T5793 |
Britannin
|
|
Apoptosis
,
Autophagy
,
AMPK
|
|
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pat... |
T10580 |
BOC-D-FMK
|
|
Caspase
,
Apoptosis
|
|
Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by ... |
TN3594 |
Cardanol (C15:1)
|
|
Others
,
Apoptosis
|
|
Cardanol (C15:1), found in cashew nut shell liquid, induces mitochondria-associated apoptosis in human melanoma cells. |
T8678 |
Naphthazarin
|
5,8-Dihydroxy-1,4-naphthoquinone , DHNQ |
Apoptosis
|
|
Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptos... |
T33296 |
Merodantoin
|
|
Apoptosis
|
|
Merodantoin is an apoptosis inducer and triggers cell apoptosis associated with ROS-dependent autophagy. Merodantoin tar... |
TN1684 |
Ginsenoside F5
|
|
Apoptosis
|
|
Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the a... |
T13009 |
STAT3-IN-1
|
|
Apoptosis
,
STAT
|
|
STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and ... |
T35329L |
EAD1 HCl
|
EAD1 HCL(1644388-26-0 Free base) |
Apoptosis
,
Autophagy
|
|
EAD1 HCL is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 HCL a... |
T14298 |
Rimiducid
|
|
Apoptosis
,
Others
,
Fatty Acid Synthase
|
|
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wi... |
T27093 |
CT-1
|
CT 1 |
p53
|
|
CT-1 is a DNA minor groove ligand and causes p53-dependent breast cancer cell apoptosis. |
T27579 |
ICL-CCIC-0019
|
ICL CCIC 0019 |
AChR
|
|
ICL-CCIC-0019 is an inhibitor of choline kinase alpha (ChoKα). ICL-CCIC-0019 induces G1 arrest, endoplasmic reticulum st... |
T41248 |
Thiocolchicine
|
|
Microtubule Associated
|
|
Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchi... |
TQ0138 |
K145 hydrochloride
|
|
Apoptosis
,
S1P Receptor
|
|
K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM. |
T40130 |
Nur77 modulator 1
|
|
Others
|
|
Nur77 modulator 1 is a good Nur77 binder (KD = 3.58 μM). Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-c... |
T9712 |
PF07104091
|
PF-07104091 |
CDK
|
|
PF-07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation. |
T60217 |
TAS1553
|
|
Others
|
|
TAS1553 is a potent, orally active protein–protein interaction (PPI) inhibitor with an IC 50 values of 0.0396 μM. TAS155... |
T11820 |
LAT1-IN-1
|
BCH |
Apoptosis
,
Others
|
|
LAT1-IN-1 (BCH) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppre... |
T11052L |
Disitertide acetate
|
Disitertide acetate(272105-42-7 Free base) , P144 acetate |
TGF-beta/Smad
|
|
Disitertide acetate is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block th... |
T5715 |
(E)-Flavokawain A
|
FLAVOKAVAIN A(P) |
P450
,
Apoptosis
|
|
Flavokavin A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protei... |
T39823L |
Apelin-12 acetate
|
|
Apelin receptor
,
p38 MAPK
,
JNK
|
|
Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 ... |