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Results for "

apoptosis

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    3623
    TargetMol | Activity
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    20
    TargetMol | inventory
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    109
    TargetMol | natural
  • Inhibitory Antibodies
    26
    TargetMol | composition
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    13
    TargetMol | Activity
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    74
    TargetMol | inventory
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    897
    TargetMol | natural
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    323
    TargetMol | composition
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    24
    TargetMol | Activity
Apoptozole
T32931054543-47-3
Apoptozole (Apoptosis Activator VII) inhibits the ATPase domain of Hsc70 and Hsp70, inducing apoptosis.
  • $30
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Apoptosis inducer 11
T78686
Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase within non-Hodgkin lymphoma cell lines [1].
  • Inquiry Price
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MDK83190
T177279183-19-0
MDK83190 (Apoptosis Activator 2) is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .
  • $34
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TargetMol | Inhibitor Sale
CD437
T4371125316-60-1
CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist.
  • $34
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TargetMol | Inhibitor Sale
Sorafenib
T0093L284461-73-0
Sorafenib (Bay 43-9006) is a multikinase inhibitor that targets Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6 22 90 15 20 20 57 58 nM) with oral activity. It exhibits antitumor properties and can induce autophagy, apoptosis, and agonistic iron death.
  • $34
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Gemcitabine
T025195058-81-4
Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.
  • $34
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Bortezomib
T2399179324-69-7
Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective. Bortezomib has antitumor activity and inhibits NF-κB, which can disrupt the cell cycle and induce apoptosis.
  • $38.4
  • $48
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
LY294002
T2008154447-36-6
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy.
  • $27.2
  • $34
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Trametinib
T2125871700-17-3
Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7 0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis.
  • $24.8
  • $31
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TargetMol | Citations Cited
Onvansertib
T62471034616-18-6
Onvansertib (NMS-1286937) is a PLK1 inhibitor (IC50=2 nM) with high selectivity and oral activity. Onvansertib has antitumor activity and inhibits tumor growth.
  • $30
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Inavolisib
T153752060571-02-8
Inavolisib (GDC-0077) is an orally available and selective inhibitor of PI3Kα (IC50=0.038 nM). Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3.
  • $80
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TargetMol | Inhibitor Hot
Deferoxamine
T12435870-51-9
Deferoxamine(Desferrioxamine B) is an iron chelator (binds Fe(III) and many other metal cations) that inhibits neuronopathy, may be used to modify the reduction of iron accumulation and deposition in tissues, and may improve neurological dysfunction by inhibiting ferroptosis and neuroinflammation following traumatic brain injury.Desferrioxamin-B has antioxidant, antiproliferative, Deferoxamine has antioxidant, antiproliferative, and antitumor activities, and can induce HIF-1α production, apoptosis and autophagy in cancer cells.Desferrioxamin-B can be used in the treatment of acute iron toxicity and COVID-19 related diseases.
  • $64
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Dinaciclib
T1912779353-01-4
Dinaciclib (SCH 727965) is a selective CDK inhibitor targeting CDK1, CDK2, CDK5, and CDK9 (IC50 = 3 1 1 4 nM). It exhibits potential antitumor activity by inhibiting the incorporation of thoracic glycan (dThd) DNA.
  • $47
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Y-27632 dihydrochloride
T1725129830-38-2
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
  • $39
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Niraparib
T32311038915-60-4
Niraparib (MK-4827) is a PARP inhibitor that selectively targets PARP1 and PARP2 (IC50=3.8 2.1 nM), exhibiting antitumor activity, inhibiting DNA damage repair, and inducing apoptosis.
  • $55
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Pexidartinib
T21151029044-16-3
Pexidartinib (PLX-3397) is a capsule containing a small-molecule receptor tyrosine kinase (RTK) inhibitor targeting KIT, CSF1R, and FLT3, with potential antineoplastic activity.
  • $40
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Erdafitinib
T37261346242-81-6
Erdafitinib (JNJ-42756493), a quinoxaline derivative, targets FGFR1 2 3 4.
  • $39
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
2-Deoxy-D-glucose
T6742154-17-6
2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.
  • $33
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Eribulin mesylate
T13687441045-17-6
Eribulin mesylate (E7389 mesylate) (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used in the treatment of metastatic breast cancer.
  • $430
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TargetMol | Inhibitor Hot
C188-9
T4650432001-19-9
C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.
  • $38
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Verteporfin
T3112129497-78-5
Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions. Verteporfin is also a photosensitizer used in photodynamic therapy. Verteporfin also induces apoptosis and inhibits autophagy.
  • $34
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Cl-amidine hydrochloride
T10831L1373232-26-8
Cl-amidine hydrochloride is an orally active peptidylarginine deiminase (PAD) inhibitor (IC50: 5.9 μM for PAD4) that induces apoptosis in cancer cells, induces microRNA (miR)-16 in vitro causing cell cycle arrest, prevents histone 3 citrullination, and inhibits neutrophil extracellular trap formation, improving survival in a murine sepsis model.
  • $97
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
MK-2206 dihydrochloride
T19521032350-13-2
MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8 12 65 nM) with orally active, highly potent and selective potency. MK-2206 dihydrochloride exhibits antitumor activity.
  • $30
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Romidepsin
T6006128517-07-7
Romidepsin (FR 901228) is an HDAC inhibitor that inhibits HDAC1 2 4 6 (IC50=36 47 510 1400 nM). Romidepsin has antitumor activity and can be used for the treatment of peripheral T-cell lymphoma and cutaneous T-cell lymphoma.
  • $98
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Girinimbine
TN609723095-44-5In house
Girinimbine (Girinimbin) is a carbazole alkaloid isolated from the plants M. koenigii, M. koenigii, and Murraya koenigii. Girinimbine exhibits a wide range of biological effects, including apoptosis, antitrypanosomal, antiplatelet, antimicrobial, anti-inflammatory, antioxidant, and antitumor activities.
  • $413
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TargetMol | Inhibitor Hot
Mdivi-1
T1907338967-87-6
Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy.
  • $39
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Fulvestrant
T2146129453-61-8
Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30. Fulvestrant has antitumor activity, inhibiting cell proliferation and inducing apoptosis and autophagy.
  • $42
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Notoginsenoside R1
T296180418-24-2
Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
  • $63
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TargetMol | Inhibitor Hot
Y-27632
T1870146986-50-7
Y-27632 is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
  • $39
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Tamoxifen
T690610540-29-1
Tamoxifen (ICI47699) is a selective and orally effective estrogen receptor modulator (SERM). Tamoxifen has both inhibitory (e.g., mammary cells) and activating (e.g., bone, liver, and uterine cells) activity against estrogens.
  • $39
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Myricetin
T0579529-44-2
Myricetin (Cannabiscetin) is a natural flavonoid and MEK1 inhibitor. Myricetin has hypoglycemic, antioxidant, hepatoprotective, anti-tumor and anti-inflammatory activities.
  • $30
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Rimiducid
T14298195514-63-7
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-linking the FKBP domains. It dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.
  • $138
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TargetMol | Inhibitor Hot
STM2457
T90602499663-01-1
STM2457 is an inhibitor of the RNA methyltransferase METTL3 (IC50=16.9 nM) with selective and oral activity.STM2457 can be used in acute myeloid leukemia (AML) studies.
  • $101
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TargetMol | Inhibitor Hot
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PROCYANIDIN C1
TN210337064-30-5
Procyanidin C1 is a natural product, with anti-inflammatory effects, and induces apoptosis.
  • $72
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Urolithin A
T71741143-70-0
Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities.
  • $42
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Elesclomol
T6170488832-69-5
Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-mediated Fe-S cluster biosynthesis.
  • $34
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Spautin-1
T19371262888-28-7
Spautin-1 is an autophagy inhibitor that suppresses the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Spautin-1 inhibits UPR and exhibits preferential cytotoxicity in glucose-starved cancer cells.
  • $33
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TargetMol | Inhibitor Hot
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Nimbolide
T1632425990-37-8
Nimbolide suppresses CDK4 CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-κB. Nimbolide is a triterpene derived from the leaves and flowers
  • $81
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
CSN5i-3
T108952375740-98-8In house
CSN5i-3 is a novel potent oral and selective CSN5/Jab1 inhibitor that inhibits CSN-catalyzed Cul1 deneddylation with an IC50 value of 5.8 nM.CSN5i-3 exhibits anticancer activity, inhibits cell proliferation and induces apoptosis in human breast cancer cells.
  • $378
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TargetMol | Inhibitor Hot
Angiotensin II human
T70404474-91-3
Angiotensin II human (Ang II) is a biologically active peptide, a vasoconstrictor. Angiotensin II interacts with AT1R and AT2R to regulate blood pressure, stimulate sympathetic nerves, and increase aldosterone biosynthesis and renal activity in humans.
  • $37
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Atezolizumab
T99021380723-44-3
Atezolizumab is an antibody inhibitor, a humanized monoclonal antibody, IgG1, which targets PD-L1 and blocks the interaction of PD-L1 with PD-1. Atezolizumab has antitumor activity and promotes T-cells to attack tumor cells.
  • $229
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TargetMol | Inhibitor Hot
Rhosin hydrochloride
T167451281870-42-5
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin h
  • $162
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TargetMol | Inhibitor Hot
Staurosporine
T668062996-74-1
Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6 15 2 3 3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces apoptosis.
  • $56
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DAPT
T6202208255-80-5
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis.
  • $53
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Thapsigargin
TQ030267526-95-8
Thapsigargin is a natural product, an inhibitor of sarcoplasmic endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking the ability of cells to pump calcium into the sarcoplasmic and endoplasmic reticulum.
  • $82
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Paclitaxel
T096833069-62-4
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
  • $34
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
AOH1996
T775202089314-64-5In house
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
  • $60
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TargetMol | Inhibitor Hot
Mezigdomide
T107032259648-80-9In house
Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.
  • $118
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TargetMol | Inhibitor Hot