Endogenous Metabolite

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as sex, age, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No.	Product name	CAS No.	Purity
TQ0285L	Spaglumic acid acetate		99.49%
TQ0285L	Spaglumic acid acetate is a neuropeptide found in millimolar concentrations in brain.
T7711	Uridine triphosphate	63-39-8	98%
T7711	Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor.
TN3910	Ecdysone	3604-87-3	100%
TN3910	Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D a...
T14063	7α,25-Dihydroxycholesterol	64907-22-8
T14063	7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholes...
T29011	Triiodothyronine Sulfate	31135-55-4
T29011	Triiodothyronine Sulfate is a prodrug to the Conventional Hormone Therapy of Hypothyroidism. Triiodothyronine sulfate is the main metabolite of thyroid hormone t...
T7475	S-Adenosyl-L-methionine	29908-03-0	98%
T7475	S-Adenosyl-L-methionine is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.
T37961	P-Tolualdehyde	104-87-0	98%
T37961	p-Tolualdehyde is a RIFM flavor that shows inhibition of mushroom tyrosinase.
T14545	Berberine chloride hydrate	68030-18-2	98%
T14545	Berberine chloride hydrate is an alkaloid commonly used as an antibiotic.Berberine chloride hydrate has antitumor activity, induces the generation of reactive ox...
T8110	(+)-Longifolene	475-20-7	98%
T8110	(+)-Longifolene is a naturally occurring.
T9455	4-hydroxyestrone-4-methyl ether	58562-33-7	98%
T9455	4-hydroxyestrone-4-methyl ether is the methylation of 4-OHE1, which is catalyzed by COMT.
T10029	1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine	35418-59-8	98%
T10029	1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine is an endogenous metabolite that has been found in the aging mouse brain.
T10185	6-Phosphogluconic acid	921-62-0	98%
T10185	6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor (Kis: 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphat...
T19443L	N-Acetylhistamine acetate		98%
T19443L	N-Acetylhistamine acetate is a histamine metabolite. It can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions.
T37991	15-keto Prostaglandin F2α	35850-13-6	98%
T37991	15-keto Prostaglandin F2α is a metabolite of Prostaglandin F2α that lowers intraocular pressure in rabbits.
T10020	1-Methyluric acid	708-79-2	98%
T10020	1-Methyluric acid acts on the bladder mucosa and increases the levels of insulin, triglycerides, cholesterol, and blood glucose.
T40887	N1,N12-Diacetylspermine dihydrochloride	77928-71-3	98%
T40887	N1,N12-Diacetylspermine dihydrochloride is a diacetylated derivative of Spermine. The occurrence of cancer is associated with the up-regulation of N1,N12-Diacety...
T8282	(S)-(−)-Perillyl alcohol	18457-55-1	98%
T8282	(S)-( )-Perillyl alcohol, a monoterpene found in lavender, inhibits the farnesylation of Ras, upregulates the mannose-6-phosphate receptor and induces apoptosis....
T19346	5'-Guanylic acid	85-32-5	98%
T19346	5'-Guanylic acid is involved in several metabolic disorders, including AICA-ribosiduria pathway, adenosine deaminase deficiency,adenine phosphoribosyltransferas...
T36667	2'-Deoxyadenosine-5'-triphosphate	1927-31-7	98%
T36667	2'-Deoxyadenosine-5'-triphosphate (dATP) is a naturally occurring small molecule nucleotide used in cells for DNA synthesis or replication. 2'-Deoxyadenosine-5'-...
T5614	3-Oxopentanedioic acid	542-05-2	98%
T5614	3-oxoglutaric acid or acetonedicarboxylic acid is a simple carboxylic acid, which may be used as a building block in organic chemistry. It has been found to be a...