12 deoxo 12α acetoxyelliptone

12-Deoxo-12alpha-acetoxyelliptone is a natural product from Derris robusta.

Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13-acetate induces THP1 cell differentiation.

3β-Acetoxyurs-12-en-11-one (11-Ketoamyrinacetate) is an ursane triterpene natural product found in the stem bark of Morus mesozygia and the leaves of Ficus hirta Vahl (Moraceae).

2α,3β,24-Trihydroxyurs-12-en-28-oic acid, a natural product, is isolated from Salvia palaestina [1].

3-Hydroxy-12-oleanene-23,28-dioic acid is a natural product for research related to life sciences. The catalog number is TN2937 and the CAS number is 226562-47-6.

4beta,12-dihydroxyguaian-6,10-diene is a natural product from Alisma orientale.

11R,12-Dihydroxyspirovetiv-1(10)-en-2-one is a natural product for research related to life sciences. The catalog number is TN2593 and the CAS number is 62574-30-5.

9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME (1 g/animal) enhances the antiviral IgA and IgG antibody responses induced by a nasal influenza hemagglutinin (HA) vaccine by 5.2- and 2-fold, respectively, in mice.4 1.Hamberg, M., and Hamberg, G.Peroxygenase-catalyzed fatty acid epoxidation in cereal seeds: Sequential oxidation of linoleic acid into 9(S),12(S),13(S)-trihydroxy-10(E)-octadecenoic acidPlant Physiol.110(3)807-815(1996) 2.Hong, S.S., and Oh, J.S.Inhibitors of antigen-induced degranulation of RBL-2H3 cells isolated from wheat branJ. Korean Soc. Appl. Biol. Chem.5569-74(2012) 3.Kim, C.S., Kwon, O.W., Kim, S.Y., et al.Five new oxylipins from Chaenomeles sinensisLipids49(11)1151-1159(2014) 4.Shirahata, T., Sunazuka, T., Yoshida, K., et al.Total synthesis, elucidation of absolute stereochemistry, and adjuvant activity of trihydroxy fatty acidsTetrahedron62(40)9483-9496(2006) 5.Fuchs, D., Tang, X., Johnsson, A.-K., et al.Eosinophils synthesize trihydroxyoctadecenoic acids (TriHOMEs) via a 15-lipoxygenase dependent processBiochim. Biophys. Acta Mol. Cell Biol. Lipids1865(4)158611(2020)

12-Hydroxyganoderic acid D is a natural product

22-Hydroxy-3-oxo-12-ursen-30-oic acid is a natural product for research related to life sciences. The catalog number is TN2812 and the CAS number is 173991-81-6.

2α,3α,24-Trihydroxyolean-12-en-28-oic acid, a triterpenoid phytoalexin, isolated from peel of unripe fruits of nectarine (Prunus persica cv Fantasia), shows antifungal activity against the fungus mentioned.

(Rac)-Phorbol-12-(2-methylbutyrate), a natural product, can be isolated from croton oil [1].

11S,12-Dihydroxyspirovetiv-1(10)-en-2-one is a natural product for research related to life sciences. The catalog number is TN2594 and the CAS number is 62623-86-3.

(2α,3β)-Olean-12-ene-2,3-diol (Compound 3) is a triterpenoid compound that possesses a lupane, oleanane, and ursane skeleton.

12-Oleanene-3,6-diol has antitumor activity, it can induce apoptosis and has inhibition effect on the proliferation in RKO cell line.

3,22-Dihydroxyolean-12-en-29-oic acid is a natural product for research related to life sciences. The catalog number is TN2860 and the CAS number is 808769-54-2.

3α-Acetoxyurs-5:12-dien-24-oic acid, a natural compound, is isolatable from Boswellia sacra Fluckiger [1].

(3β)-3-Hydroxyoleanan-12-one (compound 23), a natural product, is isolated from Codonopsis ovata [1].

(3ξ,4ξ,5ξ,6ξ,7ξ,11ξ)-3,6-Dihydroxy-8-oxo-9-eremophilene-12-oic acid, a phytotoxin recently identified in Alternaria alternata ssp. tenuissima isolates, is associated with fruit spots on apples.

3,19-Dihydroxy-6,23-dioxo-12-ursen-28-oic acid is a natural product for research related to life sciences. The catalog number is TN2853 and the CAS number is 261768-88-1.

2α,3α,24-Trihydroxyurs-12-en-28-oic acid, a triterpenoid phytoalexin, shows antifungal activity against the fungus mentioned. It also shows in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.

9(11),12-Oleanadien-3-ol is a natural product from Euonymus maackii.

6,19-Dihydroxyurs-12-en-3-oxo-28-oic acid is a natural product for research related to life sciences. The catalog number is TN3143 and the CAS number is 194027-11-7.

12-Hydroxy-2,3-dihydroeuparin is a natural product of Eupatorium, Asteraceae. The catalog number is TN2596 and the CAS number is 68776-42-1. 12-Hydroxy-2,3-dihydroeuparin can be used as a reference standard.

10-Phenyl-[12]-cytochalasins Z16 (Compound 5), a member of the cytochalasins, exhibits inhibition of wheat root elongation with an IC50 of 17.35 μM [1].

2,3-Dihydroxy-olean-12-en-28-oic acids show a low cytotoxicity towards several human tumor cell lines.

The compound is extracted from Croton tiglium dried fruit.

Phorbol 12-tiglate, a derivative of Phorbol, which in turn is a hydrolyzed product of Croton oil, plays a role in tumor promotion through activation of protein kinase C. This compound and its related derivatives are employed in the construction of carcinogenic models for biomedical research [1].

'(12β)-20-(β-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-3-one is a naturally occurring compound isolated from Cladosporium microorganisms [1].'

2β,3β,23α-Trihydroxy-12-oleanen-28-oic acid shows cytotoxic activities to human lung adenocarcinoma(A-549)cell lines. 2α,3β,23-Trihydroxyolean-12-en-28-oic acid and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibit cytotoxicity in vitro against the growth of human cancer cells lines HepG-2,with IC50 values of 16.13 ± 3.83, 15.97 ± 2.47 uM, respectively.

12-Oxograndiflorenic acid is a natural product that can be extracted from Anemone and Porphyra and is cytotoxic to some cells.

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay o

12-O-Methylinophyllum D is a natural product for research related to life sciences. The catalog number is TN5897 and the CAS number is 40883-10-1.

12-Ursene-3,16,22-triol is a natural product for research related to life sciences. The catalog number is TN2603 and the CAS number is 1242085-06-8.

12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE. 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via a leukotriene B4 receptor or a common activation sequence.

Tenacigenin B, a component of the plant Poria cocos, is identified as 3-O-β-Allopyranosyl-(1→4).

3(Z),6(Z),9(Z),12(Z),15(Z)-Octadecapentaenoic acid, a microalgal polyunsaturated fatty acid (PUFA), is identified in G. kowalevskii and serves as a chemotaxonomic biomarker for microalgae and dinoflagellates.

14-Deoxy-12-hydroxyandrographolide is a natural product of Andrographis, Acanthaceae. The catalog number is TN5586 and the CAS number is 219721-33-2. 14-Deoxy-12-hydroxyandrographolide can be used as a reference standard.

12-Hydroxy-8(17),13-labdadien-16,15-olide is a natural product for research related to life sciences. The catalog number is TN2598 and the CAS number is 958885-86-4.

Olean-12-ene-3,24-diol is a natural product for research related to life sciences. The catalog number is TN4703 and the CAS number is 119318-15-9.

8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].

3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid is a natural product from Uncaria sessilifructus.

3,6,19-Trihydroxy-23-oxo-12-ursen-28-oic acid is a natural product for research related to life sciences. The catalog number is TN2903 and the CAS number is 131984-82-2.

12- Epinapelline is a diterpene alkaloid which displays anaesthetic activity as toxic neurological agents. Similar to aconitine, its suggested that modulation of voltage gated Na+ channels are responsible for these observations.

1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid is a natural product for research related to life sciences. The catalog number is TN2480 and the CAS number is 113558-03-5.

19-O-beta-D-carboxyglucopyranosyl-12-O-beta-D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene is a natural product of Pinus, Pinaceae. The catalog number is TN6493 and the CAS number is 1011714-20-7. 19-O-beta-D-carboxyglucopyranosyl-12-O-beta-D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene can be used as a reference standard.

12-Acetoxyabietic acid is a natural product for research related to life sciences. The catalog number is TN2595 and the CAS number is 83905-81-1.

Cardiotoxin Analog IV (6-12) TFA, a partial peptide of Cardiotoxin Analog IV, is derived from the venom of the Taiwan Cobra, showcasing the unique properties of snake venom cardiotoxin[1].

12-Hydroxyjasmonic acid glucoside is a COI1-JAZ-independent activator of leaf-closing movement in samanea saman.