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Autophagy Autophagy

Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.
Cat No. product name
T0026 Sulfalen Sulfalene, a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.
T0087 Sulfacetamide sodium salt hydrate Sulfacetamide sodium monohydrate is a sulfonamide antibiotic. It has been investigated for the treatment of rosacea and pityriasis versicolor.
T0087L Sulfacetamide sodium Sulfacetamide Sodium is an anti-infective agent. It is used topically to treat orally for urinary tract infections and skin infections.
T0123 Sulfanilamide Sulfanilamide can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
T0251 GemcitabineHOT Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
T0415 Guanidine hydrochloride Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
T0510 Sulfaguanidine Sulfaguanidine, a sulfonamide, is served as an anti-infective agent.
T0618 Indole-3-Glyoxylyl Chloride Indole-3-Glyoxylyl Chloride is an organic compunds with molecular fomula C10H6ClNO2.
T0747 Sulfathiazole Sulfathiazole, an organosulfur compound, has been served as a short-acting sulfa medicine.
T0749 Succinylsulfathiazole Succinylsulfathiazole is a sulfonamide. An ultra long-acting drug.
T0750 Sulfisoxazole Sulfisoxazole is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits...
T0754 Sulfamethizole Sulfamethizole is a sulfathiazole antibacterial reagent.
T0757 Omeprazole Omeprazole is a proton pump inhibitor (PPI), Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
T0767 Sulfapyridine Sulfapyridine is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.
T0836 Sulfadoxine Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.
T0885 Sulfamethoxazole Sulfamethoxazole is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification ...
T0913 Sulfamerazine Sulfamerazine is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para...
T0930 Sulfadiazine Sulfadiazine is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing wi...
T0987 Gimeracil Gimeracil is a competitive,reversible inhibitor of dihydropyrimidine dehydrogenase.
T10247 Adenosine 5'-diphosphoribose sodium Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a NAD+ metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channe...
T10607 BRD5631 BRD5631 is an autophagy enhancer through an mTOR-independent pathway. It affects several cellular disease phenotypes linked to autophagy, including cell surviva...
T11142 EACC  EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. EACC is a reversible autoph...
T11372 GC7 Sulfate GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
T1248 Sulfanitran Sulfanitran is a sulfonamide antibiotic used in the poultry industry.
T12831L SAR405 SAR405 suppresses autophagy induced either by starvation or by mTOR inhibition. SAR405 is a first-in-class and ATP-competitive inhibitor of PI3K class III isofo...
T14149 AICAR phosphate AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proin...
T14552 Dactolisib Tosylate Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolis...
T15024 Silmitasertib sodium salt Silmitasertib sodium salt is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
T15412 GPP78 GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y...
T1662 ALA hydrochloride Aminolevulinic acid hydrochloride is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
T16777 ROC-325 ROC-325 is a novel autophagy inhibitor.
T19188 ALLO-1 ALLO-1 is an autophagy receptor and is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 throu...
T2128 SBI-0206965 SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.
T2187 2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide is a molecule containing the sulfonamide functional group attached to an aniline.
T2731 Usnic Acid Usnic acid is an antimicrobial,antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces...
T2754 Oxymatrine Oxymatrine is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis...
T2888 Pterostilbene Pterostilbene is extracted from Pterocarpus indicus.
T2S2382 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 µM for...
T3155 SMER28 SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and ...
T3685 SR9009 SR9009, a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009...
T3688 SR9011 SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).
T4123 LYN-1604 <p>LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.</p>
T4187 Gemcitabine monophosphate sodium salt hydrate Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
T4219 Autophinib Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapam...
T4414 PRIMA-1Met PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredo...
T4519 Alisol A Alisol A may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cell...
T4977 Sofalcone Sofalcone, a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
T5045 GSK4112 GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
T5080 Spermidine hydrochloride Spermidine, a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
T5143 Corynoxine hydrochloride(6877-32-3(free base)) Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
T5162 MRT67307 HCl (1190378-57-4(free base)) MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
T5181 CA-5f CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
T5356 MRT68921 HCl MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively).
T5403 ULK-101 ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.
T5515 Hemin Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.
T5538 DC661 DC661 is palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity
T5793 Britannin Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
T5840 Hoechst 33342 Hoechst 33342, is a Benzimidazole fluorescent dye and a Cell permeable fluorescent DNA stain; binds minor groove of AT-rich regions. HOE 33342 trihydrochlorde i...
T5S0658 Corynoxine Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
T5S2102 Leonurine Leonurine is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory.
T6056 Thiamet G Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal –hexosaminidase.
T6474 Divalproex Sodium Divalproex Sodium binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentra...
T6799 IITZ-01 IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)
T6858 Hydroxyprogesterone caproate Hydroxyprogesterone Caproate is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibi...
T6899 MRT68921 MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.
T7174 Urolithin A Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T7311 Oxyphenisatin acetate Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.
T7370 Talarozole Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.4...
T8081 LC3-mHTT-IN-AN1 LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.   LC3-mHTT-IN-AN1 targeted mHTT to autophag...
T8166 Pennogenin 3-O-beta-chacotrioside Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla with anti-colorectal cancer activity. It modulates autophagy via increas...
T8200 Ginkgolide K Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.
T8308 NL-1 NL-1 is a mitoNEET inhibitor with antileukemic effect.
T8322 BL-918 BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM. 
T8689 CHLOROQUINE Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria an...
T9931 meplazumab meplazumab is a humanized anti-CD147 antibody, as add-on therapy in patients with COVID-19 pneumonia.
TMA1012 Ganoderiol F Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency vir...
TMA1570 Sappanone A Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
TN1087 Deoxypodophyllotoxin Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
TN1563 Dehydropachymic acid Dehydropachymic acid shows antiinflammatory activity.
TN1702 Glycycoumarin Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
TN2118 Pulsatilla saponin D Pulsatilla saponin D exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activity of...
TN2646 16-Hydroxycleroda-3,13-dien-15,16-olide 16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or alter...
TN3057 4-O-Methylbutein 4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of...
TN3144 6,4'-Dihydroxy-7-methoxyflavanone 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and functio...
TN3609 Catalposide Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and H...
TN3694 Coniferaldehyde Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 de...
TN3726 Cudraflavone B Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and m...
TN3806 Dehydroglyasperin C Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
TN3910 Ecdysone Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D ...
TN4038 Eupatolide Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
TN4064 Flavoglaucin Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
TN4213 Hirsutenone Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid per...
TN4234 Hydrangenol Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PC...
TN4420 Latifolin Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
TN4661 Nodosin Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 express...
TN4774 Physalin A Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate can...
TN4778 Physalin H Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR indu...
TQ0081 JPH203 JPH203 is an effective and specific L-type amino acid transporter 1 (LAT-1) inhibitor.
TQ0258 Corynoxine B Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese).
TQ0309 Glaucocalyxin B Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM)...
Sulfalen
T0026CAS 152-47-6
Sulfalene, a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.
Sulfacetamide sodium salt hydrate
T0087CAS 6209-17-2
Sulfacetamide sodium monohydrate is a sulfonamide antibiotic. It has been investigated for the treatment of rosacea and pityriasis versicolor.
Sulfacetamide sodium
T0087LCAS 127-56-0
Sulfacetamide Sodium is an anti-infective agent. It is used topically to treat orally for urinary tract infections and skin infections.
Sulfanilamide
T0123CAS 63-74-1
Sulfanilamide can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
Gemcitabine HOT
T0251CAS 95058-81-4
Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
Guanidine hydrochloride
T0415CAS 50-01-1
Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
Sulfaguanidine
T0510CAS 57-67-0
Sulfaguanidine, a sulfonamide, is served as an anti-infective agent.
Indole-3-Glyoxylyl Chloride
T0618CAS 22980-09-2
Indole-3-Glyoxylyl Chloride is an organic compunds with molecular fomula C10H6ClNO2.
Sulfathiazole
T0747CAS 72-14-0
Sulfathiazole, an organosulfur compound, has been served as a short-acting sulfa medicine.
Succinylsulfathiazole
T0749CAS 116-43-8
Succinylsulfathiazole is a sulfonamide. An ultra long-acting drug.
Sulfisoxazole
T0750CAS 127-69-5
Sulfisoxazole is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits...
Sulfamethizole
T0754CAS 144-82-1
Sulfamethizole is a sulfathiazole antibacterial reagent.
Omeprazole
T0757CAS 73590-58-6
Omeprazole is a proton pump inhibitor (PPI), Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
Sulfapyridine
T0767CAS 144-83-2
Sulfapyridine is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.
Sulfadoxine
T0836CAS 2447-57-6
Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.
Sulfamethoxazole
T0885CAS 723-46-6
Sulfamethoxazole is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification ...
Sulfamerazine
T0913CAS 127-79-7
Sulfamerazine is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para...
Sulfadiazine
T0930CAS 68-35-9
Sulfadiazine is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing wi...
Gimeracil
T0987CAS 103766-25-2
Gimeracil is a competitive,reversible inhibitor of dihydropyrimidine dehydrogenase.
Adenosine 5'-diphosphoribose sodium
T10247CAS 68414-18-6
Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a NAD+ metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channe...
BRD5631
T10607CAS T10607
BRD5631 is an autophagy enhancer through an mTOR-independent pathway. It affects several cellular disease phenotypes linked to autophagy, including cell surviva...
EACC
T11142CAS 864941-31-1
 EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. EACC is a reversible autoph...
GC7 Sulfate
T11372CAS 150417-90-6
GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
Sulfanitran
T1248CAS 122-16-7
Sulfanitran is a sulfonamide antibiotic used in the poultry industry.
SAR405
T12831LCAS 1523406-39-4
SAR405 suppresses autophagy induced either by starvation or by mTOR inhibition. SAR405 is a first-in-class and ATP-competitive inhibitor of PI3K class III isofo...
AICAR phosphate
T14149CAS 681006-28-0
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proin...
Dactolisib Tosylate
T14552CAS 1028385-32-1
Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolis...
Silmitasertib sodium salt
T15024CAS 1309357-15-0
Silmitasertib sodium salt is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
GPP78
T15412CAS 1202580-59-3
GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y...
ALA hydrochloride
T1662CAS 5451-09-2
Aminolevulinic acid hydrochloride is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
ROC-325
T16777CAS 1859141-26-6
ROC-325 is a novel autophagy inhibitor.
ALLO-1
T19188CAS 37468-32-9
ALLO-1 is an autophagy receptor and is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 throu...
SBI-0206965
T2128CAS 1884220-36-3
SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.
2-Aminobenzenesulfonamide
T2187CAS 3306-62-5
2-Aminobenzenesulfonamide is a molecule containing the sulfonamide functional group attached to an aniline.
Usnic Acid
T2731CAS 125-46-2
Usnic acid is an antimicrobial,antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces...
Oxymatrine
T2754CAS 16837-52-8
Oxymatrine is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis...
Pterostilbene
T2888CAS 537-42-8
Pterostilbene is extracted from Pterocarpus indicus.
3'-Hydroxypterostilbene
T2S2382CAS 475231-21-1
3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 µM for...
SMER28
T3155CAS 307538-42-7
SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and ...
SR9009
T3685CAS 1379686-30-2
SR9009, a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009...
SR9011
T3688CAS 1379686-29-9
SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).
LYN-1604
T4123CAS 2088939-99-3
<p>LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.</p>
Gemcitabine monophosphate sodium salt hydrate
T4187CAS 1638288-31-9
Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
Autophinib
T4219CAS 1644443-47-9
Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapam...
PRIMA-1Met
T4414CAS 5291-32-7
PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredo...
Alisol A
T4519CAS 19885-10-0
Alisol A may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cell...
Sofalcone
T4977CAS 64506-49-6
Sofalcone, a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
GSK4112
T5045CAS 1216744-19-2
GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
Spermidine hydrochloride
T5080CAS 334-50-9
Spermidine, a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
Corynoxine hydrochloride(6877-32-3(free base))
T5143CAS T5143
Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
MRT67307 HCl (1190378-57-4(free base))
T5162CAS T5162
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
CA-5f
T5181CAS 1370032-19-1
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
MRT68921 HCl
T5356CAS 2070014-87-6
MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively).
ULK-101
T5403CAS T5403
ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.
Hemin
T5515CAS 16009-13-5
Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.
DC661
T5538CAS 1872387-43-3
DC661 is palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity
Britannin
T5793CAS 33627-28-0
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
Hoechst 33342
T5840CAS 23491-52-3
Hoechst 33342, is a Benzimidazole fluorescent dye and a Cell permeable fluorescent DNA stain; binds minor groove of AT-rich regions. HOE 33342 trihydrochlorde i...
Corynoxine
T5S0658CAS 6877-32-3
Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
Leonurine
T5S2102CAS 24697-74-3
Leonurine is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory.
Thiamet G
T6056CAS 1009816-48-1
Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal –hexosaminidase.
Divalproex Sodium
T6474CAS 76584-70-8
Divalproex Sodium binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentra...
IITZ-01
T6799CAS 1807988-47-1
IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)
Hydroxyprogesterone caproate
T6858CAS 630-56-8
Hydroxyprogesterone Caproate is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibi...
MRT68921
T6899CAS 1190379-70-4
MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.
Urolithin A
T7174CAS 1143-70-0
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
Oxyphenisatin acetate
T7311CAS 115-33-3
Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.
Talarozole
T7370CAS 201410-53-9
Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.4...
LC3-mHTT-IN-AN1
T8081CAS 486443-73-6
LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.   LC3-mHTT-IN-AN1 targeted mHTT to autophag...
Pennogenin 3-O-beta-chacotrioside
T8166CAS 55916-52-4
Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla with anti-colorectal cancer activity. It modulates autophagy via increas...
Ginkgolide K
T8200CAS 153355-70-5
Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.
NL-1
T8308CAS 188532-26-5
NL-1 is a mitoNEET inhibitor with antileukemic effect.
BL-918
T8322CAS 2101517-69-3
BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM. 
CHLOROQUINE
T8689CAS 54-05-7
Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria an...
meplazumab
T9931CAS T9931
meplazumab is a humanized anti-CD147 antibody, as add-on therapy in patients with COVID-19 pneumonia.
Ganoderiol F
TMA1012CAS 114567-47-4
Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency vir...
Sappanone A
TMA1570CAS 102067-84-5
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
Deoxypodophyllotoxin
TN1087CAS 19186-35-7
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
Dehydropachymic acid
TN1563CAS 77012-31-8
Dehydropachymic acid shows antiinflammatory activity.
Glycycoumarin
TN1702CAS 94805-82-0
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
Pulsatilla saponin D
TN2118CAS 848784-85-0
Pulsatilla saponin D exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activity of...
16-Hydroxycleroda-3,13-dien-15,16-olide
TN2646CAS 141979-19-3
16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or alter...
4-O-Methylbutein
TN3057CAS 13323-67-6
4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of...
6,4'-Dihydroxy-7-methoxyflavanone
TN3144CAS 189689-32-5
6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and functio...
Catalposide
TN3609CAS 6736-85-2
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and H...
Coniferaldehyde
TN3694CAS 20649-42-7
Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 de...
Cudraflavone B
TN3726CAS 19275-49-1
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and m...
Dehydroglyasperin C
TN3806CAS 199331-35-6
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
Ecdysone
TN3910CAS 3604-87-3
Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D ...
Eupatolide
TN4038CAS 6750-25-0
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
Flavoglaucin
TN4064CAS 523-73-9
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
Hirsutenone
TN4213CAS 41137-87-5
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid per...
Hydrangenol
TN4234CAS 480-47-7
Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PC...
Latifolin
TN4420CAS 10154-42-4
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
Nodosin
TN4661CAS 10391-09-0
Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 express...
Physalin A
TN4774CAS 23027-91-0
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate can...
Physalin H
TN4778CAS 70241-09-7
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR indu...
JPH203
TQ0081CAS 1037592-40-7
JPH203 is an effective and specific L-type amino acid transporter 1 (LAT-1) inhibitor.
Corynoxine B
TQ0258CAS 17391-18-3
Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese).
Glaucocalyxin B
TQ0309CAS 80508-81-2
Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM)...