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Apoptosis

Apoptosis is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay.
Cat No. product name
TN4673 (+)-Nortrachelogenin (+)-Nortrachelogenin 是一种从 Wikstroemia indica C.A. Meyer (百里香科)中分离出来的木脂素。 (+)-Nortrachelogenin 具有抗白血病活性。
T9625 Sandalore Sandalore 通过减少细胞凋亡和增加外根鞘中延长生长期的生长因子 IGF-1 的产生来延长人类头发的生长。 Sandalore 是嗅觉受体 OR2AT4 的选择性激动剂。
T30480 BiP inducer X BiP inducer X 是免疫球蛋白重链结合蛋白 (BiP)/GRP78 的选择性诱导剂和 ER 伴侣诱导剂。 BiP inducer X 可防止神经元和视网膜细胞系中的细胞死亡。
TN6732 Oenothein B Oenothein B 是一种聚(ADP-核糖)糖水解酶的特异性抑制剂。 Oenothein B 具有抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。
TN3594 Cardanol (C15:1) Cardanol (C15:1) 存在于腰果壳液中,可诱导人黑色素瘤细胞线粒体相关的细胞凋亡。
T36573 NHWD-870 NHWD-870 是一种有效且特异性的 BET 家族溴结构域抑制剂,仅与 BRD2、BRD3、BRD4 (IC50 = 2.7 nM) 和 BRDT 结合。 NHWD-870 具有强大的抗肿瘤功效,并通过增加肿瘤细胞凋亡和抑制肿瘤增殖来抑制癌细胞-巨噬细胞相互作用。
T33296 Merodantoin Merodantoin 是一种凋亡诱导剂,可引发与 ROS 依赖性自噬相关的细胞凋亡。 Merodantoin 靶向表达参与 Akt 依赖性 ROS 产生的 KRAS 突变的癌细胞。
T16901 SMIP004 SMIP004 是一种 SKP2 E3 连接酶抑制剂。 SMIP004 是人前列腺癌细胞的癌细胞特异性凋亡诱导剂。
TN1658 Ganoderenic acid D Ganoderenic acid D是从灵芝提取物 (GLE) 的有效化合物中分离出来的天然产物。 Ganoderenic acid D 诱导细胞周期停滞和细胞凋亡并抑制癌细胞的增殖。
T22661 CHM-1 CHM-1 是细胞凋亡的诱导剂,通过激活 Cdc2 激酶活性在人肝细胞癌中显示出有效的抗肿瘤能力。 CHM-1 在体外和体内抑制微管蛋白聚合。
T6818 DEL-22379 DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ~0.5 μM.
T6055 Quisinostat Quisinostat (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and ...
T8325 SR-4835 SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TNB...
T7081 CCCP CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondr...
T2P2806 Hederacolchiside A1 Hederacolchiside A1 shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering mem...
T2341 KW-2449 KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
T0826 Meloxicam Meloxicam is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxic...
T0125 Epirubicin hydrochloride Epirubicin hydrochloride is an antineoplastic agent which can inhibit Topoisomerase.
T4957 Carnosic acid Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties.
T0877 Gallic acid Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T2921 Sinomenine hydrochloride Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.
T3923 Calycosin Calycosin acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 famil...
T3410 Momordin Ic Momordin Ic might represent a potential anticancer activity, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAP...
T8866 GW779439X GW779439X is an inhibitor of CDK.
T6897 Monomethyl auristatin E Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug c...
T4414 Eprenetapopt PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredox...
T2S0618 β-Elemonic Acid 1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antica...
T6563 LDC000067 LDC000067 is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.
T3384 Wedelolactone Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
T4134L OTS514 OTS514 is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell l...
T3340 SCR7 SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).
T4135 OTS964 hydrochloride OTS964 is a potent and selective TOPK inhibitor with potential anticancer activity.
T6419 BMS-536924 BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
T0432 Diclofenac diethylamine Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).
T2875 Angelicin Angelicin, is a furanocoumarin with anti-Y, antiviral, anti-inflammatory activity.
T9251 Fedratinib hydrochloride hydrate Fedratinib hydrochloride hydrate is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.
T7150 BTdCPU BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
T6318 AZ 628 AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.
T0093L Sorafenib Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-4/B-Raf).
T3078 SGI-1776 SGI-1776 has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.
T0414 D-Mannitol Mannitol is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any ...
T2060 ELR510444 ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter ...
T1199 Mitotane Mitotane is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormone...
T8296 5,​7,​4'-​Trimethoxyflavone 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
T6342 NSC 23766 trihydrochloride NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42.
T3602 D-Pantothenic acid sodium D-Pantothenate Sodium, the sodium salt of D-pantothenate, is a derivative of vitamin B5 which is an an essential nutrient and plays important roles in the oxidat...
T0835 Tamoxifen Citrate Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
T1829 Ruxolitinib Ruxolitinib is a potent and selective JAK1/2 inhibitor (IC50: 3.3/2.8 nM) and is relatively less selective for JAK3 (IC50: 322 nM).
TN6714 Geranylgeraniol Geranylgeraniol is an isoprenoid found in fruits, vegetables, and grains, including rice. Geranylgeraniol inhibits growth and induces apoptosis of various tumor ...
T8560 Angiotensin II human acetate Angiotensin II acetate is a vasoconstrictor that mainly acts on the AT1 receptor.
(+)-Nortrachelogenin
TN4673
(+)-Nortrachelogenin 是一种从 Wikstroemia indica C.A. Meyer (百里香科)中分离出来的木脂素。 (+)-Nortrachelogenin 具有抗白血病活性。...
Sandalore
T9625
Sandalore 通过减少细胞凋亡和增加外根鞘中延长生长期的生长因子 IGF-1 的产生来延长人类头发的生长。 Sandalore 是嗅觉受体 ...
BiP inducer X
T30480
Oenothein B
TN6732
Oenothein B 是一种聚(ADP-核糖)糖水解酶的特异性抑制剂。 Oenothein B 具有抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。
Cardanol (C15:1)
TN3594
Cardanol (C15:1) 存在于腰果壳液中,可诱导人黑色素瘤细胞线粒体相关的细胞凋亡。
NHWD-870
T36573
Merodantoin
T33296
SMIP004
T16901
SMIP004 是一种 SKP2 E3 连接酶抑制剂。 SMIP004 是人前列腺癌细胞的癌细胞特异性凋亡诱导剂。
Ganoderenic acid D
TN1658
CHM-1
T22661
DEL-22379
T6818
DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ~0.5 μM.
Quisinostat
T6055
Quisinostat (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and ...
SR-4835
T8325
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TNB...
CCCP
T7081
CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochond...
Hederacolchiside A1
T2P2806
Hederacolchiside A1 shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering mem...
KW-2449
T2341
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1...
Meloxicam
T0826
Meloxicam is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxic...
Epirubicin hydrochloride
T0125
Epirubicin hydrochloride is an antineoplastic agent which can inhibit Topoisomerase.
Carnosic acid
T4957
Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties.
Gallic acid
T0877
Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
Sinomenine hydrochloride
T2921
Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.
Calycosin
T3923
Calycosin acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 famil...
Momordin Ic
T3410
Momordin Ic might represent a potential anticancer activity, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAP...
GW779439X
T8866
GW779439X is an inhibitor of CDK.
Monomethyl auristatin E
T6897
Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug c...
Eprenetapopt
T4414
PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredox...
β-Elemonic Acid
T2S0618
1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antica...
LDC000067
T6563
LDC000067 is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.
Wedelolactone
T3384
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
OTS514
T4134L
OTS514 is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell l...
SCR7
T3340
SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).
OTS964 hydrochloride
T4135
OTS964 is a potent and selective TOPK inhibitor with potential anticancer activity.
BMS-536924
T6419
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
Diclofenac diethylamine
T0432
Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).
Angelicin
T2875
Angelicin, is a furanocoumarin with anti-Y, antiviral, anti-inflammatory activity.
Fedratinib hydrochloride hydrate
T9251
Fedratinib hydrochloride hydrate is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.
BTdCPU
T7150
BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
AZ 628
T6318
AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.
Sorafenib
T0093L
Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-4/B-Raf).
SGI-1776
T3078
SGI-1776 has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.
D-Mannitol
T0414
Mannitol is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any ...
ELR510444
T2060
ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter ...
Mitotane
T1199
Mitotane is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormone...
5,​7,​4'-​Trimethoxyflavone
T8296
5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
NSC 23766 trihydrochloride
T6342
NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42.
D-Pantothenic acid sodium
T3602
D-Pantothenate Sodium, the sodium salt of D-pantothenate, is a derivative of vitamin B5 which is an an essential nutrient and plays important roles in the oxidat...
Tamoxifen Citrate
T0835
Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
Ruxolitinib
T1829
Ruxolitinib is a potent and selective JAK1/2 inhibitor (IC50: 3.3/2.8 nM) and is relatively less selective for JAK3 (IC50: 322 nM).
Geranylgeraniol
TN6714
Geranylgeraniol is an isoprenoid found in fruits, vegetables, and grains, including rice. Geranylgeraniol inhibits growth and induces apoptosis of various tumor ...
Angiotensin II human acetate
T8560
Angiotensin II acetate is a vasoconstrictor that mainly acts on the AT1 receptor.
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