T60220 |
ROS kinases-IN-1
|
|
ROS Kinase
|
|
ROS kinases-IN-1 is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activi... |
T33296 |
Merodantoin
|
|
Apoptosis
|
|
Merodantoin is an apoptosis inducer and triggers cell apoptosis associated with ROS-dependent autophagy. Merodantoin tar... |
T19229 |
Catalase
|
|
Others
|
|
Catalase is an essential enzyme in the metabolism of H2O2 and reactive oxygen species (ROS). The expression and localiza... |
T29017 |
TrxR1-IN-B19
|
Go-Y015 , TrxR1 IN B19 , TrxR1INB19 , Go Y015 |
Others
|
|
TrxR1-IN-B19, a TrxR1 inhibitor, selectively kills gastric cancer cells by a small molecule via targeting TrxR1 and ROS-... |
T7709 |
(E/Z)-GSK5182
|
GSK5182(Z/E) |
Estrogen/progestogen Receptor
,
ROS
|
|
(E/Z)-GSK5182 is a racemate of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active inve... |
T36902 |
RA375
|
|
Proteasome
|
|
RA375 is a inhibitor of RPN13 (26S proteasome regulatory subunit). RA375 activates UPR signaling, ROS production and apo... |
T2S2172 |
Nerolidol
|
(±)-Nerolidol , Peruviol |
Others
,
Endogenous Metabolite
,
Antibacterial
,
Parasite
,
Antifungal
|
|
1. Nerolidol shows sedative effects in animals, oxidative process plays a crucial role on neuronal pathological conseque... |
T9560 |
MAO-B-IN-2
|
|
|
|
MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC 50 values of 0.51 and 7.00 μM, respectivel... |
T8033 |
Sodium Thiocyanate
|
|
Reactive Oxygen Species
,
Others
,
Interleukin
|
|
Sodium Thiocyanate, one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharma... |
T5793 |
Britannin
|
|
Apoptosis
,
Autophagy
,
AMPK
|
|
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pat... |
T23046 |
N-tert-butyl-α-Phenylnitrone
|
(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide |
ROS
,
COX
|
|
COX-2 inhibitor |
T2597 |
Norgestrel
|
SH-850 , WY-3707 , SH-70850 , FH 122-A |
Reactive Oxygen Species
,
Estrogen/progestogen Receptor
|
|
Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel... |
T0860L |
Mefloquine
|
Ro215998 , Ro-215998 , Ro 215998 , WR 142490 , Lariam |
Others
|
|
Mefloquine is a phospholipid-interacting antimalarial drug effective against Plasmodium Falciparium with very few side e... |
T6S1653 |
Albiflorin
|
Alibiflorin |
Reactive Oxygen Species
|
|
1. Albiflorin has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action again... |
TL0006 |
Cichoric Acid
|
Chicoric Acid , Dicaffeoyltartaric acid |
Reactive Oxygen Species
,
HIV Protease
|
|
Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tiss... |
T0956 |
Avermectin B1
|
Avermectin B1a-Avermectin B1b mixt. , Abamectin |
Antibiotic
,
Autophagy
,
Parasite
|
|
Avermectin B1 (Abamectin) is served as anthelmintic and insecticide. |
T5739 |
Paederosidic acid
|
|
Apoptosis
,
BCL
|
|
Paederosidic acid has significant anti-tumor, anticonvulsant and sedative effects. Paederosidic acid increases brain gam... |
T2787 |
Picroside I
|
6'-Cinnamoylcatalpol |
MMP
,
STAT
|
|
Picroside I, a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B. It has antioxidant,... |
T6307 |
Lubiprostone
|
RU-0211 , SPI-0211 |
Chloride channel
|
|
Lubiprostone, an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation. |