T0026 |
Sulfalen |
Sulfalene, a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria. |
T0087 |
Sulfacetamide sodium salt hydrate |
Sulfacetamide sodium monohydrate is a sulfonamide antibiotic. It has been investigated for the treatment of rosacea and pityriasis versicolor. |
T0087L |
Sulfacetamide sodium |
Sulfacetamide Sodium is an anti-infective agent. It is used topically to treat orally for urinary tract infections and skin infections. |
T0123 |
Sulfanilamide |
Sulfanilamide can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM. |
T0251 |
GemcitabineHOT |
Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy. |
T0415 |
Guanidine hydrochloride |
Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
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T0510 |
Sulfaguanidine |
Sulfaguanidine, a sulfonamide, is served as an anti-infective agent. |
T0618 |
Indole-3-Glyoxylyl Chloride |
Indole-3-Glyoxylyl Chloride is an organic compunds with molecular fomula C10H6ClNO2. |
T0747 |
Sulfathiazole |
Sulfathiazole, an organosulfur compound, has been served as a short-acting sulfa medicine. |
T0749 |
Succinylsulfathiazole |
Succinylsulfathiazole is a sulfonamide. An ultra long-acting drug. |
T0750 |
Sulfisoxazole |
Sulfisoxazole is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits...
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T0754 |
Sulfamethizole |
Sulfamethizole is a sulfathiazole antibacterial reagent. |
T0757 |
Omeprazole |
Omeprazole is a proton pump inhibitor (PPI), Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). |
T0767 |
Sulfapyridine |
Sulfapyridine is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine. |
T0836 |
Sulfadoxine |
Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties. |
T0885 |
Sulfamethoxazole |
Sulfamethoxazole is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification ...
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T0913 |
Sulfamerazine |
Sulfamerazine is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para...
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T0930 |
Sulfadiazine |
Sulfadiazine is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing wi...
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T0987 |
Gimeracil |
Gimeracil is a competitive,reversible inhibitor of dihydropyrimidine dehydrogenase. |
T10247 |
Adenosine 5'-diphosphoribose sodium |
Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a NAD+ metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channe...
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T10607 |
BRD5631 |
BRD5631 is an autophagy enhancer through an mTOR-independent pathway. It affects several cellular disease phenotypes linked to autophagy, including cell surviva...
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T11142 |
EACC |
EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. EACC is a reversible autoph...
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T11372 |
GC7 Sulfate |
GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor. |
T1248 |
Sulfanitran |
Sulfanitran is a sulfonamide antibiotic used in the poultry industry. |
T12831L |
SAR405 |
SAR405 suppresses autophagy induced either by starvation or by mTOR inhibition. SAR405 is a first-in-class and ATP-competitive inhibitor of PI3K class III isofo...
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T14149 |
AICAR phosphate |
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proin...
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T14552 |
Dactolisib Tosylate |
Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolis...
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T15024 |
Silmitasertib sodium salt |
Silmitasertib sodium salt is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α). |
T15412 |
GPP78 |
GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y...
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T1662 |
ALA hydrochloride |
Aminolevulinic acid hydrochloride is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. |
T16777 |
ROC-325 |
ROC-325 is a novel autophagy inhibitor. |
T19188 |
ALLO-1 |
ALLO-1 is an autophagy receptor and is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 throu...
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T2128 |
SBI-0206965 |
SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2. |
T2187 |
2-Aminobenzenesulfonamide |
2-Aminobenzenesulfonamide is a molecule containing the sulfonamide functional group attached to an aniline. |
T2731 |
Usnic Acid |
Usnic acid is an antimicrobial,antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces...
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T2754 |
Oxymatrine |
Oxymatrine is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis...
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T2888 |
Pterostilbene |
Pterostilbene is extracted from Pterocarpus indicus. |
T2S2382 |
3'-Hydroxypterostilbene |
3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 µM for...
|
T3155 |
SMER28 |
SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and ...
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T3685 |
SR9009 |
SR9009, a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009...
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T3688 |
SR9011 |
SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ). |
T4123 |
LYN-1604 |
<p>LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.</p> |
T4187 |
Gemcitabine monophosphate sodium salt hydrate |
Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine. |
T4219 |
Autophinib |
Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapam...
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T4414 |
PRIMA-1Met |
PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredo...
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T4519 |
Alisol A |
Alisol A may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cell...
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T4977 |
Sofalcone |
Sofalcone, a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium. |
T5045 |
GSK4112 |
GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. |
T5080 |
Spermidine hydrochloride |
Spermidine, a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA). |
T5143 |
Corynoxine hydrochloride(6877-32-3(free base)) |
Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells. |
T5162 |
MRT67307 HCl (1190378-57-4(free base)) |
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively). |
T5181 |
CA-5f |
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. |
T5356 |
MRT68921 HCl |
MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively). |
T5403 |
ULK-101 |
ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy. |
T5515 |
Hemin |
Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer. |
T5538 |
DC661 |
DC661 is palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity |
T5793 |
Britannin |
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells. |
T5840 |
Hoechst 33342 |
Hoechst 33342, is a Benzimidazole fluorescent dye and a Cell permeable fluorescent DNA stain; binds minor groove of AT-rich regions. HOE 33342 trihydrochlorde i...
|
T5S0658 |
Corynoxine |
Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells. |
T5S2102 |
Leonurine |
Leonurine is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory. |
T6056 |
Thiamet G |
Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal –hexosaminidase. |
T6474 |
Divalproex Sodium |
Divalproex Sodium binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentra...
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T6799 |
IITZ-01 |
IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.) |
T6858 |
Hydroxyprogesterone caproate |
Hydroxyprogesterone Caproate is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibi...
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T6899 |
MRT68921 |
MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. |
T7174 |
Urolithin A |
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties. |
T7311 |
Oxyphenisatin acetate |
Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. |
T7370 |
Talarozole |
Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.4...
|
T8081 |
LC3-mHTT-IN-AN1 |
LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophag...
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T8166 |
Pennogenin 3-O-beta-chacotrioside |
Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla with anti-colorectal cancer activity. It modulates autophagy via increas...
|
T8200 |
Ginkgolide K |
Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity. |
T8308 |
NL-1 |
NL-1 is a mitoNEET inhibitor with antileukemic effect. |
T8322 |
BL-918 |
BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM. |
T8689 |
CHLOROQUINE |
Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria an...
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T9931 |
meplazumab |
meplazumab is a humanized anti-CD147 antibody, as add-on therapy in patients with COVID-19 pneumonia. |
TMA1012 |
Ganoderiol F |
Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency vir...
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TMA1570 |
Sappanone A |
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
|
TN1087 |
Deoxypodophyllotoxin |
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
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TN1563 |
Dehydropachymic acid |
Dehydropachymic acid shows antiinflammatory activity. |
TN1702 |
Glycycoumarin |
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6. |
TN2118 |
Pulsatilla saponin D |
Pulsatilla saponin D exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activity of...
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TN2646 |
16-Hydroxycleroda-3,13-dien-15,16-olide |
16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or alter...
|
TN3057 |
4-O-Methylbutein |
4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of...
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TN3144 |
6,4'-Dihydroxy-7-methoxyflavanone |
6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and functio...
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TN3609 |
Catalposide |
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and H...
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TN3694 |
Coniferaldehyde |
Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 de...
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TN3726 |
Cudraflavone B |
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and m...
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TN3806 |
Dehydroglyasperin C |
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
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TN3910 |
Ecdysone |
Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D ...
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TN4038 |
Eupatolide |
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
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TN4064 |
Flavoglaucin |
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
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TN4213 |
Hirsutenone |
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid per...
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TN4234 |
Hydrangenol |
Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PC...
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TN4420 |
Latifolin |
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
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TN4661 |
Nodosin |
Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 express...
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TN4774 |
Physalin A |
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate can...
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TN4778 |
Physalin H |
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR indu...
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TQ0081 |
JPH203 |
JPH203 is an effective and specific L-type amino acid transporter 1 (LAT-1) inhibitor. |
TQ0258 |
Corynoxine B |
Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese). |
TQ0309 |
Glaucocalyxin B |
Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM)...
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