 97628-92-7) is a valuable organic compound for life sciences research.

Thalidomide-5-COOH is a useful organic compound for research related to life sciences. The catalog number is T64600 and the CAS number is 1216805-11-6.

N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in synthesizing antibody-drug conjugates (ADCs) and is essential in producing the ADC compound Gemcitabine-O-Si(di-iso)-O-Mc [1].

CC-17368 is a bio-active chemical.

Thalidomide 5'-amine-alkylC6-amine serves as a specialized cereblon ligand for PROTAC research and development, combining an E3 ligase ligand and an alkylC6 linker with a terminal amine for target protein ligand conjugation. It is among a series of functionalized tool molecules designed for PROTAC R&D.

DiZPK Hydrochloride is a structural analog of pyrrolysine (Pyl), acting as a photocrosslinker for identifying direct protein-protein interactions in living prokaryotic and eukaryotic cells.

Thalidomide-Piperazine 5-fluoride is a compound synthesized as an E3 ligase ligand-linker conjugate, incorporating a cereblon ligand derived from Thalidomide and utilizing a linker commonly employed in PROTAC technology.

1-Cbz-3-Hydroxyazetidine (catalog number: T66502, CAS number: 128117-22-6) is a valuable organic compound for life sciences research.