1,3 bis(carboxyethoxy) 2,2 bis(carboxyethoxy)propane

1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane is a polyethylene glycol (PEG)-based linker compound suitable for the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

NH-bis(C1-Boc) is an uncleavable linker used for antibody-drug conjugates (ADC).

Diethylene glycol bis(p-toluenesulfonate) (Bis-Tos-PEG2) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker used in the synthesis of MT802 and SJF620, which are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively [1].

Bis-Tos-PEG4 (PROTAC Linker 16) is a PEG-based linker utilized in the synthesis of PROTACs.

Bis-Tos-PEG7 is a PEG-based PROTAC linker used in PROTAC synthesis.

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.

Bis-PEG23-endo-BCN, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PROTAC ERRα ligand 2 is an inverse agonist for the estrogen-related receptor α (ERRα) with an IC50 of 5.67 nM.

TSPO ligand-2 (Carbonic acid) is a ligand of AUTAC1 which contains a p-fluorobenzylguanine and a Fumagillol moiety.

Hydroxy-PEG4-(CH2)2-Boc is an uncleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and can also be employed in the synthesis of PROTAC.

N-Mal-N-bis(PEG2-NHS ester) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

NH-bis-PEG4 is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable linker compound used in the synthesis of antibody-drug conjugates (ADCs) [1].

Bis-Mal-PEG5 is a PEG-based linker for PROTACs, joining two essential ligands necessary for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-PEG8-acid, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs)[1]. It serves as a cleavable ADC linker, facilitating the development of specialized compounds.

PEG3-bis(phosphonic acid diethyl ester) is a polyethylene glycol (PEG) derivative linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Bis-PEG3-t-butyl ester, a PEG-based linker for PROTACs, joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

N-Boc-N-bis(PEG2-propargyl) is a PEG-derived linker used in synthesizing PROTACs [1].

PROTAC BRD4 Ligand-2 Hydrochloride serves as a ligand targeting the BRD4 protein, specifically designed for use with PROTAC CFT-2718.

Methyl 1-Cbz-azetidine-3-carboxylate acts as a stable ADC linker for synthesizing antibody-drug conjugates (ADCs) and as an alkyl chain-based PROTAC linker in developing PROTACs[1].

N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a polyethylene glycol (PEG)-based linker compound intended for the synthesis of PROTACs [1].

N-(Azido-PEG3)-N-bis(PEG4-Boc) is a polyethylene glycol (PEG) derivative designed specifically as a linker for PROteolysis TArgeting Chimeras (PROTACs)[1].

Bis-Mal-Lysine-PEG4-TFP ester, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].

Bis-acrylate-PEG6 is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-PEG9-PFP ester is a PEG-based linker for PROTACs [which joins two essential ligands, crucial for forming PROTAC molecules]. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-(Boc-PEG5)-N-bis(PEG4-acid) is a polyethylene glycol (PEG)-derived PROTAC linker used in PROTAC synthesis[1].

PROTAC BET-binding moiety 2 is an inhibitor of the BET bromodomain.

cIAP1 Ligand-Linker Conjugates 2 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. This compound is particularly useful in the design of SNIPERs [1].

Bis-PEG25-TFP ester, a PEG-based linker for PROTACs, connects two essential ligands necessary for the formation of PROTAC molecules, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

NH-bis-PEG2 is a non-cleavable 2-unit PEG ADC linker used in synthesizing antibody-drug conjugates (ADCs).

PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This compound is designed to specifically degrade estrogen-related receptor alpha (ERRα), acting as an ERRα degrader[1].

NH-bis(PEG4-acid) is a PEG-based linker used in PROTACs to connect two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

N-(Amino-PEG3)-N-bis(PEG3-Boc) is a polyethylene glycol-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Bis-PEG11-NHS ester is a PEG-based linker (PROTACs) that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Bis-PEG1-NHS ester is a non-cleavable 1-unit PEG linker used in antibody-drug conjugation (ADC) to link antibodies with drugs.

1-Boc-azetidine-3-yl-methanol [catalog number T66497, CAS number 142253-56-3] is a valuable organic compound for life sciences research.

SNIPER(TACC3)-2 targets TACC3 protein degradation via the ubiquitin-proteasome pathway. It induces cancer cell death.

PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.

PROTAC VEGFR-2 Degrader-1 (PROTAC-1), a specific degrader of PROTAC VEGFR-2, demonstrates minimal inhibition of VEGFR-2 (IC50 > 1 μM) and exhibits low anti-proliferative effects on EA.hy926 cells (IC50 > 100 μM) [1].

PROTAC VEGFR-2 degrader-2 (PROTAC-4), a specific degrader of VEGFR-2, demonstrates minimal inhibition of VEGFR-2 (IC50 > 1 μM) and low anti-proliferative activity towards EA.hy926 cells (IC50 > 100 μM) [1].

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker, incorporating a cereblon ligand based on Thalidomide and a 3-unit PEG linker, specifically designed for PROTAC technology applications.

C2-Bis-phosphoramidic acid diethyl ester is an alkyl chain-derived PROTAC linker used in the synthesis of PROTACs [1].

(R)-Azetidine-2-carboxylic acid, with catalog number T66331 and CAS number 7729-30-8, is a valuable organic compound for life sciences research.

N-(Azido-PEG4)-N-bis(PEG4-NHS ester), a PEG-based PROTAC linker, is an essential component in PROTAC synthesis [1].

6-O-2-Propyn-1-yl-D-galactose functions as an irreversible glycolinker, facilitating the attachment of cytotoxic drugs for applications in antibody-drug conjugation (ADC).