Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat No.	product name
T0026	Sulfalen	Sulfalene, a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.
T0087	Sulfacetamide sodium salt hydrate	Sulfacetamide sodium monohydrate is a sulfonamide antibiotic. It has been investigated for the treatment of rosacea and pityriasis versicolor.
T0087L	Sulfacetamide sodium	Sulfacetamide Sodium is an anti-infective agent. It is used topically to treat orally for urinary tract infections and skin infections.
T0123	Sulfanilamide	Sulfanilamide can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
T0194	Chloroquine diphosphateHOT	Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
T0251	GemcitabineHOT	Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
T0415	Guanidine hydrochloride	Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
T0510	Sulfaguanidine	Sulfaguanidine, a sulfonamide, is served as an anti-infective agent.
T0607	Dihydroartemisinin	Dihydroartemisinin is a metabolite of artemisinin.
T0618	Indole-3-Glyoxylyl Chloride	Indole-3-Glyoxylyl Chloride is an organic compund with molecular fomula C10H6ClNO2.
T0722	Ursolic acid	Ursolic acid(Bungeolic acid), a natural pentacyclic triterpenoid carboxylic acid, shows anti-tumor effects.
T0747	Sulfathiazole	Sulfathiazole, an organosulfur compound, has been served as a short-acting sulfa medicine.
T0749	Succinylsulfathiazole	Succinylsulfathiazole is a sulfonamide. An ultra long-acting drug.
T0750	Sulfisoxazole	Sulfisoxazole is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits...
T0754	Sulfamethizole	Sulfamethizole is a sulfathiazole antibacterial reagent.
T0757	Omeprazole	Omeprazole is a proton pump inhibitor (PPI), Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
T0767	Sulfapyridine	Sulfapyridine is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.
T0828	Bromhexine hydrochloride	Bromhexine hydrochloride is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
T0836	Sulfadoxine	Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.
T0885	Sulfamethoxazole	Sulfamethoxazole is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification ...
T0913	Sulfamerazine	Sulfamerazine is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para...
T0930	Sulfadiazine	Sulfadiazine is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing wi...
T0982	(+)-Emetine dihydrochloride hydrate	Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root.
T0987	Gimeracil	Gimeracil is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.
T10247	Adenosine 5'-diphosphoribose sodium	Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a NAD+ metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channe...
T1035	Hesperidin	Hesperidin is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowering activ...
T10607	BRD5631	BRD5631 is an autophagy enhancer through an mTOR-independent pathway. It affects several cellular disease phenotypes linked to autophagy, including cell surviva...
T11142	EACC	EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. EACC is a reversible autophag...
T11372	GC7 Sulfate	GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
T12352L	Oxidopamine hydrobromide	Oxidopamine hydrobromide is a neurotransmitter dopamine antagonist.
T1248	Sulfanitran	Sulfanitran is a sulfonamide antibiotic used in the poultry industry.
T12831L	SAR405
T14149	AICAR phosphate	AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proin...
T14552	Dactolisib Tosylate	Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolis...
T15024	Silmitasertib sodium salt	Silmitasertib sodium salt is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
T1537	RapamycinHOT	Rapamycin, a macrolide compound obtained from Streptomyces hygroscopicus, is a potent and specific mTOR inhibitor (IC50: 0.1 nM in HEK293 cells).
T15412	GPP78	GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y...
T1554	Iohexol	Iohexol is an X-ray contrast medium containing iohexol in various concentrations, from 140 to 350 milligrams of iodine per milliliter.
T1660	Silibinin	Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of s...
T1662	5-Aminolevulinic acid hydrochloride	Aminolevulinic acid hydrochloride is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.