8-cpt-2me-camp, sodium

8-CPT-2Me-cAMP sodium is a sodium salt compound that selectively activates exchange proteins activated by cAMP (Epac), which are cAMP-sensitive guanine nucleotide exchange factors (GEFs) responsible for activating small GTPases Rap1 and Rap2. It specifically activates Epac1 with an EC50 value of 2.2 μM, while showing no activation of PKA with an EC50 value greater than 10 μM [1]. Additionally, 8-CPT-2Me-cAMP sodium stimulates the Epac-mediated release of calcium ions (Ca2+) in vitro in pancreatic β-cells [2].

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity, catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. It binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.

8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimulated insulin release.

Sodium 2-hydroxybutanoate (alpha-hydroxybutyrate) is formed as a by-product of the formation of alpha-ketobutyrate via a reaction catalyzed by lactate dehydrogenase (LDH) or alpha-hydroxybutyrate dehydrogenase (alphaHBDH).

2-Deoxy-2-sulfoamino-D-glucose sodium (GlcN-2S) can potentially influence arthritis.

Sodium 2-oxopropanoate (Sodium pyruvate) is a antioxidant potentially used to treatment of chronic obstructive pulmonary disease.

Sodium 2-mercaptoethanesulfonate (Uromitexan) is a sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from antineoplastic agents, such as ifosfamide or cyclophosphamide.

D-Fructose-1,6-bisphosphate sodium salt hydrate is the intermediate in carbohydrate metabolism, including glycolysis and gluconeogenesis. During glycolysis, it is produced by phosphorylation of fructose-6-phosphate by phosphofructokinase. The reverse reaction mediated by fructose-1, 6-diphosphatase-1 is one of the rate-limiting steps of gluconeogenesis. The same reaction occurs in the chloroplasts of plants, D-Fructose-1,6-bisphosphate sodium salt hydrate as part of the reducing pentose phosphate cycle. Since cancer cells use glycolysis as a primary source of metabolic energy production, this pathway has become a major target for cancer chemotherapy.

2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.

2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- (Ulinastatin) ,as an urinary trypsin inhibitor (UTI), is a glycoprotein that is isolated from healthy human urine or synthetically produced.

Pep 2-8 ammonium salt is Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.

sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate is an organosulfur compound. It has been used as a model compound to study the effects of sulfur-containing compounds on enzymatic activities and metabolic pathways. It has also been used to study the effects of sulfur-containing compounds on the regulation of bacterial growth and gene expression.

Angiotensin 1/2 + A (2 - 8) Acetate is a Vasoconstrictor.

1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-(pyridin-4-yl)urea is a useful organic compound for research related to life sciences. The catalog number is T67700 and the CAS number is 1144075-47-7.

TLR7 8 9 antagonist 2 is an orally active and highly bioavailable vTLR7 8 9 antagonist. It inhibits HEK hTLR7, HEK hTLR8, and HEK hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7 8 9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.

8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase（PKA）, but resistant to degradation by cyclic AMP phosphodiesterase.

HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-α-mediated NF-κB activation compared to HOIPIN-1. HOIPIN-8 is a promising tool to explore cellular functions of LUBAC.

8-Hydroxyquinoline-2-carboxaldehyde serves as a pharmaceutical intermediate.

His-[D-2-ME-Trp]-Ala is a peptide fragment of the growth hormone hexarelin.

H-Phe(2-Me)-OH is a valuable organic compound for life sciences research, catalog number T66208.

E-2078, known chemically as (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8), is a stable analog of Dynorphin A (1–8) and functions as a kappa opioid receptor (KOR) agonist [1].

Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate is employed in lipid nanoparticle (LNP) delivery systems for mRNA vaccine delivery [1].

8-Chloro-4-(2-chloro-4-fluorophenoxy)quinoline is a bioactive chemical.

Ethyl 8-hydroxy-alpha-(2-propynylamino)-5-quinolinepropanoate is a bioactive chemical.

5-Acetyl-8-(benzyloxy)quinolin-2(1H)-one is a useful organic compound for research related to life sciences. The catalog number is T66336 and the CAS number is 93609-84-8.

Apigenin 6-C-(2-O-feruloyl)glucoside 8-C-glucoside is a useful organic compound for research related to life sciences and the catalog number is T126101.

2-Methoxyfuranoguaia-9-ene-8-one is a natural product for research related to life sciences. The catalog number is TN6585 and the CAS number is 88010-62-2.

8-Glucosyl-5,7-dihydroxy-2-isopropylchromone is a natural product for research related to life sciences. The catalog number is TN5698 and the CAS number is 188785-44-6.

(D(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin, serving as an oxytocin receptor antagonist, effectively nullifies the augmentation of inhibitory postsynaptic currents in CA1 pyramidal neurons by oxytocin [1].

Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS .[1] It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II.2 By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.[2],[3]

Nucleoside Derivatives - 2’-Modified nucleosides, 8-Modified purine nucleosides, Halo-nucleosides, Fluoro-modified nucleosides

1-Octylnonyl 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl](2-hydroxyethyl)amino]octanoate is a PEG lipid used in drug delivery research [1].

3'-Deoxy-2',5'-di-O-acetyl-8-hydroxyguanosine is a Nucleoside Derivative - 8-Modified purine nucleoside; 3'-Deoxy nucleoside.

Nucleoside Derivatives - 8-Aza-7-deaza-purine nucleoside

8-Methyl-2'-deoxyguanosine is a Nucleoside Derivative - 8-Modified purine nucleoside.

3-Cyanovinyl-9-(5’-O-(4,4’-dimethoxytrityl)-2’-deoxyribofuranosyl)carbazole (trans: CAS#1044273-26-8) is a useful organic compound for research related to life sciences and the catalog number is TNU0955.

3'-O-Me-C(Bz)-2'-phosphoramidite is a Nucleoside Phosphoramidite.

8-Acetyl-2-(dipropylamino)tetralin is a 5-HT(1A) receptor agonist; both isomers are active, but the (S)-isomer is the most potent.

2'-Deoxy-8-methylthio-adenosine is a Nucleoside Derivative - 8-Modified purine nucleoside.

[(2R,3S,4R,5R)-3,4-diacetyloxy-5-[2-amino-7-(cyclopropylmethyl)-8-oxopurin-9-yl]oxolan-2-yl]methyl acetate is a useful organic compound for research related to life sciences and the catalog number is TNU1306.

Sp-2'-Deoxycytidine-5'-O-(1-thiotriphosphate) (Sp-dCTP-α-S), an isomer of the sulfur-containing nucleotide derivative dCTP-α-S, functions as an inhibitor of the deoxynucleoside triphosphate triphosphohydrolase SAMHD1, with an inhibition constant (Ki) of 6.3 µM.

Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) (Rp-dUTP-α-S), a sulfur-containing nucleotide isomer and purinergic P2Y2 receptor agonist, preferentially promotes inositol phosphate accumulation in 1321N1 astrocytoma cells with P2Y2 receptors (EC50 = 12.5 µM) compared to those expressing P2Y4 receptors at a concentration of 10 µM.

Nucleoside Derivatives –8-Modified purine nucleosides

2-Amino -7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-2,3,5-tri-O-actyl-xylofuranosyl)purine is a useful organic compound for research related to life sciences. The catalog number is TNU1331 and the CAS number is 2389988-52-5.

Sodium 3-methyl-2-oxobutanoate, a precursor of pantothenic acid in Escherichia coli, can be enhanced in vitro along with alpha-ketoisocaproic (ac).

Nucleoside Derivatives –8-Modified purine nucleosides; Alpha-nucleosides

8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.

2-AHA-cAMP is an analog of the natural signaling molecule cAMP and an activator of cAMP-dependent protein kinase. It features a free terminal primary amine group that can be used for coupling to gels or fluorescent dyes.