3hydroxy midostaurind5

3-Hydroxy Midostaurin-D5 (CGP52421-D5) is a deuterium-labeled 3-Hydroxy Midostaurin which is a metabolite of PKC412. PKC412 effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation (IC50s: 132 nM and 9.8 μM in culture medium and plasma).

3-Hydroxy Desloratadine-d4 is a deuterated compound of 3-Hydroxy Desloratadine.

(4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid is a deuterated compound of (4-Hydroxy-3-methoxyphenyl)acetic Acid. (4-Hydroxy-3-methoxyphenyl)acetic Acid has a CAS number of 306-08-1. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

3 Hydroxy Midostaurin Epimer 1-d5 is a deuterated compound of 3 Hydroxy Midostaurin Epimer 1. 3 Hydroxy Midostaurin Epimer 1 has a CAS number of 945260-14-0.

5-Hydroxy-L-tryptophan-4,6,7-d3 is a deuterated compound of 5-Hydroxy-L-tryptophan. 5-Hydroxy-L-tryptophan has a CAS number of 314062-44-7.

5-Hydroxyindole-3-acetic Acid-d6 is a deuterated compound of 5-Hydroxyindole-3-acetic Acid. 5-Hydroxyindole-3-acetic Acid has a CAS number of 54-16-0. 5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors (NCI).

5-Hydroxy Propafenone-d5 HCl is a deuterated compound of 5-Hydroxy Propafenone HCl.

5-Hydroxy Propafenone D5 HCl is the deuterium labeled 5-Hydroxy Propafenone.

3-Hydroxy agomelatine D3 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).

5-Hydroxy Saxagliptin-13C-d2 HCl the 13C and deuterated compound of 5-Hydroxy Saxagliptin HCl. 5-Hydroxy Saxagliptin HCl has a CAS number of 841302-24-7.

1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PE serves as an internal standard for quantifying 1-palmitoyl-2-hydroxy-sn-glycero-3-PE, a lysophospholipid naturally found to inhibit L. donovani promastigotes growth (GI50= 8 µM). Its levels are reduced in mice after alcohol-induced liver damage, in hepatocellular carcinoma mouse xenografts, and in humans following a rigorous three-day exercise regimen of 2.5 hours running daily and 14 hours post-regimen. This compound is also applied in measuring saturated lysophosphoethanolamines, highlighting its broad utility in biochemical research and disease model studies.

1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PA (1-palmitoyl-d9LPA) serves as an internal standard for the quantification of 1-palmitoyl LPA using GC- or LC-MS. This compound, an analog of LPA with palmitic acid at the sn-1 position, activates reporter gene expression in PC12 cells fitted with human lysophosphatidic acid receptor 4 (LPA4) at 0.01 to 10 µM concentrations. Additionally, 1-palmitoyl LPA prompts aggregation in isolated human platelets within the 12-300 µM range, a process reversible by prostaglandin E1 (PGE1), theophylline, or EDTA. It also interacts with calcium and magnesium to boost the efficacy of ampicillin, piperacillin, and ceftazidime against P. aeruginosa strains from cystic fibrosis patients.

5-Hydroxy tryptophol β-D glucuronide-d4 is a deuterated compound of 5-Hydroxy tryptophol β-D glucuronide.

3 Hydroxy Midostaurin Epimer 2-d5 is a deuterated compound of 3 Hydroxy Midostaurin Epimer 2.3 Hydroxy Midostaurin Epimer 2 has a CAS number of 155848-20-7.

3-Hydroxy Repaglinide-d5 is a deuterated compound of 3-Hydroxy Repaglinide.

DL-4-Hydroxy-3-methoxymandelic-d3 acid is a deuterated compound of DL-4-Hydroxy-3-methoxymandelic acid.