Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
TQ0215	Salinomycin sodium salt	55721-31-8	98%
TQ0215	Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
TN3910	Ecdysone	3604-87-3	100%
TN3910	Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D a...
T4187	Gemcitabine monophosphate sodium salt hydrate	1638288-31-9
T4187	Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
TQ0258	Corynoxine B	17391-18-3	98%
TQ0258	Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese).
TN4038	Eupatolide	6750-25-0	98%
TN4038	Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
T14545	Berberine chloride hydrate	68030-18-2	98%
T14545	Berberine chloride hydrate is an alkaloid commonly used as an antibiotic.Berberine chloride hydrate has antitumor activity, induces the generation of reactive ox...
TN3057	4-O-Methylbutein	13323-67-6	98%
TN3057	4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of ...
T5143	Corynoxine hydrochloride(6877-32-3(free base))	T5143	98%
T5143	Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
TN1953	Morusinol	62949-93-3	98%
TN1953	Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, ...
T6769	Elaiophylin	37318-06-2	98%
T6769	Elaiophylin shows antiprotozoal activity against Plasmodium falciparum K1a and Trypanosoma brucei brucei GUTat 3.1 strains with IC50 of 0.36 μM and 0.45 μM, resp...
T7162	R1487 Hydrochloride	449808-64-4	98%
T7162	R1487 (Hydrochloride) is an orally bioavailable and highly selective inhibitors of p38α.
TN4774	Physalin A	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T9207	GW406108X	1644443-92-4	98%
T9207	GW108X is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW837331X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block aut...
T10607	BRD5631	2446154-91-0	98%
T10607	BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked t...
T6178	PTC-209 hydrobromide	1217022-63-3	98%
T6178	PTC-209 HBr is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of ca...
TMA1570	Sappanone A	102067-84-5	98%
TMA1570	Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
T14149	AICAR phosphate	681006-28-0	98%
T14149	AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proinf...
TN4064	Flavoglaucin	523-73-9	98%
TN4064	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
T6562	Latrepirdine dihydrochloride	97657-92-6	98%
T6562	Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
T8156	Saquinavir mesylate	149845-06-7	98%
T8156	Saquinavir mesylate is an Inhibitor of HIV Proteaseused in antiretroviral therapy