4-methylumbelliferyl-a-l-iduronide

4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure the activity of α-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis.

RSV L-protein-IN-4 (Compound C) is a noncompetitive inhibitor of the RSV polymerase with an IC50 of 0.88 μM. It demonstrates potent antiviral activity against RSV strains, with an EC50 of 0.25 μM [1].

4-Methylumbelliferyl β-D-N,N'-diacetylchitobioside (4-μU-(GlcNAc)2) is a fluorogenic substrate for chitinases and chitobiosidases. 4-μU-(GlcNAc)2 is cleaved by chitinases and chitobiosidases to release the fluorescent moiety 4-μU. 4-μU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.

4-Chloro-L-phenylalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis.4-Chloro-L-phenylalanine is also a non-specific antagonist of tryptophan hydroxylase (TPH1 and TPH2).

Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside (Compound 12), a cardiac glycoside extracted from Thevetia peruviana seeds, exhibits cytotoxic effects on SW1990 and MGC-803 cells with IC50 values of 9.52 and 7.70 μM, respectively [1].

2-Desoxypleniradin-4-O-α-L-rhamnopyranoside, a flavonoid, can be isolated from Helenium radiatum [1].

Ellagic acid 4-O-α-L-arabinopyranoside, extracted from Dimocarpus longan Lour. (syn. Euphoria longan Lam.), exhibits antioxidative activity [1].

cis-L-Hydroxyproline inhibits the synthesis and extracellular deposition of collagen. The growth inhibition of pancreatic cancer cells induced by the Hyp isomer could be due to endoplasmatic reticulum stress.

4-Aminophenyl 6-deoxy-α-L-mannopyranoside is a glycoside isolated from the seeds of Camellia oleifera.

L-Aspartic Acid 4-Benzyl Ester is a chelating agent that forms stable complexes with metal ions. It has been used to study the effect of metal ions on enzyme activity and to investigate the role of metal ions in the regulation of gene expression.

N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction[2].

Compound 1, (25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside, is a steroidal saponin that can be isolated from the roots of Ophiopogon japonicus [1].

4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside (compound 3), a natural anticancer agent extracted from Lilium regale, exhibits potent inhibitory effects on the proliferation of A549 lung cancer cells and holds promise for applications in cancer research [1].

L-4-Oxalysine hydrochloride has shown antitumor activities, is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China.

Methyl ((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-L-valinate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65280 and the CAS number is 482577-59-3.

Methyl cis-4-Hydroxy-L-proline Hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65222 and the CAS number is 40126-30-5.

1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(4-methyl)benzoyl-L-ribofuranose is a useful organic compound for research related to life sciences and the catalog number is TNU1138.

1-(3',5'-dimethoxy)phenyl-2-[4''-O-β-D-glucopyranosyl (6→1)-O-α-L-rhamnopyranosyl]phenylethane showed cytotoxic activities to Hela and hep2 cell lines.

N-Boc-cis-4-hydroxy-L-proline is a useful organic compound for research related to life sciences. The catalog number is T66248 and the CAS number is 87691-27-8.

Algestone is a synthetic dihydroxy derivative of Progesterone, wherein the acetonide group possesses anti-inflammatory properties.

4-Methylumbelliferyl caprylate (MUCAP) is a fluorogenic substrate for C8 esterase. MUCAP is cleaved by C8 esterase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.

4-Fluoro-L-Phenylalanine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67672 and the CAS number is 64231-54-5.

3-O-methylellagic acid 4'-O-alpha-L-rhamnopyranoside is a natural product for research related to life sciences. The catalog number is TN6494 and the CAS number is 51768-39-9.

4-Amino-L-phenylalanine is an endogenous metabolite.

Boc-L-aspartic acid 4-benzyl ester (Boc-Asp(OBzl)-OH) is an aspartic acid derivative.

Cyclo(L-Phe-trans-4-hydroxy-L-Pro) (Cyclo(L-phenylalanyl-trans-4-hydroxy-L-proline)) is a natural product found in Phellinus igniarius.

4-Azido-L-phenylalanine hydrochloride (p-Azido-L-phenylalanine hydrochloride) is an unnatural amino acid used as an effective vibrational reporter of local protein environments.

4-Methylumbelliferyl β-D-glucuronide is a useful organic compound for research related to life sciences. The catalog number is T65323 and the CAS number is 6160-80-1.

4-(Trifluoromethyl)-L-phenylalanine is a useful organic compound for research related to life sciences and the catalog number is T65695.

4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a fluorogenic substrate for β-hexosaminidases. Upon enzymatic cleavage by β-hexosaminidases, 4-methylumbelliferone (4-μU) is released and its fluorescence can be used to quantify β-hexosaminidase activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside has been used to quantify β-hexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses such as Tay-Sachs disease, which is characterized by defects in the α subunit of β-hexosaminidase.

Genistein 7-O-beta-D-glucopyranoside-4'-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside] is a natural product

4-Methylumbelliferyl-β-D-N,N',N''-triacetylchitotrioside is a fluorogenic substrate for chitinases and chitotriosidases. 4-Methylumbelliferyl-β-D-N,N',N''-triacetylchitotrioside is cleaved by chitinases and chitotriosidases to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. It has been used to screen plasma samples for reduced chitotriosidase activity that may be indicative of lysosomal storage disorders.

4-Methylumbelliferyl-β-D-Glucopyranoside (4-MU-GLU) is used in the GCase activity assay based on the catalytic hydrolysis of 4-methylumbelliferyl β-D-glucopyranoside that releases the highly fluorescent 4-methylumbelliferyl (4-MU).

4-Methylumbelliferyl-α-D-glucopyranoside serves as a fluorogenic substrate for α-glucosidase, used in enzymatic assays. This compound undergoes cleavage by α-glucosidase, releasing 4-methylumbelliferyl (4-MU), a compound whose fluorescence intensity varies with pH. Specifically, 4-MU exhibits excitation peaks at 320 nm and 360 nm in acidic (pH 1.97-6.72) and alkaline environments (pH 7.12-10.3), respectively, and its emission peak ranges between 445 nm and 455 nm, with brightness increasing as the pH drops. Utilizing these properties, 4-Methylumbelliferyl-α-D-glucopyranoside has been effectively applied in the measurement of α-glucosidase activity within infant blood spot samples, acting as a diagnostic marker for Fabry and Pompe diseases. These illnesses are types of lysosomal storage disorders caused by α-glucosidase enzyme deficiency.

Cyclo(L-Leu-trans-4-hydroxy-L-Pro) is a natural product from Phellinus igniarius.

N-(4-Aminobenzoyl)-L-glutamic acid is an oxidation product and a metabolite of tetrahydrofolate.1Levels of N-(4-aminobenzoyl)-L-glutamic acid are increased in the plasma of mice fed a high folic acid-containing diet.2 1.Reed, L.S., and Archer, M.C.Oxidation of tetrahydrofolic acid by airJ. Agric. Food Chem.28(4)801-805(1980) 2.Burton, M.A., Antoun, E., Penailillo, R.S., et al.Folic acid induces intake-related changes in the mammary tissue transcriptome of C57BL/6 miceNutrients12(9)2821(2020)

N-Boc-4-(trifluoromethyl)-L-phenylalanine is a useful organic compound for research related to life sciences. The catalog number is T65536 and the CAS number is 114873-07-3.

6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]cyclosporin A is a useful organic compound for research related to life sciences and the catalog number is T64488.

4-Borono-L-phenylalanine has antitumor activity and may be used in clinical trials of boron neutron capture therapy for the treatment of melanoma and glioblastoma multiforme.

4-Methylumbelliferyl-α-D-Galactopyranoside (4MU-α-Gal) (4-MU-α-Gal) is a fluorogenic substrate of α-galactosidase. In addition to its use in characterizing novel α-galactosidases, 4-MU-α-Gal is used in assays to evaluate deficiency in α-galactosidase activity related to Fabry disease.

4-Iodo-N-[(phenylmethoxy)carbonyl]-L-phenylalanine is a useful organic compound for research related to life sciences. The catalog number is T66874 and the CAS number is 220400-04-4.

Fmoc-L-(4-thiazolyl)-Alanine is a useful organic compound for research related to life sciences and the catalog number is T65194.

cis-4-Hydroxy-L-proline hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65954 and the CAS number is 441067-49-8.

Otophylloside B 4'''-O-alpha-L-cymaropyranoside is a natural product for research related to life sciences. The catalog number is TN4719 and the CAS number is 171422-82-5.

L-Proline 4-methoxy-β-naphthylamide hydrochloride, also known as H-Pro-4MβNA hydrochloride, is a chemical compound utilized in the preparation of Fap-activated anti-tumor compounds.

4-Methylumbelliferyl-β-D-xylopyranoside (4-Methylumbelliferyl-β-D-xyloside) exhibits bursting steady-state kinetics in biological experiments, which supports the conclusion of rapid hydrolysis of the glycosidic bond of the substrate 4-Methylumbelliferyl-β-D-xylopyranoside 4-Methylumbelliferyl-β-D-xylopyranoside can be used for β- xylosidase activity studies.

Qingyangshengenin 3-O-α-L-cymaropyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside is a natural product for research related to life sciences. The catalog number is TN5301 and the CAS number is 1808159-02-5.

4-Azido-L-phenylalanine (p-Azido-L-phenylalanine) is an amino acid derivative that acts as a photoaffinity marker and can be used to detect localized protein environments.