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Autophagy Autophagy

Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.
Cat No. product name
T0026 Sulfalen Sulfalene, a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.
T0087 Sulfacetamide sodium salt hydrate Sulfacetamide sodium monohydrate is a sulfonamide antibiotic. It has been investigated for the treatment of rosacea and pityriasis versicolor.
T0087L Sulfacetamide sodium Sulfacetamide Sodium is an anti-infective agent. It is used topically to treat orally for urinary tract infections and skin infections.
T0123 Sulfanilamide Sulfanilamide can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
T0251 GemcitabineHOT Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
T0415 Guanidine hydrochloride Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
T0510 Sulfaguanidine Sulfaguanidine, a sulfonamide, is served as an anti-infective agent.
T0618 Indole-3-Glyoxylyl Chloride Indole-3-Glyoxylyl Chloride is an organic compunds with molecular fomula C10H6ClNO2.
T0747 Sulfathiazole Sulfathiazole, an organosulfur compound, has been served as a short-acting sulfa medicine.
T0749 Succinylsulfathiazole Succinylsulfathiazole is a sulfonamide. An ultra long-acting drug.
T0750 Sulfisoxazole Sulfisoxazole is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.
T0754 Sulfamethizole Sulfamethizole is a sulfathiazole antibacterial reagent.
T0757 Omeprazole Esomeprazole is the S-isomer of omeprazole, with gastric proton pump inhibitor activity.
T0767 Sulfapyridine Sulfapyridine is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.
T0836 Sulfadoxine Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.
T0885 Sulfamethoxazole Sulfamethoxazole is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification ...
T0913 Sulfamerazine Sulfamerazine is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para...
T0930 Sulfadiazine Sulfadiazine is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing wi...
T0987 Gimeracil Gimeracil is a competitive,reversible inhibitor of dihydropyrimidine dehydrogenase.
T1248 Sulfanitran Sulfanitran is a sulfonamide antibiotic used in the poultry industry.
T2128 SBI-0206965 SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.
T2187 2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide is a molecule containing the sulfonamide functional group attached to an aniline.
T2731 Usnic Acid Usnic acid is an antimicrobial,antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces...
T2754 Oxymatrine Oxymatrine is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis...
T2888 Pterostilbene Pterostilbene is extracted from Pterocarpus indicus.
T3155 SMER28 SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and ...
T3685 SR9009 SR9009, a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009...
T3688 SR9011 SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).
T4123 LYN-1604 <p>LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.</p>
T4187 Gemcitabine monophosphate sodium salt hydrate Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
T4219 Autophinib Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapam...
T6056 Thiamet G Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal –hexosaminidase.
T6474 Divalproex Sodium Divalproex Sodium binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentra...
T6858 Hydroxyprogesterone caproate Hydroxyprogesterone Caproate is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibi...
T6899 MRT68921 MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.
T4414 PRIMA-1Met PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredo...
T5S0658 Corynoxine Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
T5045 GSK4112 GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
T4977 Sofalcone Sofalcone, a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
T5143 Corynoxine hydrochloride(6877-32-3(free base)) Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
T5162 MRT67307 HCl (1190378-57-4(free base)) MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
T5181 CA-5f CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
T5356 MRT68921 HCl MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively).
T5403 ULK-101 ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.
T5080 Spermidine hydrochloride Spermidine, a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
T5515 Hemin Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.
T5538 DC661 DC661 is palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity
T5793 Britannin Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
T6799 IITZ-01 IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)
T5840 Hoechst 33342 Hoechst 33342, is a Benzimidazole fluorescent dye and a Cell permeable fluorescent DNA stain; binds minor groove of AT-rich regions. HOE 33342 trihydrochlorde i...
Sulfalen
T0026CAS 152-47-6
Sulfalene, a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.
Sulfacetamide sodium salt hydrate
T0087CAS 6209-17-2
Sulfacetamide sodium monohydrate is a sulfonamide antibiotic. It has been investigated for the treatment of rosacea and pityriasis versicolor.
Sulfacetamide sodium
T0087LCAS 127-56-0
Sulfacetamide Sodium is an anti-infective agent. It is used topically to treat orally for urinary tract infections and skin infections.
Sulfanilamide
T0123CAS 63-74-1
Sulfanilamide can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
Gemcitabine HOT
T0251CAS 95058-81-4
Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
Guanidine hydrochloride
T0415CAS 50-01-1
Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
Sulfaguanidine
T0510CAS 57-67-0
Sulfaguanidine, a sulfonamide, is served as an anti-infective agent.
Indole-3-Glyoxylyl Chloride
T0618CAS 22980-09-2
Indole-3-Glyoxylyl Chloride is an organic compunds with molecular fomula C10H6ClNO2.
Sulfathiazole
T0747CAS 72-14-0
Sulfathiazole, an organosulfur compound, has been served as a short-acting sulfa medicine.
Succinylsulfathiazole
T0749CAS 116-43-8
Succinylsulfathiazole is a sulfonamide. An ultra long-acting drug.
Sulfisoxazole
T0750CAS 127-69-5
Sulfisoxazole is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.
Sulfamethizole
T0754CAS 144-82-1
Sulfamethizole is a sulfathiazole antibacterial reagent.
Omeprazole
T0757CAS 73590-58-6
Esomeprazole is the S-isomer of omeprazole, with gastric proton pump inhibitor activity.
Sulfapyridine
T0767CAS 144-83-2
Sulfapyridine is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.
Sulfadoxine
T0836CAS 2447-57-6
Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.
Sulfamethoxazole
T0885CAS 723-46-6
Sulfamethoxazole is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification ...
Sulfamerazine
T0913CAS 127-79-7
Sulfamerazine is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para...
Sulfadiazine
T0930CAS 68-35-9
Sulfadiazine is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing wi...
Gimeracil
T0987CAS 103766-25-2
Gimeracil is a competitive,reversible inhibitor of dihydropyrimidine dehydrogenase.
Sulfanitran
T1248CAS 122-16-7
Sulfanitran is a sulfonamide antibiotic used in the poultry industry.
SBI-0206965
T2128CAS 1884220-36-3
SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.
2-Aminobenzenesulfonamide
T2187CAS 3306-62-5
2-Aminobenzenesulfonamide is a molecule containing the sulfonamide functional group attached to an aniline.
Usnic Acid
T2731CAS 125-46-2
Usnic acid is an antimicrobial,antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces...
Oxymatrine
T2754CAS 16837-52-8
Oxymatrine is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis...
Pterostilbene
T2888CAS 537-42-8
Pterostilbene is extracted from Pterocarpus indicus.
SMER28
T3155CAS 307538-42-7
SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and ...
SR9009
T3685CAS 1379686-30-2
SR9009, a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009...
SR9011
T3688CAS 1379686-29-9
SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).
LYN-1604
T4123CAS 2088939-99-3
<p>LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.</p>
Gemcitabine monophosphate sodium salt hydrate
T4187CAS 1638288-31-9
Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
Autophinib
T4219CAS 1644443-47-9
Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapam...
Thiamet G
T6056CAS 1009816-48-1
Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal –hexosaminidase.
Divalproex Sodium
T6474CAS 76584-70-8
Divalproex Sodium binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentra...
Hydroxyprogesterone caproate
T6858CAS 630-56-8
Hydroxyprogesterone Caproate is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibi...
MRT68921
T6899CAS 1190379-70-4
MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.
PRIMA-1Met
T4414CAS 5291-32-7
PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredo...
Corynoxine
T5S0658CAS 6877-32-3
Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
GSK4112
T5045CAS 1216744-19-2
GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
Sofalcone
T4977CAS 64506-49-6
Sofalcone, a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
Corynoxine hydrochloride(6877-32-3(free base))
T5143CAS T5143
Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
MRT67307 HCl (1190378-57-4(free base))
T5162CAS T5162
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
CA-5f
T5181CAS 1370032-19-1
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
MRT68921 HCl
T5356CAS 2070014-87-6
MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively).
ULK-101
T5403CAS T5403
ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.
Spermidine hydrochloride
T5080CAS 334-50-9
Spermidine, a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
Hemin
T5515CAS 16009-13-5
Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.
DC661
T5538CAS 1872387-43-3
DC661 is palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity
Britannin
T5793CAS 33627-28-0
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
IITZ-01
T6799CAS 1807988-47-1
IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)
Hoechst 33342
T5840CAS 23491-52-3
Hoechst 33342, is a Benzimidazole fluorescent dye and a Cell permeable fluorescent DNA stain; binds minor groove of AT-rich regions. HOE 33342 trihydrochlorde i...