3b-methoxy-2,3-dihydrowithaferin a

Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb- -T cell activation.

2-Hydroxy-3-methoxy chalcone has anticancer activity and inhibits colon cancer.

4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomeric counterpart of SSR-125543. SSR-125543 is a potent CRF-R1 antagonist with Ki = 1.0 nM for human CRF-R1.

1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (Xanthohumol) , prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus,is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection.

3-[7 ,7- dimethyl-5-oxo -6H-pyrrolo[3,4-b]pyridin-2-yI]-1H-indole-7 -carbonitrile is an androgen receptor modulator.

(+)-6-(2-Hydroxy-3-methoxy-3-methylbutyl is a structural isomer of Ent-toddalolactone, which belongs to the coumarin group.

1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID targets GRK2.

b-Casomorphin (1-3) Acetate is a tri-peptide with an opioid effect.

Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including diabetes, cardiovascular disease, bloo

sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate is an organosulfur compound. It has been used as a model compound to study the effects of sulfur-containing compounds on enzymatic activities and metabolic pathways. It has also been used to study the effects of sulfur-containing compounds on the regulation of bacterial growth and gene expression.

Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM. Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is the R-isomer of Aleglitazar.

2,3-dihydroxy-3-methylbutanoic acid is a natural metabolite of the branched-chain amino acid leucine. It acts by activating the mTOR signaling pathway to promote the synthesis of new muscle proteins and reduce the breakdown of existing proteins, thereby increasing muscle mass and improving recovery from exercise.

rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine has an EC50 value of ≤ 0.05 μM and an E.max value of > 250 μM for TREM2.

3-methoxy-9H-carbazole is a photosensitizer, a natural compound from Klauseneria heptaphylla and Klauseneria indica.3-methoxy-9H-carbazole has anti-breast cancer activity and induces apoptosis.

2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE has a wide range of applications in life science related research.

(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one is a sesquiterpene lactone featuring a complex bicyclic structure [1].

2-(4-Hydroxy-3-methoxyphenyl)-7-methoxy-5-benzofuranpropanol is a natural product for research related to life sciences. The catalog number is TN5407 and the CAS number is 144735-57-9.

6-Methoxy-2-[2-(3'-methoxyphenyl)ethyl]chromone, designated as compound 12, is a type of chromone [1].

α,β-Dihydro-4,6-dihydroxy-2-methoxy-3-methylchalcone (compound 7), a natural product, can be isolated from the Dragon's blood of Daemonorops draco [1].

7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine is a building block.1It has been used in the synthesis of PI3K inhibitors. 1.Scott, W.J., Hentemann, M.F., Rowley, R.B., et al.Discovery and SAR of novel 2,3-dihydroimidazo[1,2-c]quinazoline PI3K inhibitors: Identification of copanlisib (BAY 80-6946)ChemMedChem.11(14)1517-1530(2016)

3'-Methoxy-3,5,4'-trihydroxyflavone-7-neohesperidoside, a flavonoid extracted from Cleome droserifolia, exhibits moderate hepatoprotective activity [1].

7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells.

4,5-Dihydroxy-2-((5-methyl-3,8-dimethylene-2-oxododecahydroazuleno[6,5-b]furan-5-yl)oxy)tetrahydro-2H-pyran-3-yl acetate is an α-arabinopyranosides analogue isolated from the aboveground parts of barley [1].

3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings.

Tenacigenin B, a component of the plant Poria cocos, is identified as 3-O-β-Allopyranosyl-(1→4).

The compound 6-[(1R,2S)-2,3-dihydroxy-1-methoxy-3-methylbutyl]-7-methoxy has been isolated from the stem of Angelica dahurica, marking its first discovery from a plant source [1].

5-Methoxy-2',3'-dehydromarmesin is a natural product for research related to life sciences. The catalog number is TN2673 and the CAS number is 54087-32-0.

1,5,8-Trihydroxy-3-methoxy-2-prenylxanthone is a natural product for research related to life sciences. The catalog number is TN2503 and the CAS number is 110187-11-6.

4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside (compound 3), a natural anticancer agent extracted from Lilium regale, exhibits potent inhibitory effects on the proliferation of A549 lung cancer cells and holds promise for applications in cancer research [1].

2,5-Dimethyl-4-methoxy-3(2H)-furanone is a natural product.

Quercetin-3-O-β-D-galactopyranosyl-(1→6)-β-D-glucopyranoside (compound 1), a flavonoid glycoside, is extractable from M. delavayi leaves [1].

25-O-Acetyl-7,8-didehydro-cimigenol-3-O-β-D-xylopyranoside is a cycloartane triterpenoid isolated from Cimicifuga acerina [1].

trans-2,3-Dihydro-3-hydroxyeuparin is a natural product for research related to life sciences. The catalog number is TN5161 and the CAS number is 64185-57-5.

2,3-dihydroxy-3-(4-hydroxyphenyl)propanoic acid is a natural product for research related to life sciences. The catalog number is TN2702 and the CAS number is 100201-57-8.

5-Hydroxy-7-methoxy-3-(4-hydroxybenzylidene)chroman-4-one is a natural product for research related to life sciences. The catalog number is TN3121 and the CAS number is 259653-54-8.

trans-2,3-Dihydro-3-ethoxyeuparin is a natural product for research related to life sciences. The catalog number is TN5160 and the CAS number is 1015698-14-2.

3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress.

5-Acetyl-3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine is a useful organic compound for research related to life sciences. The catalog number is T67591 and the CAS number is 25961-11-9.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxycarbonyl)amino)phenyl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66719 and the CAS number is 174132-31-1.

DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram-positive strains [1].

Ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65575 and the CAS number is 112811-71-9.

Nucleoside Derivatives - 8-Aza-7-deaza purine nucleosides, Halo-nucleosides

2,3-Di(3',4'-methylenedioxybenzyl)-2-buten-4-olide is a natural product for research related to life sciences. The catalog number is TN2692 and the CAS number is 137809-97-3.

m-Acetanisidide, N-(2-(diethylamino)ethyl)-2-(p-isopropoxyphenoxy)-, monohydrochloride is a bioactive chemical.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T67561 and the CAS number is 109425-51-6.

Nucleoside Derivatives - 7-Deaza-8-aza purine nucleosides; Halo-nucleosides; 6-Modified purine nucleosides

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66536 and the CAS number is 256376-65-5.

3-Epimeliasenin B is a natural product for research related to life sciences. The catalog number is TN5953 and the CAS number is 1222475-77-5.

2-Amino-4-chloro-5-iodo-N2-pivaloyl-7-[2-deoxy-3,5-di-O- (4-methylbenzoyl)-b-D-ribofuanosyl]-7H-pyrrolo[2,3-d]pyrimidine is a Nucleoside Derivative - 7-Deazapurine nucleoside; Halo-nucleoside.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(o-tolyl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65861 and the CAS number is 211637-75-1.