1,2-diaminocyclohexane

(1R,2R)-(-)-1,2-Diaminocyclohexane ((1R,2R)-Cyclohexane-1,2-diamin) has anticancer and antitumor activity and can be used to study malignant tumors.

1-Phenyl-1, 2-ethanediol is O-benzyl oxime ether derivatives and used as pesticides.

1-Phenylpropane-1,2-dione (Acetyl benzoyl) is a eukaryotic metabolite produced in plant metabolic reactions.

2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv showed high local anti-inflammatory potency and high lung selectivity when tested on Sprague Dawley rats.

(1R,2R)-Trans-N-Boc-1,2-Cyclohexanediamine (N-Boc-trans-1,2-diaminocyclohexane) is an intermediate in organic synthesis.

4,4'-(Cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-2-carbaldehydE) is a useful organic compound for research related to life sciences and the catalog number is T64484.

threo-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol is a natural product for research related to life sciences. The catalog number is TN5142 and the CAS number is 848031-94-7.

4-(1-Ethoxy-2-hydroxyethyl)benzene-1,2-diol is a useful organic compound for research related to life sciences and the catalog number is T126255.

(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol, an active compound found in the aerial parts of Angelica sinensis, exhibits significant anti-growth properties against Aeromonas hydrophila and possesses anticoagulative and antibiotic activities [1].

(2S,4R)-1-((9H-Fluoren-9-yl)methyl) 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate, with catalog number T66076 and CAS number 122350-59-8, is a valuable organic compound for life sciences research.

4-C-(Iodomethyl)-1,2-di-O-(1-methylethylidene)-3,5-bis-O-(phenylmethyl)-a-D-ribofuranose is a Carbohydrate Derivative.

4-Fluorobenzo[c][1,2]oxaborol-1(3H)-ol is a useful organic compound for research related to life sciences. The catalog number is T64514 and the CAS number is 174671-88-6.

(S)-1-Benzyl 2-tert-butyl pyrrolidine-1,2-dicarboxylate is a useful organic compound for research related to life sciences. The catalog number is T65611 and the CAS number is 16881-39-3.

erythro-1-Phenylpropane-1,2-diol is a natural product for research related to life sciences. The catalog number is TN4002 and the CAS number is 40421-52-1.

β-Aflatrem is a natural product of Chloranthus, Chloranthaceae. The catalog number is TN2486 and the CAS number is 20133-19-1. β-Aflatrem can be used as a reference standard.

4-(2-Hydroxy-1-methoxyethyl)-1,2-benzenediol, a natural product (catalog number: TN3001, CAS number: 577976-26-2), is used for research in life sciences.

1-tert-Butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate is a useful organic compound for research related to life sciences. The catalog number is T66754 and the CAS number is 251924-83-1.

(S)-1-Benzyl 2-methyl pyrrolidine-1,2-dicarboxylate is a useful organic compound for research related to life sciences. The catalog number is T65353 and the CAS number is 5211-23-4.

N-(1-((6aR,8R,9aR)-9-Cyano-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide is a useful organic compound for research related to life sciences and the catalog number is T67388.

1,2-Epoxy-1-hydroxymethylpyrrolizidine is a useful organic compound for research related to life sciences and the catalog number is T125765.

erythro-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol is a natural product for research related to life sciences. The catalog number is TN4001 and the CAS number is 1280602-81-4.

Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Via generating a transcriptionally active complex with β-catenin, CREB acts as a mediator of Wnt signaling.ICG-001 is an inhibitor of β-catenin/CREB mediated transcription. The direct cellular target of ICG-001 is CREB. the inhibitory IC50of ICG-001 against β-catenin/CREB mediated transcription was 3 μM. ICG-001 treatment at the concentration of 25 μM for 24h significantly increased caspase activity in both colon cancer cell lines SW480 and HCT116 cell lines but not in normal colonic epithelial cells CCD-841Co. In a cell growth inhibition assay, the IC50s of ICG-001 against SW480 and HCT116 cells were 4.43 μM and 5.95 μM, respectively.In a SW620 nude mouse xenograft model, an water-soluble analog of ICG-001 given at the dose of 150 mg/kg i.v. once in every 2 days dramatically suppressed tumor growth. In a bleomycin-induced pulmonary fibrosis mice model, ICG-001 given at the dose of 5 mg/kg per day reversed pulmonary fibrosis. In a rat myocardial infarction model, ICG-001 was administrated subcutaneously at the dose of 50 mg/kg/day for 10 days which significantly improved cardiac contractile function after myocardial infarction in the rats.

(S)-1-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate, with catalog number T66075 and CAS number 16217-15-5, is a valuable organic compound for life sciences research.

1-Benzyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate is a valuable organic compound for life sciences research [Catalog No. T65605, CAS No. 155075-23-3].