5-hydroxy diclofenac

5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4. Diclofenac is a non-selective COX inhibitor. It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 μM, respectively. Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.

Methyl 5-hydroxy-1H-indole-3-carboxylate (5-hydroxy-1H-indole-3-carboxylic acid methyl ester) is a marine derived natural products found in Hyrtios erectus.

5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. 5-Hydroxy-1-methylhydantoin is a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. 5-Hydroxy-1-methylhydantoin inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that 5-Hydroxy-1-methylhydantoin may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.

5-Hydroxy-7-acetoxy-8-methoxyflavone is a flavonoid compound that inhibits lipid peroxidation and may have anti-influenza virus activity.

5-hydroxy-3,7-dimethoxy-2-phenylchromen- (4H-1-Benzopyran-4-one, 5-hydroxy-3,7-dimethoxy-2-phenyl-),a natural product obtained from the resinous exudate of Heliotropium huascoense.

4-Hydroxy-5-methyl-3-furanone (4-Hydroxy-5-methylfuran-3(2H)-one) is a natural product isolated from Eurycotis floridana.

Compound 5936-0108 may has modulationg effect on β-Amyloid.

2-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate is a pro-neurotropic drug used to enhance cognitive function by increasing the synthesis and release of acetylcholine in the brain as well as by inhibiting the breakdown of acetylcholine by acetylcholinesterase.

Pyrazinecarboxamide, 3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo- is a useful organic compound for research related to life sciences. The catalog number is TNU0422L and the CAS number is 356783-01-2.This compound is unstable in powder form and other related salt forms are recommended.

7-Hydroxy-5-methoxycoumarin, a phloroglucinol-type furocoumarin, serves as a potent natural insect antifeedant [1].

2-((1R,2R)-2-Formyl-1,3,3-trimethylcyclohexyl)-4-hydroxy-5-isopropylbenzaldehyde is a naturally occurring compound [1].

(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one is a sesquiterpene lactone featuring a complex bicyclic structure [1].

5-hydroxy Thiabendazole (5-OH TBZ) is a major metabolite of the anthelmintic thiabendazole . Unlike thiabendazole, 5-OH TBZ has no effect on the growth of third-stage A. caninum larvae.

3-Hydroxy-4',5-dimethoxystilbene is a natural product of Dracaena, Liliaceae. The catalog number is TN2941 and the CAS number is 58436-29-6. 3-Hydroxy-4',5-dimethoxystilbene can be used as a reference standard.

3-(2,4-Dihydroxybenzyl)-5-hydroxy is a natural product for research related to life sciences. The catalog number is TN2848 and the CAS number is 149180-48-3.

3,6-Dibenzyl-2-hydroxy-5-methoxypyrazine is a natural product for research related to life sciences. The catalog number is TN2905 and the CAS number is 132213-65-1.

5-Hydroxy-canthin-6-one is a natural product for research related to life sciences. The catalog number is TN3122 and the CAS number is 64118-73-6.

5-hydroxy Omeprazole is a major metabolite of omeprazole , an inhibitor of the gastric H+/K+-ATPase pump.[1] 5-hydroxy Omeprazole is produced from omeprazole by the action of cytochrome P450 (CYP) isoform 2C19, a monooxygenase. [2][3] CYP2C19 polymorphisms significantly influence the metabolism of omeprazole, and individuals may be classified as homozygous extensive metabolizers, heterozygous extensive metabolizers, and poor metabolizers.[1]

2-(4-Hydroxy-3-methoxyphenyl)-7-methoxy-5-benzofuranpropanol is a natural product for research related to life sciences. The catalog number is TN5407 and the CAS number is 144735-57-9.

4-Hydroxy-1,10-secocadin-5-ene-1,10-dione is a natural product of Casearia, Flacourtiaceae. The catalog number is TN3031 and the CAS number is 226904-40-1. 4-Hydroxy-1,10-secocadin-5-ene-1,10-dione can be used as a reference standard.

5-alpha-Hydroxy-Laxogenin is an stress hormone cortisol inhibitor

5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) is a pancreatic lipase inhibitor, it shows antihyperlipidemic activity.

7-Hydroxy-5-methylflavon is a natural product for research related to life sciences. The catalog number is TN3233 and the CAS number is 15235-99-1.

5-Hydroxy-1,7-bis(4-hydroxyphenyl)heptan-3-yl acetate is a natural product for research related to life sciences. The catalog number is TN3115 and the CAS number is 1269839-24-8.

2'-Hydroxy-5'-methoxyacetophenone (5-Methoxy-2-hydroxyacetophenone) is an active biochemical.

5-hydroxy Propranolol is a metabolite of propranolol , a β-adrenergic receptor antagonist. Propranolol is primarily metabolized in the liver, with cytochrome P450 isoform 2D6 directing ring hydroxylation and the generation of 5-hydroxy propranolol and related metabolites.

5-hydroxy Flunixin is a metabolite of the COX inhibitor flunixin .1 1.Daeseleire, E., Mortier, L., De Ruyck, H., et al.Determination of flunixin and ketoprofen in milk by liquid chromatography-tandem mass spectrometryAnal. Chim. Acta488(1)25-34(2003)

1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one shows strong inhibition of collagen-induced, arachidonic acid-induced, and adenosine diphosphate-induced platelet aggregation of human whole blood.

5-Hydroxy-1,7-diphenylhept-6-en-3-one is a natural product for research related to life sciences. The catalog number is TN6357 and the CAS number is 155239-30-8.

5'-hydroxy Meloxicam is one of the metabolites of meloxicam (MEL).

5-hydroxy-Nω-methyl Tryptamine is a metabolite of serotonin in humans that has also been found in plants. It is an agonist of the 5-HT receptor subtype 5-HT7 (IC50 = 23 pM in a radioligand binding assay). 5-hydroxy-Nω-methyl Tryptamine increases intracellular cyclic AMP production in HEK293 cells expressing 5-HT7 (EC50 = 22 nM). It inhibits serotonin uptake in HEK293 cells expressing human serotonin transporters (IC50 = 490 nM). Elevated levels of urinary 5-hydroxy-Nω-methyl tryptamine have been found in patients with schizophrenia, depression, and epilepsy.

5-Hydroxy-2′,3,4′,7-tetramethoxyflavone shows weak ABCG2 inhibitory potency with IC50s of 3.27 and 3.89 µM in the Hoechst 33342 and pheophorbide A assays.

5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine . It is formed from (S)-duloxetine via a 5- or 6-hydroxy duloxetine intermediate, which is formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6, and a catechol duloxetine intermediate. 5-hydroxy-6-methoxy (S)-Duloxetine binds to the serotonin (5-HT), norepinephrine, and dopamine transporters with Ki values of 266, 920, and 2,814 nM, respectively.

5-Hydroxy-3,6,7,4'-tetramethoxyflavone is a natural product for research related to life sciences. The catalog number is TN6143 and the CAS number is 14787-34-9.

(R)-5-Hydroxy-1,7-diphenylheptan-3-one ((5R)-Dihydroyashabushiketol) is extracted from the rhizomes of Alpinia officinarum, a Chinese medicinal herb. (R)-5-Hydroxy-1,7-diphenylheptan-3-one inhibits melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.

8-Hydroxy-3,5,7,3',4',5'-hexamethoxyflavone is a natural product for research related to life sciences. The catalog number is TN3279 and the CAS number is 202846-95-5.

5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole acts as a competitive inhibitor at the Qo site of the cytochrome bc1 complex (cytochrome c oxidoreductase) in Saccharomyces cerevisiae [1].

ETHYL 5-HYDROXY-2-METHYLINDOLE-3-CARBOXYLATE is useful for preparation and study of hypoxia-selective cytotoxicity of indolequinone antitumor agents.

5-Hydroxy-7-methoxy-6-methylflavone is a useful organic compound for research related to life sciences and the catalog number is T131521.

Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone is a neuroprotective agent that exhibits marked neuroprotective activity by mitigating glutamate-induced neurotoxicity in primary rat cortical cell cultures [1].

Compound 1, (2,4,6-Trichloro-3-hydroxy-5-methoxyphenyl)methyl β-D-glucopyranoside, is a chlorophenyl glycoside extractable from Lilium regale, a species utilized in lung ailment research [1].

5-Hydroxy-7-methoxy-3-(4-hydroxybenzylidene)chroman-4-one is a natural product for research related to life sciences. The catalog number is TN3121 and the CAS number is 259653-54-8.

5-Hydroxy-3-(4-hydroxybenzyl)-7-methoxychroman-4-one is a natural product of Agave, Amaryllidaceae. The catalog number is TN3072 and the CAS number is 108001-32-7. 5-Hydroxy-3-(4-hydroxybenzyl)-7-methoxychroman-4-one can be used as a reference standard.

3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide is a natural product of Xanthium, Asteraceae. The catalog number is TN2939 and the CAS number is 1093207-99-8. 3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide can be used as a reference standard.

3β-hydroxy-5-Cholestenoic Acid is one of the metabolites of cholesterol found in high concentrations (40-80 ng/ml) in human circulation.

8-Hydroxy-5-O-beta-D-glucopyranosylpsoralen is a natural product of Psoralea, Fabaceae. The catalog number is TN3281 and the CAS number is 425680-98-4. 8-Hydroxy-5-O-beta-D-glucopyranosylpsoralen can be used as a reference standard.

5-hydroxy Indomethacin is a metabolite of indomethacin .1It is formed from indomethacin in rabbit hepatic microsomes. 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism in isolated neonatal and fetal rabbit hepatocytesPediatr. Res.15(11)1406-1410(1981)

Benzaldehyde, m-hydroxy-, (5-nitro-2-pyridyl)hydrazone is a bioactive chemical.

5-(1-Hydroxy)(methoxycarbonyl)methyl uridine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside; Naturally modified ribo-nucleoside.

4'-Hydroxydiclofenac is a diclofenac metabolite.