20 carboxy arachidonic acid

20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 μM) and PPARγ (Kd = 1.7 ± 0.5 μM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.

Arachidonic acid (Immunocytophyte) is an unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.

20-(tert-Butoxy)-20-oxoicosanoic acid is an alkyl-chain-based, non-cleavable PROTAC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

5-Carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidine   acetic acid benzyl ester is a useful organic compound for research related to life sciences and the catalog number is TNU1477.

(S)-4-(Amino(carboxy)methyl)-3-methylbenzoic acid hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64800.

Omega-3 Arachidonic Acid ethyl ester, a rare polyunsaturated fatty acid with limited presence in dietary sources, is crucial for infant growth and development and offers protection against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune disorders. In human platelet membranes, it impedes arachidonyl-CoA synthetase, exhibiting a Ki of 14 μM, and shows similar inhibitory effects on arachidonoyl-CoA synthetase in calf brain extract with an IC50 of roughly 5 μM. The ethyl arachidonate derivative offers enhanced lipophilicity compared to its free acid counterpart.

1-((2'-Carboxy-[1,1'-biphenyl]-4-yl)methyl)-4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66382 and the CAS number is 884330-12-5.

8(17),12E,14-Labdatrien-20-oic acid is a natural product from Isodon yuennanensis.

6-Hydroxy-3-oxo-20(29)-lupen-28-oic acid is a useful organic compound for research related to life sciences. The catalog number is T126463 and the CAS number is 106327-33-7.

3alpha-Acetoxy-20-oxo-29-norlupane-23,28-dioic acid is a natural product for research related to life sciences. The catalog number is TN2989 and the CAS number is 262272-76-4.

5-Carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidine acetic acid is a PNA-related Derivative; Heterocyclic Compound - Fused polyheterocycle.

5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position. It inhibits 5-LO in rat basophilic leukemia cells, with a Ki value of 15 μM. In guinea pig leukocytes, 5-LO is inhibited by 5,6-dehydro arachidonic acid with an IC50 value of 10 μM.

Benzeneboronic acid, m-carboxy- is a bioactive chemical.

20-Hydroxyganoderic acid G is a lanosterane triterpenoid obtained from the ethanolic extract of Ganoderma curtisii (Ganoderma curtisii) cotyledons. 20-Hydroxyganoderic Acid G inhibited LPS-activated BV-2 microglia, with an IC50 value of 21.33 μM. 20-Hydroxyganoderic Acid G was used to study neuroinflammatory diseases associated with LPS activation. 20-Hydroxyganoderic Acid G was used to study neuroinflammatory diseases associated with microglia activated by LPS.

20-Carboxy-Leukotriene B4 (20-COOH LTB4), a metabolite of Leukotriene B4 (LTB4), exhibits high affinity for the BLT1 receptor and significantly inhibits LTB4-mediated neutrophil responses such as migration, degranulation, and leukotriene biosynthesis [1].

20(21)-dehydrolucidenic acid A is a natural product from Ganoderma lucidum.

3-Hydroxy-(28-4-coumaroyloxy)lup-20(29)-en-27-oic acid is from stem bark & twigs of Caraipa densifolia Mart. (Theaceae).

20-Hydroxy-3-oxo-28-lupanoic acid is a natural product for research related to life sciences. The catalog number is TN2800 and the CAS number is 93372-87-3.

3-Hydroxylup-20(29)en-23,28-dioic acid is a bioactive chemical.

Carboxy-PEG4-sulfonic acid is a PEG-based linker frequently used in PROTAC synthesis [1].

3α, 27-Dihydroxylupen-20(29)-en-28-oic acid methyl ester is a topoisomerase II inhibitor.

Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types by inhibiting autophagic flux and synergistically enhancing the effectiveness of chemotherapeutic agents against HeLa cells. Pulsatilla saponin D demonstrates strong haemolytic activity.

20-hydroxy Arachidic acid is a hydroxylated fatty acid that has been found in the suberin component of silver birch (B. pendula) outer bark as well as the leaves, roots, and wood of Q. ilex from Cala Violina and Colognole, Italy. 20-hydroxy Arachidic acid was identified as a potential inhibitor of human rhinovirus coat protein in a structure-based virtual screen.

Arachidonic acid sodium salt (Immunocytophyt), a polyunsaturated omega-6 fatty acid, is a key component of biomembranes and serves as a substrate for different lipid mediators, like prostaglandins (PGs). It enhances cognitive and cardiovascular functions [1].

Carboxy-PEG2-sulfonic acid, a polyethylene glycol (PEG)-derived linker, is specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid exhibits potent inhibition of superoxide-anion generation with 86.9 ± 2.8% inhibition at 1 uM.

Carboxy-PEG5-sulfonic acid, a PEG-based PROTAC linker, is utilized for the synthesis of PROTACs[1].

3alpha-Acetoxy-20(29)-lupene-23,28-dioic acid is a natural product for research related to life sciences. The catalog number is TN2988 and the CAS number is 83725-41-1.

Arachidonic acid leelamide is a phospholipase A2 inhibitor. Phospholipase A is a hydrolase responsible for the release of arachidonic acid from the sn2 position of phospholipids. The released arachidonic acid is then converted to mediators of inflammation

Lup-20(29)-en-28-oic acid, 3-hydroxy-, 10-carboxydecyl ester, (3beta)- is a bioactive chemical.

Carboxy-PEG4-phosphonic acid, a polyethylene glycol (PEG)-derived linker, is utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-uptake of free arachidonate are all important aspects of cell signalling and inflammation. Arachidonic acid-biotin was designed to allow arachidonic acid to be detected in complexes with protein binding partners such as fatty acid binding proteins (FABPs). It is thus a tool to be used in the general elucidation of the signaling and transport of free arachidonic acid.

Carboxy-PEG4-phosphonic acid ethyl ester is a PEG-based PROTAC linker used in the synthesis of PROTACs, serving as an integral compound [1].