Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T4123	LYN-1604	2088939-99-3	98%
T4123	LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
T15412	GPP78	1202580-59-3	98%
T15412	GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y ...
TN3806	Dehydroglyasperin C	199331-35-6	98%
TN3806	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
T64374	QN523	878581-60-3	98%
T64374	QN523 represents a novel scaffold with drug-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 shows significant in ...
TN4064	Flavoglaucin	523-73-9	98%
TN4064	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
T6806	Cilengitide TFA	199807-35-7	98%
T6806	Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectiv...
T10247	Adenosine 5′-diphosphoribose sodium	68414-18-6	98%
T10247	Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a NAD+ metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel...
T6036	Brivanib	649735-46-6	98%
T6036	Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.
T0161	Pantoprazole Sodium Hydrate	164579-32-2	98%
T0161	Pantoprazole is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease....
T0242L	Sitagliptin phosphate monohydrate	654671-77-9	98%
T0242L	Sitagliptin phosphate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
TMA1570	Sappanone A	102067-84-5	98%
TMA1570	Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
TN4213	Hirsutenone	41137-87-5	98%
TN4213	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
T35329	EAD1	1644388-26-0	98%
T35329
T6314	(R)-(-)-Gossypol	90141-22-3	98%
T6314	AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM.
T8156	Saquinavir mesylate	149845-06-7	98%
T8156	Saquinavir mesylate is an Inhibitor of HIV Proteaseused in antiretroviral therapy
T15378	Gemcitabine elaidate	210829-30-4	98%
T15378	Gemcitabine elaidate, is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential ...
T39705	ATG7-IN-1	2226229-87-2	98%
T39705	ATG7-IN-1 is a selective ATG7 inhibitor with an IC50 of 62 nM.
T6085	PF-543	1415562-82-1	98%
T6085	PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
TQ0215	Salinomycin sodium salt	55721-31-8	98%
TQ0215	Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
TQ0258	Corynoxine B	17391-18-3	98%
TQ0258	Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese).